• Journal of Life Science
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• v.34 no.4
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• pp.271-278
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• 2024

Redox factor (Ref)-1, a ubiquitously expressed protein, acts as a modulator of redox-sensitive tran- scription factors and as an endonuclease in the repair pathway of damaged DNA. However, the function of Ref-1 in the differentiation of monocytes into macrophages has not been defined. In this study, we investigated the effects of Ref-1 on the monocyte differentiation process using the human monocytic cell line THP-1. The differentiation agent PMA increased cell adhesion over time and showed a sig- nificant increase in phagocytic function but decreased the intracellular amount of Ref-1. Ref-1 inhibitor E3330 and Ref-1 knockdown using the siRNA technique reduced cell adhesion and the expression of differentiation markers, such as CD14, ICAM-1, and CD11b, by PMA stimulation. This means that the role of Ref-1 is absolutely necessary in the initial process of differentiating THP-1 cells stimulated by PMA. Next, the distribution of Ref-1 was examined in the cytoplasm and nucleus of THP-1 cells stimulated with PMA. Surprisingly, PMA stimulation resulted in the rapid translocation of Ref-1 to the nucleus. To prove that movement of Ref-1 to the nucleus is required for monocyte differentiation, a Ref-1 vector with the nuclear localization sequence (NLS) deleted was used. As a result, overexpression of ∆NLS Ref-1, which restricted movement to the nucleus, suppressed the expression of differentiation markers and notably reduced phagocytic function in PMA-stimulated THP-1 cells. In conclusion, these data suggest that the differentiation of monocytic THP-1 cells requires Ref-1 nuclear translocation during the initial process of biochemical events following stimulation from PMA.

• Korean Journal of Environment and Ecology
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• v.37 no.6
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• pp.429-438
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• 2023

The forest in the lower Tumen River serves as an important ecosystem spanning the territories of North Korea, Russia, and China, and it provides habitat and movement corridors for diverse mammals, including the endangered Amur tiger (Panthera tigris) and Amur leopard (Panthera pardus). This study focuses on the Mijiang area, situated as a potential ecological corridor connecting North Korea and China in the lower Tumen River, playing a crucial role in conserving and restoring the biodiversity of the Korean Peninsula. This study aimed to identify mammal species and estimate their relative abundance, occupancy, and distribution based on the 48 camera traps installed in the Mijiang area from May 2019 to May 2021. The results confirmed the presence of 18 mammal species in the Mijiang area, including large carnivores like tigers and leopards. Among the dominant mammals, four species of ungulates showed high occupancy and detection rates, particularly the Roe deer (Capreolus pygargus) and Wild boar (Sus scrofa). The roe deer was distributed across all areas with a predicted high occupancy rate of 0.97, influenced by altitude, urban residential areas, and patch density. Wild boars showed a predicted occupancy rate of 0.73 and were distributed throughout the entire area, with factors such as wetland ratio, grazing intensity, and spatial heterogeneity in aspects of the landscape influencing their occupancy and detection rates. Sika deer (Cervus nippon) exhibited a predicted occupancy rate of 0.48, confined to specific areas, influenced by slope, habitat fragmentation diversity affecting detection rates, and the ratio of open forests impacting occupancy. Water deer (Hydropotes inermis) displayed a very low occupancy rate of 0.06 along the Tumen River Basin, with higher occupancy in lower altitude areas and increased detection in locations with high spatial heterogeneity in aspects. This study confirmed that the Mijiang area serves as a habitat supporting diverse mammals in the lower Tumen River while also playing a crucial role in facilitating animal movement and habitat connectivity. Additionally, the occupancy prediction model developed in this study is expected to contribute to predicting mammal distribution within the disrupted Tumen River basin due to human interference and identifying and protecting potential ecological corridors in this transboundary region.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.31 no.2
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• pp.43-57
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• 2013

