• 통합자연과학논문집
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• 제6권3호
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• pp.163-169
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• 2013

The chemokine receptor CCR1 a GPCR super family protein contains seven transmembrane domains. It plays an important role in rheumatoid arthritis, organ transplant rejection, Alzheimer's disease and also causes inflammation. Because of its role in disease processes, antagonism of CCR1 became an attractive therapeutic target. In the current study, we have taken a novel series of recently reported CCR1 antagonist of 1-(4-Phenylpiperazin-1-yl_-2-(1H-Pyrazol-1-yl) ethanone derivatives and performed a HQSAR analysis. The model was developed with Atom (A) and bond (B) parameters and with different set of atom counts to improve the model. The results of HQSAR showed good predictive ability in terms of $r^2$ (0.904) and $q^2$ (0.590) with 0.710 as standard error of prediction and 0.344 as standard error of estimate. The contribution map depicted the atom contribution in inhibitory effect. Compound-14 which was reported to be a highly active compound showed positive atom contribution in three R groups ($R^3$. $R^{5a}$ and $R^{2b}$) in inhibitory effect, which could be the reason why this compound is highly active compound whereas, the lowest active compound-6 showed negative contribution to inhibitory effect.

• Nuclear Engineering and Technology
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• 제55권11호
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• pp.4002-4018
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• 2023

An integrated neutron interrogation system has been developed for non-destructive assay of highly-radioactive special nuclear materials, to accumulate knowledge of the method through developing and using it. The system combines a differential die-away (DDA) measurement system for the quantification of nuclear materials and a prompt gamma-ray analysis (PGA) system for the detection of neutron poisons which disturb the DDA measurements; a common D-T neutron generator is used. A special care has been taken for the selection of materials to reduce the background gamma rays produced by the interrogation neutrons. A series of measurements were performed to test the basic performance of the system. The results show that the DDA system can quantify plutonium of as small as 20 mg and it is not affected by intense neutron background up to 1.57 × 10⁷ s^-1 and gamma ray of 4.43 × 10¹⁰ s^-1. The gamma-ray background counting rate at the PGA detector was reduced down to 3.9 × 10³ s^-1 even with the use of the D-T neutron generator. The test measurements show that the PGA system is capable of detecting 0.783 g of boron and about 86.8 g of gadolinium in 30 min.

• 대한화학회지
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• 제29권5호
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• pp.557-558
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• 1985

• 가족자원경영과 정책
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• 제18권2호
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• pp.1-15
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• 2014

The purpose of this study was to investigate the impact of lifestyle on the perceived value of children in university students. Questionnaires were distributed to 467 university students with questions covering topics including general personal information and characteristics, lifestyle type, and value of children. First, a cluster analysis based on lifestyle showed that the subjects could be categorized into three groups: negative-leisure types, active-achievement types, and affirmative-fidelity types. The negative-leisure type was highly leisure-oriented and showed a negative self-value; the active-achievement type showed a perspective that valued personal and occupational self-development and a high level of labor-oriented value; and the affirmative-fidelity type favored materialism, seeking occupational aptitude and worth and showing a positive self-value. Second, an investigation of the impact of these three lifestyle types on the students' value of children revealed that the active-achievement type group had high level of belief in the necessity of childbirth, the affirmative-fidelity type group highly valued fulfilling an active parent role, and the active-achievement type group were inclined to delay childbirth. Further, the negative-leisure type group wanted the lowest number of children, while the affirmative-fidelity type group wanted the highest number of children. This study reveals that university students' lifestyle does have an effect on their value of children. It is therefore proposed that a value-focused population education for increasing fertility should relate not only to individuals' value of children but also to their broader lifestyle.

• 한국자동차공학회논문집
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• 제20권4호
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• pp.1-9
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• 2012

The NCF control algorithm for an active suspension system was proposed and investigated. The NCF algorithm using spring dynamic variation force and suspension relative velocity was applied to the 1/4 vehicle model and numerical analysis was performed. Vehicle's performances such as vehicle displacement, vehicle acceleration, suspension deflection, tire deflection and absorbed power were calculated and compared with those of the passive, semi-active and LQR active suspension system that use full state feedback. Numerical results show that the proposed NCF active suspension system has superior performance compared with the passive and semi-active suspension system and has very similar performance compared with the LQR active suspension system. So the proposed NCF algorithm is considered as a highly practical algorithm because it requires only one displacement sensor in a 1/4 vehicle model.

• 공업화학
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• 제9권1호
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• pp.115-120
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• 1998

메타세시스에 높은 활성을 나타내는 고분산 레늄촉매을 제조하기 위한 레늄카보닐 침착의 표면화학 및 활성점 생성에 관하여 연구하였다. 알루미나는 773K(PDA)와 1223K(DA)에서 각각 처리하여 담체로 사용하였고, 메타세시스 활성은 순수한 프로펜을 사용하여 상압하의 298K에서 조사하였다. PDA상의 레늄 산화가는 상당히 높았으나, DA에서는 저산화가의 레늄으로 담지되어 있었다. 제조한 Re/DA촉매를 고온에서 열분해시킨 다음 저온에서 산소로 처리하면 메타세시스 활성이 나타났고, 그 활성은 극히 낮은 담지율에서도 Re/PDA이나 통상의 $Re_2O_7/Al_2O_3$촉매에 비해 높은 활성을 보여, 레늄 카보닐을 출발물질로 하고 DA를 사용하는 것이 효과적이었다. 열분해하여 얻은 Re/DA촉매상의 레늄이온은 알루미나의 산소원자 2개와 결합하여 2가를 가지고, 산소처리에 의하여 4가만큼 증가한 6가의 레늄이온이 되며, 메타세시스는 그 6가이온에 의해 생성된 카르벤착체를 통하여 진행됨을 알았다.

