• 동의신경정신과학회지
• /
• 제20권2호
• /
• pp.1-17
• /
• 2009

Objectives : Alzheimer's disease(AD) is the most common form of dementia, which is characterized by progressive deterioration of memory and higher cortical functions that ultimately results in total degradation of intellectual and mental activities. Nokyongdaebo-tang(Lurongdabutang) has been usually used for the treatment for the deficiency syndrome dementia and amnesia. This experiment was designed to investigate the effect of the Nokyongdaebo-tang(Lurongdabutang) hot water extract on pathological AD model. Methods : The effects of the Nokyongdaebo-tang(Lurongdabutang) hot water extract on cultured spinal cord cells induced by ${\beta}$-amyloid were investigated. The effects of the Nokyongdaebo-tan(Lurongdabutang) hot water extract on the memory deficit mice induced by scopolamine were investigated. Results : 1. ${\beta}$-amyloid treatment on cultured spinal cord cells increased both GFAP-staining intensity of astrocytes and caspase 3 immunoreactivity on cultured cells. Then, Nokyongdaebo-tang(Lurongdabutang) treatment reduced the labeling intensity for both GFAP and caspase 3 proteins in culture cells. 2. Scopolamine treatment into mice increased levels of GFAP-positive astrocytes and caspase 3-labeled cells of the hippocampal subfields dentate hilar region, CA3 and CA1 area. In vivo administration of Nokyongdaebo-tang(Lurongdabutang) attenuated labeling intensity for those two proteins in the same hippocampal areas. Similar effects were observed by the treatment of galanthamine, an inhibitor of acetylcholinesterase. Conclusions : This experiment shows that the Nokyongdaebo-tang(Lurongdabutang) may play a protective role in damaged neural tissues. Since neuronal damage seen in degenerative brains such as AD are largely unknown, the current data may provide possible insight into therapeutic strategies for AD treatments. Nokyongdaebo-tang(Lurongdabutang) might be effective for the prevention and treatment of AD.

• 소성∙가공
• /
• 제11권3호
• /
• pp.211-216
• /
• 2002

The mechanical and thermal load, and thermal softening occuring by the rush temperature of die, in warm and hot forging, cause wear, heat cracking and plastic deformation, etc. This paper describes the effects of solid lubricants and surface treatments for warm forging die. Because cooling effect and low friction are essential to the long life of dies, optimal surface treatments and lubricants are very important to hot and warm forging process. The main factors affecting die hardness and heat transfer, are surface treatments and lubricants, which are related to heat transfer coefficient, etc. To verify the effects, experiments are performed for heat transfer coefficient in various conditions - different initial billet temperatures and different loads. Carbonitriding and ionitriding are used as surface treatments, and oil-base and water-base graphite lubricants are used. The effects of lubricant and surface treatment for warm and hot forging die life are explained by their thermal characteristics, and the new developed technique in this study for predicting tool life can give more feasible means to improve the tool life in hot forging process.

• 한국자원식물학회지
• /
• 제20권4호
• /
• pp.267-271
• /
• 2007

본 연구는 자귀나무의 종자의 주요발아촉진법인 열탕처리에 있어 구체적인 처리시간을 구명하고자 실시하였다. 각각 0.5, 1.0, 2.0, 3.0, 5.0, 10.0분 동안 열탕처리된 종자와 무처리 종자, 24시간 침지종자의 발아특성 및 수분흡수특성을 비교한 결과, 발아율의 경우 열탕처리시 그 효과가 현저하였으며, 특히, 2.0분에서 그 효과가 가장 뛰어나 적정처리시간으로 판단되었다(p<0.01). 그러나 평균발아일수는 무처리구와 처리구간에 차이를 보이지 않았다(p=0.502). 즉, 시간별 열탕처리는 자귀나무 종자의 발아소요일수 단축에는 효과가 없었다. 발아속도 및 발아균일지수는 발아율과 유사한 경향을 나타내었다. 수분흡수특성 중 수분흡수율과 수분흡수속도상수는 무처리구와 현저한 차이를 나타내었다. 또한, 발아특성과 수분흡수특성과의 상관관계를 분석한 결과 발아특성 중 평균발아일수를 제외한 모든 특성이 수분흡수율 및 수분흡수속도상수 (24시간 침지)와 높은 상관성을 나타내었다($r=0.854{\sim}0.931$, p<0.01). 그러나 초기수분흡수속도와는 상관관계가 없었다. 한편, 발아특성들 간에는 평균 발아일수를 제외하고 모두 높은 상관을 나타내었으며(p<0.01), 수분흡수특성들 간에는 수분흡수율과 수분흡수속도상수만이 상관성을 나타내었다(r=0.9508, p<0.01).

