• Advances in Traditional Medicine
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• v.6 no.4
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• pp.293-299
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• 2006

By using high-performance liquid chromatography-photodiode array detection, a simple and accurate chromatographic fingerprint method was developed for the identification of Radix Codonopsis (roots of Codonopsis) from different sources. Eighteen herbs of Codonopsis at different habitats in China, including roots from Codonopsis pilosula, Codonopsis pilosula var. modesta and Codonopsis tangshen were analyzed by the fingerprint. The amount of lobetyolin was calibrated, which was found to be more consistent in roots of Codonopsis pilosula as compared to that of Codonopsis pilosula var. modesta and Codonopsis tangshen. Having the fingerprint results, hierarchical clustering analyses were performed to classify the eighteen herbs into three groups: Codonopsis pilosula, Codonopsis pilosula var. modesta and Codonopsis tangshen. This clustering analysis agrees very well with the pharmacognostic identification result, and which could be used as a tool in the quality control of Radix Codonopsis.

• Journal of Korea Game Society
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• v.13 no.3
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• pp.55-68
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• 2013

This study examined the factors determining experience of flow in mobile social network games. Built upon the literature on flow experience in the Internet and online games, this study classified the determining factors into three categories. The first category is the content factor which includes graphic design, challenge, and incentive; the second is the device factor including ease of access and ease of control; the third is the social factor including social interaction and community activities. A correlation analysis was conducted to examine the association between each of the seven determining factors and flow experience. Additionally, a hierarchical regression analysis was performed to evaluate which of the selected factors would exert a relatively strong influence on experience of flow. Both analyses reached the same conclusions as follows: Graphic design, incentive, and community activities increase flow experience while challenge and ease of control exert little influence on flow experience. In addition, graphic design was the most influential element in determining flow experience, followed by community activities and incentive, respectively.

• Korean Journal of Adult Nursing
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• v.29 no.2
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• pp.109-118
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• 2017

Purpose: To identify the risk factors for suicidal ideation across the life cycle among Korean adults using data from 2015 Korean Psycho-social Anxiety Survey. Methods: The data were statistically analyzed using hierarchical logistic regression analysis. Results: The factors associated with suicidal ideation among the young adult group were education level (odds ratio [OR] 1.62, 95% confidence interval [CI] 1.05~2.49), self-esteem (OR 1.19, 95% CI 1.12~1.27), stress (OR 3.26, 95% CI 2.07~5.15), anger control problems (OR 3.58, 95% CI 2.34~5.50), and depression (OR 2.59, 95% CI 1.66~4.04) whereas among the middle-aged adults the factors were education level (OR 1.58, 95% CI 1.12~2.23), existence of a spouse (OR 2.55, 95% CI 1.72~3.78), self-esteem (OR 1.13, 95% CI 1.08~1.18), stress (OR 2.46, 95% CI 1.81~3.33), anger control problems (OR 1.70, 95% CI 1.22~2.36), and depression (OR 2.64, 95% CI 1.91~3.64). Among the older adult group the findings were the existence of a spouse (OR 2.16, 95% CI 1.37~3.39), self-esteem (OR 1.22, 95% CI 1.13~1.32), stress (OR 2.21, 95% CI 1.38~3.54), anxiety (OR 2.42, 95% CI 1.46~4.02), and depression (OR 2.48, 95% CI 1.30~4.72). Conclusion: The findings suggest that there may be a need for different suicide intervention programs to decrease suicidal ideation across the life cycle.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.3
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• pp.950-975
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• 2016

Device-to-Device (D2D) communication underlaying cellular networks is a promising add-on component for future radio communication systems. It provides more access opportunities for local device pairs and enhances system throughput (ST), especially when mobile relays (MR) are further enabled to facilitate D2D links when the channel condition of their desired links is unfavorable. However, mutual interference is inevitable due to spectral reuse, and moreover, selecting a suitable transmission mode to benefit the correlated resource allocation (RA) is another difficult problem. We aim to optimize ST of the hybrid system via joint consideration of mode selection (MS) and RA, which includes admission control (AC), power control (PC), channel assignment (CA) and relay selection (RS). However, the original problem is generally NP-hard; therefore, we decompose it into two parts where a hierarchical structure exists: (i) PC is mode-dependent, but its optimality can be perfectly addressed for any given mode with additional AC design to achieve individual quality-of-service requirements. (ii) Based on that optimality, the joint design of MS, CA and RS can be viewed from the graph perspective and transferred into the maximum weighted independent set problem, which is then approximated by our greedy algorithm in polynomial-time. Thanks to the numerical results, we elucidate the efficacy of our mechanism and observe a resulting gain in MR-aided D2D communication.

