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Heparanase mRNA and Protein Expression Correlates with Clinicopathologic Features of Gastric Cancer Patients: a Meta-analysis

  • Li, Hai-Long;Gu, Jing;Wu, Jian-Jun;Ma, Chun-Lin;Yang, Ya-Li;Wang, Hu-Ping;Wang, Jing;Wang, Yong;Chen, Che;Wu, Hong-Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.18
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    • pp.8653-8658
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    • 2016
  • Background: Heparanase is believed to be involved in gastric carcinogenesis. However, the clinicopathologic features of gastric cancer with high heparanase expression remain unclear. Aim : The purpose of this study was to comprehensively and quantitatively summarize available evidence for the use of heparanase mRNA and protein expression to evaluate the clinicopathological associations in gastric cancer in Asian patients by meta-analysis. Materials and Methods: Relevant articles listed in MEDLINE, CNKI and the Cochrane Library databases up to MARCH 2015 were searched by use of several keywords in electronic databases. A meta-analysis was performed to clarify the impact of heparanase mRNA and protein on clinicopathological parameters in gastric cancer. Combined ORs with 95%CIs were calculated by Revman 5.0, and publication bias testing was performed by stata12.0. Results: A total of 27 studies which included 3,891 gastric cancer patients were combined in the final analysis. When stratifying the studies by the pathological variables of heparanase mRNA expression, the depth of invasion (633 patients) (OR=4.96; 95% CI=2.38-1.37; P<0.0001), lymph node metastasis (639 patients) (OR=6.22; 95%CI=2.70-14.34, P<0.0001), and lymph node metastasis (383 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002) were all significant. When stratifying the studies by the pathological variables of heparanase protein expression, this was the case for depth of invasion (1250 patients) (OR=2.76; 95% CI=1.52-5.03; P=0.0009), lymph node metastasis (1178 patients) (OR=4.79 ; 95% CI=3.37-6.80, P<0.00001), tumor size (727 patients) (OR=2.06 ; 95% CI=1.31-3.23; P=0.002) (OR=2.61; 95% CI=2.09-3.27; P=0.000), and TNM stage (1233 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002). Egger's tests suggested publication bias for depth of invasion, lymph node metastasis, lymph node metastasis and tumor size of heparanase mRNA and protein expression. Conclusions: This meta-analysis suggests that higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis and TNM stage at mRNA and protein levels, and of tumor size only at the protein level. Egger's tests suggested publication bias for these clinicopathologic features of heparanase mRNA and protein expression, and which may be caused by shortage of relevant studies. As a result, although abundant reports showed heparanase may be associated with clinicopathologic features in gastric cancer, this meta-analysis indicates that more strict studies were needed to evaluate its clinicopathologic significance.

Studies on the Effects of Several Physico-Chemical Properties of Soils on the Growth, Nodulation and Yield in Soybeans (토양(土壤)의 몇가지 이화학적(理化學的) 성질(性質)이 대두(大豆)의 생육(生育), 근류형성(根瘤形成) 및 수량(收量)에 미치는 영향(影響))

  • Choi, Chang-Yoel
    • Korean Journal of Agricultural Science
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    • v.2 no.2
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    • pp.309-329
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    • 1975
  • Studies were carried out to find the effect of various soil properties on the growth, nodulation and yield using a soybean variety, 'Tongbuktae', at various soils. The results of the study are summarized as follow: 1. The formation ratios of various characters in soybeans were different before and after flowering. The root length(89.3%), stem diameter(82.1%), plant height(77.8%), number of nodes(67.4%), and number of nodes(67.9%) gave the high formation ratio before flowering. However, the formation of number of nodules(66.3%), top dry weight(74.9%) and total dry weight(71.7%)was accomplished mainly after flowering. The ratio of the formation in root dry weight was appeared to be about same in the growth period before and after flowering. 2. Nodulation ratio after flowering shelved significantly positive correlation with dry matter accumulation. 3. T/R, top dry weight/plant height and plant height/root length were significantly associated with yield. The tested soils with higher ratio mentioned above, also showed higher yield. 4. pH, oraganic matter, phosphate, potassium, total nitrogen and molybdenum in the soils were significantly correlated with nodulation and yield. Content of calcium in the soils only showed significant association with yield. 5. Soil properties influenced yield were molybdenum, calcium, organic matter, pH, number of nodules, magnesium, phosphate, total nitrogen and potassium in the order of importance. This order was varied according to the soils employed in these studies.

