• Title/Summary/Keyword: human leukemia

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Steroid compounds from the marine sponge Raspilia hirsute

  • Rho Jung-Rae
    • Journal of the Korean Magnetic Resonance Society
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    • v.10 no.1
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    • pp.89-95
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    • 2006

  • The methanolic extract of the marine sponge Raspilia hirsute collected from Keomun Island resulted in three types of sterols: a mixture of (24S)-Poriferasta-5, 25-diene-$3\beta$, 24-diol and (24R)-Stigmasta-5, 25-diene-$3\beta$, 24 -diol (1), 25,26,27-Trinorcholest-5-en-$3\beta$,24-diol (2), and Pregn-5-en-20-on-$3\beta$-ol (3). The isolation and structural determination of these sterols are reported here. Compound 1 showed moderate cytotoxicity against human Leukemia cell line K562.

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Thioredoxin System and Redox Signaling; Defence against Stress and Toxicity

  • Yodoi, Junji;Masutani, Hiroshi;Nakamura, Hajime
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.84-88
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    • 2001

  • Human Thioredoxin (TRX) with with redox-active dithiol (C-C-Y-C-) in the active site has been cloned as adult T cell leukemia derived factor produced by HTLV-I transformed cells. Thioredoxin (TRX) is one of the major components of the thiol-reducing system and plays multiple roles in cellular processes such as proliferation, apoptosis and gene expression.(omitted)

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8-Hydroxyguanine in DNA Mediates Cell Death of KG-1, a Human Leukemia Cell Line by Inducing Cell Cycle Arrest and Apoptosis

  • Hyun, Jin-Won
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.89-93
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    • 2001

  • All that is presently known about the actions of 8-hydroxyguanine (8-oxoguanine; oh$^{8}$ Gua) in DNA is that it harms genetic integrity. This is even speculation based upon scattered in vitro experimental data such as the mismatch of oh$^{8}$ Gua with A in stead of C and the GC longrightarrow TA transversion observed in the DNA polymerase reaction using an oh$^{8}$ Gua containing oligonucleotide.(omitted)

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Eupatilin, A Pharmacologically Active Flavone Derived From Artemisia Plants, Inhibits Growth of H-Ras Transformed Human Breast Epithelial Cells Through Cell Cycle Arrest

  • Kim, Do-Hee;Na, Hye-Kyung;Surh, Young-Joon
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.05a
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    • pp.89-90
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    • 2003

  • Extracts of Artemisia asiatica Nakai (Asteraceae) have been shown to have anti-inflammatory and anti-oxidative activities. Eupatilin (5,7-dihydroxy-3,4,6-tri-methoxy-flavone), one of the pharmacologically active ingredients derived from Artemisia asiatica, has been shown to induce apoptosis in promyelocytic leukemia (HL-60) cells. (omitted)

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RADIATION SENSITIVITY DEPENDS ON OGG1 ACTIVITY STATUS IN HUMAN LEUKEMIA CELL LINES

  • Hyun, Jin-Won;Chung, Myung-Hee
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.83-83
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    • 2002

  • To assess the role of 8-oxoguanine glycosylase (OGG1) in the cell defense against radiation injury, the radiation-induced cytotoxicities were compared between the mutant type KG-1 featuring a loss of OGG1 activity due to a homozygous mutation of Arg 229 G1n, and the wild type U937.(omitted)

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