• Title/Summary/Keyword: human induced load

Search Result 35, Processing Time 0.024 seconds

Study on Structural Safety of Car Securing Equipment for Coastal Carferry: Part I Estimation of Hull Acceleration using Direct Load Approach (국내 연안 카페리 차량 고박 장치 안전성에 관한 연구: 제I부 직접하중계산법을 이용한 선체 운동 가속도 산정)

  • Choung, Joonmo;Jo, Huisang;Lee, Kyunghoon;Lee, Young Woo
    • Journal of Ocean Engineering and Technology
    • /
    • v.30 no.6
    • /
    • pp.440-450
    • /
    • 2016
  • The capsizing and consequent sinking of a coastal car ferry was recently reported, with numerous human casualties. The primary cause was determined to be a sudden turn with improperly stowed and secured cargo. Part I of this study introduces how long term acceleration components are determined from seakeeping analyses. A carferry with a displacement of 1,633 tonf was selected as the target vessel. Sea data that included the significant wave heights and periods were collected at four observation buoys, some of which were far away from two main voyage routes: Incheon-Jeju and Pusan-Jeju. Frequency response analyses were performed to obtain the linearized radiation force coefficients, hydrostatic stiffnesses, and wave excitation forces. Time response analyses were sequentially performed to produce the motion-induced acceleration processes. The probabilistic distributions of the acceleration components were determined using a peak and valley counting method. Long term extreme acceleration components were proposed as a final result.

Effects of NOS Inhibitors on Arthritis and Arthritic Pain in Rats

  • Min, Sun-Seek
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.11 no.6
    • /
    • pp.253-257
    • /
    • 2007
  • Among the arthritis symptoms, chronic pain is the most serious, and it can profoundly affect the quality of human life. Unfortunately, the mechanism of development in arthritis and arthritic pain has not yet been precisely elucidated. Accumulating evidence indicates that nitric oxide (NO) plays a pivotal role in nociceptive processing in the spinal cord. However, the modulation mechanism of NO in the peripheral site of arthritis and arthritic pain has not been clarified. Therefore, I determined in the present study which nitric oxide synthase (NOS) was involved in the induction of arthritis and arthritic pain. Monoarthritis was induced by intra-articular injection of carrageenan (2%, $50{\mu}l$) into rats, and resulted in the reduction of weight load on the injected leg, increase of knee joint diameter and inflammatory response. Pre-treatment of rats with L-N6-(1-iminoethyl)-lysine (L-NIL, $500{\mu}g$, in $50{\mu}l$), an inhibitor of inducible NOS (iNOS), partially prevented the induction of pain-related behavior and partially reduced inflammatory response in the synovial membrane in the knee joint. These results suggest that iNOS in the knee joint may play an important role in the induction of pain-related behavior and inflammation, and that NO produced by iNOS may be associated with nociceptive signaling in the peripheral site.

Bavachin Suppresses Alpha-Hemolysin Expression and Protects Mice from Pneumonia Infection by Staphylococcus aureus

  • Tao, Ye;Sun, Dazhong;Ren, Xinran;Zhao, Yicheng;Zhang, Hengjian;Jiang, Tao;Guan, Jiyu;Tang, Yong;Song, Wu;Li, Shuqiang;Wang, Li
    • Journal of Microbiology and Biotechnology
    • /
    • v.32 no.10
    • /
    • pp.1253-1261
    • /
    • 2022
  • Staphylococcus aureus (S. aureus) infection causes dramatic harm to human health as well as to livestock development. As an important virulence factor, alpha-hemolysin (hla) is critical in the process of S. aureus infection. In this report, we found that bavachin, a natural flavonoid, not only efficiently inhibited the hemolytic activity of hla, but was also capable of inhibiting it on transcriptional and translational levels. Moreover, further data revealed that bavachin had no neutralizing activity on hla, which did not affect the formation of hla heptamers and exhibited no effects on the hla thermal stability. In vitro assays showed that bavachin was able to reduce the S. aureus-induced damage of A549 cells. Thus, bavachin repressed the lethality of pneumonia infection, lung bacterial load and lung tissue inflammation in mice, providing potent protection to mice models in vivo. Our results indicated that bavachin has the potential for development as a candidate hla inhibitor against S. aureus.

