• Title/Summary/Keyword: hp(3)

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Effect of Tocopherol Supplementation on HDL Subfraction and Lipoprotein Pattern in Rabbits Fed High Polyunsaturated Fatty Acids (Tocopherol 첨가가 고불포화지방 식이를 먹인 토끼의 HDL Subfraction과 Lipoprotein Pattern에 미치는 영향)

  • Park, Bum-Soon;Park, Hyun-Suh
    • Journal of Nutrition and Health
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    • v.18 no.1
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    • pp.29-35
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    • 1985
  • This study was designed to evaluate the effects of tocopherol supplementation on serum $HDL_{2}$ and $HDL_{3}$ subfraction and lipoprotein pattern of young rabbits fed the different levels of dietary polyunsaturated fatty acids. White male rabbits with an average bo요 weight of 90kg were assigned into 4 groups : LP( Low PUFA) ; HP( High PUFA) ; LPT( Tocopheror added to LP), HPT(Tocopherol added to HP) by feeding safflower oil or coconut oil at loft( w/w )in addition to thew diet with or without tocopherol for 4 weeks. HDL-Chol and HDL subfractions were determined by polyanionic precipitation method, and the relative amount of lipoprotein by electrophoresis. Serum total cholesterol and TG wer slightly lowered in the group of high PUFA diet and its effect was more in the case of tocopherol supplemented. HDL-Chol level was reduced in the high PUFA diet with or without tocopherol, but overall, HDL-Chol level was not influenced by tocopherol addition and also no significant change in lipoprotein pattern when tocopherol added to the HP diet. $HDL_{2}$ level was increased in HPT group but not in LPT group when tocopherol was added to each HP and LP group, respectively. $HDL_{3}$ levels of both LP and HP groups were reduced with tocopherol supplement, but the reduction was less in the high PUFA groups so that $HDL_{2}$ : $HDL_{3}$ ratio of HP was rather close to that of LP, but it was increased when tocopherol supplemented to the HP diet. Therefore, high PUFA diet could improve the anti atherogenic factor when tocopherol supplemented.

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HP-GPC Analysis for Characteristics Change of Asphalt Cement Due to Aging (노화(老化)에 의한 아스팔트 시멘트 형질변화(形質變化)의 HP-GPC 분석(分析))

  • Kim, Kwang Woo;Yeon, Kyu Seok;Choi, Joong Dae
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.12 no.4
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    • pp.49-57
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    • 1992
  • This study was conducted to evaluate physical property change of asphalt cement chromatograms (by HP-GPC) were experimentally obtained from 3 types of AC-20 virgin ACs, 5 and 24-hour artificially aged ACs, and naturally aged 4 ACs that were recovered from 4 different roads. Absolute viscosity, kinematic visoosity and penetration were the physical properties tested. THF was used for mobil phase and RI detector was used as a detector for Hp-GPC testing. Correlation between each physical property change and the chromatogram variation was evaluated. Each chromatogram was divided into ten-equal-time slices. The percentage areas of 10 slices and each physical property were used for statistical correlation evaluation. Statistical analysis results showed that eaoh physical property had a strong correlation with the chromatogram characteristics. Aging was identified as a mechanism of change of molecular size distribution - increasing large size molecules and reducing coresponding samll size molecules.

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Comparative Study on the Health Promotion Policy in Korea and Japan (한국과 일본의 건강증진정책 비교)