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Analysis of Factors that Influence to Dental Utilization of Mothers (어머니의 치과의료이용에 영향을 미치는 요인분석)

  • Kim, Soo-Kyung
    • Journal of dental hygiene science
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    • v.5 no.4
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    • pp.171-177
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    • 2005
  • This study aims to analyze effects of mothers' socioeconomic features, and knowledge and behavior of oral health on experience and purpose of using dentistry. By survey to 103 mothers of 5-6 year old children, who use day care centers in seoul, the results are obtained as follows: 1. As for the rate of experiencing dental care classified by its purpose, 56.7% for dental treatment, 23.3% for regular check-up and 20.0% for precaution 2. There was no significant difference of correlativity between mothers' socioeconomic features and knowledge of oral health and experience of using dental care, while the lower rate of using dental floss, the higher rate of experiencing dental care(p < 0.01). 3. In respect of correlativity between mother's socioeconomic features and purpose of using dental care, the purpose of regular checkup was high in a group of mothers between 33 and 35 years old(71.4%) by ages and in a group of mothers who graduated from college(57.1%) by academic background(p < 0.05). 4. In correlativity between mothers' behavior of oral health and purpose of using dental care, the result showed that the higher the rate of using dental floss was, the higher the rate of experiencing dental care for a regular check-up was(p < 0.001) and the higher the rate of using fluoride dentifrices was, the higher the rate of using dental care for cure was(p < 0.05). 5. Multiple regression based on dependent variable of experience in using dental care showed that average monthly income(less than 2,500,000 won) was significant explanatory factor with 65% of explanatory variance. On the other hand, multiple regression based on dependent variable of purpose of using dental care showed that vocation(professional job) and age(between 33 and 35 years old) was significant explanatory factor with 70% of explanatory variance for a regular check-up, age(between 33 and 35 years old) and average monthly income (less than 2,500,000 won) was significant factor with 78% of explanatory variance for precaution and age(less than 32 years old) was significant explanatory factor with 33% of explanatory variance for treatment.

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A Comparative Study on for the Use of Auxiliary Oral Hygiene Devices and Tooth Brushing between Dental Hygiene Students and Non-Dental Hygiene Students (치위생과와 비치위생과 학생의 잇솔질과 구강위생보조용품의 사용실태 비교연구)

  • Oh, Hye-Seung
    • Journal of dental hygiene science
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    • v.9 no.1
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    • pp.121-127
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    • 2009
  • A comparative analysis was conducted through this study on tooth brushing and a use of auxiliary oral hygiene devices for oral hygiene for 287 S Health College students some of whom major dental hygiene and some of whom don't relate to the department, and then has drawn out the results as below. 1. Relating to the frequency of tooth brushing, 2-3 times a day was the utmost case in both departments(p < 0.05). 2. In use of toothbrush bristle, the students of dental hygiene department used medium bristle(51.2%), while the student of other department used soft bristle(51.5%)(p > 0.05). 3. In the term of tooth brush used, 2~5 months was the utmost case in both departments(p > 0.05). 4. In tooth- brushing method, all the student of both departments said they knew how to do it(p > 0.05). 5. In the acquisition of tooth brushing methods, the students of dental hygiene acquired it from dentistry 44.4%, and the students of other department from TV or Radio 47.5% (p > 0.05)which was a quite high rate. 6. In reference to recognition level on auxiliary oral hygiene devices, dental hygiene students said Yes 79.8%, and the other side students said No 63.9%(p < 0.05). In reuse of auxiliary oral hygiene devices, a great number of students of both departments said No (p < 0.05). 8. In reference to the chance to use auxiliary oral hygiene devices, 58.1% of dental hygiene students chose them with their own judgement, and 37.8% of other department students recommended by dentist's offices(p < 0.05). 9. Relating to the reason for not using auxiliary oral hygiene devices, 38.9% of the dental hygiene students said it's bothersome, and 56.7% of the other department students said they didn't know about these things(p < 0.05). 10. In the recognition level of dental floss, in knowing the way to use it, whether or not of using it, the students of both department showed a significant difference (p < 0.05). 11. In the recognition level of floss holder and the yes or not of using it, there was an insignificant difference(p > 0.05), while in understanding of it, there was a significant difference(p < 0.05). 12. Relating to the recognition level of electric tooth brush, yes or no of using it, there wasn't a significant difference(p > 0.05). 13. In the cognition level of rubber stimulator, yes or no of using it, there wasn't much difference, while in understanding to use it, there was a significant difference(p < 0.05). 14. In the understanding level of water pik, yes or not of using it, there wasn't a great deal of difference(p < 0.05), but in inquiry of whether or not of using it, there was no difference (p > 0.05), 15. In the understanding level of tongue scraper, whether or not of using it, there wasn't much difference(p > 0.05), but in understanding to use it, there was a great deal of difference(p < 0.05). 16. In the recognition of garglin, understanding of it, and whether or not of using it, the two departments didn't show a significant difference(p < 0.05).

