• Journal of Korean Society of Industrial and Systems Engineering
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• v.27 no.1
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• pp.109-120
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• 2004

In large scale complex system such as a nuclear power plant, it is important to select guidelines and/or checklist to evaluate the system performance, especially human performance for visual information while the number of evaluation items of the guidelines and checklist is voluminous. This paper presents the methodology and experiment for the relative weights or priority selection of evaluation items on the advanced information display of main control room in a nuclear power plant. To summarize this, 1) many human factors guidelines of Visual Display Terminal(VDT) displays are collected, 2) the collected guidelines are integrated and unified based on some rules in a way to avoid confusion or errors about work performances of operator groups, 3) using the unified guidelines, the more important items are defined when the advanced information indexes are applied by using the Analytic Hierarchy Process(AHP). For employing the AHP, the decisions and response of many human factors evaluation specialists in this field are collected to get the priority order of the evaluation items of VDT. The result of this paper will be applied for the evaluation of the usability of next generation of nuclear power plant which is focused on the visual information display on VDT.

• Biomedical Science Letters
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• v.14 no.2
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• pp.119-122
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• 2008

The baculovirus/insect cell expression system is of great value in the study of structure-function relationships in mammalian glucose-transport proteins by site-directed mutagenesis and for the large-scale production of these proteins for mechanistic and biochemical studies. In order to exploit this, the effects of substitution at the highly conserved residue glutamine 282 of the human erythrocyte-type glucose transporter have been examined by in vitro site-directed mutagenesis. The modified human transport protein has been expressed in Spodoptera frugiperda 21 cells by using the recombinant baculovirus AcNPV-GTL. To assess the functional integrity of the expressed transporter, measurements of the transport inhibitor cytochalasin B binding were performed, involving the membranes prepared from 4 days post infection with no virus, with wild-type virus or AcNPV-GTL virus. Data obtained showed that there was little or no D-glucose-inhibitable binding in cells infected with the wild type or no virus. Only the recombinant virus infected cells exhibited specific binding, which is inhibitable by D- but not by L-glucose. However, there was a notable reduction in the affinity for the potent inhibitor cytochalasin B when binding measurements of AcNPV-GTL were compared with those of AcNPV-GT, which has no substitution. It is thus suggested that although the modified and unmodified human transporters differed slightly in their affinity for cytochalasin B, the glutamine substitution did not interfere the heterologous expression of the human transporter in the insect cells.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.3
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• pp.1595-1613
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• 2017

The IR camera and laser-based IR projector provide an effective solution for real-time collection of moving targets in RGB-D videos. Different from the traditional RGB videos, the captured depth videos are not affected by the illumination variation. In this paper, we propose a novel feature extraction framework to describe human activities based on the above optical video capturing method, namely spatial-temporal texture features for 3D human activity recognition. Spatial-temporal texture feature with depth information is insensitive to illumination and occlusions, and efficient for fine-motion description. The framework of our proposed algorithm begins with video acquisition based on laser projection, video preprocessing with visual background extraction and obtains spatial-temporal key images. Then, the texture features encoded from key images are used to generate discriminative features for human activity information. The experimental results based on the different databases and practical scenarios demonstrate the effectiveness of our proposed algorithm for the large-scale data sets.

• International journal of advanced smart convergence
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• v.10 no.2
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• pp.86-96
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• 2021

This cross-sectional survey research carried out with the inquisitive agenda on satisfaction of the translation outcomes as performed by human translation and (machine translation) post-editing. The survey group consisted of 166 Korean translators primarily working with the English, Chinese, and Japanese languages. They were asked to rate the satisfactory level with accuracy, fluency, idiomatic expression, and terminology in the Richter's scale of four. The result reveals that human translation is more satisfactory than post-editing with respect to accuracy, but it is uneasy to assert that accuracy is unsatisfactory in post-editing. On the other hand, the Korean translators are less satisfied with fluency, idiomatic expression, and terminology than accuracy. It can be assumed that although human translation is more satisfactory than post-editing, the accuracy of post-editing seems to be more acknowledged than fluency, idiomatic expression, and terminology, which lead the translators to take the accuracy of raw machine-translation products and to go on to improve the fluency, idiomatic expression, and terminology. Nevertheless, Korean translators believe Korean idiomatic expressions cannot be satisfactorily produced in post-editing, while fluency and terminology can be improved in post-editing.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.2
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• pp.563-570
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• 2021

The importance of cooperative financial management is expected to be able to encourage the needs of the community especially towards the supervision of cooperatives and human resources. The study was conducted aiming to determine the effect of human resources, financial attitudes, and coordination on cooperative financial management. Research with quantitative methods. The study was conducted with multiple regression methods, while the sampling technique was based on a random sample of samples with the data collection method using a survey method in the form of a questionnaire that was measured with a Likert scale. The method of determining the research sample is done by calculating the Slovin formula, determining the research sample of 166 cooperatives in Buleleng Regency, Bali Province. The results of the research prove that partial human resources have a significant positive effect on cooperative financial management, financial attitude variables have a significant positive effect on cooperative financial management and coordination variables have a significant positive effect on cooperative financial management. The results of this study can be stated that the better the financial management of cooperatives, better will be the impact on cooperative growth so that the need for more competent resources in cooperative management.

