• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.520-525
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• 2012

Prostaglandin (PG) $E_2$, the most abundant prostaglandin in the human body, is synthesized from arachidonic acid via the actions of cyclooxygenase (COX) enzymes. $PGE_2$ exerts homeostatic, cytoprotective, inflammatory, and in some cases anti-inflammatory effects. Also, it has been reported that $PGE_2$ is involved in hair growth. Diphlorethohydroxycarmalol (DPHC) is a phlorotannin compound isolated from the brown algae Ishige okamurae, with various biological activities in vitro and in vivo. In this study, the biological effect and mechanism of action of DPHC on prostaglandin synthesis in HaCaT human keratinocytes was examined. The results showed that, in these cells, DPHC significantly and dose-dependently induced $PGE_2$ synthesis by increasing the protein and mRNA levels of COX-1 and COX-2. Interestingly, DPHC-induced COX-1 expression preceded that of COX-2. Also, while both rofecoxib and indomethacin inhibited $PGE_2$ production, the latter was seems to be the more potent. From above results, we can expect that DPHC has some beneficial effects via increasing of $PGE_2$ production.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.23 no.55
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• pp.97-106
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• 2000

In this paper, we would be searching for the complemental aspects in industrial relations of Korea compared with that of Japan. It is very reasonable that historical, geographical, and especially gene analysis data are almost identical, considering that the general evaluations to the motive of Japan's industry are $\ulcorner$the modernization of the tradition$\lrcorner$. Although it is reported Korea accomplished the high economic growth rate, the economic growth rate(efficiency) could not be continued. This reason looks like that Korean proper(eigen) traits(:Gene-ware) have been oppressed and concealed by social climate such as jealousy, stratagem and hatred, we can find one of this facts in the criminal and complaint numbers as social trust measurement. There are many cases that Korean industry was distorted by the superiority/inferiority relations, for examples, the loss of the native(eigen or proper) resources, a distorted introduction of the production method and the unfolding of the industry which be not related to the characteristics of region. In this reasons, Korean industry could not play the role of Human-ware function which activates Gene-ware or, Gene-Nascence. In this Human-ware aspects, Japanese characteristics, such as $\ulcorner$Getting the basic right$\lrcorner$ and $\ulcorner$Tendency to the origin$\lrcorner$, are to be useful in the Nascence of Gene-ware in Korean industry.

• Proceedings of the KIEE Conference
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• 2000.07d
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• pp.3037-3040
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• 2000

Real-Time object tracking has emerged as an important component in several application areas including machine vision. surveillance. Human-Computer Interaction. image-based control. and so on. And there has been developed various algorithms for a long time. But in many cases. they have showed limited results under uncontrolled situation such as illumination changes or cluttered background. In this paper. we present a novel. computationally efficient algorithm for tracking human face robustly under illumination changes and cluttered backgrounds. Previous algorithms usually defines color model as a 2D membership function in a color space without consideration for illumination changes. Our new algorithm developed here. however. constructs a 3D color model by analysing plenty of images acquired under various illumination conditions. The algorithm described is applied to a mobile head-eye robot and experimented under various uncontrolled environments. It can track an human face more than 100 frames per second excluding image acquisition time.

• Archives of Pharmacal Research
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• v.27 no.2
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• pp.127-135
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• 2004

Multiple drug administration is common in elderly, HIV, and cancer patients. Such treatments may result in drug-drug interactions due to interference at the metabolic enzyme level, and due to modulation of transporter protein functions. Both kinds of interference may result in altered drug distribution and toxicity in the human body. In this review, we have dealt with drug-drug interactions related to the most studied human transporter, P-glycoprotein. This transporter is constitutively expressed in several sites in the human body. Its function can be studied in vitro with different cell lines expressing P-glycoprotein in experiments using methods and equipment such as flow cytometry, cell proliferation, cell-free ATP as activity determination and Transwell culture equipment. In vivo experiments can be carried out by mdr1a(-/-) animals and by noninvasive methods such as NMR spectrometry. Some examples are also given for determination of possible drug-drug interactions using the above-mentioned cell lines and methods. Such preclinical studies may influence decisions concerning the fate of new drug candidates and their possible dosages. Some examples of toxicities obtained in clinics and summarized in this review indicate careful consideration in cases of polypharmacy and the requirement of preclinical studies in drug development activities.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.346-349
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• 2018

In North-East asian countries, laver cultivation has been an important marine industry in coastal areas as well as fishery because laver (Porphyra) is nutrient-rich food and has been used in many Asian cuisines. Laver is characterized by high concentrations of fiber and minerals, a low fat content, and, in some cases, relatively high protein levels. In this paper we inplimented design of fully automatic laver harvesting, nowdays most peoples are used to collect a laver harvesting by human, it is very defficult working, due to wind, waves, and the weather conditions which is hard to stand on the ship and holding the seaweed nets it can be injurced human, this is the reason to we are developed automatic harvesting method, in this project we proposed automatic harvesting collect method which is operated without human. Mainly we design and developed automated ship, This ship is devided in to three parts frist part is supporting roller, second part is drum screener, thried part is lifting mechanism. Thise are operated with hydro pnumatic equimpment, this divice are control with micro controller. The system prototype has implemented and satisfied by the performance to realize the further level.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.1896-1897
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• 2007

