• Journal of Korean Neurosurgical Society
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• 제41권3호
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• pp.186-189
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• 2007

Metastasizing mixed tumors [MMT] of salivary glands are inexplicably metastasize maintaining benign histology. There is no pathologic and flow cytometric analysis criteria to predict the metastasis. MMT is known to metastasize by local implantation, vascular and lymphatic embolization after multiple surgery to local recurrences of primary tumor. However, multiple metastasis including cranium and spine occurred even without surgery to the primary tumor in this case. No pathological evidence of malignancy could be found in both primary and metastatic tumor. MMT is considered as an low grade malignancy based on clinical behavior rather than histologic evidence, such as low mortality rate, long delay of metastasis after primary lesion. Cranial metastasis is also extremely rare and only two cases have been reported. We report this unusual case with a literature review.

• Journal of Chest Surgery
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• 제23권4호
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• pp.745-749
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• 1990

A wide variety of histologically or clinically different tumors and cysts can occur from the many anatomical structures located within the mediastinum. We report the analysis of the 26 cases of mediastinal tumors and cysts, experienced in the Department of Thoracic and Cardiovascular Surgery, College of Medicine, Hallym University from March 1983 to February 1990. Sex ratio of male to female was 1:1.16 and mean age was 33.4 years. Malignant tumors were 8 cases[30.7%], benign tumors were 18 cases[69.2%] The most common histologic types were thymoma, 6 cases[23%] and teratoma, 6 cases [23%] followed by neurogenic tumor, 4 cases[15%] and mediastinal tuberculoma, 3 cases [11.5%]. The most frequent symptoms were chest pain and discomfort. Most of benign tumors were completely removed and malignant tumors were treated with anticancer chemotherapy and radiotherapy after operation. Postoperative complications were developed in 4 cases[15.3%] and hospital mortality was 3.8%.

• Imaging Science in Dentistry
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• 제34권4호
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• pp.219-223
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• 2004

Metastases to the jawbones are found predominantly in the mandible and are rare in relation to the overall spectrum of oral malignancy. Analysis of the literature shows that the most frequent primary sites are the breast, lung, kidney, thyroid, and prostate. Adenocarcinoma of the mandible, whether primary or metastatic, are usually difficult to diagnose clinically. We report a case illustrating the clinical, radiographic, and histologic findings of a metastatic lung adenocarcinoma of the anterior mandible in a 58-year-old male.

• 대한세포병리학회:학술대회논문집
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• 대한세포병리학회 1993년도 제7차 춘계학술대회 초록집
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• pp.13.2-14
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• 1993

• 치과방사선
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• 제25권2호
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• pp.561-567
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• 1995

Pleomorphic adenoma is a benign salivary gland tumor with histologic diversity. The majority of these tumor occurs in the parotid gland. The authors experienced the patients, who complained the tumor-like soft tissue mass on the palatal area. After careful analysis of clinical, radiological and histopathological findings, we diagnosed it as pleomorphic adenoma in the palatal area, and obtained characteristic features were as follows: 1. Main clinical symptom was a painless, slow growing, soft tissue mass with normal intact overlying mucosa on the palatal area. 2. In the radiographic examminations, well encapsulated homogeneous soft tissue mass was shown in the lesion site, and cortical thinning on the palate was also observed. 3. In histopathologic examminations, proliferated cellular components in the hyaline stroma were observed as double layered duct-like structure and densely solid sheet appearance.

• Journal of Ginseng Research
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• 제20권2호
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• pp.154-158
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• 1996

To investigate the protective effect of Korean red ginseng (RG) against oxidative damage, rats were intoxicated by carbon tetrachloride and liver tissues and blood were taken and analyzed histopathologically and biochemically. Light microscopy of the liver showed that RG prevented the necrosis of hepatocytes remarkably and reduced the change of fat. RG increased the capability for serum to suppress oxygen radical in the generating system. It is suggested that RG enhanced the antioxidative potential of the body against $CCl_4$, which would prevent the necrosis of hepatocytes in vivo.

• Journal of Breast Cancer
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• 제21권4호
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• pp.463-467
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• 2018

Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An $^{18}F$-fluoro-deoxy-D-glucose positron emission tomography scan was performed for staging, and low uptakes were observed in the left supraclavicular and cervical lymph nodes. High uptake was seen in the posterior and lower left lobe of the thyroid. Histologic findings indicated lobular breast carcinoma (positive GATA3, loss of E-cadherin expression) metastatic to the thyroid with a luminal profile. Immunohistochemical analysis was negative for primary thyroid or parathyroid carcinoma. To our knowledge, this is the first report of a patient presenting a metastatic invasive lobular carcinoma in the thyroid and lymph nodes without a prior diagnosis of breast cancer.