The purpose of this study is to identify potential semantic landscape makeup of "the Forty Eight Poems of Soswaewon" according to Yin-Yang and Five Elements Principle(陰陽五行論). that speculation system between human's nature and cosmical universal order. Existing academic discussions made so far concerning this topic can be summed up as follows: 1. Among Yin-Yang-based landscape makeups of the Forty Eight Poems of Soswaewon, poetic writings for embodiment of interactions between nature and human behaviors focused on depicting dynamic aspects of a poetic narrator when he appreciates or explores hills and streams as of to live free from worldly cares. Primarily, many of those writings were created on the east and south primarily through assignment of yang. On the other hand, poetic writings for embodiment of nature and seasonal scenery - as static landscape makeup of yin - were often created on or near the north and west for many times. Those writings focusing on embodiment of nature and artificial scenery as a work are divided into two categories: One category refers to author Kim In-hu's expression of semantic landscape from seasonal scenery in nature. The other refers to his depiction of realistic garden images as they are. In the Forty Eight Poems of Soswaewon, the poetic writings show that author Kim focused on embodying seasonal scenery rather than expressing human behaviors. In addition, both Poem No. 1 and Poem No. 48(last poem; titled 'Jangwon Jeyeong') were created in a same place, which author Kim sought to understand the place as a space of beginning and end where yin and yang - i.e. the principle of natural cycle - are inherent. 2. According to construction about landscape in the Forty Eight Poems of Soswaewon on the basis of Ohaeng-ron (five natural element principle), it was found that tree(木) and fire(火) are typical examples of a world combined by emanation. First, many of poetic writings depicting the sentiments of tree focused on embodying seasonal scenery and were located in the place of Ogogmun(五曲門) area in the east, from overall perspective of Soswaewon. The content of these poems shows generation and curve / straightness in flexibility and simplicity. Many of poems depicting the sentiments of fire(火) focused on embodying human behaviors, and they were created in Aeyangdan area on the south of Soswaewon over which sun rises at noon. These poems are all on a status of side movement that is characterized by emanation and ascension which belong to attributes of yang. 3. With regard to Ohaeng-ron's interpretation about landscape in the Forty Eight Poems of Soswaewon, it was found that metal(金) and water(水) are typical examples of world combined by convergence. First, it was found that all of poems depicting sentiments of metal focused on embodying seasonal scenery, and were created in a bamboo grove area on the west from overall perspective of Soswaewon. They represent scenery of autumn among 4 seasons to symbolize faithfulness vested in a man of virtue(seonbi) with integrity and righteousness. Poems depicting sentiments of water were created in vicinity of Jewoldang on the north, possibly topmost of Soswaewon. They were divided into two categories: One category refers to poems embodying actions of welcoming the first full moon deep in the night after sunset, and the other refers to poems embodying natural scenery of snowscape. All of those poems focused on expressing any atmosphere of turning into yin via convergence. 4. With regard to Ohaeng-ron's interpretation of landscape in the Forty Eight Poems of Soswaewon, it was found that poems depicting sentiments of earth(土), a complex body of convergence and emanation, were created in vicinity of mountain stream around Gwangpunggak which is located in the center of Soswaewon. These poems focused on carrying actions of author Kim by way of natural phenomena and artificial scenery.

• Journal of Sasang Constitutional Medicine
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• v.11 no.2
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• pp.1-26
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• 1999

