• Steel and Composite Structures
• /
• v.45 no.3
• /
• pp.389-408
• /
• 2022

Residual capacity is defined as the load carrying capacity of an RC column after undergoing severe damage. Evaluation of residual capacity of RC columns is necessary to avoid damage initiation in RC structures. The central aspect of the current research is to propose an empirical formula to estimate the residual capacity of RC columns after undergoing severe damage. This formula facilitates decision making of whether a replacement or a repair of the damaged column is adequate for further use. Available literature mainly focused on the simulation of explosion loads by using simplified pressure time histories to develop residual capacity of RC columns and rarely simulated the actual explosive. Therefore, there is a gap in the literature concerning general relation between blast damage of columns with different explosive loading conditions for a reliable and quick evaluation of column behavior subjected to blast loading. In this paper, the Arbitrary Lagrangian Eulerian (ALE) technique is implemented to simulate high fidelity blast pressure propagations. LS-DYNA software is utilized to solve the finite element (FE) model. The FE model is validated against the practical blast tests, and outcomes are in good agreement with test results. Multivariate linear regression (MLR) method is utilized to derive an analytical formula. The analytical formula predicts the residual capacity of RC columns as functions of structural element parameters. Based on intensive numerical simulation data, it is found that column depth, longitudinal reinforcement ratio, concrete strength and column width have significant effects on the residual axial load carrying capacity of reinforced concrete column under blast loads. Increasing column depth and longitudinal reinforcement ratio that provides better confinement to concrete are very effective in the residual capacity of RC column subjected to blast loads. Data obtained with this study can broaden the knowledge of structural response to blast and improve FE models to simulate the blast performance of concrete structures.

• Journal of Animal Reproduction and Biotechnology
• /
• v.38 no.3
• /
• pp.99-108
• /
• 2023

Background: Efficient gene editing technology is needed for successful knock-in. Homologous recombination (HR) is a major double-strand break repair pathway that can be utilized for accurately inserting foreign genes into the genome. HR occurs during the S/G2 phase, and the DNA mismatch repair (MMR) pathway is inextricably linked to HR to maintain HR fidelity. This study was conducted to investigate the effect of inhibiting MMR-related genes using CdCl₂, an MMR-related gene inhibitor, on HR efficiency in HC11 cells. Methods: The mRNA and protein expression levels of MMR-related genes (Msh2, Msh3, Msh6, Mlh1, Pms2), the HR-related gene Rad51, and the NHEJ-related gene DNA Ligase IV were assessed in HC11 cells treated with 10 μM of CdCl₂ for 48 hours. In addition, HC11 cells were transfected with a CRISPR/sgRNA expression vector and a knock-in vector targeting Exon3 of the mouse-beta casein locus, and treated with 10 μM cadmium for 48 hours. The knock-in efficiency was monitored through PCR. Results: The treatment of HC11 cells with a high-dose of CdCl₂ decreased the mRNA expression of the HR-related gene Rad51 in HC11 cells. In addition, the inhibition of MMR-related genes through CdCl₂ treatment did not lead to an increase in knock-in efficiency. Conclusions: The inhibition of MMR-related gene expression through high-dose CdCl₂ treatment reduces the expression of the HR-related gene Rad51, which is active during recombination. Therefore, it was determined that CdCl₂ is an inappropriate compound for improving HR efficiency.

• Nuclear Engineering and Technology
• /
• v.56 no.9
• /
• pp.3700-3716
• /
• 2024

Owing to spatial effects and vortex flow, flow in research reactors that use plate-type fuels can be maldistributed to the parallel channels of the core, which significantly impacts the reactor safety. In this study, the core flow of an advanced research reactor was measured in a real-scale facility under various hydraulic conditions. For flow measurement, integrated pressure lines were embedded in the mockups of 22 fuel assemblies and six fission molybdenum assemblies. Each assembly mockup was individually calibrated to obtain the relationship between the pressure drop and flow rate. Real-scale facility, which implements the characteristics of the hydraulic conditions in research reactors, was then used to evaluate the assembly-to-assembly flow distribution under normal operating condition, a partially withdrawn condition for the follower fuel assemblies, no flow for the pool water management system, and 1:1.5 asymmetric inlet flow condition. As a parallel channel system, core flow distribution was analyzed with conventional header design approach. Taking into account the measuring uncertainty, the core flow was uniformly distributed within 5 % under all conditions. This was mainly because the core flow resistance was sufficiently high and the vortex flow was minimized by the perforated plate.