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GIS-based Disaster Management System for a Private Insurance Company in Case of Typhoons(I) (지리정보기반의 재해 관리시스템 구축(I) -민간 보험사의 사례, 태풍의 경우-)

  • Chang Eun-Mi
    • Journal of the Korean Geographical Society
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    • v.41 no.1 s.112
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    • pp.106-120
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    • 2006
  • Natural or man-made disaster has been expected to be one of the potential themes that can integrate human geography and physical geography. Typhoons like Rusa and Maemi caused great loss to insurance companies as well as public sectors. We have implemented a natural disaster management system for a private insurance company to produce better estimation of hazards from high wind as well as calculate vulnerability of damage. Climatic gauge sites and addresses of contract's objects were geo-coded and the pressure values along all the typhoon tracks were vectorized into line objects. National GIS topog raphic maps with scale of 1: 5,000 were updated into base maps and digital elevation model with 30 meter space and land cover maps were used for reflecting roughness of land to wind velocity. All the data are converted to grid coverage with $1km{\times}1km$. Vulnerability curve of Munich Re was ad opted, and preprocessor and postprocessor of wind velocity model was implemented. Overlapping the location of contracts on the grid value coverage can show the relative risk, with given scenario. The wind velocities calculated by the model were compared with observed value (average $R^2=0.68$). The calibration of wind speed models was done by dropping two climatic gauge data, which enhanced $R^2$ values. The comparison of calculated loss with actual historical loss of the insurance company showed both underestimation and overestimation. This system enables the company to have quantitative data for optimizing the re-insurance ratio, to have a plan to allocate enterprise resources and to upgrade the international creditability of the company. A flood model, storm surge model and flash flood model are being added, at last, combined disaster vulnerability will be calculated for a total disaster management system.

Development of Cotton Farming and Transformation of Rural Area in Sanliurfa Prefecture, Turkey (터키 샹르울파주 목화농업의 전개와 지역사회의 변화)

  • Kang, Sukkyeong
    • Journal of the Korean Geographical Society
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    • v.48 no.1
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    • pp.87-111
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    • 2013
  • Regional disparities between eastern and western regions is the most of serious problem for balanced regional development in Turkey. The Southeastern Anatolia Project (GAP) is being implemented to eliminate these regional development disparities. The work that was initially planned as predominantly for hydraulic energy production to utilize water resources of the Tigris and Euphrates rivers more effectively was later transformed into an integrated multi-sector regional development project. This study noted that this region had very limited cash crop production because of the constraints of semi-arid climate of the southeastern region, however, later, it has changed Turkey's major cotton producing region since Southeastern Anatolia Project carried out. Therefore, this study investigated background, process, and content of the Southeastern Anatolia Project with respect to high cotton productivity in this region and examined the dynamic changes of cotton productivity in this region. In addition, Sanliurfa prefecture is one of the main development axes of the Southeastern Anatolia Project, because government investments are concentrated on this prefecture. Therefore, this study examined the background and process of cotton farming growth in this prefecture. In 2011, Sanliurfa prefecture produced 37.6% of Turkey's total cotton production. This is mainly due to agricultural infrastructure expansion such as land consolidation, irrigation, roads and farm roads. Also, it is one of the main factor that subsidies paid to farmers for cotton cultivation. The introduction of irrigation has dramatically changed the direction of seasonal migration of this area. Prior to irrigation, this area had a serious social issue about out-migration for seasonal labor to other areas. However, the introduction of irrigation made this area that changed to in-migration and intramigration for cotton cultivation. Irrigation water is supplied to farmers through the WUAs (Water User Associations) that handed over irrigation water management, operation from DSI (General Directorate of State of Hydraulic Works). However, the WUAs are under the influence of Ashiret, a traditional feudal social structure. Because of this reason, it does not have an efficient management for farmers. Also, it is one of the reasons that this area does not have autonomous farmer organization.

