• Proceedings of the Korean Society for Bioinformatics Conference
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• 2001.10a
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• pp.165-196
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• 2001

DNA chip 또는 microarray는 다수의 유전자 또는 유전자 조각을 (보통 수천내지 수만 개)칩상에 고정시켜 놓고 DNA hybridization 반응을 이용하여 유전자들의 발현 양상을 분석할 수 있는 기술이다. 이러한 high-throughput기술은 예전에는 생각하지 못했던 여러가지 분자생물학의 문제에 대한 해답을 제시해 줄 수 있을 뿐 만 아니라, 분자수준에서의 질병 진단, 신약 개발, 환경 오염 문제의 해결 등 그 응용 가능성이 무한하다. 이 기술의 실용적인 적용을 위해서는 DNA chip을 제작하기 위한 하드웨어/웻웨어 기술 외에도 이러한 데이터로부터 최대한 유용하고 새로운 지식을 창출하기 위한 bioinformatics 기술이 핵심이라고 할 수 있다. 유전자 발현 패턴을 데이터마이닝하는 문제는 크게 clustering, classification, dependency analysis로 구분할 수 있으며 이러한 기술은 통계학과인공지능 기계학습에 기반을 두고 있다. 주로 사용된 기법으로는 principal component analysis, hierarchical clustering, k-means, self-organizing maps, decision trees, multilayer perceptron neural networks, association rules 등이다. 본 세미나에서는 이러한 기본적인 기계학습 기술 외에 최근에 연구되고 있는 새로운 학습 기술로서 probabilistic graphical model (PGM)을 소개하고 이를 DNA chip 데이터 분석에 응용하는 연구를 살펴본다. PGM은 인공신경망, 그래프 이론, 확률 이론이 결합되어 형성된 기계학습 모델로서 인간 두뇌의 기억과 학습 기작에 기반을 두고 있으며 다른 기계학습 모델과의 큰 차이점 중의 하나는 generative model이라는 것이다. 즉 일단 모델이 만들어지면 이것으로부터 새로운 데이터를 생성할 수 있는 능력이 있어서, 만들어진 모델을 검증하고 이로부터 새로운 사실을 추론해 낼 수 있어 biological data mining 문제에서와 같이 새로운 지식을 발견하는 exploratory analysis에 적합하다. 또한probabilistic graphical model은 기존의 신경망 모델과는 달리 deterministic한의사결정이 아니라 확률에 기반한 soft inference를 하고 학습된 모델로부터 관련된 요인들간의 인과관계(causal relationship) 또는 상호의존관계(dependency)를 분석하기에 적합한 장점이 있다. 군체적인 PGM 모델의 예로서, Bayesian network, nonnegative matrix factorization (NMF), generative topographic mapping (GTM)의 구조와 학습 및 추론알고리즘을소개하고 이를 DNA칩 데이터 분석 평가 대회인 CAMDA-2000과 CAMDA-2001에서 사용된cancer diagnosis 문제와 gene-drug dependency analysis 문제에 적용한 결과를 살펴본다.

• IEIE Transactions on Smart Processing and Computing
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• v.5 no.4
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• pp.256-266
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• 2016

Concurrently detected and annotated abnormal events can have a significant impact on surveillance systems. By considering the specific domain of pedestrian trajectories, this paper presents two main contributions. First, as introduced in much of the work on trajectory-based anomaly detection in the literature, only information about pedestrian paths, such as direction and speed, is considered. Differing from previous work, this paper proposes a framework that deals with additional types of trajectory-based anomalies. These abnormal events take places when a person enters prohibited areas. Those restricted regions are constructed by an online learning algorithm that uses surrounding information, including detected pedestrians and background scenes. Second, a simple data-boosting technique is introduced to overcome a lack of training data; such a problem particularly challenges all previous work, owing to the significantly low frequency of abnormal events. This technique only requires normal trajectories and fundamental information about scenes to increase the amount of training data for both normal and abnormal trajectories. With the increased amount of training data, the conventional abnormal trajectory classifier is able to achieve better prediction accuracy without falling into the over-fitting problem caused by complex learning models. Finally, the proposed framework (which annotates tracks that enter prohibited areas) and a conventional abnormal trajectory detector (using the data-boosting technique) are integrated to form a united detector. Such a detector deals with different types of anomalous trajectories in a hierarchical order. The experimental results show that all proposed detectors can effectively detect anomalous trajectories in the test phase.