• Nuclear Engineering and Technology
• /
• v.56 no.8
• /
• pp.3210-3223
• /
• 2024

International Commission on Radiological Protection (ICRP) recently developed the adult and pediatric meshtype reference computational phantoms (MRCPs) in high-quality/fidelity mesh format, featuring high deformability into various body sizes and poses. Utilizing this feature, the adult MRCPs-based body-size-dependent phantom library was developed for individualized dosimetry. To complete the full phantom library set, the present study produced the pediatric-MRCPs-based body-size-dependent pediatric phantom library. The library comprises a total of 637 phantoms (356 males and 281 females) with varying standing heights and body weights, covering a wide range of body sizes (i.e., including from 1st to 99th percentile height and weight values) for infants, children, and adolescents, offering a realistic representation of body shapes by reflecting ten secondary anthropometric parameters. The phantoms were automatically constructed utilizing automatic deformation program. The dosimetric impact of the library was investigated by calculating organ doses for external exposures to broad parallel photon beams in anterior-posterior direction. Compared with the values of the pediatric MRCPs, significant differences were observed at energies <0.05 MeV, showing larger values for underweight phantom and smaller values for obese phantom. The results highlight the importance of using the pediatric phantom library for accurate dose estimates of individual children with various body sizes.

• Journal of Korea Water Resources Association
• /
• v.56 no.10
• /
• pp.641-653
• /
• 2023

As climate change and urbanization are causing unprecedented natural disasters in urban areas, it is crucial to have urban flood predictions with high fidelity and accuracy. However, conventional physically- and deep learning-based urban flood modeling methods have limitations that require a lot of computer resources or data for high-resolution flooding analysis. In this study, we propose and implement a method for improving the spatial resolution of urban flood analysis using a deep learning based super-resolution technique. The proposed approach converts low-resolution flood maps by physically based modeling into the high-resolution using a super-resolution deep learning model trained by high-resolution modeling data. When applied to two cases of retrospective flood analysis at part of City of Portland, Oregon, U.S., the results of the 4-m resolution physical simulation were successfully converted into 1-m resolution flood maps through super-resolution. High structural similarity between the super-solution image and the high-resolution original was found. The results show promising image quality loss within an acceptable limit of 22.80 dB (PSNR) and 0.73 (SSIM). The proposed super-resolution method can provide efficient model training with a limited number of flood scenarios, significantly reducing data acquisition efforts and computational costs.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.5
• /
• pp.1-9
• /
• 2016

Railroad bridges account for 25% of the entire high-speed rail network. Railway bridges are subject to gradual structural degradation or fatigue accumulation due to consistent and repeating excitation by fast moving trains. Wireless sensing technology has opened up a new avenue for bridge health monitoring owing to its low-cost, high fidelity, and multiple sensing capability. On the other hand, measuring the transient response during train passage is quite challenging that the current wireless sensor system cannot be applied due to the intrinsic time delay of the sensor network. Therefore, this paper presents a framework for monitoring such transient responses with wireless sensing systems using 1) real-time excessive vibration monitoring through ultra-low-power MEMS accelerometers, and 2) post-event time synchronization scheme. The ultra-low power accelerometer continuously monitors the vibration and trigger network when excessive vibrations are detected. The entire network of wireless smart sensors starts sensing through triggering and the post-event time synchronization is conducted to compensate for the time error on the measured responses. The results of this study highlight the potential of detecting the impact load and triggering the entire network, as well as the effectiveness of the post-event time synchronized scheme for compensating for the time error. A numerical and experimental study was carried out to validate the proposed sensing hardware and time synchronization method.