• 대한한의학회지
• /
• 제28권2호통권70호
• /
• pp.137-154
• /
• 2007

Objective : This experiment was designed to investigate the effect of the GYZB hot water extract & ultra-fine powder on the Alzheimer's disease model induced by amyloid ${\beta}$ protein (${\beta}A$). Method : We measured the effects of the GYZB hot water extract on expression of $IL-1{\beta}$, IL-6 mRNA and production of IL-6, $TNF-{\alpha}$ in the BV2 microglial cell line treated with lipopolysaccharide (LPS). The effects of the GYZB hot water extract & ultra-fine powder on (1) the behavior, (2) expression of $IL-1{\beta}$ and $TNF-{\alpha}$, (3) glucose in serum, (4) the infarction area of the hippocampus, and brain tissue injury in mice induced with Alzheimer's diseased by ${\beta}A$ were investigated. Results : The GYZB hot water extract suppressed the expression of $IL-1{\beta}$ and IL-6 mRNA and significantly suppressed the production of IL-6 and $TNF-{\alpha}$ in the BV2 microglial cell line treated with LPS. The GYZB hot water extract & ultra-fine powder showed a significant inhibitory effect on the memory deficit of the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency. The GYZB ultra-fine powder significantly suppressed the expression of $IL-1{\beta}$ and $TNF-{\alpha}$ protein, and the GYZB hot water extract significantly suppressed the expression of $TNF-{\alpha}$ protein in the microglial cell of mice with Alzheimer's disease induced by ${\beta}A$. The GYZB hot water extract & ultra-fine powder reduced the infarction area of hippocampus in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusions : These results suggest that GYZB hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of GYZB for Alzheimer's disease is suggested for future research.

• 한국식품저장유통학회지
• /
• 제10권3호
• /
• pp.261-266
• /
• 2003

풋고추의 저장성 향상을 위한 저장전 열처리 조건을 구명하기 위하여 풋고추를 50, 55, 60, $65^{\circ}C$의 온수에 각각 10초 침지하여 열처리를 하였다 $65^{\circ}C$에서 10초 열처리한 경우는 열처리 직후 과육표면에 가열장해 현상이 나타났다. 온수에서 침지한 풋고추를 1$0^{\circ}C$의 저장고에서 4주 동안 저장하면서 관능적 품질, 화학적 품질과 미생물학적 품질을 측정하였다. 표면 색도 중 L 값은 저장 중 조금씩 감소하는 경향을 보였으며, a 값과 b 값은 저장 3주까지는 거의 변화가 없다가 저장 4주에서는 대조구의 경우 열처리구에 비해서 a값은 높아지고 b값은 낮아진 결과를 볼 때 저장 4주가 되면 대조구의 경우 열처리구에 비해서 표면색도가 초록색이 옅어짐을 알 수 있었다. 중량감소는 대조구와 열처리구 사이에 유의한 차이를 나타내지 못하였으나, 대조구의 경도와 생균수는 저장 3주까지는 차이가 없다가 4주에서 경도는 낮아지고 생균수는 높게 나타났다. 매운맛 성분인 capsaicin과 dihydrocapsaicin은 열처리 유무에 관계없이 저장 중 감소하는 경향을 나타내었으며, 대조구의 경우가 약간 높게 나타났다. 풋고추의 관능적 품질은 55$^{\circ}C$ 온수에서 10초 동안 열처리한 경우가 가장 우수하게 나타나 이 조건이 풋고추의 저장성 향상을 위한 저장전 열처리 조건으로 구명되었다. 풋고추를 3, 10, 17$^{\circ}C$에서 저장한 결과 대조구의 경우는 3$^{\circ}C$에서 저온장해를 받았으나 열처리구의 경우는 3$^{\circ}C$에서도 우수한 품질을 나타내어 열처리가 풋고추의 저온장해를 억제하는 효과가 있는 것으로 추정할 수 있었다.

• 한국작물학회지
• /
• 제54권3호
• /
• pp.320-326
• /
• 2009

우리나라 재래 수집종인 제비콩, 갓끈동부와 쥐눈이콩은 종피가 매우 두껍고 딱딱하여 물 흡수가 어려워 발아율이 각각 26%, 17%와 5%에 불가하다. 이들 종자는 저장성에서 그 가치가 높이 평가되지만, 포장에 파종할 때 발아율이 낮아 문제가 되고 있다. 본 연구에서는 이들 종자의 발아율을 향상시키기 위하여 몇 가지 종피약화 처리를 실시하여 가장 효과적인 방법을 도출하였다. 종피약화 처리방법 중 가장 정상묘율이 높은 것은 제비콩은 tap water ($20^{\circ}C$)에서 24시간 침지 했을 때 85%이였으며, 갓끈동부는 hot water에서 8시간 침지했을 때 45%이였다. 그러나 소립이고 경도가 높은 쥐눈이콩은 진한 sulfuric acid에 10분간 침지 했을 때 72%의 정상묘율을 보였다.

