• Clinical and Experimental Pediatrics
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• v.59 no.sup1
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• pp.53-56
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• 2016

Familial Mediterranean fever (FMF) is the most common Mendelian autoinflammatory disease, characterized by uncontrolled activation of the innate immune system that manifests as recurrent brief fever and polyserositis (e.g., peritonitis, pleuritic, and arthritis). FMF is caused by autosomal recessive mutations of the Mediterranean fever gene, MEFV which encodes the pyrin protein. Although FMF predominantly affects people from Mediterranean and Middle Eastern ethnic origins, 3 cases of FMF have been reported in Korea since 2012. We report another case of FMF in Korea in which the patient presented with a month-long fever without serositis. After treatment with colchicine was initiated, the patient's symptoms quickly subsided. The response to colchicine was helpful for diagnosis. We compare the FMF genotypes in Korea with in other countries. Studying FMF cases in Korea will help establish the best MEFV exons to use for screening and diagnosis of Korean FMF.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10585-10589
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• 2015

Breast cancer susceptibility gene 1 (BRCA1), mapped on chromosome 17q21, is implicated in the mechanisms of cellular DNA repair. Inactivation of this gene is involved in the development of many human cancers, including breast cancer. This study aimed to investigate the prognostic value of BRCA1 promoter hypermethylation and expression in breast cancer cases. Sixty-one breast cancers were examined for BRCA1 hypermethylation by methylation-specific polymerase chain reaction (PCR), and 45 paired normal breast tissues were analyzed for altered BRCA1 mRNA levels by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). Aberrant methylation status in BRCA1 was detected in 15 of 61 cases (24.6%), while reduced expression was found in 7 of 45 (15.6%). BRCA1 hypermethylation was statistically associated with tumor grade III (p=0.04), a high frequency of stage IIB (p=0.02), and triple-negative phenotype (OR= 3.64, 95%CI =1.1-12.3, p=0.03). Our findings indicated that BRCA1 promoter hypermethylation is a useful prognostic marker for breast cancer.

• Proceedings of the KSME Conference
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• 2001.06a
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• pp.951-955
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• 2001

The experimental comparison between bonded and unbonded types stem-cement interface was carried out on axisymmetric stem-cement-aluminum model of the femoral component of a total hip replacement. Human femur was modeled in non-tapered and tapered($7.5^{\circ}$) aluminum hollow cylinders to emulate the diaphyseal and metaphyseal segments of the femur. For unbonded type, we tested stems with three different taper angles($5^{\circ},\;7.5^{\circ},\;10^{\circ}$). In every case, the cement-aluminum interface was designed to endure 8MPa shear strength. (a measured value at cement-bone interface) We tested aluminum models under axial loading for both cases. As an experimental result, it was found that unbonded stem sustained more axial load as bonded stem in both cases, diaphyseal and metaphyseal models. The unbonded types failed in cement mantle under axial compressive load, while the bonded ones failed in shear at cement-aluminum interface. These results suggest that a polished stem will sustain much higher axial load than a roughened stem. And a polished stem will make more stable cement-bone interface that may promote better osteosythesis around the stem.

• Journal of Korean Physical Therapy Science
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• v.5 no.4
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• pp.837-843
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• 1998

The purpose of this study was to examine the effect of optic pathway on human body during Proprioceptive Neuromuscular Facilitation(PNF) treatment. Specifically, it's intened to find out through electromyography(EMG), what kind on change occurred in a patient's muscle when the patient saw the motor direction or when the patient didn't. A pilot experiment Was made over the sophomores of Mokpo Science College the following findings were given; As an EMG was taken over three of muscles that worked during Flexion-Adduction-Ext. Rot., one of the PNF pattern, a patient showed relatively stronger muscle power while watching the movement with his eyes open than the same patient did with his eyes closed, and the disparity between the two cases Was statistically significant(P<0.05). In the pattern of Extension-Abduction-Int.Rot., a patient also showed relatively stronger muscle power while watching the movement than the same patient did without watching it, and the disparity between the two cases also were significant(P<0.05). As seen above, the effect of motor treatment, among physiotherapy methods seemed to be greater if a patient watched the motor direction during treatment, because it gave a stimulus to proprioception.

• Parasites, Hosts and Diseases
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• v.39 no.1
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• pp.77-80
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• 2001

Cutaneous larva migrans (CLM) is a rare serpiginous cutaneous eruption caused by accidental penetration and migration in the skin with infective larvae of nematode that normally do not have the human as their host. Although CLM has a worldwide distribution, the infection is most frequent in warmer climates. More recently, they have been increasingly imported from the tropics or subtropics by travelers. We experienced two patients who had prutitic serpiginous linear eruption in their skin for a few weeks after traveling to the endemic areas (Brazil and Thailand, respectively) . After the treatment with albendazole, the skin lesions resolved with post-inflammatory hyperpigmentation. We report herein two cases of cutaneous larva migrans successfully treated with albendazole.