• Geophysics and Geophysical Exploration
• /
• v.11 no.3
• /
• pp.177-183
• /
• 2008

The sub-salt imaging technique becomes more crucial to detect the hydro-carbonates in petroleum exploration as the target reservoirs get deeper. However, the weak reflections from the sub-salt structures prevent us from obtaining high fidelity sub-salt image. As an effort to overcome this difficulty, we applied the waveform inversion by implementing multi-grid technique to the sub-salt imaging. Through the comparison between the conventional waveform inversion using fixed grid and the multi-grid technique, we confirmed that the waveform inversion using multi-grid technique has advantages over the conventional fixed grid waveform inversion. We showed that the multi-grid technique can complement he velocity estimation result of the waveform inversion for imaging the sub-salt structures, of which velocity model cannot be obtained correctly by the conventional fixed grid waveform inversion.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.34 no.5
• /
• pp.541-547
• /
• 2010

The rigorous validation of the accuracy of metamodels is an important topic in research on metamodel techniques. Although a leave-k-out cross-validation technique involves a considerably high computational cost, it cannot be used to measure the fidelity of metamodels. Recently, the mean$_0$ validation technique has been proposed to quantitatively determine the accuracy of metamodels. However, the use of mean$_0$ validation criterion may lead to premature termination of a sampling process even if the kriging model is inaccurate. In this study, we propose a new validation technique based on the mean and variance of the response evaluated when sequential sampling method, such as maximum entropy sampling, is used. The proposed validation technique is more efficient and accurate than the leave-k-out cross-validation technique, because instead of performing numerical integration, the kriging model is explicitly integrated to accurately evaluate the mean and variance of the response evaluated. The error in the proposed validation technique resembles a root mean squared error, thus it can be used to determine a stop criterion for sequential sampling of metamodels.

• Journal of computational fluids engineering
• /
• v.20 no.2
• /
• pp.7-15
• /
• 2015

This paper attempts to evaluate the accuracy and efficiency of a design optimization procedure by combining wavelets-based multi resolution analysis method and proper orthogonal decomposition (POD) technique. Aerodynamic design procedure calls for high fidelity computational fluid dynamic (CFD) simulations and the consideration of large number of flow conditions and design constraints. Thus, even with significant computing power advancement, current level of integrated design process requires substantial computing time and resources. POD reduces the degree of freedom of full system by conducting singular value decomposition for various field simulations. In this research, POD combined Design Optimization model is proposed and its efficiency and accuracy are to be evaluated. For additional efficiency improvement of the procedure, multi resolution analysis method is also being employed during snapshot constructions (POD training period). The proposed design procedure was applied to the optimization of wing aerodynamic performance. Throughout the research, it was confirmed that the POD/MRA design procedure could significantly reduce the total design turnaround time and also capture all detailed complex flow features as in full order analysis.

• Smart Structures and Systems
• /
• v.25 no.2
• /
• pp.155-167
• /
• 2020

This paper demonstrates a real-time hybrid substructuring (RTHS) shake table test to evaluate the seismic performance of a base isolated building. Since RTHS involves a feedback loop in the test implementation, the frequency dependent magnitude and inherent time delay of the actuator dynamics can introduce inaccuracy and instability. The paper presents a robust stability and performance analysis method for the RTHS test. The robust stability method involves casting the actuator dynamics as a multiplicative uncertainty and applying the small gain theorem to derive the sufficient conditions for robust stability and performance. The attractive feature of this robust stability and performance analysis method is that it accommodates linearized modeled or measured frequency response functions for both the physical substructure and actuator dynamics. Significant experimental research has been conducted on base isolators and dampers toward developing high fidelity numerical models. Shake table testing, where the building superstructure is tested while the isolation layer is numerically modeled, can allow for a range of isolation strategies to be examined for a single shake table experiment. Further, recent concerns in base isolation for long period, long duration earthquakes necessitate adding damping at the isolation layer, which can allow higher frequency energy to be transmitted into the superstructure and can result in damage to structural and nonstructural components that can be difficult to numerically model and accurately predict. As such, physical testing of the superstructure while numerically modeling the isolation layer may be desired. The RTHS approach has been previously proposed for base isolated buildings, however, to date it has not been conducted on a base isolated structure isolated at the ground level and where the isolation layer itself is numerically simulated. This configuration provides multiple challenges in the RTHS stability associated with higher physical substructure frequencies and a low numerical to physical mass ratio. This paper demonstrates a base isolated RTHS test and the robust stability and performance analysis necessary to ensure the stability and accuracy. The tests consist of a scaled idealized 4-story superstructure building model placed directly onto a shake table and the isolation layer simulated in MATLAB/Simulink using a dSpace real-time controller.