• 대한의용생체공학회:의공학회지
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• 제44권6호
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• pp.363-376
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• 2023

According to the COVID-19, development of various medical software based on IoT(Internet of Things) was accelerated. Especially, interest in a central software system that can remotely monitor and control ventilators is increasing to solve problems related to the continuous increase in severe COVID-19 patients. Since medical device software is closely related to human life, this study aims to develop central monitoring system that can remotely monitor and control multiple ventilators in compliance with medical device software development standards and to verify performance of system. In addition, to ensure the safety and reliability of this central monitoring system, this study also specifies risk management requirements that can identify hazardous situations and evaluate potential hazards and confirms the implementation of cybersecurity to protect against potential cyber threats, which can have serious consequences for patient safety. As a result, we obtained medical device software manufacturing certificates from MFDS(Ministry of Food and Drug Safety) through technical documents about performance verification, risk management and cybersecurity application.The purpose of this study is to conduct a usability assessment to ensure that ergonomic design has been applied so that the ventilator central monitoring system can improve user satisfaction, efficiency, and safety. The rapid spread of COVID-19, which began in 2019, caused significant damage global medical system. In this situation, the need for a system to monitor multiple patients with ventilators was highlighted as a solution for various problems. Since medical device software is closely related to human life, ensuring their safety and satisfaction is important before their actual deployment in the field. In this study, a total of 21 participants consisting of respiratory staffs conducted usability test according to the use scenarios in the simulated use environment. Nine use scenarios were conducted to derive an average task success rate and opinions on user interface were collected through five-point Likert scale satisfaction evaluation and questionnaire. Participants conducted a total of nine use scenario tasks with an average success rate of 93% and five-point Likert scale satisfaction survey showed a high satisfaction result of 4.7 points on average. Users evaluated that the device would be useful for effectively managing multiple patients with ventilators. However, improvements are required for interfaces associated with task that do not exceed the threshold for task success rate. In addition, even medical devices with sufficient safety and efficiency cannot guarantee absolute safety, so it is suggested to continuously evaluate user feedback even after introducing them to the actual site.

• Journal of Electrical Engineering and Technology
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• 제10권1호
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• pp.364-371
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• 2015

In this study, we developed a feasible structure of a textile-based inductive sensor using a machine embroidery method, and applied it to a non-contact type vital sign sensing device based on the principle of magnetic-induced conductivity. The mechanical heart activity signals acquired through the inductive sensor embroidered with conductive textile on fabric were compared with the Lead II ECG signals and with respiration signals, which were simultaneously measured in every case with five subjects. The analysis result showed that the locations of the R-peak in the ECG signal were highly associated with sharp peaks in the signals obtained through the textile-based inductive sensor (r=0.9681). Based on the results, we determined the feasibility of the developed textile-based inductive sensor as a measurement device for the heart rate and respiration characteristics.

• BMB Reports
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• 제36권1호
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• pp.1-11
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• 2003

The causative role of polycyclic aromatic hydrocarbons (PAH) in human carcinogenesis is undisputed. Measurements of PAH-DNA adduct levels in easily accessible white blood cells therefore represent useful early endpoints in exposure intervention of chemoprevention studies. The successful applicability of DNA adducts as early endpoints depends on several criteria:i.adduct levels in easily accessible surrogate tissues should reflect adduct levels in target-tissues, ii. toxicokinetics and the temporal relevance should be properly defined.iii. sources of inter- and intra-individual variability must be known and controllable, and finally iv. adduct analyses must have advantages as compared to other markers of PAH-exposure. In general, higher DNA adduct levels or a higher proportion of subjects with detectable DNA adduct levels were found in exposed individuals as compared with non-exposed subjects, but saturation may occur at high exposures. Furthermore, DNA adduct levels varied according to changes in exposure, for example smoking cessation resulted in lower DNA adduct levels and adduct levels paralleled seasonal variations of air-pollution. Intra-individual variation during continuous exposure was low over a short period of time (weeks), but varied significantly when longer time periods (months) were investigated. Inter-individual variation is currently only partly explained by genetic polymorphisms in genes involved in PAH-metabolism and deserves further investigation. DNA adduct measurement may have three advantages over traditional exposure assessment: i. they can smooth the extreme variability in exposure which is typical for environmental toxicants and may integrate exposure over a longer period of time. Therefore, DNA adduct assessment may reduce the monitoring effort. ii. Biological monitoring of DNA adducts accounts for all exposure routes. iii. DNA adducts may account for inter-individual differences in uptake, elimination, distribution, metabolism and repair amongst exposed individuals. In conclusion, there is now a sufficiently large scientific basis to justify the application of DNA adduct measurement as biomarkers in exposure assessment and intervention studies. Their use in risk-assessment, however, requires further investigation.