• BMB Reports
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• v.50 no.11
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• pp.572-577
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• 2017

In most clinical applications, human mesenchymal stem cells (hMSCs) are expanded in large scale before their administration. Prolonged culture in vitro results in cellular senescence-associated phenotypes, including accumulation of reactive oxygen species (ROS) and decreased cell viabilities. Profiling of stem cell-related genes during in vitro expansion revealed that numerous canonical pathways were significantly changed. To determine the effect of selenocysteine (Sec), a rare amino acid found in several antioxidant enzymes, on the replicative senescence in hMSCs, we treated senescent hMSCs with Sec. Supplementation of Sec in the culture medium in late-passage hMSCs reduced ROS levels and improved the survival of hMSCs. In addition, a subset of key antioxidant genes and Sec-containing selenoproteins showed increased mRNA levels after Sec treatment. Furthermore, ROS metabolism and inflammation pathways were predicted to be downregulated. Taken together, our results suggest that Sec has antioxidant effects on the replicative senescence of hMSCs.

• BMB Reports
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• v.49 no.12
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• pp.662-670
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• 2016

The human oral cavity contains a highly personalized microbiome essential to maintaining health, but capable of causing oral and systemic diseases. Thus, an in-depth definition of "healthy oral microbiome" is critical to understanding variations in disease states from preclinical conditions, and disease onset through progressive states of disease. With rapid advances in DNA sequencing and analytical technologies, population-based studies have documented the range and diversity of both taxonomic compositions and functional potentials observed in the oral microbiome in healthy individuals. Besides factors specific to the host, such as age and race/ethnicity, environmental factors also appear to contribute to the variability of the healthy oral microbiome. Here, we review bioinformatic techniques for metagenomic datasets, including their strengths and limitations. In addition, we summarize the interpersonal and intrapersonal diversity of the oral microbiome, taking into consideration the recent large-scale and longitudinal studies, including the Human Microbiome Project.

• Interdisciplinary Bio Central
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• v.2 no.2
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• pp.3.1-3.4
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• 2010

In the present research, we assessed the utility of the structural information of drugs for predicting human in vivo intrinsic clearance from in vitro intrinsic clearance data obtained by human hepatic microsome experiment. To compare with the observed intrinsic clearance, human intrinsic clearance values for 51 drugs were estimated by the classical methods using in vivo-in vitro scale-up and by the new methods using the in vitro experimental data and selected molecular descriptors of drugs by the forward selection technique together. The results showed that taking consideration of molecular descriptors into prediction from in vitro experimental data could improve the prediction accuracy. The in vitro experiment is very useful when the data can estimate in vivo data accurately since it can reduce the cost of drug development. Improvement of prediction accuracy in the present approach can enhance the utility of in vitro data.

• Korean Journal of Human Ecology
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• v.13 no.6
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• pp.903-915
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• 2004

Now in Korea, many factors-for example, unemployment rate rise, consumer prices, corporate restructuring, etc.-are threatening family economy. Thus many households are faced with an economic crisis. In this circumstances, it is the role of households as a subsystem of family system to keep family and household economy stable for the sake of family growth and development. Economic well-being is differentiated by criterion of household economic status. But it has a large scale of spectrum: household income, asset, consumption, debt and the like. Moreover, these indices have been understood and measured differently by many researchers. In this thesis, we made efforts to distinguish subjective satisfaction from objective satisfaction, and then focus on the former. The data were collected from 399 housewives living in Pusan through questionnaires.

• Journal of Microbiology and Biotechnology
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• v.12 no.6
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• pp.916-920
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• 2002

This report describes a high-level expression of human alpha-2a interferon ($IFN{\alpha}-2a$) in Escherichia coli and its pilot scale purification by using a monoclonal antibody-independent chromatographic procedure that is based on anion-exchange, cation-exchange, hydrophobic interaction, and gel filtration. The recombinant E. coli produced much more $IFN{\alpha}-2a$ in a soluble form, when cultivated at low temperatures than at high-temperature fermentation. However, if the bacterial growth was taken into consideration, fermentation at $30^{\circ}C$ seemed optimal for the interferon production. By using our new protocol, we recovered approximately 160 mg of $IFN{\alpha}-2a$ with a specific activity of $3.59{\times}10^8$ IU/mg from 201 of the broth. The gel permeation chromatographic and SDS-PAGE indicated that the interferon preparation was purified to homogeneity and was of the correctly folded fast-migrating monomer.