• 대한치과보철학회지
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• 제52권1호
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• pp.9-17
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• 2014

연구 목적: 본 연구에서는 외과적으로 형성한 골 결손부에 이종골 이식과 함께 식립한 지르코니아 임플란트의 골유착에 대한 기계적 안정성과 조직학적 반응을 타이타늄 임플란트와 비교하고자 하였다. 연구 재료 및 방법: 6마리 돼지의 경골에 인위적으로 형성한 골 결손 부위에 대조군인 18개의 상용 타이타늄 나사형 임플란트와 실험군인 18개의 샌드블라스팅한 지르코니아(Y-TZP) 나사형 임플란트를 각각 식립하고 차폐막을 이용하여 이종골을 이식하였으며 1주, 4주, 12주후에 각각 2마리씩 희생시켜 조직 시편을 제작하였다. 식립 직후와 식립 1주, 4주, 12주 후에 각각 페리오테스트를 이용하여 임플란트의 안정성을 측정하였고, 광학현미경으로 조직학적 관찰과 조직계측학적 분석을 하였으며 주사전자현미경으로 임플란트의 표면 특성과 골-임플란트 계면을 관찰하였다. 결과: 페리오테스트를 이용한 임플란트 안정성 분석 결과, 대조군과 실험군 사이에 유의한 차이가 없었고, 조직학적 분석 결과, 각 군 모두 4주에 이식골의 재흡수와 조골세포의 활발한 활동에 의해 신생골이 형성되기 시작하였다. 골-임플란트 접촉률 분석 결과, 대조군과 실험군 사이에 유의한 차이가 있었으며(P<.05), 특히 4주와 12주에서 실험군과 대조군 사이에 2시점에서 유의한 차이를 보였다(P<.05). 골 면적률 분석 결과, 대조군과 실험군 사이에 유의한 차이가 없었다. 주사전자현미경 관찰 결과, 대조군은 균일한 다공성의 거친 표면을 나타냈고 실험군은 무정형 입자들이 불규칙하게 산재된 표면을 보여 주었다. 각 군 모두 4주에 임플란트 표면과 골 조직 사이에 빈 공간이 관찰되었고 12주에는 일부 공간에서 골 조직으로 채워진 양상을 보였다. 결론: 차폐막을 이용한 이종골 이식을 동반하는 경우 본 실험에 사용된 지르코니아 임플란트의 골-임플란트 접촉률은 양극산화 표면처리를 한 타이타늄 임플란트에 크게 미치지 못하므로 지르코니아 임플란트의 실용화를 위해서는 표면 처리 방법 등에 대한 지속적인 연구를 통한 개선이 필요하다고 사료된다.

• 대한치과보철학회지
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• 제33권3호
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• pp.550-568
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• 1995

The purpose of this study was to observe the effects of early functional on bone formation around titanium plsama sprayed IMZ implants. 15 IMZ implants were inserted on the mandibular premolar areaa in 5 mondgrel dogs. The inplants were divided into 4 groups according to it’s loading schedule : Temporary abutments were connected for functional loading 6weeks, 9weeks, and 12weeks after implants installation in group I, II, and III, respectively. Abutments were not connected in the control group. After polyfluorochrome sequential labeling, all animals were sacrificed and bone sections includig implants and the 1st. molar were removed and processed for histologic evaluation. From light and fluorescence microscopic evaluation as well as histomorphometric and EPMA analysis, following results were obtained : 1. Light microscopically, the osteoid tissues were observed much in the compact bone of unloaded group, and cancellous bone formation observed more in early loaded group. 2. Calcification and remodeling of bone took place faster in loaded group, especially in 6 weeks group. 3. Moderate to severe marginal bone resorption was observed in 6 weeks group, mainly on buccal crest. 4. There was no difference in the percentages of bone-to-metal contact among the experimental groups. 5. In quantitative analysis using EPMA, there was no difference in the content of calcium and phosphorus among the experimental groups, regardless of distance.

• 대한세포병리학회지
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• 제6권2호
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• pp.133-139
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• 1995

To evaluate the sensitivity and specificity of transthoracic fine needle aspiration cytology(TFNAC) in the preoperative diagnosis of pulmonary nodules, a retrospective analysis was carried out on a consecutive series of 200 TFNACs. They included 186 primary malignant tumors, 66 squamous cell carcinomas, 65 adenocarcinomas, 36 small cell carcinomas, 7 large ceil carcinomas, 4 carcinomas, 8 others, 9 metastatic tumors, and 5 benign tumors. On cytohistologic correlation of malignant pulmonary tumors, the procedure had a sensitivity of 97.3% and a specificity of 100%. A 86.6% correct correlation between the cytologic and histologic diagnoses was achieved. Five out of the 7 undifferentiated large cell carcinomas, 10 out of the 65 adenocarcinomas, 2 out of the 36 small cell carcinomas, and 2 out of the 66 squamous cell carcinomas were turned out to be mistyped in cytologic diagnosis. We concluded that TFNAC is a highly sensitive and specific preoperative diagnostic procedure in the investigation of patients with discrete pulmonary nodules in whom the specific ceil type of the malignant neoplasm has important implications in treatment modality and prognosis.