• Journal of Sasang Constitutional Medicine
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• v.15 no.3
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• pp.62-73
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• 2003

Lee, Jema recognized human being as human figure and human nature according to 'if threre is a thing, there are a law to explain the thing'. And he thought Sa-Sang is the most basic and proper concept to explain things and changes. This paper is to find his medical view why human beings are classified into four types. 1. A medical clue to classify human being is different viscera function. 2. The size of viscera means the strength and weakness of metabolic function of viscera. 3. The essence of different viscera function is related to metabolism of water and food, air and fluid. Lungs and Liver do metabolic function through exhale and inhale of air and fluid. Spleen and Kidneys do metabolic function through intake an d output water and food. 4. It is most important to consider and to treat the condition of small size viscera.

• The Korean Journal of Physiology and Pharmacology
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• v.11 no.6
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• pp.259-262
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• 2007

Diffuse panbronchiolitis (DPB) is a pulmonary disease characterized by chronic inflammation of the bronchioles and chronic infiltration of inflammatory cells in the lungs. Macrolides are effective therapeutic agents for chronic respiratory tract diseases, such as DPB. However, the mechanisms by which macrolides modulate the immune responses in patients with DPB remain unclear. To understand clinical efficacy for the treatment of DPB by macrolides, the effects of erythromycin (EM) on the expression of pro-inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-8 (IL-8) by human neutrophils were examined. Pre-treatment with EM significantly decreased the expression of IL-6 and IL-8 transcripts by lipopolysaccharide (LPS)-stimulated human neutrophils. EM also reversed the enhanced survival of human neutrophils by LPS. These data indicate that EM has achieved therapeutic effect for patients with DPB, in part, through decreasing the expression of pro-inflammatory cytokines and the survival of neutrophils.

• Journal of Sasang Constitutional Medicine
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• v.18 no.1
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• pp.1-10
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• 2006

1. Objectives The purpose of study is to find Lee Je-Ma's thoughts about Great Absolute-Mind in his writings. 2. Methods the concept of Lee Je-Ma's Great Absolute-Mind versus preexisted Great Absolute-Mind is compared and analysed in this study. 3. Results and Conclusions (1) Lee Je-Ma composed his Great Absolute-Mind based on its concept of the science of divination, Confucianism and medicine. However his Great Absolute-Mind is rooted in preexisted meaning, it was disputed desides the controversy between the science of divination, Confucianism and medicine. For this reason, Lee Je-Ma's Great Absolute-Mind is such an originative concept unable to be explained with a simple substitution this concept for the preexisted one of the science of divination, Confucianism and medicine. (2) Lee Je-Ma's Great Absolute-Mind is the human being itself and it can include the humanity from human being itself. (3) There are not only physical meaning of heart but also abstract metaphysical concept of heart included in Lee Je-Ma's Great Absolute-Mind. (4) The talent for comprehending principles is organically connected with the ability to attain their will. And the talent and ability is devided into Two Modes(兩儀) like Mind & Body(心身), Perception & Action(知行) and Nature & Emotion(性情). (5) The supervision of Lee Je-Ma’s Great Absolute-Mind affects physical part of body as well as spiritual part and is not devided into two but one. (6) The source of the supervision is rooted on Lungs Spleen liver Kidney(肺脾肝腎), Sasang(四象), even though it exists in the Great Absolute-Mind. So Sasang(四象), which is Lungs Spleen Liver Kidney(肺脾肝腎), is organically related to the Great Absolute-Mind in its effect and origin.

• Journal of Biomedical Engineering Research
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• v.19 no.4
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• pp.423-429
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• 1998

Human pharynx is unique, acting as a complex interchange between the oral cavity and esophagus, and between the nasal cavity and lungs. It is actively involved in the transport of food and liquid, producing the forces that guide that bolus into the upper esophagus and away from the adjacent larynx and lungs. This study intended to develop a biomechanical model of the human pharynx, utilizing Finite Element Method(FEM). Within each model changes in cross sectional intralumenal area were calculated and compared with the area from the computer-generated FE model. Area matching allowed estimation of intraluminal pressure gradients during swallow. The estimated pharyngeal pressure gradient varies from one region to another. The estimated pharyngeal pressure gradients showed different patterns for upper four levels and lower four levels. The contraction velocity for upper four levels is much higher than lower four levels. The higher contraction velocities and pressure gradients in the upper levels are consistent with the bolus velocities required for efficient swallow.

• Journal of Biomedical Engineering Research
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• v.38 no.2
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• pp.62-73
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• 2017

To identify a solution for the restricted availability of healthy lungs and the high risk of immune rejections following organ transplantation, tissue engineering techniques for culturing lungs have been studied by many research groups. The most promising method for culturing lungs is the utilization of a bio-scaffold that was prepared using harvested organs from human donors or other animals by removing their original cells. In this study, a pulsatile perfusion pump was used to alleviate the cell removal effect with the high fluid-dynamic power of the perfusion stream during the decellularization process, while other conventional studies focused on chemical methods to identify efficient detergents. The purpose of this study was to analyze the developed device by using energy equivalent pressure (EEP), which is an indicator of pulsatility, to understand the characteristics of pulsatile energy transmitted according to the load size by using the artificial model and compare it with the measured EEP. The pulsatility of the device can be estimated with the concept of fluid-dynamic energy during a particular constant time period or fluid-dynamic power represented as EEP and EEP increment. Because the measured EEP of perfusion flow during decellularization can be changed by the amount of fluid leakage and the degree of clogging in the capillary vessels, EEP should be measured to determine whether the decellularization is progressing without problems. The decrement of EEP caused by the high perfusion resistance was observed from some experimental results that were obtained with artificial models. EEP can be used to monitor the decellularization process after analyzing the varying EEP according to the amount of load. It was confirmed that the EEP was maintained at a high level in the experiment using the harvested lungs from 12-13-week-old rats. In addition, it was confirmed that the cell removal time was faster than when continuous perfusion was performed. In this study, pulsatile power delivered to the lungs was measured to monitor the process of cell removal, and it serve as the evidence for efficient decellularization.

