• Clinical and Experimental Reproductive Medicine
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• v.44 no.3
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• pp.141-145
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• 2017

Objective: Delaying embryo transfer (ET) enables us to select among the embryos available for transfer and is associated with positive effects on implantation and pregnancy outcomes. However, the optimal day for ET of human cleavage-stage embryos remains controversial. Methods: A retrospective study of 3,124 in vitro fertilization/intracytoplasmic sperm injection cycles (2,440 patients) was conducted. We compared the effects of day 2 and 3 ET on rates of implantation and pregnancy outcomes between young maternal age (YMA; < 38 years old, n = 2,295) and old maternal age (OMA; ${\geq}38years\;old$, n = 829) patient groups. Results: The YMA and OMA groups did not differ in terms of patient characteristics except for the proportion of unexplained factor infertility, which was significantly greater in the OMA group, and the proportion of arrested embryos, which was significantly greater in the YMA group. However, the biochemical pregnancy, clinical pregnancy, ongoing pregnancy, abortion, and implantation rates per cycle were not significantly different between day 2 and 3 ET in the YMA group or the OMA group. Conclusion: We suggest that offering patients the opportunity to decide which day would be suitable for ET could be part of a patient-friendly protocol that takes into consideration an infertile woman's circumstances and work schedule by allowing ET to be performed on day 2 instead of the traditional transfer on day 3.

• Molecules and Cells
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• v.44 no.9
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• pp.688-695
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• 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a global health concern. Various SARS-CoV-2 vaccines have been developed and are being used for vaccination worldwide. However, no therapeutic agents against coronavirus disease 2019 (COVID-19) have been developed so far; therefore, new therapeutic agents are urgently needed. In the present study, we evaluated several hepatitis C virus direct-acting antivirals as potential candidates for drug repurposing against COVID-19. Theses include asunaprevir (a protease inhibitor), daclatasvir (an NS5A inhibitor), and sofosbuvir (an RNA polymerase inhibitor). We found that asunaprevir, but not sofosbuvir and daclatasvir, markedly inhibited SARS-CoV-2-induced cytopathic effects in Vero E6 cells. Both RNA and protein levels of SARS-CoV-2 were significantly decreased by treatment with asunaprevir. Moreover, asunaprevir profoundly decreased virion release from SARS-CoV-2-infected cells. A pseudoparticle entry assay revealed that asunaprevir blocked SARS-CoV-2 infection at the binding step of the viral life cycle. Furthermore, asunaprevir inhibited SARS-CoV-2 propagation in human lung Calu-3 cells. Collectively, we found that asunaprevir displays broad-spectrum antiviral activity and therefore might be worth developing as a new drug repurposing candidate for COVID-19.

• The Korean Journal of Archival Studies
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• no.68
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• pp.243-279
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• 2021

Rep. Roh Hoe-chan is a representative politician in Korean progressive politics. From the labor movement to the workers' political organization movement, they devoted themselves to the movement to build a progressive party. As a member of the 17th, 19th, and 20th National Assembly, he carried out legislative activities. The record he left is the record of the political power of workers, the record of the progressive party, and the record of a politician who suffers and practices. Also, as the son of a displaced person, as a student activist suffering from the restoration period, it is also a record of a human being of cultural literacy who played the cello. Archivist's basic research is expected to play a role in creating a virtuous cycle of archive management by structuring the archive and presenting various access points to various users, allowing more diverse research and use in the future.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.614-627
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• 2022

The purpose of this study was to explore the various data and methods employed by HR analytics studies. The researchers selected 78 KCI-indexed empirical articles on HR analytics and categorized them using the Employee Life Cycle framework. This yielded several important findings. First, employee retention has been the most common subject of extant studies, followed by performance management. Second, HR analytics studies have used a variety of data (structured and unstructured) according to their research questions, and the data sources have ranged from organizations' internal systems to national databases. Third, most domestic HR analytics studies have been descriptive and diagnostic, whereas predictive and prescriptive studies have been rare. These results have important theoretical and practical implications for future HR analytics research.

