• Title/Summary/Keyword: highly active

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Isolation and identification of antifungal compounds from Reynoutria elliptica (호장근(Reynoutria elliptica)으로부터 항균활성 물질의 분리 및 구조결정)

  • Hwang, Joo-Tae;Park, Young-Sik;Kim, Young-Shin;Kim, Jin-Cheol;Lim, Chi-Hwan
    • Korean Journal of Agricultural Science
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    • v.39 no.4
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    • pp.583-589
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    • 2012
  • In the continued research on natural fungicides for the control of plant diseases by using plant-derived products, we found that Reynoutria elliptica. had a strong fungicidal activity against several plant pathogens. R. elliptica (3.2 kg) were extracted with 80% aq. MeOH and the concentrated extracted was partitioned with n-hexane, EtOAc, n-BuOH and $H_2O$ successively. The four layers were tested their disease control efficacies against 4 plant disease such as rise blast (RCB), tomato grey mold (TGM), tomato late blight (TLB), and barly powdery mildew (BPM). The n-hexane fraction was highly active showing over 95% control against TLB and BPM. and the EtOAc fraction was highly active showing over 95% control against RCB, TLB, and BPM. By using silica gel chromatography, MPLC, and HPLC, three compounds that were expected to have antifungal activity were isolated. Their chemical structures were elucidated as physcion, emodin, and emodie-8-O-glucoside by EI-MS and NMR spectroscopic analyses.

Highly stable amorphous indium.gallium.zinc-oxide thin-film transistor using an etch-stopper and a via-hole structure

  • Mativenga, M.;Choi, J.W.;Hur, J.H.;Kim, H.J.;Jang, Jin
    • Journal of Information Display
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    • v.12 no.1
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    • pp.47-50
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    • 2011
  • Highly stable amorphous indium.gallium.zinc-oxide (a-IGZO) thin-film transistors (TFTs) were fabricated with an etchstopper and via-hole structure. The TFTs exhibited 40 $cm^2$/V s field-effect mobility and a 0.21 V/dec gate voltage swing. Gate-bias stress induced a negligible threshold voltage shift (${\Delta}V_{th}$) at room temperature. The excellent stability is attribute to the via-hole and etch-stopper structure, in which, the source/drain metal contacts the active a-IGZO layer through two via holes (one on each side), resulting in minimized damage to the a-IGZO layer during the plasma etching of the source/drain metal. The comparison of the effects of the DC and AC stress on the performance of the TFTs at $60^{\circ}C$ showed that there was a smaller ${\Delta}V_{th}$ in the AC stress compared with the DC stress for the same effective stress time, indicating that the trappin of the carriers at the active layer-gate insulator interface was the dominant degradation mechanism.

The Lifespan of Social Hub In Social Networking Sites: The Role of Reciprocity, Local Dominance and Social Interaction

  • Han, Sangman;Magee, Christopher L.;Kim, Yunsik
    • Asia Marketing Journal
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    • v.17 no.1
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    • pp.69-95
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    • 2015
  • This paper examines a highly used social networking site (SNS) by studying the behavior of more than 11 million members over a 20 month period. The importance of the most highly active members to the overall network is demonstrated by the significant fraction of total visits by extremely active members in a given period but such members have surprisingly short lifespans (an average of only 2.5 months) as social hubs. We form and test a number of hypotheses concerning these social hubs and the determinants of their lifespan. We find that the speed of achieving social hub status increases the lifespan of a social hub. The norm of reciprocity is strongly confirmed to be present in the social hub population as visits are reciprocated. We also find that increasing local dominance in terms of activities over neighboring agents leads to a longer lifespan of a social hub. Contrary to expectations, local clustering in the vicinity of social hubs is smaller (rather than larger) than overall clustering. We discuss managerial implications in the paper.

Fabrication of Flexible Surface-enhanced Raman-Active Nanostructured Substrates Using Soft-Lithography

  • Park, Ji-Yun;Jang, Seok-Jin;Yeo, Jong-Seok
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.411-411
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    • 2012
  • Over the recent years, surface enhanced Raman spectroscopy (SERS) has dramatically grown as a label-free detecting technique with the high level of selectivity and sensitivity. Conventional SERS-active nanostructured layers have been deposited or patterned on rigid substrates such as silicon wafers and glass slides. Such devices fabricated on a flexible platform may offer additional functionalities and potential applications. For example, flexible SERS-active substrates can be integrated into microfluidic diagnostic devices with round-shaped micro-channel, which has large surface area compared to the area of flat SERS-active substrates so that we may anticipate high sensitivity in a conformable device form. We demonstrate fabrication of flexible SERS-active nanostructured substrates based on soft-lithography for simple, low-cost processing. The SERS-active nanostructured substrates are fabricated using conventional Si fabrication process and inkjet printing methods. A Si mold is patterned by photolithography with an average height of 700 nm and an average pitch of 200 nm. Polydimethylsiloxane (PDMS), a mixture of Sylgard 184 elastomer and curing agnet (wt/wt = 10:1), is poured onto the mold that is coated with trichlorosilane for separating the PDMS easily from the mold. Then, the nano-pattern is transferred to the thin PDMS substrates. The soft lithographic methods enable the SERS-active nanostructured substrates to be repeatedly replicated. Silver layer is physically deposited on the PDMS. Then, gold nanoparticle (AuNP) inks are applied on the nanostructured PDMS using inkjet printer (Dimatix DMP 2831) to deposit AuNPs on the substrates. The characteristics of SERS-active substrates are measured; topology is provided by atomic force microscope (AFM, Park Systems XE-100) and Raman spectra are collected by Raman spectroscopy (Horiba LabRAM ARAMIS Spectrometer). We anticipate that the results may open up various possibilities of applying flexible platform to highly sensitive Raman detection.

