• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.4
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• pp.158-168
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• 2000

Vehicle driving simulators can provide engineers with benefits on the development and modification of vehicle models. One of the most important factors to realistic simulations is the fidelity given by a motion system and a real-time visual image generation system. Virtual reality technology has been widely used to achieve high fidelity. In this paper the virtual environment including a visual system like a head-mounted display is developed for a vehicle driving simulator system by employing the virtual reality technique. virtual vehicle and environment models are constructed using the object-oriented analysis and design approach. Accordint to the object model a three dimensional graphic model is developed with CAD tools such as Rhino and Pro/E. For the real-time image generation the optimized IRIS Performer 3D graphics library is embedded with the multi-thread methodology. Compared with the single loop apprach the proposed methodology yields an acceptable image generation speed 20 frames/sec for the simulator.

• BMB Reports
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• v.31 no.6
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• pp.585-589
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• 1998

The herpes simplex virus type-1 (HSV-1)-encoded DNA polymerase consists of two subunits, the products of the UL30 and UL42 genes. UL30 and UL42 were coexpressed in Sf9 cells infected with recombinant baculoviruses carrying the two genes. The UL30 and UL42 gene products remained tightly associated throughout the purification, which led to a near homogeneous heterodimer composed of the DNA polymerase and UL42 protein. The DNA polymerase-UL42 protein heterodimer, purified from the recombinant baculovirus-infected Sf9 cells, showed the same high degree of processivity of deoxynucleotide polymerization as the enzyme purified from the HSV-1 infected primate cells. Like the latter, it contained a 3'-5' exonuclease activity that specifically hydrolyzes an incorrectly matched nucleotide at the 3' terminus of a primer, thereby contributing to the fidelity of DNA replication.

• Journal of Korean Academy of Nursing
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• v.41 no.4
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• pp.433-443
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• 2011

Purpose: Clinical training for nursing students is limited to rudimentary skills to avoid potential risks. Simulation-Based Training (SBT) can overcome the shortcomings of clinical training. We evaluated the educational effect of SBT for obstetrical nursing students using high-fidelity simulation courses. Methods: We developed a simulation program for obstetrical nursing students to practice nursing skills that are necessary to provide quality care. The program consisted of four sessions. 1st: An orientation and a preliminary test. 2nd: Learning core skills required in obstetrical nursing. 3rd: Testing each student with scenario. 4th: Providing a debriefing session. At the beginning of the program, students were surveyed about their self-confidence in obstetrical nursing care, and at the end of the program, they were surveyed about the adequacy of SBT as well as self-confidence. Results: Students' self-confidence showed a significant difference before and after simulation. Mean adequacy of SBT was $7.15{\pm}1.35$ (out of 10). Most students became more interested in Women's Health Nursing after SBT. Conclusion: The results from evaluating the effects of simulation-based obstetrical nursing training show that SBT provides invaluable clinical experience for obstetrical nursing students by overcoming the lack of actual clinical involvement in clinical training programs.

• Journal of Microbiology and Biotechnology
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• v.15 no.6
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• pp.1408-1413
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• 2005

Elevated expression of carcinoembryonic antigen (CEA) has been implicated in various biological aspects of neoplasia such as tumor cell adhesion, metastasis, blocking of cellular immune mechanisms, and antiapoptosis function. Thus, the CEA could be an important target for anticancer therapy. In this study, we developed Tetrahymena group 1 intron-based trans-splicing ribozymes that can specifically target and replace CEA RNA. To this end, we first determined which regions of the CEA RNA were accessible to ribozymes by employing an RNA mapping strategy that was based on a trans-splicing ribozyme library. Next, we assessed the ribozyme activities by comparing the trans-splicing activities of several ribozymes that targeted different regions of the CEA RNA, and then the ribozyme that could target the most accessible site was observed to be the most active with high fidelity in vitro. Moreover, the specific trans-splicing ribozyme was found to react with and altered the target CEA transcripts in mammalian cells with high fidelity. These results suggest that the Tetrahymena ribozyme can be utilized to replace CEA RNAs in tumors with a new RNA-harboring anticancer activity, thereby hopefully reverting the malignant phenotype.

• Computers and Concrete
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• v.8 no.1
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• pp.23-41
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• 2011

The behaviour of concrete confined by transverse reinforcement is a classical topic. Numerous studies have been conducted to establish the stress-strain relationships for concrete under various confining reinforcement arrangements. Many empirical and semi-empirical formulas exist. Simplified analytical models have also been proposed to evaluate the increase in the strength and ductility of confined concrete. However, relatively few studies have been conducted to utilise advanced computational models for a realistic simulation of the behaviour of concrete confined by transverse reinforcement. As a matter of fact, high fidelity simulations using the latest numerical solvers in conjunction with advanced material constitutive models can be a powerful means to investigating the mechanisms underlying the confining effects of different reinforcement schemes. This paper presents a study on the use of high fidelity finite element models for the investigation of the behaviour of concrete confined by stirrups, as well as the interpretation of the numerical results. The development of the models is described in detail, and the essential modelling considerations are discussed. The models are then validated by simulating representative experimental studies on short columns with different confining reinforcement schemes. The development and distribution of the confining stress and the subsequent increase in the axial strength are examined. The models are shown to be capable of reproducing the behaviour of the confined concrete realistically, paving a way for systematic parametric studies and investigation into complicated confinement, load combination, and dynamic loading situations.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.190-193
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• 2013

Before Smartphone releases, playing music form previous cellphone is very limited, so we need mp3 player instead. However, when Smartphone releases, a function of playing multimedia became one of the important things in Samrtphone including all functions of mp3 player. Even though it is easier to use since you can play music and multimedia in one device, it still has problem issues on the sound quality. This thesis will discuss about functions of EQ from Smartphone music players. After that, we will to achieve high fidelity sound through balance adjustment of Right Mark Audio Analyzer program.