Medical equipment of high frequency has been presently applied to various parts of human body and novel treatment effects have been shown by it. Recently there are many cases that high frequency apparatus has been used in dermatology as the interest in beauty has been growing. Especially used in skin, blood volume is increased by keeping surface temperature of skin at around $43^{\circ}C$ and domodex folliculorum are treated by applying high electric field. It is the aspect we consider that increasing blood volume and domodex folliculorum treatment take effect on hair loss. In this study, high frequency electrotherapy apparatus was proposed to be applied to hair loss treatment. For that, human body was experimented with varying output voltage and frequency. The adjustable switching signal for treatment was obtained from 100[kHz] to 1000[kHz] by using DSP. Stable output specific was also obtained by feedback control to protect human body. The best hair growth conditions were the output voltage of 1.2[kV], the frequency of near 300[kHz] and the maximum current of 2[mA]. We apply this high frequency electrotherapy apparatus to two bald men, 46-year-old and 45-year-old. After treatment for a month they had thick and strong hair.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.6
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• pp.3037-3054
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• 2019

Public bicycle system (PBS) is a new emerging and popular mode of public transportation. PBS data can be adopted to analyze human movement patterns. Previous work usually focused on specific scales, and the relationships between different levels of hierarchies are ignored. In this paper, we introduce a multi-scale and interactive visual analytics system to investigate human cycling movement and PBS usage condition. The system supports level-of-detail explorative analysis of spatio-temporal characteristics in PBS. Visual views are designed from global, regional and microcosmic scales. For the regional scale, a bicycle network is constructed to model PBS data, and an flow-based community detection algorithm is applied on the bicycle network to determine station clusters. In contrast to the previous used Louvain algorithm, our method avoids producing super-communities and generates better results. We provide two cases to demonstrate how our system can help analysts explore the overall cycling condition in the city and spatio-temporal aggregation of stations.

• Journal of the Korean Society of Safety
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• v.33 no.6
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• pp.85-92
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• 2018

This study aimed to reduce of traps incident of metro train door by suggesting preventive actions throughout analyzing why railway drivers and passengers commit unsafe behaviors which are human factors making occurrence of the incidents. The incident cases were analyzed and Incident Tree was structured by brainstorming with safety experts. In addition, the questionnaire survey was conducted for comparison with the analysis results. As the result, this study suggested driver's factors, passenger's factors, and public relation plan for safe use of metro in order to reduce the frequency of the incidents. For driver's factors, implementing job-rotation systems between railway and non-railway drivers, installing Object Detection Sensors between the metro doors and PSD, and flexible operation of dwell time were suggested. For passenger's factors, placing a platform safety person, installing a safety fence in front of the stairs and the elevators, and country wide public relations through mass media were suggested.

• Journal of the Korean Society of Clothing and Textiles
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• v.45 no.1
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• pp.73-93
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• 2021

This study typifies fashion mobile plays in a digital environment and explores the experiential value created by them through a case study of a fashion brand mobile app. For the case analysis, mobile plays were divided into four types: intrinsic motivation/active participation, intrinsic motivation/passive participation, external motivation/active participation, and external motivation/passive participation, depending on the mobile players motivation and level of participation. Among the global fashion brand mobile apps released from 2009 to 2019, 16 cases suitable for the analytical framework were used for final analyses. The main results are as follows. First, mobile play value include characteristics such as networkability, immersion, hyper-spatiality, and super-temporality in addition to the attributes of a traditional play such as spontaneity, uncertainty, regularity, and playfulness. Second, the four types of mobile play provide participants with an experiential value such as creative value, emotional value, social value, and exploitative value. This study has academic implications in terms of introducing a new framework that can typify mobile plays and suggest practical implications for what experiential value fashion companies can give consumers through mobile app marketing.

• The Research Journal of the Costume Culture
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• v.30 no.2
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• pp.173-188
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• 2022

The purpose of this study is to analyze the collaboration and artification of the Issey Miyake fashion brand and to suggest the best course of artification that can secure the brand's value. The research methods are as follows: i) identifying the companies' strategy and flow through collaboration concepts and examples from Issey Miyake; ii) selecting Issey Miyake fashion brands and carrying out a literature review through websites, articles, and books; and iii) examining prior studies on the relationship between fashion and art. Results are as follows. The exhibition is divided into spaces for brand intangible assets, artistic collaboration with partners, art co-creation, and the aesthetics and tradition of the brand. Using exhibitions to share the artistic work of collaboration partners is expected to positively affect the brand's likability. The exhibit shares art collaborations in display cases for clothes and photographs. Artists and brands appear as an extension of the creative space and convergence design area. The artist's improvisation forms the creative space that communicates with the audience, and the convergence design area is expanded through the unifying organic connection between the various media in the fashion brand. The photographers and brands section displays the nature images of Pleats Please, as well as human and prism garment images. In these images, the viewer can perceive a story in the interplay between the human body and nature.