  • 남은우;조은주;남정자
    • Korean Journal of Health Education and Promotion
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    • v.21 no.3
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    • pp.19-33
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    • 2004
  • The focus of this paper is to critically evaluate the contemporary health promotion policy of g Korea and Japan. The primary purpose of this comparative research project is to stimulate policy debate and to strengthen the design and implementation of evidence-based policies that improve population health and reduce health related disparities. For the purpose of the research object we adopted analysis of health promotion(HP) sources. The HP Source which is still under development in Europe, is a potentially valuable tool for global use. This European Commission funded project lead by the London School of Hygiene and Tropical Medicine has brought together organisations from all of the European Union Member States, plus Norway, Iceland, Latvia, Switzerland and the Czech Republic to contribute their data. The findings of this research will be conclude by making recommendations for further comparative studies and in particular how EUHPID and the HP Source tool and database can be expanded for use at global level through the IUHPE. The result as follows: 1. The Health Promotion Act enacted 1995 in Korea and 2000 in Japan. The government has a national document on HP titled Health Plan 2010 and Healthy Korea 2010 in Korea and Healthy Japan 21 in Japan. 2. The Health Plan 2010 of Korea contains 14 goals, i.e. life expectancy, smoking, nutrition, mental health, dental health, reproductive health, hypertension, cerebrovascular diseases, arthritis, diabetes mellitus, cardiovascular diseases, and cancer. It should be emphasized that the Korean HP national document adds 3 goals of health expectancy, reproductive health, and arthritis to its Japanese counterpart. Health Plan 2010 of Korea specifies 37 objectives in 14 goals, and Healthy Japan 21 proposes 48 objectives and 80 targets in 9 goals. 3. Health Plan 2010 and Healthy Japan 21 have not been evaluated yet, and no regular systematic monitoring reporting of HP policies is available in Korea and Japan yet. 4. National Health Promotion Fund is a financial source of HP programs at the national level in Korea. Its annual amount is 736 billion Won(equivalent to approximately 640 million US$), otherwise no specific Health Promotion Fund in Japan.

Comparison of the non-invasive diagnostic methods, stool antigen test and PCR assay, for Helicobacter felis detection in dogs

  • Hong, Sunhwa;Lee, Hak-Yong;Kim, Tae-Wan;Kim, Okjin
    • Korean Journal of Veterinary Service
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    • v.38 no.1
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    • pp.37-42
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    • 2015
  • The aim of the present study was to compare the non-invasive methods for the diagnosis of H. felis with HpSA kit-based detection method and H. felis-specific PCR assay with dog's stool samples without sacrifice. Male Beagle dogs (n=6) were infected with H. felis ATCC 49179 ($1.0{\times}10^9CFU/dog$) by intra-gastric inoculation two times at 3-day intervals, and the stool specimens of dogs were collected 1, 3, 5, 7, 14, 21 days after infection to submit to HpSA test and H. felis-specific PCR. As the results, the sensitivity of the HpSA and the PCR analysis was 50.0%, 83.3% respectively. Although HpSA test is less sensitive, it could be used for rapid, cheap and easy screening assay for H. felis infection in dog and cats. We suggest that the H. pylori stool antigen kit, HpSA, is useful and effective for monitoring H. felis infection. If HpSA test would be made with H. felis antibodies in the future, its sensitivity could be increased. Also, PCR assay could be successfully used to detect the H. felis in stools. Applying the H. pylori stool antigen kit and PCR assay may be the recommended non-invasive strategy to identify H. felis in dog and cats.

Structures of antimicrobial peptides HP (2-20) and interactions between HP(2-20) and membrain studied by NMR spectroscopy

  • Lee, Kwang-Hwan;Lee, Dong-Gun;Park, Yoonkyung;Hahm, Kyung-Soo;Kim, Yangmee
    • Proceedings of the Korean Biophysical Society Conference
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    • 2003.06a
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    • pp.68-68
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    • 2003
  • HP(2-20) (AKKVFKRLEKLEKLFSKIQNDK) derived from the N-terminus of Helicobacter pylori Ribosomal Protein L1 shows potent antimicrobial activity against bacterial, fungi and cancer cells without cytotoxic effect. In order to investigate the relationships between antimicrobial activity and the structures, several analogues have been designed and synthesized. The structures of these peptides in SDS micelles have been investigated using NMR spectroscopy and they revealed that analogue 3 has the longest, well-defined alpha-helix from Val5 to Trp19. NOESY experiments performed on HP and its analogues in nondeuterated SDS micelles show that protons in the indole ring of Trp16 are in close contact with methylene protons of SDS micelles. In order to probe the position of HP and its analogues relative to the SDS micelles, spin-labeled stearate was added. Large effects are observed for the chemical shifts and the intensities of Phe5, Glu9, Phe12, and Trp16 within the helix region by 16-doxylstearate. This result implies that 16-doxylstearate is located in the center of the micelles and the hydrophobic phase of the amphiphilic ${\alpha}$-helix is located in contact with the acyl chains of the micelles. Also, Lys3 and Lys4 at N-terminus and Lys20 at C-terminus may produce an optimal arrangement for electrostatic interactions between the sulfate head groups of the SDS and the positively charged lysyl N$\sub$3/$\^$+/. Interactions between the indole ring of Trp and the membrane, as well as the amphiphilic ${\alpha}$-helical structure of HP induced by Trp at the C-terminus may allow HP to span the lipid bilayer. These structural features are crucial for their potent antibiotic activities.