This paper was written in order to understand each constitutional symptoms and diseases with two aspects. The first was to trace the courses to accomplish constitutional symptoms and diseases from that of oriented medicine through "Dongyi Bogam" and the original writing such as "Shanghanlun". The second was to analyze the constitutional diseases with Lee Je-ma's own recognition on human being and the society which was based on the "Dongyi Suse Bowon". The original concepts of 'The Interior Disease' and 'The Exterior Disease' were based on the Nature and the Emotion, the Environmental Frames and the Human Affairs, the Ears Eyes Nose Mouth and the Lung Spleen Liver Kidney. The exterior disease were caused by the abilities of ears to listen, eyes to see, nose to smell, and mouth to taste on the environmental frames which were related one's recognition to society. The interior diseases were caused by the abilities of lung to study, spleen to ask, liver to think, kidney to judge on human affairs which were related the relationship between me and others. So the titles of constitutional diseases were named by these views on his first writing of "Dongyi Suse Bowon" in 1894. So the titles of Taeyangin diseases, 'The lumbar Vertebae Disease Induced by Exopathogen' and 'The Small Intestine Disease Induced by Endopathogen' were still remained as the first writing. But the titles of constitutional diseases were rewritten such as present titles in 1900. In order to express pathology and mechanism of constitutional diseases exactly, he rewrote titles which contained the manifestation sites of diseases, and the symptoms of febrile and cold, and the different congenital formations of organs. The exterior diseases and interior diseases had three characteristics. The first was that the exterior disease injured by the nature which had a tendency to progress slowly and the interior disease injured by the emotion which had a tendency to progress rapidly. The second was not that the interior disease and the exterior disease were separated, but that one influenced the other and these were revealed as a disease together when the diseases continued for a long time. The third was that even though the disease caught together it was included the beginning disease. The symptoms in ordinary times was the origin and clue to recognize the constitutional symptoms and diseases. It enabled to establish the constitutional medicine which treated by different ways according to constitution. It had two characteristics which were different from the Traditional Chinese Medicine in appearance of diseases. The first was that the disease was progressed to the next step from the symptoms in ordinary times. The second was that each constitution had different symptoms which were due to symptoms in ordinary times under the same disease, The third was the manifestation of disease were different from symptoms in ordinary times in the same constitution. But the most important thing was that Lee Je-ma recognized these symptoms in ordinary times as four categories and he presented constitutional symptoms and constitutional disease. The four categories were the method to recognize the human being and the diseases for him As the symptoms and diseases of Sasang Constitutional Medicine were compared to Traditional Chinese Medicine, the constitutional diseases of "Dongyi Suse Bowon" could be classified into two groups. The first group was the unique diseases and symptoms, which were not in the Traditional Chinese Medicine, and which were established by the Lee Je-ma. These contained the diseases of taeyangin, the exterior disease of taeumin, the exterior disease of soyangin. The second group used the unique methods to treat disease, which were not in Traditional Chinese Medicine, and which were established by Lee Je-ma. This contained the interior disease of taeumin, the delirium diseases from the MangYin of soyangin, the treatment to help the Yang-Qi ascend and to supplement the ql In the exterior disease of soeumin. Especially, the diseases of taeyangin and taeumin which were caused by the metabolism disorders of Qi-Yack(氣液) were the great achievement to establish constitutional symptoms and diseases. The discourse of taeyangin diseases presented his original thought to recognize the symptoms and diseases through the Shin Gi Hyul Jeong(神氣血精) and the Qi-Yack, the discourse of taeumin diseases presented the disperse of Qi-Yack through the forward and backward of sweat, the discourse of soyangin disease presented the sweat of hand and feet which was manifested that yin-qi of spleen descended to yin qi of kidney, and the bowel movement which was manifested that yang qi of large intestine ascend to head, face and four extremities, the discourse of soeumin disease presented the Jueyin syndrome without the abdominal pain and diarrhea as the exterior disease and made importance to the nervous mind And the classification of exterior diseases and interior diseases were not due to the pharmacology but due to the symptoms and diseases according to the constitution.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.46 no.3
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• pp.75-88
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• 2009

This paper presents a video quality assessment method based on quality degradation factors of real-time multimedia streaming services. The video quality degradation is caused by video source compression and network states. In this paper, we propose a blocky metric on an image domain to measure quality degradation by video compression. In this paper, the proposed boundary strength index for the blocky metric is defined by ratio of the variation of two pixel values adjacent to $8{\times}8$ block boundary and the average variation at several pixels adjacent to the two boundary pixels. On the other hand, unnatural image movement caused by network performance deterioration such as jitter and delay factors can be observed. In this paper, a temporal-Jerkiness measurement method is proposed by computing statistics of luminance differences between consecutive frames and play-time intervals between frames. The proposed final Perceptual Video Quality Metric (PVQM) is proposed by consolidating both blocking strength and temporal-jerkiness. To evaluate performance of the proposed algorithm, the accuracy of the proposed algorithm is compared with Difference of Mean Opinion Score (DMOS) based on human visual system.