• 비파괴검사학회지
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• 제35권1호
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• pp.68-72
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• 2015

초음파 로봇 검사시스템은 발전설비 등 상시감시가 요구되는 구조물의 감시를 위해 연구와 개발이 활발히 진행되고 있다. 그러나 이러한 설비의 구조물은 형상과 구조가 매우 다양하고 복잡하여 단순한 패턴으로 이동과 검사가 가능한 로봇으로는 상시감시에 한계를 가지게 된다. 복잡한 구조물의 정밀검사는 정교한 행동이 가능한 로봇 시스템이 필요하다. 로봇의 제어를 초음파검사 작업자의 손의 형상에 따라 직관적으로 움직이도록 한다면 보다 정밀한 검사 로봇의 개발이 가능할 것으로 판단된다. 폴리머 굽힘센서는 대변형의 측정이 가능하고 곡면에 적용성이 높아 최근 인체 형상 측정 및 재활보조 등 다양한 활용을 위한 연구가 활발히 진행되고 있다. 본 연구에서는 구조물의 상시감시를 위한 초음파검사 로봇이 작업자의 손동작에 따라 동작이 가능한 직관적 제어를 위해 폴리머 굽힘센서를 이용하여 사람 손의 형상 감시 연구를 수행하였다. 다수의 센서를 적용하여 손의 다양한 움직임을 추정하고 실험적 검증을 통해 사람 손의 형상에 따른 직관적 로봇의 제어가 가능함을 확인하였다.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.289-294
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• 2011

A rapid and specific high performance liquid chromatography-tandem mass (LC/MS/MS) method for the analysis of montelukast in human plasma has been developed and validated. After cold acetonitrile-induced precipitation of the plasma samples, montelukast and glipizide (internal standard, IS) were eluted on a reverse-phase $C_{18}$ column by isocratic mobile phase consisted of 10 mM ammonium formate buffer (adjusted to pH 3.5 with formic acid) and acetonitrile (3:97, v/v). Acquisition was performed with multiple reaction monitoring (MRM) mode by monitoring the transitions: m/z 587.2${\rightarrow}$ 423.2 for montelukast and m/z 446.0${\rightarrow}$321.2 for IS. Ranges of concentration for calibration curves (10-1000 ng/mL) showed correlation coefficients ($r^2$) were better than 0.9948. Precision of intra- and inter-day ranged from 3.70 to 11.68% and from 3.04 to 12.95%, accuracy of intra-day and inter-day ranged from 93.34 to 102.75% and from 100.79 to 107.63%, respectively. The described method provides a fast and sensitive analytical tool for determining montelukast levels in plasma, and was successfully applied to a pharmacokinetic study in 16 healthy human subjects after oral administration of 10mg tablet formulation of montelukast sodium under fasting conditions.

• Spatial Information Research
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• 제16권4호
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• pp.421-439
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• 2008

본 연구의 최종목표는 7대 시설물의 주요 정보를 획득하기 위해 지하 환경에 적합한 센서 네트워크(USN: Ubiquitous Sensor Network)를 개발하여 지하시설물의 모니터링 및 긴급처리와 통합관리시스템 개발을 통하여 지능형 도시지하시설물 관리체계를 구축하는 것이며 이를 위하여 국토연구원을 포함한 5개의 기관이 공동으로 연구 과제를 수행하였다. 총 6차년 도에 걸쳐 UFSN(Underground Facility Sensor Network) 기반의 지능형 관리체계를 구축하는 것을 목표로 우선 $1{\sim}2$차년 도에는 상하수도에 초점을 두고 지하시설물 관리체계 구축기반기술 연구에 중점을 두었다. 국토연구원에서는 지하시설물 통합관리 기술개발을 위해 기존 상하수도 단위 업무시스템 연계방안을 연구하였고 모니터링 기술개발을 위해서 상하수도 모니터링 항목을 도출하였으며 신규/기설 지하시설물별 센서 설치방안에 대한 기초 연구를 수행하였다. 본 연구는 국토연구원에서 수행한 $1{\sim}2$차년 도의 연구 성과를 토대로 작성되었다.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2008년도 International Meeting of the Microbiological Society of Korea
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• pp.171-171
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• 2008