• Perspectives in Nursing Science
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• v.8 no.2
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• pp.86-96
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• 2011

Purpose: This study examined the effects of simulation-based education on knowledge about and self-confidence in maternity nursing care in senior students. Methods: One group, pre-post design, was utilized with 28 students. The simulation-based maternity nursing education that consisted of two sessions each 2 hours long for intrapartum and postpartum care was provided to 4 small groups. An expert panel of 3 maternity clinical instructors developed the module with a high-fidelity maternal simulator. Core items of knowledge about and self-confidence in maternity nursing care were measured with 13 items before and after the sessions. Results: The knowledge score did not increase significantly (z=-1.95, p=.05); however, self-confidence in maternity nursing care showed a significant change in the posttest (z=-2.82, p<.001). The subjective evaluation of the students indicated that the simulation-based education was helpful in preparing for clinical practicum as far as interaction with clients, psychological readiness to practice, and learning efficiencies. Conclusion: The simulation-based nursing education was useful in improving self-confidence in clinical performance for childbirth and postpartum care in nursing students. Along with the application of diverse scenarios in simulations, modules with standard patients and role-plays are also recommended for maternity nursing practicum to empower the competency of the students.

• Nuclear Engineering and Technology
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• v.52 no.5
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• pp.878-888
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• 2020

This paper presents the validation of UNIST in-house Monte Carlo code MCS used for the high-fidelity simulation of commercial pressurized water reactors (PWRs). Its focus is on the accurate, spatially detailed neutronic analyses of startup physics tests for the initial core of the Watts Bar Nuclear 1 reactor, which is a vital step in evaluating core phenomena in an operating nuclear power reactor. The MCS solutions for the Consortium for Advanced Simulation of Light Water Reactors (CASL) Virtual Environment for Reactor Applications (VERA) core physics benchmark progression problems 1 to 5 were verified with KENO-VI and Serpent 2 solutions for geometries ranging from a single-pin cell to a full core. MCS was also validated by comparing with results of reactor zero-power physics tests in a full-core simulation. MCS exhibits an excellent consistency against the measured data with a bias of ±3 pcm at the initial criticality whole-core problem. Furthermore, MCS solutions for rod worth are consistent with measured data, and reasonable agreement is obtained for the isothermal temperature coefficient and soluble boron worth. This favorable comparison with measured parameters exhibited by MCS continues to broaden its validation basis. These results provide confidence in MCS's capability in high-fidelity calculations for practical PWR cores.

• Nuclear Engineering and Technology
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• v.53 no.10
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• pp.3133-3150
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• 2021

This work deals with the validation of a high-fidelity multiphysics system coupling the Serpent 2 Monte Carlo neutron transport code with SUBCHANFLOW, a subchannel thermalhydraulics code, and TRANSURANUS, a fuel-performance analysis code. The results for a full-core pin-by-pin burnup calculation for the ninth operating cycle of the Temelín II VVER-1000 plant, which starts from a fresh core, are presented and assessed using experimental data. A good agreement is found comparing the critical boron concentration and a set of pin-level neutron flux profiles against measurements. In addition, the calculated axial and radial power distributions match closely the values reported by the core monitoring system. To demonstrate the modeling capabilities of the three-code coupling, pin-level neutronic, thermalhydraulic and thermomechanic results are shown as well. These studies are encompassed in the final phase of the EU Horizon 2020 McSAFE project, during which the Serpent-SUBCHANFLOW-TRANSURANUS system was developed.

• Nuclear Engineering and Technology
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• v.53 no.6
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• pp.1893-1908
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• 2021

In light of the importance of helium production in influencing the behaviour of fast reactor fuels, in this work we present a burn-up module with the objective to calculate the production of helium in both in-pile and out-of-pile conditions tracking the evolution of 23 alpha-decaying actinides. This burn-up module relies on average microscopic cross-section look-up tables generated via SERPENT high-fidelity calculations and involves the solution of the system of Bateman equations for the selected set of actinide nuclides. The results of the burn-up module are verified in terms of evolution of actinide and helium concentrations by comparing them with the high-fidelity ones from SERPENT, considering two representative test cases of (U,Pu)O₂ fuel in fast reactor conditions. In addition, a code-to-code comparison is made with the independent state-of-the-art module TUBRNP (implemented in the TRANSURANUS fuel performance code) for the same test cases. The herein presented burn-up module is available in the SCIANTIX code, designed for coupling with fuel performance codes.