• Archives of Pharmacal Research
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• 제27권10호
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• pp.1037-1042
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• 2004

Study of the effects of the methanolic extract of Tagetes patula roots on blood pressure led to the isolation of well known citric (1) and malic acid (7) as hypotensive, and pyridine hydrochloride (4) as hypertensive constituents of the plant along with a new constituent, 2-hydroxy, 5- hydroxymethyl furan (9). Citric acid and malic acid caused 71% and 43% fall in Mean Arterial Blood Pressure (MABP) of rats at the doses of 15 mg/kg and 30mg/kg respectively while pyridine hydrochloride produced 34% rise in the MABP of rats at the dose of 30mg/kg. $LD_{50}\;and\;LD_{100}$ of citric acid in mice have been determined as 545 mg/kg and 1000 mg/kg, respectively.

• 한국식품과학회지
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• 제24권4호
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• pp.315-319
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• 1992

제주도 다원에서 생산된 녹차 생엽을 적채 시기별(1번차, 2번차, 3번차)로 혐기적으로 처리하여, ${\gamma}-aminobutyric$ acid(GABA) 및 기타 주요성분의 함량변화를 측정한 결과 차엽의 질소가스 치환처리 및 진공처리 모두 GABA와 alanine의 함량은 현저하게 증가한 반면에 glutamic acid는 현저하게 감소하였다. 또한 theanine, arginine, caffein 및 polyphenol의 함량은 거의 변화가 없었으며, vit.C의 함량은 혐기처리 시간의 경과에 따라 조금씩 감소하는 것으로 나타났다. 혈압강하작용 성분인 GABA의 생성량은 원엽의 아미노산의 함량, 특히 glutamic acid의 함량에 비례하였으며, 최적 혐기처리 시간은 약 12시간으로 나타났다. 한편, 차엽의 혐기적 처리조건에 있어서 질소가스 치환 처리와 진공처리 사이의 효과에 있어서의 차이는 거의 없었다.

• Preventive Nutrition and Food Science
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• 제15권1호
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• pp.14-18
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• 2010

Stevia rebaudiana (SR) is an herb used traditionally as a sweetener in Paraguay and Brazil, whose use is spreading to other countries, such as Japan, Korea and China. In addition to its low calorie sweet taste, SR appears to have other beneficial properties, such as hypotensive capabilities and inflammation reduction. To identify the bioactive natural constituents exerting anti-inflammatory activities, we examined the EtOAc fraction of SR. In the inflammatory mediator inhibitory assay from lipopolysaccharide (LPS)-activated macrophages, the EtOAc fraction significantly, and dose dependently, inhibited the enhanced production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression. We also found that treatment of cells with the EtOAc fraction significantly inhibited LPS-stimulated nuclear factor-${\kappa}B$ (NF-${\kappa}B$) reporter gene expression. Such inhibition of NF-${\kappa}B$ was closely associated with the inhibition of interleukin-6 (IL-6) and the monocyte chemoattractant protein-1 (MCP-1). Therefore, we suggest that SR has the potential for development as a functional food for the treatment of immune diseases, such as rheumatoid arthritis and lupus.