A Study on Fire Resistance Character of a Tunnel and an Underground Structure (터널 및 지하구조물의 내화특성에 관한 연구)

  • Yoo, Sang-Gun;Kim, Jung-Joo;Park, Min-Yong;Kim, Eun-Kyum;Lee, Jun-Suk
    • Journal of the Korean Society for Railway
    • /
    • v.13 no.2
    • /
    • pp.194-200
    • /
    • 2010
  • Recently, a longitudinal tunnel construction has increased because of subway construction extension, geomorphological effect and the development of construction Technologies etc. When the fire occurs in a tunnel and an underground structure, the many damage of human life and the economic losses are caused. In Korea, fire resistance character study of a tunnel and an underground structure is proceeding. However, when a concrete is exposed to high temperature, study of load carrying capacity reduction and stability evaluation for spalling of a concrete is not enough. Therefore in this study, fire resistance character of a concrete evaluated according to time heating temperature curve(RABT and RWS) and a result compared on virtual fire accident in order to apply fire scenario. Also this study performed thermo-mechanical coupled analysis of a FEM-based numerical technique and estimated fire-induced damage of a tunnel and an underground structure.

A Two-Stage Learning Method of CNN and K-means RGB Cluster for Sentiment Classification of Images (이미지 감성분류를 위한 CNN과 K-means RGB Cluster 이-단계 학습 방안)

  • Kim, Jeongtae;Park, Eunbi;Han, Kiwoong;Lee, Junghyun;Lee, Hong Joo
    • Journal of Intelligence and Information Systems
    • /
    • v.27 no.3
    • /
    • pp.139-156
    • /
    • 2021
  • The biggest reason for using a deep learning model in image classification is that it is possible to consider the relationship between each region by extracting each region's features from the overall information of the image. However, the CNN model may not be suitable for emotional image data without the image's regional features. To solve the difficulty of classifying emotion images, many researchers each year propose a CNN-based architecture suitable for emotion images. Studies on the relationship between color and human emotion were also conducted, and results were derived that different emotions are induced according to color. In studies using deep learning, there have been studies that apply color information to image subtraction classification. The case where the image's color information is additionally used than the case where the classification model is trained with only the image improves the accuracy of classifying image emotions. This study proposes two ways to increase the accuracy by incorporating the result value after the model classifies an image's emotion. Both methods improve accuracy by modifying the result value based on statistics using the color of the picture. When performing the test by finding the two-color combinations most distributed for all training data, the two-color combinations most distributed for each test data image were found. The result values were corrected according to the color combination distribution. This method weights the result value obtained after the model classifies an image's emotion by creating an expression based on the log function and the exponential function. Emotion6, classified into six emotions, and Artphoto classified into eight categories were used for the image data. Densenet169, Mnasnet, Resnet101, Resnet152, and Vgg19 architectures were used for the CNN model, and the performance evaluation was compared before and after applying the two-stage learning to the CNN model. Inspired by color psychology, which deals with the relationship between colors and emotions, when creating a model that classifies an image's sentiment, we studied how to improve accuracy by modifying the result values based on color. Sixteen colors were used: red, orange, yellow, green, blue, indigo, purple, turquoise, pink, magenta, brown, gray, silver, gold, white, and black. It has meaning. Using Scikit-learn's Clustering, the seven colors that are primarily distributed in the image are checked. Then, the RGB coordinate values of the colors from the image are compared with the RGB coordinate values of the 16 colors presented in the above data. That is, it was converted to the closest color. Suppose three or more color combinations are selected. In that case, too many color combinations occur, resulting in a problem in which the distribution is scattered, so a situation fewer influences the result value. Therefore, to solve this problem, two-color combinations were found and weighted to the model. Before training, the most distributed color combinations were found for all training data images. The distribution of color combinations for each class was stored in a Python dictionary format to be used during testing. During the test, the two-color combinations that are most distributed for each test data image are found. After that, we checked how the color combinations were distributed in the training data and corrected the result. We devised several equations to weight the result value from the model based on the extracted color as described above. The data set was randomly divided by 80:20, and the model was verified using 20% of the data as a test set. After splitting the remaining 80% of the data into five divisions to perform 5-fold cross-validation, the model was trained five times using different verification datasets. Finally, the performance was checked using the test dataset that was previously separated. Adam was used as the activation function, and the learning rate was set to 0.01. The training was performed as much as 20 epochs, and if the validation loss value did not decrease during five epochs of learning, the experiment was stopped. Early tapping was set to load the model with the best validation loss value. The classification accuracy was better when the extracted information using color properties was used together than the case using only the CNN architecture.