• Applied Microscopy
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• v.29 no.3
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• pp.291-301
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• 1999

The differentiation and ultrastructural characteristics of type II pneumocyte was investigated using 7 cases of human fetal lungs from 9 to 20 weeks of gestation by transmission electron micropscopy. The result obtained were as follows. 1. From the pattern of epithelium, type II pneumocyte was not discernable, but with the gradual development of gestation, the epithelium of the future pulmonary alveoli was transformed from pseudostratified columnar into simple cuboidal epithelium after 15 weeks of geatation. 2. The multilamellar body very specific to type II pneumocyte was observed at first at 9 weeks of gestation. Besides, another characteristics of the cell were also observed such as cytoplasmic inclusion body, granular inclusionbody,multivesicularinclusionbodyanddensebody. 3. The number and size of multilamellar body increased, but those of other inclision bodies decreased at 19 and 20 weeks of gestation. In summary, type II pneumocytes (or precursor cells) with multilamellar body and another characteristic inclusion bodies were observed in the human fetal lungs from 9 weeks of gestation. And so, it is suggested that the differentiation of type II pneumocyte starts at or before 9 weeks of gestation.

• Clinical and Experimental Pediatrics
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• v.46 no.6
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• pp.536-540
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• 2003

Purpose : Aspiration of foreign material into the lungs can cause acute or chronic pulmonary diseases. It is difficult to detect small amounts of aspiration due to the lack of safe, sensitive and specific diagnostic tests. Recently, in animal or human studies, it has been reported that immunochemistry for lactalbumin can be used to detect the minimal aspiration. So, the authors' investigation was designed to determine whether human milk phagocytized alveolar macrophages can be detected in human milk aspirated mice. Methods : Sixty four male mice, 6-8 weeks old and 30-40 gm weighing, were used for this study. About 0.05 mL of human milk or normal saline were given intranasally once per day for 1 day or 3 days. Under anesthesia with ketamine and xylazine, the trachea of each mouse was cannulated with an 18G Jelco needle and then, each mouse's lungs were lavaged three times with 0.5 mL of phosphate buffer solution at 2, 8, 24, and 48 hours after the last milk or normal saline instillation. Cells in bronchoalveolar lavage fluid were stained with Oil Red O and immunocytochemistry for alpha-lactalbumin. Results : Immunocytochemical reactivity for alpha-lactalbumin or lipid-laden alveolar macrophages were not observed in the normal saline aspirated groups. Immunocytochemical reactivity for alpha-lactalbumin were observed in the human milk aspirated groups. They showed a peak at 8 hours and decreased markedly at 24 hours but persisted even at 48 hours after aspiration. Immunocytochemical stain positive alveolar macrophages were noted similarly in number between single and multiple aspiration groups. Conclusion : These observations suggested that alveolar macrophages for lactalbumin could be more easily detected on immunocytochemistry than Oil Red O stain, and immunocytochemistry could be used as a sensitive and specific diagnostic test for the detection of human milk aspiration.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.55 no.5
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• pp.231-238
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• 2006

This paper analysed the induced current density inside human body of hot-line worker for 765kV double circuit transmission line according to locations of human body. Human model was composed of several organs and other parts, whose shapes were expressed by spheroids or cylinders. Organs such as the brain, heart, lungs, liver and intestines were taken into account. Applying the 3 dimensional boundary element method, we calculated induced current density in case a worker was located inside and outside a lowest phase of 765 kV transmission line in which a 60% current of maximum load flowed. As results of study, we found a maximum induced current density in all organs was less than $10mA/m^2$ when a wonder was outside. As one in brain and heart was higher than $10mA/m^2$ when a worker was inside, we propose a method for lowering current density.

• Parasites, Hosts and Diseases
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• v.59 no.3
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• pp.291-296
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• 2021

Alveolar echinococcosis (AE) is considered as a fatal zoonosis caused by the larvae of Echinococcus multilocularis. The lungs and brain are the most common metastatic organs. We report a human case of hepatic alveolar echinococcosis accompanied by lung and brain metastasis. In particular, the patient had a history of tuberculosis and the lung lesions were easily misdiagnosed as lung abscesses. The lesions of liver and lung underwent radical resection and confirmed as alveolar echinococcosis by pathological examination. The patient had no surgical complications after operation and was discharged after symptomatic treatment. Unfortunately, the patient later developed multiple intracerebral AE metastases. We required the patient to take albendazole orally for life and follow up.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05d
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• pp.17-22
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• 1996

Individual internal monitoring program by in-vivo measurement technique at the Korea Atomic Energy Research Institute includes the capability for the assessment of uranium and americium lung burdens. This capability is an important part of the health and safety program. This article addresses the lung burden assessment portion of our in vivo measurement capabilities.