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Backbone 1H, 15N, and 13C Resonance Assignments and Secondary-Structure of Conserved Hypothetical Protein HP0894 from Helicobacter pylori

  • Han, Kyung-Doo;Park, Sung-Jean;Lee, Bong-Jin
    • Molecules and Cells
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    • v.20 no.3
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    • pp.442-445
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    • 2005
  • HP0894 (SwissProt/TrEMBL ID O25554) is an 88-residue conserved hypothetical protein from Helicobacter pylori strain 26695 with a calculated pI of 8.5 and a molecular weight of 10.38 kDa. Proteins with sequence similarity to HP0894 exist in Vibrio choierae, Enterococcus faecalis, Campylobacter jejuni, Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli O157, etc. Here we report the sequence-specific backbone resonance assignments of HP0894. About 97.5% (418/429) of the HN, N, CO, $C{\alpha}$, $C{\beta}$ resonances of the 88 residues of HP0894 were assigned. On the basis of these assignments, three helical regions and four strand regions were identified using the CSI program. This study is a prerequisite for calculating the solution structure of HP0894, and studying its interaction with its substrates, if any, and/or with other proteins.

Studies on the Varietal Differences of the Electrophoretic Protein Patterns in the Pupal Haemolymph of the Silkworm, Bombyx mori (가잠용에 있어서 체액단백질의 품종간 차이에 대하여)

  • Lee, Sang-Mong;Park, Gwang-Ui;Mun, Jae-Yu
    • Journal of Sericultural and Entomological Science
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    • v.26 no.1
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    • pp.35-51
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    • 1984
  • In order to know the similarity of the electrophoretic protein patterns, distributional aspects of the frequency in each protein band, differences of protein patterns between female and male, and the number of the total protein bands of each variety in the haemolymph of the silkworm pupae according to their geographical origin, the silkworm varieties, and both the sexes, variable electrophoretic protein patterns were observed by polyacrylamide gel electrophoresis, using the silkworm strains which have been reared in the sericultural experiment station. 1. The total number of electrophoretic protein bands classified were twenty-eight, and nearly fourteen bands were shown by each variety on an average. 2. According to their geographical origin, the mean values of the similarity were 20.0%, 28.3% and 14.3% in Japanese, Chinese and European respectively, and the highest similarity was observed between Chinese varieties. 3. The similarity of 129 varieties were tested and it was 22.5%, 23.5% in female and male respectively. 4. The electrophoretic protein patterns in 129 varieties were tested and variation was found in 109 patterns in female and 112 in male. 5. The frequency of the each specified protein band in female and male having variation in protein bands in each variety was found averagely 6.6%. 6. The distribution frequency of the classified 28 protein bands in both the sexes within each geographical origin was variable from 0% to 100%. 7. Among the classified 28 protein bands, HP 11 protein band was found common in all the varieties tested. 8. HP 3 and HP 4 protein bands in female showed high density in electropherograms than in male.