• Parasites, Hosts and Diseases
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• v.33 no.1
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• pp.61-64
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• 1995

Gymnopholloides seoi, a new intestinal trematode of humans transmitted by oysters on a southwestern island of Korea, dry medical attentions because of its possible relationship with evoking pancreatitis or other pancreatic diseases. We experienced ho interesting cases of G. seoi infection who were accompanied with diabetes mellitus. In routine stool examination, eggs of a gymnophallid were detected from two patients, and after treatment with praziquantel and purgation, 772 and 10 adult flukes were recovered respectively. They were identified as G. seoi The first patient was a 62-year old man who lived in Mokpo, nearby the known endemic area, and the second patient, a 54-year old woman who lived in Inchon. They used to eat raw oysters. It should be ruled out that G. seoi infection has some relationship with pancreatic diseases.

• The Journal of Korean Society for School & Community Health Education
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• v.12 no.1
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• pp.71-89
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• 2011

Objectives: The purpose of this study is to identify risk behavior related to the school accident between male and female elementary school students. Methods: 838 School accident data provided by Seoul School Safety Council were analyzed by gender. Based on the results above, survey questionnaires on characteristics of school accident were developed. Self-reported data were collected from a sample population of 433 students in grade 5 to 6 students attending 4 elementary schools in Seoul. Results: The students who answered they experienced the accident in school for the past 1 year, accounts 60.5% of male and 39.5% of females students, which has statistically significant difference. The male's cases happened most around corridor/door, while female's cases happened most in the playground/gymnasium. As for the accident risk behavior, male students had the risk behavior by using the personal belongings/toys, while the female students had much risk behavior related to physical facility/playground. When classifying the characteristics of risk behaviors according to the accident causes, male students showed higher score in the accident risk behaviors related to play/fight than in those of the female students(p<0.05). Conclusions: Health care providers should develop school safety programs by characteristics of risk behavior between male and female elementary school students.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.42 no.3
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• pp.169-172
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• 2016

Following anti-retroviral therapy (ART) or highly active antiretroviral therapy, there is an increased response to latent infections such as herpes zoster, which may lead to their reactivation. This is a result of improved immunity brought about by ART, also termed immune recovery syndrome. A 75-yearold male patient arrived at our institute with widespread vesicles and scabs on the right half of his face and oral cavity, suggesting the involvement of the trigeminal nerve. The patient had a history of being on ART two months earlier and a history of tooth extraction eight days prior to his arrival at our institute. The incidence of human immunodeficiency virus (HIV)-positive cases amongst herpes zoster cases is high, and these patients become susceptible to infections following ART. Therefore, regardless of the presence of risk factors, every herpes zoster patient should be tested for HIV infection, and high anti-retroviral therapy should be commenced/reinstituted as soon as possible. In addition, the treating physician should maintain a high level of vigilance for the patient during the first few months of ART, the peak incidence of immune recovery inflammatory disease.

• Tuberculosis and Respiratory Diseases
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• v.40 no.4
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• pp.436-441
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• 1993

Human lung injury caused by the inhalation of nitrogen dioxide($NO_2$) has been reported in occupational situations other than agriculture, including arc welding, production of nitric acid or explosives, and blasting operations. Nitrogen dioxide reacts with the water in the respiratory tract to form nitric acid. The nitrates and nitrites formed from dissociation of nitric acid cause extensive local and systemic tissue damage. We present two cases of acute lung injury due to accidental inhalation of $NO_2$ gas in occupational situtions with a review of the literature.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.1
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• pp.81-88
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• 1999

A fibrin adhesive have been widely used in oral and maxillofacial surgery for microvascular anastomosis, autogenous chip bone grafts, many kinds of soft tissue surgery (vestibuloplasty, bleeding control after extraction, primary healing by covering of suture of a gum after the extirpation of large cysts). There are two principal components in adhesive systems biologically: lyophilized human fibrinogen and bovine thrombin. The fibrinogen component contains coagulation factor XIII and enhance the initial wound healing, which polymerizes soluble fibrin monomers into an insoluble clot. The thrombin is dissolved in a solution of calcium chloride to provide the second component. We applied fibrin adhesive, Beriplast (Behring, Behringwerke AG, D-3350, Marburg, FRD), to 4 patients for fixation of free skin grafting donors who had facial scar around eye, nose, mouth corner which received from accidents, or burn. We have experienced initial accelerated graft fixation between donor and recipient sites with no additional fixation. And It's made easy bleeding control and easy manipulation during operation. But two cases showed partial hypertrophic scar engrowth in above 3 months follow up, but no significant. Histopathological reviews in general were showed similar scar findings such as abundant collagen bundles in H&E, M/T stain, but slight positive signs in elastic and collagen antibody immunopathologic findings in hypertrophic scar cases.