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Cable with discrete negative stiffness device and viscous damper: passive realization and general characteristics

  • Chen, Lin;Sun, Limin;Nagarajaiah, Satish
    • Smart Structures and Systems
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    • v.15 no.3
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    • pp.627-643
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    • 2015
  • Negative stiffness, previously emulated by active or semi-active control for cable vibration mitigation, is realized passively using a self-contained highly compressed spring, the negative stiffness device (NSD).The NSD installed in parallel with a viscous damper (VD) in the vicinity of cable anchorage, enables increment of damper deformation during cable vibrations and hence increases the attainable cable damping. Considering the small cable displacement at the damper location, even with the weakening device, the force provided by the NSD-VD assembly is approximately linear. Complex frequency analysis has thus been conducted to evaluate the damping effect of the assembly on the cable; the displacement-dependent negative stiffness is further accounted by numerical analysis, validating the accuracy of the linear approximation for practical ranges of cable and NSD configurations. The NSD is confirmed to be a practical and cost-effective solution to improve the modal damping of a cable provided by an external damper, especially for super-long cables where the damper location is particularly limited. Moreover, mathematically, a linear negative stiffness and viscous damping assembly has proven capability to represent active or semi-active control for simplified cable vibration analysis as reported in the literature, while in these studies only the assembly located near cable anchorage has been addressed. It is of considerable interest to understand the general characteristics of a cable with the assembly relieving the location restriction, since it is quite practical to have an active controller installed at arbitrary location along the cable span such as by hanging an active tuned mass damper. In this paper the cable frequency variations and damping evolutions with respect to the arbitrary assembly location are then evaluated and compared to those of a taut cable with a viscous damper at arbitrary location, and novel frequency shifts are observed. The characterized complex frequencies presented in this paper can be used for preliminary damping effect evaluation of an adaptive passive or semi-active or active device for cable vibration control.

The recess gate structure for the improvement of breakdown characteristics of GaAs MESFET (GaAs MESFET의 파괴특성 향상을 위한 recess게이트 구조)

  • 장윤영;송정근
    • Electrical & Electronic Materials
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    • v.7 no.5
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    • pp.376-382
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    • 1994
  • In this study we developed a program(DEVSIM) to simulate the two dimensional distribution of the electrostatic potential and the electric field of the arbitrary structure consisting of GaAs/AlGaAs semiconductor and metal as well as dielectric. By the comparision of the electric field distribution of GaAs MESFETs with the various recess gates we proposed a suitable device structure to improve the breakdown characteristics of MESFET. According to the results of simulation the breakdown characteristics were improved as the thickness of the active epitaxial layer was decreased. And the planar structure, which had the highly doped layer under the drain for the ohmic contact, was the worst because the highly doped layer prevented the space charge layer below the gate from extending to the drain, which produced the narrow spaced distribution of the electrostatic potential contours resulting in the high electric field near the drain end. Instead of the planar structure with the highly doped drain the recess gate structure having the highly doped epitaxial drain layer show the better breakdown characteristics by allowing the extention of the space charge layer to the drain. Especially, the structure in which the part of the drain epitaxial layer near the gate show the more improvement of the breakdown characteristics.

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Condition index and hemocyte apoptosis as a health indicator for the Pacific oysters, Crassostrea gigas cultured in the western coastal waters of Korea (서해안 굴, Crassostrea gigas의 건강도 평가를 위한 Condition index와 혈구 apoptosis 분석)

  • Lim, Hyun Jeong;Lim, Mae Soon;Lee, Won Young;Choi, Eun Hee;Yoon, Ju Hyun;Park, Seung Yoon;Lee, Seung Min;Kim, Su Kyoung
    • The Korean Journal of Malacology
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    • v.30 no.3
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    • pp.189-196
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    • 2014
  • A significant production decrease has been witnessed for the Pacific oysters, Crassostrea gigas farmed in the western coastal waters of Korea, presumably by the loss of physiological viability. We evaluated the viability in terms of health indicators, the condition indices and hemocyte apoptosis rates of the oysters inhabiting two representative farming sites, Incheon and Taean each with different environmental variables. In our monthly measurements for the whole year 2013, the indicators were location specific. The condition indices of Incheon were highly variable, 1.67-8.58%, while those of Taean were less, 2.28-5.57%. The condition indices decreased during the spawning seasons, July and September in common. The two oysters exhibited also differed in the apoptotic activities of hemocyte, highly active, 4.03-30.15% for Incheon oysters and less active, 2.87-17.48% for Taean oysters. One thing we could identify was the two measurements were adverse during the critical seasons of spawning, reminiscent of being a useful tool for a health indicator for the oysters. Similar trend was also observed in the time when change in temperature was extreme. The findings in this study are highly indicative of health indicators for the oyster aquaculture.

