• Journal of Microbiology and Biotechnology
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• 제14권1호
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• pp.128-133
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• 2004

The secretion capacity of two E. coli strains (JM109 and AF1000) was evaluated through the expression of two human proinsulin fusion proteins using the translocation signal sequence from Staphylococcal protein A (SpA). Although a 7 to 11-fold difference in the expression levels was attained by the use of different promoters (SpA and malK promoters) and copy-number vectors (700 and 50 copies per cell), the maximum translocation rates for all the systems were around 140,000 amino acids $cell^{-1} min^{-1}$. Moreover, the secretion capacity was found to be independent of the size of the exiting peptide and its translational rate.

• World Technopolis Review
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• 제8권2호
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• pp.104-119
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• 2019

Innovation clusters are essential in the economic development of many developed countries across the world. While they present ways for under-developed and developing countries to grow their economies, fully operational innovation clusters are yet to be established in Nigeria. Many experts argue that learning from experience is an effective way of galvanizing economic development. Therefore, in this study, an empirical analysis involving a multi-variable quantitative analysis was used to examine the factors that influence the performance of the Daedeok Innopolis Innovation Cluster (South Korea). The results obtained show that the investment in education, Research and Development (R&D), labor capacity of key players within the innovation cluster, and the transfer of technology (within the cluster) were essential factors that influence the performance of the Daedeok Innopolis Innovation Cluster.

• Journal of Ginseng Research
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• 제37권2호
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• pp.144-166
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• 2013

Actoprotectors are preparations that increase the mental performance and enhance body stability against physical loads without increasing oxygen consumption. Actoprotectors are regarded as a subclass of adaptogens that hold a significant capacity to increase physical performance. The focus of this article is studying adaptogen herbs of genus Panax (P. ginseng in particular) and their capabilities as actoprotectors. Some animal experiments and human studies about actoprotective properties of genus Panax attest that P. ginseng (administered as an extract) significantly increased the physical and intellectual work capacities, and the data provided suggests that ginseng is a natural source of actoprotectors. Preparations of ginseng can be regarded as potential actoprotectors which give way to further research of its influence on physical and mental work capacity, endurance and restoration after exhaustive physical loads while compared with reference actoprotectors.

• 한국컴퓨터정보학회논문지
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• 제29권7호
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• pp.221-229
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• 2024

경제발전 수준이 높아짐에 따라 인적자본에 대한 관심은 더욱 높아지고 있다. 본 연구는 중국의 31개 지역을 대상으로 2002-2019년 기간 지역별 혁신적 인적자본을 추계 비교하고 있다. 본 연구의 혁신적 인적자본은 학력형 인적자본, 논문형 인적자본 그리고 특허형 인적자본으로 구성된다. 특히 본 연구는 기존 연구와 달리 특허형 인적자본과 논문형 인적자본의 가중치를 학력형 인적자본보다 높게 가정하고 있다. 왜냐하면 단순한 학력보다는 특허와 논문이 지역의 혁신역량에 상대적으로 더욱 큰 영향을 초래할 것이기 때문이다. 본 논문의 분석결과는 세 가지로 요약할 수 있다. 첫째, 중국의 지역별 혁신적 인적자본이 지역별 격차를 나타내고 있다. 지역경제발전 수준이 높은 지역일수록 혁신적 인적자본의 수준도 높다. 둘째, 지역별 혁신적 인적자본이 동태적으로 변하고 있다. 셋째, 북경시, 상해시, 광동성, 강소성을 중심으로 지역별 집중 현상이 더욱 가속화되고 있다. 따라서 본 연구결과는 지역경제발전에서 혁신적 인적자본의 역할이 중요함을 강조하고 있다.