• Journal of Advanced Technology Convergence
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• v.1 no.2
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• pp.57-62
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• 2022

In order to support women with career breaks to re-enter the labor market, it is not only necessary to discover and select promising jobs, but also to provide objective and accurate job information on selected promising jobs so that women with career breaks can make reasonable career choices. need arises. It can be pointed out that the government support course has no burden of tuition compared to the general course, and because the quality of education is high, it is possible to select trainees with a high willingness to find employment through competition in the recruitment process. In addition, the government support process secures relatively high-quality programs and instructors, increasing trainees' concentration, satisfaction, and willingness to find a job. Job literacy and employment preparation education are obligatory, job design support through job counseling, and continuous follow-up support. The system also works. Accordingly, if systematic and continuous development and support are made in the process of selecting promising occupations for women with career breaks and designing education and training programs, it is expected that women with career breaks will be more active in their re-entry into the labor market.

• Korean Journal of Environment and Ecology
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• v.37 no.6
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• pp.464-472
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• 2023

Middle-aged women experience a lot of physical and mental stress during their developmental cycle. This stress reduces the quality of life because it leads to chronic pain and disease. Forest therapy is attracting attention as an alternative to this. Forest therapy refers to improving human health through the therapeutic elements of forests. Accordingly, this study was conducted to determine whether a sensory insight-based forest therapy program was effective in reducing stress in middle-aged women. For this purpose, middle-aged women who wanted to participate in the forest therapy program were recruited, 20 each were randomly assigned to an experimental group and a control group, and pre- and post-tests were conducted. The forest therapy program consisted of 8 sessions of 6 hours based on sense and insight. The forest therapy program was held at Saryeoni Forest in Jeju, and the measurement tools were compared by measuring perceived stress, leisure satisfaction, and stress index through pulse wave testing. The results of the study showed that the forest therapy program lowered stress and improved leisure satisfaction.

• Korean Journal of Social Welfare Studies
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• v.41 no.3
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• pp.29-56
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• 2010

One of the most popular keywords in 21th century is "Information Society". Information Society improves the overall quality of human life, but increases the negative aspects such as internet addiction and digital divide. The purpose of this study is to understand the vicious cycle between socio-economic disparities and digital divide. This study analyzed the effects of poverty on school maladjustment and academic achievement and mediation effects by using parental monitoring and internet use types as mediators. Data were obtained from the Korea Youth Panel Survey(KYPS). Structural equation modeling was employed for statistical analyses. The result showed that poverty reduced parental monitoring and information-oriented type of internet use. Youth who used less information-oriented type showed more school maladjustment and less academic achievement. However, the relationship between poverty and entertainment-oriented type was non-significant. Thus, parental monitoring and the internet use types were one of the main pathways which can affect school maladjustment and academic achievement among youth in poverty. There was the possible vicious cycle between poverty and digital divide. Based on this study, we strongly suggest improvement of the media competence to solve the problem of digital divide among youth in poverty.

• Archives of design research
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• v.17 no.2
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• pp.335-350
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• 2004

Design takes concrete form from the things which are not yet exist to the molded reality. Creation of value which is accompanied by the rational value could be possible only through the searching examination of the basic concept. All designs are under circumstances because the results and the character of the problems are different under the given conditions and circumstances which are the characteristic of the design. The aim of this study is searching for the differential design conce- pt which is the most appropriate and reasonable in the basic design process in which the phase of the analysis, synthesis and evaluation of the problem. First of all the pursuit value of the times and the change of the view point of value of the product design. How the pursuit value of times were searched and analyzed. Analyze the successful product design realization of the typical trend of the modern design which are 3-2. function-focused design, 3-3. emotion-centered design, 3-4. image communicative design through the metaphor, 3-5. environmental affinity design. On the base of the case analysis how to apply the differential design concept which is coming as a trend in the future society which are sustainable developing society was examined closely. The outcome through the analysis of the success cases are as follows, \circled1 the value of the spirit of the times should be emphasized as the design image, \circled2 environmental appropriateness should be taken into consideration as the first primary factor, \circled3 the realization of value of the fulfillment of differential consumer's needs, \circled4 lead to prolong the life cycle of the product, \circled5 promote the sustaining growth of enterprise, \circled6 user-centered product value should be the first consideration. \circled7 It is necessary to overcome the cultural andinguistic barriers and to reflect the metaphor which people remember well. \circled8 The application of human's true character should be decided beforehand. It is the commonness of values of times and customs. \circled9 The differentiated design concept which meets our mental satisfaction, not material one, will be required. In addition to this the creative and differentiated design concepts which are accompanied by the good design factor under the base of product could achieve the emotional consensus from the consumers. That is, the value of all designs should be estimated by the base of the humanism ' The human beings are the barometer of all things".ngs".uot;.