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Evaluation of Tensions and Prediction of Deformations for the Fabric Reinforeced -Earth Walls (섬유 보강토벽체의 인장력 평가 및 변형 예측)

  • Kim, Hong-Taek;Lee, Eun-Su;Song, Byeong-Ung
    • Geotechnical Engineering
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    • v.12 no.4
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    • pp.157-178
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    • 1996
  • Current design methods for reinforced earth structures take no account of the magnitude of the strains induced in the tensile members as these are invariably manufactured from high modulus materials, such as steel, where straits are unlikely to be significant. With fabrics, however, large strains may frequently be induced and it is important to determine these to enable the stability of the structure to be assessed. In the present paper internal design method of analysis relating to the use of fabric reinforcements in reinforced earth structures for both stress and strain considerations is presented. For the internal stability analysis against rupture and pullout of the fabric reinforcements, a strain compatibility analysis procedure that considers the effects of reinforcement stiffness, relative movement between the soil and reinforcements, and compaction-induced stresses as studied by Ehrlich 8l Mitchell is used. I Bowever, the soil-reinforcement interaction is modeled by relating nonlinear elastic soil behavior to nonlinear response of the reinforcement. The soil constitutive model used is a modified vertsion of the hyperbolic soil model and compaction stress model proposed by Duncan et at., and iterative step-loading approach is used to take nonlinear soil behavior into consideration. The effects of seepage pressures are also dealt with in the proposed method of analy For purposes of assessing the strain behavior oi the fabric reinforcements, nonlinear model of hyperbolic form describing the load-extension relation of fabrics is employed. A procedure for specifying the strength characteristics of paraweb polyester fibre multicord, needle punched non-woven geotHxtile and knitted polyester geogrid is also described which may provide a more convenient procedure for incorporating the fablic properties into the prediction of fabric deformations. An attempt to define improvement in bond-linkage at the interconnecting nodes of the fabric reinforced earth stracture due to the confining stress is further made. The proposed method of analysis has been applied to estimate the maximum tensions, deformations and strains of the fabric reinforcements. The results are then compared with those of finite element analysis and experimental tests, and show in general good agreements indicating the effectiveness of the proposed method of analysis. Analytical parametric studies are also carried out to investigate the effects of relative soil-fabric reinforcement stiffness, locked-in stresses, compaction load and seepage pressures on the magnitude and variation of the fabric deformations.

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Exploring the Future Direction of School Population Education through Analysis of National Curriculum: Focused on the 7th Curriculum through 2015-Revised Curriculum (교육과정 분석을 통한 학교 인구교육의 미래 방향 탐색: 제7차 교육과정 ~ 2015 개정 교육과정을 중심으로)

  • Wang, Seok-Soon
    • Journal of Korean Home Economics Education Association
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    • v.32 no.2
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    • pp.141-157
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    • 2020
  • This study analyzed the content of national-level curriculum documents for the purpose of reviewing the overall status of population education in elementary and secondary schools in South Korea. Based on the results of the analysis, directions for the future of population education at school were proposed. Both the 2007-Revised Curriculum and the 2009-Revised Curriculum contain the contents of population education as a 'Cross-curricular learning topic' in the general curriculum influenced by the low birth rate and ageing society, yet not in the current 2015-Revised Curriculum. Furthermore, when the curriculum documents for the ten common subjects corresponding to the 'National Common Basic Curriculum' proposed by the 7th Curriculum were examined, only 'Home Economics' curriculum at the secondary school level and 'Social Studies' curriculum at the elementary and the secondary school levels adequately reflected the subject goals, characteristics, contents and achievement standards that correspond to those of population education. Based on the results of the curriculum analysis, the following five directions for population education at school are drawn. First, the purpose of population education at school should be stated using gender-neutral terms of 'response to low-birth and aging society' and it has to be emphasized that it is not to intervene in natural childbirth. Second, the subject which deals directly with the goals, content elements, and achievement standards of population education should be designated as the leading subject for population education. Third, with its inter-disciplinary nature, population education should be able to provide quality contents for convergence education. Fourth, the government should provide policy support to the leading subjects for population education so that more high schools may select the subjects as elective courses. Fifth, teacher education should be improved to enhance teachers' perceptions on population. This study asserts that 'Home economics,' which deals with human daily lives, is an optimal subject that can reflect population education in connection with real life. To this end, policy support should be provided for 'Home economics' so that it may fulfill the mission as a leading subject of population education.