• Korean Journal of Environment and Ecology
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• v.26 no.3
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• pp.297-312
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• 2012

This study was carried out to investigate the flora of Mt. Seoungma (Gyeonggi-do). The vascular plant were collected 13 times (from March to October 2011), and 384 taxa in total were identified, including 94 families, 260 genera, 340 species, 5 subspecies, 37 varieties and 2 forms. Korean endemic plants of this area were nine taxa; Clematis brachyura, Rhododendron mucronulatum, Forsythia koreana, Paulownia coreana, etc. Rare plants (IUCN) by the Korean Forest Service and Korean National Arboretum three taxa were recorded; one Critically Endangered species (CR), Prunus yedoensis, one Vulnerable species (VU), Epimedium koreanum, one Least Concemed species (LC), Phacelurus latifolius. The floristic regional indicator plants found in this area were 15 taxa comprising two taxa of grade V and III, one taxa of grade II, 10 taxa of grade I. Furthermore, therophytes (28.3%), hemicryptophytes (23.0%), hydrophytes (14.3%) showed high proportional ratio in life form spectrum. The naturalized plants were identified as 43 taxa and the percent of naturalized index (NI) was 11.2% of total 384 taxa vascular plants. The vegetation status of investigated area was comparatively well conserved, but the degree of damage was increasing rapidly by the disturbances of human beings. Therefore, a long-term monitoring of vegetation changes and movement grasp must become accomplished.

• The Journal of Fisheries Business Administration
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• v.24 no.1
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• pp.65-86
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• 1993

In this paper, fishery economics is reviewed to extend a basic opportunity for developing new fishery economics and to evaluate the effects of the import liberalization on the fish trade structure of Korea. The principle outline of extensions emphasis to realize the modern fishery problems based on fishery economics and develop the practical methodology in order to analyze the impacts of the import liberalization on the fishery and fishermen welfare. During the process of export - oriented industrilization, the role and position of fishery in the economy is changed dynamically. When faced with the imperative of the role and position of fishery in the economy, fishery economists and domestic policy makers must decide how to organize themselves for solving fishery problems under the new regime in the import liberalization on the fish trade. Fishery problems impacted by the new regime can not be solved by fishery itself but be solved by the centralized efforts of all contributors in national views. Therefore the new systematic analytical methodology must be develop and the traditional fishery economics must be related to the regional development strategy and fishery sociology as subsidiary theories specialized. Due to the impacts of the import liberalization on the fish trade structure, fishery economists face with radical changes in the domestic fishery : a place of the resources harvest to place of the combination resource harvest and its demand, a fishing as a resource exploitation to a fishing as a resource management, a traditional small scale costal fishing to a modernized and scaled fishing, fishery using the given natural resource itself to fishery as technology intensive industry, and a food supply industry to a welfare indusry based on the regional and economic resource and social environment. As these changes, fishery and its community's regional and economic resource and social environments as multiple roles of the regional economic development are emphasized in fishery economics under the new regime in the import liberalization on the fish trade. Furthermore, domestic policy makers and administrators in a public sector must realize the above radical changing trends in fishery and understand a social and economic environment in fishery and develop a new fishery structure focusing on the fishing system and the fishery laws. As this point, they make efforts to improve and develop fishery as a food supply industry. Japan, for example, has a non - governmental organization to conflict the problem of international fishery such as a movement of a civil environmental protection. Also fishermen in Japan already realized conservation and pollution problems in fishing as fundamental issues of human being.