Effect of Career Decision-making Self-efficacy and Career Identity by Health Science College Students on Job Preparation Behavior (일부 보건계열 대학생들의 진로결정자기효능감 및 진로정체감이 취업준비행동에 미치는 영향)

  • Bae, Sung-Suk;Noh, Hie-Jin;Mun, So-Jung
    • The Journal of Korean Society for School & Community Health Education
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    • v.15 no.1
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    • pp.45-59
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    • 2014
  • Objectives: This study is designed to evaluate the influential factors of career decision-making self-efficacy and career identity by health science college students on their job preparation beaviors. Methods: The total 714 questionnaires were distributed to juniors and seniors of health science college, and the result was statistically analyzed through IBM SPSS statistics 20.0. Results: 1. There was no significant difference of job preparation behavior between male students and female students, and while seniors showed highly active job preparation behaviors, those who had high satisfaction level toward their major studies, high academic achievement, and outgoing personality had highly active job preparation behaviors. 2. Students with high satisfaction level toward their major studies, high academic achievement, outgoing personality, and high expected salaries showed high career decision-making self-efficacy level. 3. Students with high satisfaction level toward their major studies, high academic achievement and highly outgoing personality showed high level of career identity. 4. Subsidiary factors of career decision-making self-efficacy were collection of job information, goal setting, planning, and self-assessment, and all of them showed correlation with job preparation behaviors. 5. Among subsidiary factors of career decision-making self-efficacy, "self-understanding" and understanding of job information showed correlation with job preparation behaviors. Conclusion: For improvement on career decision-making self-efficacy and career identity of health science college students, individual support, psychological support, educational support and other supports regarding job employment to provide wide paths and methods for job preparation behaviors are essential, and through various job employment education program and graded counseling, job preparation behaviors shall be promoted as a great strategy.

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Semi-active control of seismically excited structures with variable orifice damper using block pulse functions

  • Younespour, Amir;Ghaffarzadeh, Hosein
    • Smart Structures and Systems
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    • v.18 no.6
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    • pp.1111-1123
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    • 2016
  • The present study aims at proposing an analytical method for semi-active structural control by using block pulse functions. The performance of the resulting controlled system and the requirements of the control devices are highly dependent on the control algorithm employed. In control problems, it is important to devise an accurate analytical method with less computational expenses. Block pulse functions (BPFs) set proved to be the most fundamental and it enjoyed immense popularity in different applications in the area of numerical analysis in systems science and control. This work focused on the application of BPFs in the control algorithm concerning decrease the computational expenses. Variable orifice dampers (VODs) are one of the common semi-active devices that can be used to control the response of civil Structures during seismic loads. To prove the efficiency of the proposed method, numerical simulations for a 10-story shear building frame equipped with VODs are presented. The controlled response of the frame was compared with results obtained by controlling the frame by the classical clipped-optimal control method based on linear quadratic regulator theory. The simulation results of this investigation indicated the proposed method had an acceptable accuracy with minor computational expenses and it can be advantageous in reducing seismic responses.

Methionine Analogue Probes Functionally Important Residues in Active Site of Methionyl-tRNA Synthetase

  • Jo, Yeong-Joon;Lee, Sang-Won;Jo, Myung-Kyun;Lee, Jee-Woo;Kang, Mee-Kyoung;Yoon, Jeong-Hyeok;Kim, Sung-Hoon
    • BMB Reports
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    • v.32 no.6
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    • pp.547-553
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    • 1999
  • Aminoacyl-tRNA synthetases are essential enzymes catalyzing the attachment of specific amino acids to cognate tRNAs. In the present work, the substrate analogue L-methionine hydroxamate was used to identify functional residues located in the active site of the E. coli methionyl-tRNA synthetase (MetRS). This compound inhibited bacteria, yeast, and human MetRS activities to a similar degree, suggesting a conserved active site structure and mechanism between MetRSs of different phylogenetic domains. Mutants of the E. coli MetRS resistant to methionine hydroxamate were also isolated. These mutants contained a substitution either at T10, Y15, or Y94. These residues are highly conserved among the different MetRSs and the mutants showed decreased aminoacylation activity, suggesting their functional and structural significances. The putative roles of these residues are discussed on a structural basis.

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