• Bulletin of the Korean Chemical Society
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• v.29 no.3
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• pp.615-619
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• 2008

Eight triterpenoids, six lanostanes 1-6, one lupenane 7, and one oleanane 8, were isolated by bioactivity-guided fractionation of the ethylacetate extract from roots of Glycine max (L.) Merr. All isolated compounds were examined for their inhibitory activities against human ACAT-1 (hACAT-1) and human ACAT-2 (hACAT-2). Among them, three triterpenoids showed potent hACAT inhibitory activities, (24R)-ethylcholest-5-ene-3,7-diol (1) and 3b -hydroxylup-20(29)-en-28-oic acid (7) exhibited more potent inhibitory activity against hACAT-1 (1: IC50 = 25.0 1.2 and 7: IC50 = 11.5 0.4 m M) than hACAT-2 (1: IC50 = 102.0 5.4 and 7: IC50 = 33.9 3.7 m M), respectively. Interestingly, 5a ,8a -epidioxy-24(R)-methylcholesta-6,22-diene-3b -ol (4) has proven to be a specific inhibitor against hACAT-1 (IC50 = 38.7 0.8 m M) compared to hACAT-2 (IC50 >200). In conclusion, this is the first study to demonstrate that triterpenoids of G. max have potent inhibitory activities against hACAT-1 and hACAT-2.

• 대한예방의학회:학술대회논문집
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• 2002.05a
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• pp.92-92
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• 2002

• Journal of Family Resource Management and Policy Review
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• v.1 no.1
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• pp.71-78
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• 1997

The purpose of this study was to establish the basic concept on the creative and better family life planning. This planning afford promise of implement about the family life tasks and preventive interventions of family life problems or issues. The conceptual forcus are on the values, interdependence, wholeness, adaptation and balance of human life. This study provide of the basic about the social education program and family life education for quality of life.

• Journal of Environmental Impact Assessment
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• v.15 no.6
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• pp.373-383
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• 2006

The spatial mapping of risk is very useful data in planning for disaster preparedness. This research presents a methodology for making the landslide life risk map in the Boeun area which had considerable landslide damage following heavy rain in August, 1998. We have developed a three-stage procedure in spatial data analysis not only to estimate the probability of the occurrence of the natural hazardous events but also to evaluate the uncertainty of the estimators of that probability. The three-stage procedure consists of: (i)construction of a hazard prediction map of "future" hazardous events; (ii) validation of prediction results and estimation of the probability of occurrence for each predicted hazard level; and (iii) generation of risk maps with the introduction of human life factors representing assumed or established vulnerability levels by combining the prediction map in the first stage and the estimated probabilities in the second stage with human life data. The significance of the landslide susceptibility map was evaluated by computing a prediction rate curve. It is used that the Bayesian prediction model and the case study results (the landslide susceptibility map and prediction rate curve) can be prepared for prevention of future landslide life risk map. Data from the Bayesian model-based landslide susceptibility map and prediction ratio curves were used together with human rife data to draft future landslide life risk maps. Results reveal that individual pixels had low risks, but the total risk death toll was estimated at 3.14 people. In particular, the dangerous areas involving an estimated 1/100 people were shown to have the highest risk among all research-target areas. Three people were killed in this area when landslides occurred in 1998. Thus, this risk map can deliver factual damage situation prediction to policy decision-makers, and subsequently can be used as useful data in preventing disasters. In particular, drafting of maps on landslide risk in various steps will enable one to forecast the occurrence of disasters.

• Journal of Korean Academy of Nursing
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• v.34 no.8
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• pp.1434-1442
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• 2004

Purpose. Professional nursing ethics is a living, dynamic set of standards for nurses' professional moral behavior. Furthermore, in daily clinical nursing training, nursing students are constantly confronted with decision-making that is moral in nature. The aim of this study was to identify the perceived ethical attitudes in the clinical training process of senior nursing students using Q-methodology to offer basic strategies for nursing ethics education and thereby improve patients' care. Methods. Q-methodology provides a scientific method for identifying perception structures that exist within certain individuals or groups. Thirty-seven participants in a university rated 38 selected Q-statements on a scale of 1-9. The collected data were analyzed using pc-QUNAL software. Results. Principal component analysis identified 3 types of ethical attitudes in nursing students in Korea. The categories were labeled Sacred-life, Science-realistic and Humane-life. Sacred-life individuals think that a life belongs to an absolute power (God), not a man, and a human life is a high and noble thing. Science-realistic individuals disagreed that allowing an induced abortion or embryo (human) duplication is unethical behavior that provokes a trend, which takes the value of a life lightly; most of them took a utilitarian position with respect to ethical decisions. Humane-life individuals exhibit a tendency toward human-centered thought with respect to ethical attitudes. Conclusion. This study will be of interest to educators of students of nursing and hospital nursing administrators. Also, the findings may provide the basis for the development of more appropriate strategies to improve nursing ethics education programs.