We monitored the occurrence of human enteric viruses in urban rivers by cell culture-PCR and RT-nested PCR. Water samples were collected monthly or semimonthly between May 2002 and March 2003 in four urban tributaries. Enteric viruses were detected by RT-nested PCR and cell culture-PCR based on a combination of Buffalo Green monkey kidney (BGMK) and A549 cell lines, followed by phylogenetic analysis of amplicons. By RT-nested PCR analysis, 45 (77.6%), 32 (55.2%), 32 (55.2%), 26 (44.8%), 12 (20.7%), 2 (3.4%), 4 (6.9%), and 4 (6.9%) of 58 samples showed positive results with adenoviruses, enteroviruses, noroviruses (NV) genogroup I (GI) and II (GII), reoviruses, hepatitis A viruses, rotaviruses and sapoviruses, respectively. Adenoviruses were most often detected and only eight (13.8%) samples were negative for adenoviruses and positive for other enteric viruses in the studied sites. Thirty-one (77.5%) of the 40 samples were positive for infectious adenoviruses and/or enteroviruses based on cell culture-PCR, and the frequency of positive samples grown on A549 and BGMK (65.0%) was higher than that grown on BGMK alone (47.5%). The occurrence of each enteric virus, except reoviruses and hepatitis A viruses was not statistically correlated with the water temperature and levels of fecal coliforms according to Binary logistic regression model. By sequence analysis, most strains of adenoviruses and enteroviruses detected in this study are similar to the causative agent of viral diseases in Korea and most NV GI- and GII-grouped strains were closely related to the reference strains from China and Japan, and GII/4-related strains had similar sequences to strains recognized as a worldwide epidemic outbreak. Our results suggested that monitoring human enteric viruses is necessary to improve microbial quality and cell culture-PCR using the combination of A549 and BGMK cells and the adenovirus detection by PCR could be useful for monitoring viral contamination in the aquatic environment.

• 해양환경안전학회지
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• 제24권5호
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• pp.504-510
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• 2018

해양사고는 주로 충돌과 좌초에 의한 것으로 인적과실이 원인이다. 한국형 e-Navigation 사업은 인적과실에 의한 해양사고 저감 및 초고속 해상무선통신(LTE-Maritime)의 구축 방안을 마련하고 있다. 그에 따른 사고취약선박 모니터링 지원 서비스(SV10)는 육상에서 수집한 선박의 위치정보를 기반으로 선박의 충돌 좌초 위험도를 평가하여 선박이 위험상황을 인식할 수 있도록 정보를 제공하고 해양사고 발생 시 육상에서 조기 대응할 수 있도록 실시간 선박 위치 및 위험상황 정보를 유관기관과 공유하는 서비스이다. 본 연구에서는 중앙해양안전심판원에서 제공된 해양사고 통계연보 및 재결서를 분석하여 SV10 서비스로 저감될 수 있는 해양사고 비율을 확인하였다.

• 대한약침학회지
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• 제12권1호
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• pp.5-12
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• 2009

Background : Anticancer effects of herbal medicine have been reported in various types of cancer, but the systematic approaches to explain molecular mechanism(s) are not established yet. Objective : To find the anticancer-effect and mechanism(s) of Water Extract of Coptis japonica (WECJ) colon cancer cell (SNU-81). Methods : We first selected 11 herbals, and anti-cancer effects of water-extracts from those herbals have been tested in human colon cancer cell line, SNU-81. Among the tested herbals, the WECJ significantly reduced proliferation of SNU-81. To establish a basis of understanding for anti-cancer mechanism, whole proteins have been obtained from SNU-81 harvested at 48 and 96 hrs after the treatment of WECJ, protein expression has been profiled by 2DE-based proteomic approach. Results : Various changes of the protein expression have been monitored, and most frequent dysregulation was found in the molecular chaperons including heat shock protein 90-alpha (Hsp90-alpha), 14-3-3 protein epsilon, T-complex protein 1 subunit alpha, protein disulfide-isomerase A3, and calreticulin. Interestingly, proliferation-associated protein 2G4 has been up-regulated, and it suggests the possible effect of Coptis japonica on ErbB3-regulated signal transduction pathway and growth control of human colon cancer cells. Conclusion : Based upon the present findings, the further study will focus on monitoring various cancer survival factors after artificial regulation of the proteins identified, and it would be the basis for the understanding of the Coptis japonica anti-cancer effect(s) at the molecular level.

• 한국융합학회논문지
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• 제8권12호
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• pp.63-69
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• 2017

본 연구는 침상의 인체 위치와 생체신호를 검출할 수 있는 스마트 침상제어시스템의 개발에 관한 것이다. 침상제어 시스템의 메인 제어보드는 인체 감지부, 모터 구동부, MCU로 구성된다. 여기서, 침상의 인체존재 확인의 신뢰성을 높이기 위해 맴브레인 센서에 의한 인체위치 검출부와 EMFI 센서의 생체신호 검출부를 인체감지부로 결합하였다. 또한 검출된 두 신호를 원격으로 앱 모드의 응용 프로그램에 연결하여, 침상위 인체정보를 모니터링할 수 있는 앱모드의 활용이 가능하도록 하였다. 본 연구에서 블루투스 통신에 의해 침상 인체 정보를 모니터링하는 원격 기능은 병원 및 요양기관의 낙상 및 침상부재사고 예방기법으로 활용될 수 있을 것이다.