• BMB Reports
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• 제43권8호
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• pp.554-560
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• 2010

Smad4 is involved in cancer progression and metastasis. Using a pair of human syngeneic epithelial ovarian cancer cells with low (HO-8910) and high (HO-8910PM) metastatic abilities, we aimed to reveal the role of Smad4 in ovarian cancer metastasis in vitro. Smad4 was down-regulated in HO-8910PM cell line relative to HO-8910 by implicating Smad4 was probably a potential tumor suppressor gene for ovarian cancer. Re-expression of Smad4 decreased the migration ability and inhibited the invasion capacity of HO-8910PM, while promoted the cell adhesion capacity for HO-8910PM. The stable expression of Smad4 increased the expression of E-cadherin, reduced the expression of plasminogen activator inhibitor-1 (PAI-1) and slightly down-regulated the expression of VEGF. Smad4 suppresses human ovarian cancer cell metastasis potential through its effect on the expressions of PAI-1, E-cadherin and VEGF. Results from current work implicate Smad4 might suppress the invasion and metastasis of human ovarian tumor cells through a TGF-$\beta$/Smad-mediated pathway.

• 한국안전학회지
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• 제36권4호
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• pp.20-28
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• 2021

With an increase in the commercialization of electricity, and the development of advanced and large electric devices and various wireless radio wave services, concerns over the effects of electromagnetic fields on human health have increased. Accordingly, the World Health Organization encouraged the development of international standards by establishing the 'International Electromagnetic Fields Project' in 1996 based on studies on the harmful effects of electromagnetic fields on the human body. Moreover, the National Institute of Environmental Health Sciences (NIEHS) classified electromagnetic fields as possible carcinogens under Group 2B category, even though they have been found to have a weak correlation with those effects on human health. Mid-to-large-sized electric facilities used at industrial sites mostly adopt a commercial frequency of 60 Hz, and workers handling these facilities are exposed to such extremely low frequency (ELF) fields for a long time. A previous study suggested that exposure to ELF electromagnetic fields with frequency ranges from 0 to 300 Hz, even for a short time, at densities higher than 100 μT may have harmful effects on human body as it affects the activation of nerve cells in the central nervous system by inducing an electric field and current and stimulating muscles and the nervous system in the body. Such studies, however, focused on home appliances used by ordinary people, and research on facilities utilizing high-capacity current and operated by workers at industrial sites is lacking. Therefore, in this study, a 3000 kilowatt generator, which is a high-capacity electric facility employed at industrial sites, was investigated, and the size of the magnetic fields generated during its no-load and high-load operations per distance to produce a map was measured to reveal spots deemed hazardous according to domestic and international exposure standards. The findings of this study is expected to alleviate workers' anxiety about the harmful effects of magnetic fields on their body and to minimize the level of exposure during operations.

• 대한본초학회지
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• 제24권1호
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• pp.133-139
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• 2009

Objectives : This study was designed to investigate the effects of alcoholic fermentation extract from ovary and rind of pear on human skin. Methods : We investigated the effects of samples on human skin in terms of clinical trial. 32 of healthy volunteers, who lived in mokpo participated in clinical trial. Effects of sample on hygroscopicity and water-holding capacity were investigated. Sebum, moisture, scabrousness and desquamation were also investigated. Facial massages were conducted 8 times in each volunteers. Results : Single treatment group showed elevated levels of hygroscopicity (Normal : 106.4$\pm$2.1%, vs Pear : 114.1$\pm$6.2) and water-holding capacity (Normal : 87.1$\pm$4.4%, vs Pear : 96.2$\pm$1.3) on forearm of 16 volunteers respectively. In addition, massage group using sample showed elevated moisture (Control : 3.8$\pm$5.8%, vs Sample : 15.2$\pm$4.7%) and lowered scabrousness levels (Control : -12.3$\pm$4.4%, vs Sample : -22.0$\pm$5.2%) significantly. However, the levels of sebum did not affected by sample. Conclusions : These result suggest that alcoholic fermentation extract from ovary and rind of pear has moisturizing effect on human skin.