• Journal of Applied Biological Chemistry
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• v.58 no.3
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• pp.281-285
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• 2015

Human neutrophil elastase (HNE) represents a good therapeutic target for the treatment of inflammatory diseases as well as invasion of microorganism. The methanol extract of a aerial part of Chelidonium majus L. showed high activity against the neutrophil elastase with an $IC_{50}$ value of $100{\mu}g/mL$. Due to its potency, subsequent bioactivity-guided fractionation of methanol extract led to six alkaloids (1-6), which were identified as dihydrosanguinarine (1), (s)-stylopine (2), arnottianamide (3), (+)-chelidonine (4), spallidamine (5), and N-trans-feruloyltyramine (6). Among of them, three alkaloids (2, 5, and 6) inhibited HNE in a dose-dependent manner with $IC_{50}$ ranging between 11.6 and $51.0{\mu}M$. Lineweaver-Burk and Dixon plots, and their secondary replots showed that alkaloids (2, 5, and 6) were mixed inhibitors of HNE. The analysis of $K_I$ and $K_{IS}$ value proved that all inhibitors (2, 5, and 6) had reversible mixed type I mechanism.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.473-479
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• 2020

Endothelial cell injury is a major contributor to cardiovascular diseases. The 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside (TSG) contributes to alleviate human umbilical vein endothelial cells (HUVECs) injury through mechanisms still know a little. This study aims to clarify the TSG effects on gene expression (mRNA and microRNA) related to oxidative stress and endoplasmic reticulum stress induced by H₂O₂ in HUVECs. We found that TSG significantly reduced the death rate of cells and increased intracellular superoxide dismutase activity. At qRT-PCR, experimental data showed that TSG significantly counteracted the expressions of miR-9-5p, miR-16, miR-21, miR-29b, miR-145-5p, and miR-204-5p. Besides, TSG prevented the expression of ATF6 and CHOP increasing. In contrast, TSG promoted the expression of E2F1. In conclusion, our results point to the obvious protective effect of TSG on HUVECs injury induced by H₂O₂, and the mechanism may through miR16/ATF6/ E2F1 signaling pathway.

• Human Ecology Research
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• v.60 no.3
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• pp.471-481
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• 2022

This study aimed at examining the mediation effects of depressive symptoms on the association between social activity participation and marital satisfaction among couples in later life. The study included 1,196 married couples aged 65 or above who participated in the 7th Korean Longitudinal Study of Aging in 2018. The study variables were husbands' and wives' social activity participation, marital satisfaction, and depressive symptoms. Covariates were individual age, education level, subjective health, couples' household income, and number of children. The Actor-Partner Interdependence Mediation Model (APIMeM) and bootstrapping techniques were used to test the significance of the mediating impacts of depressive symptoms based on the dyadic data structure. The results showed that for both husbands and wives, active participation in social activities had significant effects on increasing marital satisfaction through lowering depressive symptoms. However, only the participation of husbands in social activities was positively associated with their own marital satisfaction by reducing their own and their partner's depressive symptoms. These findings suggest that the active social participation of individuals salient for promoting the quality of marital relationships in later life, particularly for preventing their own and their spouse's depressive symptoms.

• Journal of Ginseng Research
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• v.42 no.2
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• pp.229-232
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• 2018

• Journal of Korean Medical classics
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• v.22 no.4
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• pp.129-143
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• 2009

In this paper, we will discuss the main characteristics of Korean traditional medicine and their bond with the philosophy of Noja(老子) to ultimately examine how "Dodeokgyeong(道德經)" affected medicine as a pragmatic field of study. Noja(老子) viewed the universe and the creatures living in it to be constituted by gi(氣), and that everything continuously moves and changes as a result of the conflicts between two opposing energies within, eum(陰) and yang(陽). "Hwangjenaegyeong(黃帝內經)" is about how this theory is applied to human lives. "Dodeokgyeong" speaks of the Heaven, Human, and Do accordance, offering the theoretical basis for the correspondence between nature and human in the "Hwangjenaegyeong", where the Heaven, Human and Do(道) accordance theory is embodied into each element of the human vital activity, establishing the identity of Korean traditional medicine as natural medicine. Noja declared life in accordance with Do(道) as an ideal way to live. "Hwangjenaegyeong" applies this idea to human vital activity setting the realization of Do the ultimate goal of life and offers actual guidelines. The preventive aspect of Korean traditional medicine is the characteristic most affected by "Dodeokgyeong". "Hwangjenaegyeong" and "Dodeokgyeong" both recognized the relativity of objects, and spoke of harmony and balance as the answer to conflicts between matters.