• Analytical Science and Technology
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• v.33 no.2
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• pp.98-107
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• 2020

Methamphetamine (MA) is currently the most abused illicit drug in Korea. MA is produced by chemical synthesis, and the final target drug that is produced contains small amounts of the precursor chemicals, intermediates, and by-products. To identify and quantify these trace compounds in MA seizures, a practical and feasible approach for conducting chromatographic fingerprinting with a suite of traditional chemometric methods and recently introduced machine learning approaches was examined. This was achieved using gas chromatography (GC) coupled with a flame ionization detector (FID) and mass spectrometry (MS). Following appropriate examination of all the peaks in 71 samples, 166 impurities were selected as the characteristic components. Unsupervised (principal component analysis (PCA), hierarchical cluster analysis (HCA), and K-means clustering) and supervised (partial least squares-discriminant analysis (PLS-DA), orthogonal partial least squares-discriminant analysis (OPLS-DA), support vector machines (SVM), and deep neural network (DNN) with Keras) chemometric techniques were employed for classifying the 71 MA seizures. The results of the PCA, HCA, K-means clustering, PLS-DA, OPLS-DA, SVM, and DNN methods for quality evaluation were in good agreement. However, the tested MA seizures possessed distinct features, such as chirality, cutting agents, and boiling points. The study indicated that the established qualitative and semi-quantitative methods will be practical and useful analytical tools for characterizing trace compounds in illicit MA seizures. Moreover, they will provide a statistical basis for identifying the synthesis route, sources of supply, trafficking routes, and connections between seizures, which will support drug law enforcement agencies in their effort to eliminate organized MA crime.

• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.5
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• pp.544-549
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• 2006

This research is to introduce about Judgment System for Intelligent Movement(JSIM) that can perform assistance work of human brain. JSIM can order autonomous command and also it can be directly controlled by user. This research assumes that control object is limited to Mobile Robot(MR) Mobile robot offers image and ultrasonic sensor information to user carrying JSIM and it performs guide to user. JSIM having PDA and Sensor-box controls velocity and direction of the mobile robot by soft-computing method that inputs user's command and information that is obtained to mobile robot. Also it controls mobile robot to achieve various movement. This paper introduces wearable JSIM that communicates with around devices and that can do intelligent judgment. To verify the possibility of the proposed system, in real environment, the simulation of control and application problem lot mobile robot will be introduced. Intelligent algorithm in the proposed system is generated by mixed hierarchical fuzzy and neural network.

• Korean Journal of Remote Sensing
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• v.34 no.6_2
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• pp.1239-1249
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• 2018

Optical remote sensing sensors provide visually more familiar images than radar images. However, it is difficult to discriminate sea ice types in optical images using spectral information based machine learning algorithms. This study addresses two topics. First, we propose a semantic segmentation which is a part of the state-of-the-art deep learning algorithms to identify ice types by learning hierarchical and spatial features of sea ice. Second, we propose a new approach by combining of semi-supervised and active learning to obtain accurate and meaningful labels from unlabeled or unseen images to improve the performance of supervised classification for multiple images. Therefore, we successfully added new labels from unlabeled data to automatically update the semantic segmentation model. This should be noted that an operational system to generate ice type products from optical remote sensing data may be possible in the near future.

• The KIPS Transactions:PartB
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• v.10B no.3
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• pp.281-286
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• 2003

A large number of features are collected for problem solving in real life, but to utilize ail the features collected would be difficult. It is not so easy to collect of correct data about all features. In case it takes advantage of all collected data to learn, complicated learning model is created and good performance result can't get. Also exist interrelationships or hierarchical relations among the features. We can reduce feature's number analyzing relation among the features using heuristic knowledge or statistical method. Heuristic technique refers to learning through repetitive trial and errors and experience. Experts can approach to relevant problem domain through opinion collection process by experience. These properties can be utilized to reduce the number of feature used in learning. Experts generate a new feature (highly abstract) using raw data. This paper describes machine learning model that reduce the number of features used in learning using heuristic function and use abstracted feature by neural network's input value. We have applied this model to the win/lose prediction in pro-baseball games. The result shows the model mixing two techniques not only reduces the complexity of the neural network model but also significantly improves the classification accuracy than when neural network and heuristic model are used separately.

• Journal of Intelligence and Information Systems
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• v.29 no.2
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• pp.323-338
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• 2023

TV advertising with deep analysis of watching pattern of audiences is important to set-top box audience targeting. Applying session-based recommendation model(SBR) to internet commercial, or recommendation based on searching history of user showed its effectiveness in previous studies, but applying SBR to the TV advertising was difficult in South Korea due to data unavailabilities. Also, traditional SBR has limitations for dealing with user preferences, especially in data with user identification information. To tackle with these problems, we first obtain set-top box data from three major broadcasting companies in South Korea(SKB, KT, LGU+) through collaboration with Korea Broadcast Advertising Corporation(KOBACO), and this data contains of watching sequence of 4,847 anonymized users for 6 month respectively. Second, we develop personalized session-based recommendation model to deal with hierarchical data of user-session-item. Experiments conducted on set-top box audience dataset and two other public dataset for validation. In result, our proposed model outperformed baseline model in some criteria.