• 한국식생활문화학회지
• /
• 제23권4호
• /
• pp.479-488
• /
• 2008

Some biological activities such as an electron donating capacity, the contents of total polyphenol compounds and flavonoids, fibrinolytic activity and $\alpha$-glucosidase inhibitory activity have been detected in hot water extracts of Ligularia fischeri and Angelica gigas Nakai. To increase the usefulness of the functional ingredients for prevention and improvement of some metabolic disorders, ethanol-treated hot water extracts of Angelica gigas Nakai were prepared. A hot water extract of Ligularia fischeri has 92% of electron donating capacity, 39.4 mg/g of total polyphenol compounds, 24.8 mg/g of flavonoids and 29.8% of $\alpha$-glucosidase inhibitory activity, but no fibrinolytic activity. A hot water extract of Angelica gigas Nakai has 94.7% of electron donating capacity, 5.8 mg/g of total polyphenol compounds, 2.6 mg/g of flavonoids, 0.48 plasmin units of fibrinolytic activity and no $\alpha$-glucosidase inhibitory activity. However, with partial purification using cold ethanol treatment, the $\alpha$-glucosidase inhibitory activity of Angelica gigas Nakai was increased to 70.5%. Thus, we expected a more useful effect with the use of the addition of a cold ethanol-treated Angelica gigas Nakai extract. The L, b values of cold buckwheat noodles using a mixture of 0$\sim$3% of Ligularia fischeri powder and 0.5% of an ethanol-treated hot water extract of Angelica gigas Nakai were decreased with the addition of an increasing amount of Ligularia fischeri powder. Among the mechanical qualities, only adhesiveness was significantly higher in 3% Ligularia fischeri noodles. From sensory evaluation data, it was determined that these two functional ingredients did not ruin the color, texture, and overall acceptance of the cold buckwheat noodles. A higher amount of the extracts improved the quality of the product with little added cost.

• 대한약침학회지
• /
• 제10권3호
• /
• pp.149-155
• /
• 2007

Objectives The purpose of this study is aimed at diagnosing and suggesting treatment plans for commonly seen clinical manifestation of heat symptom in the upper body and coldness in the lower body, also known as hot above, cold below syndrome. Methods Various reasons attribute to the presence of hot above, cold below syndrome, but mainly contributed by blockage of normal Qi flow by abnormality of heart-kidney root, spleen-stomach axis, and liver-lung axis. Diagnosing these abnormalities and timely alleviation to the healthy state is presented in the study. Results 1For heat in the upper body, Huang Lian Jie Du Tang(黃連解毒湯), CF, or JsD pharmacopuctures are injected on GB21, GB20. Qi stagnation in the thoracic area is treated with BUM injection on CV17. For impairment of transportation and transformation in the middle energizer, BUM pharmacopuncture is injected on CV12. Coldness in the lower energizer was relieved by bee venom or Sweet BV(Bee Venom free from enzymes) on CV6. Conclusion Above proposed methods of regulating water-fire were effective in treating hot above, cold below syndrome in clinical manifestations. But once the symptom subsides, treatment focused on eliminating innate cause should be rendered to achieve more successful results.

• 공업화학
• /
• 제8권1호
• /
• pp.67-75
• /
• 1997

LLDPE와 미분말 상태인 강산성 양이온 교환 수지를 사용하여 압출기를 통해 막상으로 성형한 후 증류수와 NaCl 포화 수용액상에서 후처리하여 불균질 양이온 교환막을 제조하고 특성화하였다. 증류수 및 NaCl 포화 수용액 중에서 후처리를 통하여 양이온 교환 수지 입자가 함수, 팽윤되어 폴리에틸렌과 이온 교환 수지 사이에 cavity가 발생하며 동시에 양이온 교환 수지의 팽윤 압력에 의해 결합제에 큰 힘이 작용하기 때문에 폴리에틸렌에 micro-crack이 생성되므로 전기 화학적, 물리적 특성 값이 향상되었다. 또한 후처리 시간 30분과 후처리 온도 $90^{\circ}C$에서 최적의 조건을 갖는 우수한 불균질 양이온 교환막이 제조되었다.

• Journal of the Korean Wood Science and Technology
• /
• 제48권4호
• /
• pp.458-471
• /
• 2020

Effect of pre-treatment and compression ratio on specific gravity (SG) and dimensional stability improvement of three lesser-used wood species from natural forest area of North Kalimantan Province, Indonesia had been investigated. Hot soaking at 80℃ for 3 hours within 2 and 5% of boron solution was applied as pre-treatment, while compression ratio applied was 20 and 40% from the initial thickness. Densification was conducted using hot pressing machine at 30 kg/㎠ of pressure and 160℃ of temperature for 15 minutes. Specific gravity was measured gravimetrically, while dimensional stability was evaluated through thickness swelling and water absorption as the indicator. Results show that SG of densified wood was influenced by wood species and compression ratio, but not by pre-treatment applied; while dimensional stability was influenced by wood species, compression ratio, and pre-treatment. Specific gravity and water absorption of densified wood was improved significantly. Specific gravity increased 28.86-63.03%, while water absorption decreased 12.80-15.89%. Thickness swelling of 20% densified wood was lower than that of 40% densified wood.