• STI Policy Review
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• 제6권2호
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• pp.105-145
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• 2015

Science, technology and innovation (STI) is crucially important to eradicating poverty, and making advances in various areas such as agriculture, health, environment, transport, industry, and telecommunications. Therefore, it is vital to the overall socioeconomic development of nations. The indispensable role of STI in the competitive globalized economy led to several attempts to measure national STI capacities. The present study outlines STI capacity around three sets of capabilities: technological capabilities, social capabilities, and common capabilities. The Global Science, Technology and Innovation Capacity (GSTIC) index was developed to provide current evidence on the national STI capacities of the countries, and to improve the composite indicators used for such purposes. The GSTIC ranks a large number of countries (167) on the basis of their STI capacities and categories them into four groups: i.e. leaders, dynamic adopters, slow adopters, and laggards. For more meaningful assessment of the STI capacities of nations, it captures the achievement gaps of individual countries with the highest achiever. The study also provides ranking and achievement gaps of nations in the nine GSTIC pillars: technology creation, R&D capacity, R&D performance, technology absorption, diffusion of old technologies, diffusion of recent innovations, exposure to foreign technology, human capital, and enabling factors. A more detailed analysis of the strengths and weaknesses in different pillars of STI capacity of ten selected countries is also provided. The results show that there are significant disparities among nations in STI capacity and its various aspects, and developing countries have much to catch-up with the developed nations. However, different countries may adopt different strategies according to their strengths and weaknesses. Useful insight into the strengths and weaknesses of the national STI capacities of different countries are provided in the study.

• 한국콘텐츠학회논문지
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• 제12권12호
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• pp.499-509
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• 2012

이 연구의 목적은 단위학교 자율역량에 대한 개념을 정의하고 이에 관한 교원들의 인식 분석을 통해 단위학교 자율역량을 향상하기 위한 시사점을 도출하는 데 있다. 이를 위해 초 중등학교 교원 260명을 대상으로 설문조사를 실시하였다. 설문 결과, 단위학교 자율역량에 관한 교원들의 인식은 직급별, 경력별에 따른 유의미한 차이가 큰 것으로 나타난 반면, 학교특성별에 따른 유의미한 차이는 거의 없는 것으로 나타났다. 이 연구 결과를 통해서 도출된 단위학교 자율역량 향상 방안은 다음과 같다. 첫째, 단위학교 자율역량 중 전략적 역량을 신장하기 위해서는 단위학교 차원으로 학교자율화를 위한 권한을 보다 확대하고 이양할 필요가 있다. 둘째, 단위학교 자율역량 중 인적자본 역량을 신장하기 위해서는 학교구성원들의 전문적 능력을 최대한 발휘할 수 있는 여건을 조성해야 한다. 셋째, 단위학교 자율역량 중 조직운영 역량을 신장하기 위해서는 단위학교 조직문화에 대한 변혁적이고 창조적인 재구조화가 요구된다.

• 한국해양공학회지
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• 제20권3호
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• pp.67-76
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• 2006

Three-dimensional information of submarine topography was acquired by assembling DGPS and Echo Sounder, which is mainly used in the marine survey. However, the features of submarine topography, derived according to mechanical data, were confirmed using human eyes. Because the dredging capacity using a submarine surveying data influences harbor public affairs, analysis and the process method of surveying data is a very special element in construction costs. In this study, information on submarine topography is acquired by assembling DGPS and Echo Sounder. Moreover, the dredging capacity in harbor public affairs has been analyzed by the interpolation method: inverse distance to a power, kriging, minimum curvature, nearest neighbor, and radial basis function. Also, utilization of DGPS and Echo Sounder method in calculation of the dredging capacity have been confirmed by comparing and analyzing the dredging capacity and the actual one, as per each interpolation. According to this comparison result, in the case of applying Radial basis function interpolation and Kriging, 3.94 % and 4.61 % of error rates have been shown, respectively. In the case of the study for application of the proper interpolation, as per characteristics of submarine topography, is preceded in calculation of the dredging capacity relevant to harbor public affairs, it is expected that more speedy and correct calculation for the dredging capacity can be made.