• Toxicological Research
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• 제34권1호
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• pp.41-48
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• 2018

The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo effects of HAART on sperm parameters and testicular oxidative stress in lean and obese rats. Wistar rats (males, n = 40, weighing 180~200 g) were assigned randomly into 4 groups and treated accordingly for 16 weeks as follows: Control (C): lean group fed with standard rat chow; Diet induced obesity (DIO): obese animals fed a high caloric diet; C + ART: lean animals treated with HAART; DIO + ART: obese animals treated with HAART. An antiretroviral drug combination of Tenofovir, Emtricitabine and Efavirenz at a dose of 17, 26 and 50 mg/kg/day was administered for the latter 6 weeks via jelly cube feeding. At the end of the experimental period, sperm analysis was performed on sperm collected from the caudal epididymis, while the testis was homogenized for antioxidant enzyme and lipid peroxidation assays. Results showed that HAART significantly decreased sperm motility (p < 0.05) in both lean and obese animals, and viability (p < 0.05) in the DIO group. Testicular glutathione, catalase and superoxide dismutase were significantly decreased (p < 0.05), while Thiobarbituric acid reactive substances (TBARS) levels were significantly increased (p < 0.05) when the DIO+ART group was compared to Control group. Thus, the decreased sperm qualities associated with HAART might be as a result of increased testicular oxidative stress prominent in obese animals.

• Journal of Ginseng Research
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• 제35권4호
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• pp.413-420
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• 2011

We investigated whether Korean red ginseng (KRG) and highly active antiretroviral therapy (HAART) affect the frequency of gross deletion in 5'LTR/gag in 20 hemophiliacs. This study is a prospective study in 20 hemophiliacs who were infected with Korean subclade B of HIV-1 from two cash-paid plasma donors in 1990. Over a 13-year period, we obtained 436 amplicons of 5'LTR/gag genes by nested polymerase chain reaction using 147 peripheral blood mononuclear cells. Of the 436 amplicons, 92 (21.1%) showed gross deletion in 5'LTR/gag. Despite of a 2.3-fold higher monthly dose of KRG intake, the frequency of gross deletion in 5'LTR/gag (16.4%) was significantly decreased during HAART compared with 28.1% prior to HAART (p<0.01). Gross deletion in 5'LTR/gag was 10% more detected on KRG-therapy than prior to KRG-therapy (p<0.05). In addition, we also obtained 28 amplicons containing premature stop codon or isoleucine at initiation codon of 254 amplicons sequenced on KRG intake (7.5%) or HAART (13.6%) compared with 0% before KRG intake. These findings indicate that high frequency of gross deletion in 5'LTR/gag and genetic defects prior to HAART are significantly associated with KRG intake and the detection of gross deletion in 5'LTR/gag is decreased by HAART.

• Smart Structures and Systems
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• 제4권4호
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• pp.493-515
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• 2008

Semi-active control systems have attracted a great deal of attention in recent years because these systems can operate on battery power alone, proving advantageous during seismic events when the main power source of the structure may likely fail. The behavior of semi-active devices is often highly non-linear and requires suitable and efficient control algorithm. This paper presents the comparative study and performance of variable semi-active friction dampers by using recently proposed predictive control law with direct output feedback. In this control law, the variable slip force of semi-active variable friction damper is kept slightly lower than the critical friction force, which allows the damper to remain in the slip state during an earthquake, resulting in improved energy dissipation capability. This control algorithm is able to produce a continuous and smooth slip forces for a variable friction damper. The numerical examples include a structure controlled with multiple variable semi-active friction dampers and with multiple passive friction dampers. A parameter, gain multiplier defined as the ratio of damper force to critical damper control force, is investigated under four different real earthquake ground motions, which plays an important role in the present control algorithm of the damper. The numerically evaluated optimum parametric value is considered for the analysis of the structure with dampers. The numerical results of the variable friction dampers show better performance over the passive dampers in reducing the seismic response of structures.

• Journal of Information Processing Systems
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• 제13권5호
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• pp.1299-1319
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• 2017

This paper presents a scalable multiple camera collaboration strategy for active tracking applications in large areas. The proposed approach is based on distributed mechanism but emulates the master-slave mechanism. The master and slave cameras are not designated but adaptively determined depending on the object dynamic and density distribution. Moreover, the number of cameras emulating the master is not fixed. The collaboration among the cameras utilizes global and local sectors in which the visual correspondences among different cameras are determined. The proposed method combines the local information to construct the global information for emulating the master-slave operations. Based on the global information, the load balancing of active tracking operations is performed to maximize active tracking coverage of the highly dynamic objects. The dynamics of all objects visible in the local camera views are estimated for effective coverage scheduling of the cameras. The active tracking synchronization timing information is chosen to maximize the overall monitoring time for general surveillance operations while minimizing the active tracking miss. The real-time simulation result demonstrates the effectiveness of the proposed method.