• Biomolecules & Therapeutics
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• v.28 no.2
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• pp.184-194
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• 2020

Histone deacetylase (HDAC) inhibitors represent a novel class of anticancer agents, which can be used to inhibit cell proliferation and induce apoptosis in several types of cancer cells. In this study, we investigated the anticancer activity of MHY4381, a newly synthesized HDAC inhibitor, against human prostate cancer cell lines and compared its efficacy with that of suberoylanilide hydroxamic acid (SAHA), a well-known HDAC inhibitor. We assessed cell viability, apoptosis, cell cycle regulation, and other biological effects in the prostate cancer cells. We also evaluated a possible mechanism of MHY4381 on the apoptotic cell death pathway. The IC₅₀ value of MHY4381 was lower in DU145 cells (IC₅₀=0.31 µM) than in LNCaP (IC₅₀=0.85 µM) and PC-3 cells (IC₅₀=5.23 µM). In addition, the IC₅₀ values of MHY4381 measured in this assay were significantly lower than those of SAHA against prostate cancer cell lines. MHY4381 increased the levels of acetylated histones H3 and H4 and reduced the expression of HDAC proteins in the prostate cancer cell lines. MHY4381 increased G2/M phase arrest in DU145 cells, and G1 arrest in LNCaP cells. It also activated reactive oxygen species (ROS) generation, which induced apoptosis in the DU145 and LNCaP cells by increasing the ratio of Bax/Bcl-2 and releasing cytochrome c into the cytoplasm. Our results indicated that MHY4381 preferentially results in antitumor effects in DU145 and LNCaP cells via mitochondria-mediated apoptosis and ROS-facilitated cell death pathway, and therefore can be used as a promising prostate cancer therapeutic.

• Journal of the Korean Home Economics Association
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• v.25 no.4
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• pp.141-152
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• 1987

The book of Sa So Jeol is about the moral training family precepts written by Yi Deok-mu (이덕무, 1739~1793) in the year of king Young Jo 51th in the Yi dynasty. The writer provides us, according to the views of Confucianists, with the principles that both elders and children of that time should abide by in the daily life, dividing the said books into 924 sections, 8 chapters, and 2 volumes. The parts concerned with children are studied in this essay. The brief conclusions are as follows. 1. Children were required to have the mental attitudes of honesty, patience, tolerance and frugality and were instructed to show such attitudes through their behavior. 2. Children were instructed to have the behavioral attitudes of nine aspects, which are the behavioral characteristics of the sages. They were instructed to emulate the personal characters of the sages through being possessed of these nine aspects, which are to be found in healthy and comfortable mental states. 3. Children were instructed to be careful and composed, in their activities. Since prudence is the basic principle of mental and behavioral attitudes, being required of men and women of all ages in a traditional society, it was emphasized from early childhood 4. The aim of instruction was taken to be becoming human, or becoming a virtuous man, rather than merely passing the classical government examamination, and for this aim the moral rules, which can be considered the order of human relations, were taught intensively. 5. As for instructional methods, the children were required to do careful or rough reading according to their abilities, and were instructed to listen to lectures politely, prudently, ardently and honestly. 6. The instructional contents are for the purpose of making children read the classical canons after increasing their perceptive ability in the various things of the sexagenary cycle, the multipicative method, the kings, lineage, and the reign-titles, and the accumulated knowledge of $\ulcorner$Kyung Mong Yo Kyul$\lrcorner$, $\ulcorner$Seong Hak Jeop Yo$\lrcorner$ and $\ulcorner$Keun Sa Lok$\lrcorner$. Because of the greater emphasis on natural talents rather than on acquired abilities, the children, however, were eudcated only after their despositions were examined. 7. The children were required to have warm-hearted, careful, polite, and prudent attitudes toward their elders, and were instructed to take precauticns against arrogance and impoliteness. Since politeness in particular was considered not only as the ground of decorum but the method of emotional regulation and maintaining composure for confucianists, it can be regarded as the principal ettiquettee demanded in all activities. 8. The main instructional contents are generally moral aspects, concentrating on introspection and virtuous conduct through emotional regulations, rather than on the natural expression of physical and mental states.