• Journal of Korean Medical Ki-Gong Academy
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• v.15 no.1
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• pp.109-136
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• 2015

Objects : The purpose of this study is to investigate the effect of Su-Gi therapy for Bell's palsy by using Y-system(Yanagihara's unweighted grading system). Methods : We investigated 25 patients with Bell's palsy who had visited in the M, H Korean medicine hospital in Gyeonggi Province from December 27th, 2010 to April 8th, 2015. The Su-Gi therapy was done by 1 times daily. And each patients had been treated more than 25 days. We evaluated the change of them by using Y-system. Results : 1. We investigated 25 patients with Bell's palsy. 80% of the patients were females(20 patients), 20% of the patients were male(5 patients). The average age of patients was 47±15.15. The average period of Adm. treatment was 64% of the patients(16 patients) have left facial palsy, 36% of the patients(9 patients) have right facial palsy. 2. The mean Y-system score before treatment was 17.80±6.2, and the mean score after 25th days treatment was 33.68±4.0. Changes in the mean Y-system Score for each case according to the treatment days was increased significantly. 3. The mean Y-system score after 4th days treatment had increased by an 1.24±2.7 as compared to before treatment, the score after 10th days treatment was 8.7±4.7, the score after 14th days treatment was 11.84±5.8, the score after 20th days treatment is 14.72±6.7, and the score after 25th days treatment was 15.88±6.9. Every score was significantly increased. Conclusions: 1. Su-Gi therapy can be defined that is mainly using the hands to touch or movement of the human body skin, meridians and acupuncture points, muscles, joints and so on. And that is the treatment to communicate and harmonize to the meridians and acupuncture points, and to prevent of diseases, and to keep health. 2. All names of An-Gyo, An-Ma, Jum-Hyul, Chu-Na, massage, and so on should be referred to as Su-Gi therapy. And that individual names are to be classified and separated as the type or method of Su-Gi therapy. 3. The results of the treatment of Hwidam's Su-Gi therapy for Bell's palsy by using Y-system were significant.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.46 no.6
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• pp.7-17
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• 2009

The precise analysis of exercise data for designing an effective rehabilitation system is very important as a feedback for planing the next exercising step. Many subjective and reliable research outcomes that were obtained by analysis and evaluation for the human motor ability by various methods of biomechanical experiments have been introduced. Most of them include quantitative analysis based on basic statistical methods, which are not practical enough for application to real clinical problems. In this situation, data mining technology can be a promising approach for clinical decision support system by discovering meaningful hidden rules and patterns from large volume of data obtained from the problem domain. In this research, in order to find relational rules between posture training type and muscle activation pattern, we investigated an application of the WAR(Weishted Association Rule) to the biomechanical data obtained mainly for evaluation of postural control ability. The discovered rules can be used as a quantitative prior knowledge for expert's decision making for rehabilitation plan. The discovered rules can be used as a more qualitative and useful priori knowledge for the rehabilitation and clinical expert's decision-making, and as a index for planning an optimal rehabilitation exercise model for a patient.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.44 no.1
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• pp.56-63
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• 2007

In this paper, an eye tracking method is presented using a neural network (NN) and mean-shift algorithm that can accurately detect and track user's eyes under the cluttered background. In the proposed method, to deal with the rigid head motion, the facial region is first obtained using skin-color model and con-nected-component analysis. Thereafter the eye regions are localized using neural network (NN)-based tex-ture classifier that discriminates the facial region into eye class and non-eye class, which enables our method to accurately detect users' eyes even if they put on glasses. Once the eye region is localized, they are continuously and correctly tracking by mean-shift algorithm. To assess the validity of the proposed method, it is applied to the interface system using eye movement and is tested with a group of 25 users through playing a 'aligns games.' The results show that the system process more than 30 frames/sec on PC for the $320{\times}240$ size input image and supply a user-friendly and convenient access to a computer in real-time operation.