• 대한인간공학회지
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• 제30권1호
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• pp.151-160
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• 2011

There have been many efforts to prevent accidents in Korea for the last 25 years. Many measures in the area of hardware sciences including electrical, mechanical, chemical engineering, etc. were applied to eliminate or at least reduce causes of accidents. However, the accidents rate has not been reduced much despite of these measures. This research aimed to find real causes of these accidents and to suggest a comprehensive model that can mainly be applied to industrial fields to find potential or existence of human errors during the pre-installation stage or after an accident. We tried to explain sequences of an operator's information process that might cause human errors on one hand, and life cycle stages of facilities involved when human errors occur on the other hand. With this comprehensive model presented in this research, one can follow up the sequence of human errors caused by operators. Further, errors made at the design stage which could be a main cause of accidents can be tracked. It is recommended that this comprehensive model should be used to prevent human errors in industrial fields since safety personnel can easily find out errors or error potentials through the life cycle stages of manmachine facilities.

• 한국생활과학회지
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• 제15권2호
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• pp.227-237
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• 2006

The purpose of this study is to find out midaged women's crisis and ways to overcome it. Another purpose is to improve their qualities of life and to provide basic data to develop their potentials. The results are as follows: First, it shows that socio-demographic characteristics have a significant influence on midaged women's crisis. Those variables include religion, jobs, family-life cycle, income, marriage duration, age, and supporting parents. Second, the variables significantly influencing the coping behavior with the crisis include age, income, religion, marriage patterns, region, marriage duration, family-life cycle, and supporting parents. Third, as a result of this research, their negative expression of action or emotion was higher as they were getting old. The general tendency was that an emotional crisis level was low when rational coping behaviors were high. Therefore, self-esteem or social activity improvement programs should be developed for midaged women.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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• pp.34-34
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• 2001

Survivin, an apoptosis inhibitor/cell-cycle regulator, is critically required for suppression of apoptosis and ensuring normal cell division in the G2/M phase of the cell cycle. It is highly expressed in a cell cycle-regulated manner and localizes together with caspase-3 on microtubules within centrosomes. Whether survivin is a physiologically relevant caspase inhibitor has been unclear due to the difficulties with obtaining correctly folded survivin and finding right conditions for inhibition assay.(omitted)

• 대한가정학회:학술대회논문집
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• 대한가정학회 1997년도 Program & Abstracts * The 7th Korea-Japan Home Economics Joint Syposium
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• pp.50-50
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• 1997

• 안전기술
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• 45호
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• pp.8-11
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• 2001

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2008년도 제49회 학술심포지움 및 국제학술대회
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• pp.23.2-23.2
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• 2008

• 한국가정과학회지
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• 제1권2호
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• pp.75-88
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• 1998

This study designed to explore the patterns of housing life-styles and the characteristics of apartment housing residents and to examine the relationships between housing life-styles and the characteristics of apartment-housing residents. The data for this study was collected by questionnaires administered to 278 homemakers living in apartment housing over 20s pyong(66$m^2$) in the Kwangju area. The major findings of this study can be summarized as follows; 1. Housing life-styles were grouped into 9 sub-categories : the Anbang-centered, the dining-centered, the pursuit of conspicuosness and conformity, orientation to change, the pursuit of orderliness, the pursuit of decoration, orientation to community, pursuit of individuality and the orientation to a natural environment. 2. Housing life-styles were significantly different according to age, educational background, and employment status of homemakers, occupation of the primary income provider, family-life cycle stage, total household income, and housing size. (Korean J Human Ecology 1(2):75~88. 1998)

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.300-300
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• 2000

Reduced life-cycle and scale of electronic products make the conventional automated manufacturing system difficult to keep on competitiveness in these days. Reduced life-cycle requires an agile adaptation of manufacturing to new products and reduced scale requires enhanced precision as well as high speed. In this research, We propose a new concept called as "One-Cell Minifactory" in which various processes are combined to produce final modules or products and human interaction can be combined easily. We hope the proposed concept can guide new developments of automated manufacturing in electronics, optics and bio-engineering.

• Molecules and Cells
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• 제41권5호
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• pp.436-443
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• 2018

The actin cytoskeleton plays a key role in the entry of mitosis as well as in cytokinesis. In a previous study, we showed that actin disruption delays mitotic entry at G2/M by sustained activation of extracellular signal-related kinase 1/2 (ERK1/2) in primary cells but not in transformed cancer cell lines. Here, we examined the mechanism of cell cycle delay at G2/M by actin dysfunction in IMR-90 normal human fibroblasts. We observed that de-polymerization of actin with cytochalasin D (CD) constitutively activated ribosomal S6 kinase (RSK) and induced inhibitory phosphorylation of Cdc2 (Tyr 15) in IMR-90 cells. In the presence of an actin defect in IMR-90 cells, activating phosphorylation of Wee1 kinase (Ser 642) and inhibitory phosphorylation of Cdc25C (Ser 216) was also maintained. However, when kinase-dead RSK (DN-RSK) was overexpressed, we observed sustained activation of ERK1/2, but no delay in the G2/M transition, demonstrating that RSK functions downstream of ERK in cell cycle delay by actin dysfunction. In DN-RSK overexpressing IMR-90 cells treated with CD, phosphorylation of Cdc25C (Ser 216) was blocked and phosphorylation of Cdc2 (Tyr 15) was decreased, but the phosphorylation of Wee1 (Ser 642) was maintained, demonstrating that RSK directly controls phosphorylation of Cdc25C (Ser 216), but not the activity of Wee1. These results strongly suggest that actin dysfunction in primary cells activates ERK1/2 to inhibit Cdc2, delaying the cell cycle at G2/M by activating downstream RSK, which phosphorylates and blocks Cdc25C, and by directly activating Wee1.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3779-3783
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• 2015

Dietary prevention has been known to reduce breast cancer risk. Sesamin is one of the major components in sesame seeds and has been widely studied and proven to have anti-proliferation and anti-angiogenic effects on cancer cells. In this study, the influence of sesamin was tested in the human breast cancer MCF-7 cell line for cell viability (MTT assay) and cell cycling (flow cytometry). Results showed that sesamin dose-dependently (1, 10 and $50{\mu}M$) reduced the cell viability and increased LDH release and apoptosis (TUNEL assay). In addition, there was a significant increase of sub-G1 phase arrest in the cell cycle after sesamin treatment. Furthermore, sesamin increased the expression of apoptotic markers of Bax, caspase-3, and cell cycle control proteins, p53 and checkpoint kinase 2. Taken together, these results suggested that sesamin might be used as a dietary supplement f or prevention of breast cancer by modulating apoptotic signal pathways and inhibiting tumor cell growth.