Channel Model and Wireless Link Performance Analysis for Short-Range Wireless Communication Applications in the Terahertz Frequency (테라헤르츠 대역 주파수에서 근거리 무선 통신 응용을 위한 채널 모델 및 무선 링크 성능 분석)

  • Chung, Tae-Jin
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.20 no.9
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    • pp.868-882
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    • 2009
  • In this paper, channel model and wireless link performance analysis for the short-range wireless communication system applications in the terahertz frequency which is currently interested in many countries will be described. In order to realize high data rates above 10 Gbps, the more wide bandwidths will be required than the currently available bandwidths of millimeter-wave frequencies, therefore, the carrier frequencies will be pushed to THz range to obtain larger bandwidths. From the THz atmospheric propagation characteristics based on ITU-R P.676-7, the available bandwidths were calculated to be 68, 48 and 45 GHz at the center frequencies of 220, 300 and 350 GHz, respectively. With these larger bandwidths, it was shown from the simulation that higher data rate above 10 Gbps can be achieved using lower order modulation schemes which have spectral efficiency of below 1. The indoor propagation delay spread characteristics were analyzed using a simplified PDP model with respect to building materials. The RMS delay spread was calculated to be 9.23 ns in a room size of $6\;m(L){\times}5\;m(W){\times}2.5\;m(H)$ for the concrete plaster with TE polarization, which is a similar result of below 10 ns from the Ray-Tracing simulation in the reference paper. The indoor wireless link performance analysis results showed that receiver sensitivity was $-56{\sim}-46\;dBm$ over bandwidth of $5{\sim}50\;GHz$ and antenna gain was calculated to be $26.6{\sim}31.6\;dBi$ at link distance of 10m under the BPSK modulation scheme. The maximum achievable data rates were estimated to be 30, 16 and 12 Gbps at the carrier frequencies of 220, 300 and 350 GHz, respectively, under the A WGN and LOS conditions, where it was assumed that the output power of the transmitter is -15 dBm and link distance of 1 m with BER of $10^{-12}$. If the output power of transmitter is increased, the more higher data rate can be achieved than the above results.

A Structural Equation Modeling on Quality of Social Roles and Health for Married Working Mothers (유배우 취업모의 사회적 역할의 질과 건강에 대한 구조모형)

  • Park, Eun-Ok
    • Research in Community and Public Health Nursing
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    • v.12 no.2
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    • pp.450-458
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    • 2001
  • Purpose: The purpose of this study was to establish a structural equation model on social roles and health for married working mothers. to determine the effects of social roles on Korean women's health and to explore the mediating role of self-esteem in the relationship between social roles qualities and health. Method Data were collected from 323 employed women with partner and children. lived in Seoul and near Seoul. Response rate was 62.3%. The instruments for measurements were Role Quality Scale developed by Park et al. (1999). Rosenberg's Self-Esteem Scale. and 31 items from SF-36 developed by Ware & Sherboune(l992). Results: The effect of marital role quality on self-esteem and the effect of parental role quality on health were not significant. Modification model fitted with the collected data very well. as evidenced by the small chi-square(0.58), the very high goodness-of-fit(GFI = 1.00), and adjusted goodness-of-fit (AGFI = 0.99), and very small root mean square residual(RMSR=0.0072), and the slope of Q-plot is over 1. 41% of the variance in self-esteem and 21% of the variance in health were accounted for by these variables. Conclusion: Further research concerned with the mediating effects of self-esteem in the role and health relationship should be covered the issue of various role combinations. And it is necessary to examine the influence of subfactor of quality of social roles on health.

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