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People Interview - 한국HP 최준근 사장

  • Korea Database Promotion Center
    • Digital Contents
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    • no.10 s.113
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    • pp.39-39
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    • 2002
  • "지난해 5월 8일 본사의 합병계획이 발표됐다. 한국은 5월 22일부터 시작돼 3개월이 시각이 흘렀다. 합병 발표후 각 사의 제품과 테크놀로지의 통합에 초점을 맞췄다. 한국HP와 컴팩코리아가 통합되면서 1400여명이 1조9000억원 매출을 달성하는 조직의 수장을 맡게 된 최준근(50) 사장은 최근 'hp-way'로 유명한 사내게시판(무기명 견해 작성)을 찾는 횟수가 일주일에 한번 수준에서 매일로 바뀌었다고 한다. 합병 후 직원들의 심리를 조금이라도 더 파악하기 위해서다. '인사가 만사임을 느낀다'는 최사장을 만나 합병3개월간의 얘기를 들어보았다.

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Effects of Dietary Nutrient on the Biological Index and Serum Chemistry of Juvenile Olive Flounder Paralichthys olivaceus Achieving Compensatory Growth

  • Cho, Sung-Hwoan
    • Fisheries and Aquatic Sciences
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    • v.15 no.1
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    • pp.69-72
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    • 2012
  • Effects of dietary nutrient content on the biological index and serum chemistry of olive flounder Paralichthys olivaceus achieving compensatory growth were investigated. Six treatments were prepared in triplicate. Fish were hand-fed with the control (C) diet twice daily for 8 weeks (8W-C) or fish were starved for 2 weeks and then hand-fed with the C, high protein (HP), high carbohydrate (HC), high lipid (HL), or intermediate protein, carbohydrate and lipid (IPCL) diets for 6 weeks, referred to as 6W-C, 6W-HP, 6W-HC, 6W-HL, and 6W-IPCL, respectively. Weight gain of fish in the 8W-C, 6W-HP, and 6W-IPCL treatments was higher than that of fish in the 6W-C treatment. Condition factor (CF) of the fish in the 6W-HP, 6W-HC and 6W-IPCL treatments was higher than that of fish in the 8W-C and 6W-C treatments. The hepatosomatic index (HSI) of fish in the 6W-HC, 6W-HL and 6W-IPCL treatments was higher than that of the fish in the 8W-C, 6W-C and 6W-HP treatments. Serum chemistry except triiodothyronine ($T_3$) was not significantly different among the treatments. In conclusion, CF and HSI of the fish could be indices reflecting compensatory growth, whereas $T_3$ seemed to play a partial role in achieving compensatory growth.

Repeatability of New Phoria Test Using Color Chart and Color Filter (색 시표와 색 필터를 이용한 새로운 사위검사의 신뢰도)

  • Lee, Sun Haeng;Park, Sun-Young;Kim, Sang-Yoeb;Lee, Dong-Yeol;Kim, Kun-Kyu;Son, Jeong-Sik;Lee, Jae Yoon;Cho, Hyun Gug
    • Journal of Korean Ophthalmic Optics Society
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    • v.15 no.3
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    • pp.269-274
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    • 2010
  • Purpose: The repeatability of a new Red-Blue phoria chart test (Red-Blue phoria chart; RBP) was appreciated. Methods: Distance (5 m) and near (40 cm) heterophoria was measured in 38 visually normal subjects. Phoria tests using RBP, Howell phoria card (HP), and MIM card (MIM) were done and the repeatability of each phoria test was compared with one another. Results: The mean of horizontal deviations was that RBP was $-0.602{\pm}0.727{\Delta}$, HP was $-0.865{\pm}1.051{\Delta}$, and MIM was $-1.501{\pm}1.346{\Delta}$, at distance, and that RBP was $-2.566{\pm}2.352{\Delta}$, HP was $-2.804{\pm}2.411{\Delta}$, MIM was $-3.838{\pm}2.603{\Delta}$, at near. The repeatability was RBP>MIM>HP in distance tests and MIM>RBP>HP in near tests. Conclusions:RBP test is identified as a reliable phoria test having high repeatability.