• Animal Systematics, Evolution and Diversity
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• v.28 no.4
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• pp.279-290
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• 2012

Plecoglossus altivelis (ayu) is an amphidromous fish widely distributed in Northeastern Asia from the East China Sea to the northern Japanese coastal waters, encompassing the Korean Peninsula within its range. The shore lines of northeastern region in Asia have severely fluctuated following glaciations in the Quaternary. In the present study, we investigate the population genetic structure and historical demographic change of P. altivelis at a population level in East Asia. Analysis of molecular variance (AMOVA) based on 244 mitochondrial control region DNA sequences clearly showed that as the sampling scope extended to a larger geographic area, genetic differentiation began to become significant, particularly among Northeastern populations. A series of hierarchical AMOVA could detect the genetic relationship of three closely located islands between Korea and Japan that might have been tightly connected by the regional Tsushima current. Neutrality and mismatch distribution analyses revealed a strong signature of a recent population expansion of P. altivelis in East Asia, estimated at 126 to 391 thousand years ago during the late Pleistocene. Therefore it suggests that the present population of P. altivelis traces back to its approximate demographic change long before the last glacial maximum. This contrasts our a priori expectation that the most recent glacial event might have the most crucial effect on the present day demography of marine organisms through bottleneck and subsequent increase of effective population size in this region.

• Genomics & Informatics
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• v.15 no.1
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• pp.28-37
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• 2017

Obesity is a highly prevalent, chronic disorder that has been increasing in incidence in young patients. Both epigenetic and genetic aberrations may play a role in the pathogenesis of obesity. Therefore, in-depth epigenomic and genomic analyses will advance our understanding of the detailed molecular mechanisms underlying obesity and aid in the selection of potential biomarkers for obesity in youth. Here, we performed microarray-based DNA methylation and gene expression profiling of peripheral white blood cells obtained from six young, obese individuals and six healthy controls. We observed that the hierarchical clustering of DNA methylation, but not gene expression, clearly segregates the obese individuals from the controls, suggesting that the metabolic disturbance that occurs as a result of obesity at a young age may affect the DNA methylation of peripheral blood cells without accompanying transcriptional changes. To examine the genome-wide differences in the DNA methylation profiles of young obese and control individuals, we identified differentially methylated CpG sites and investigated their genomic and epigenomic contexts. The aberrant DNA methylation patterns in obese individuals can be summarized as relative gains and losses of DNA methylation in gene promoters and gene bodies, respectively. We also observed that the CpG islands of obese individuals are more susceptible to DNA methylation compared to controls. Our pilot study suggests that the genome-wide aberrant DNA methylation patterns of obese individuals may advance not only our understanding of the epigenomic pathogenesis but also early screening of obesity in youth.

• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.245-253
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• 2011

Objectives In the current study, we quantitatively estimated changes in appetite and eating behavior of bipolar disorder patients during the pharmacotherapy. We also investigated their contribution to the weight gain and their association with specific food-craving characteristics of the patients. Methods Subjects included forty-one bipolar disorder patients and fifty-six controls. Currently sustained natures of food craving were assessed using the General-Food Craving Questionnaire-Trait (G-FCQ-T) and changes in appetite and eating behavior were measured using the Drug-Related Eating Behavior Questionnaire (DR-EBQ). Results Compared to the control group, the patients' group showed significantly higher body mass index (t=2.028, p=0.045). The patients' group had significantly higher 'Preoccupation with food' factor score of G-FCQ-T (p=0.016) than that of the control group. Hierarchical multiple regression analysis showed that only 'preoccupation with food' factor independently predicted psychotropic medication-induced appetite change. Conclusions Appetite change while receiving psychotropic medication seems to be related to the weight-gain and associated with craving natures of 'preoccupation with food' in bipolar disorder. Appetite and/or eating behavioral changes measured by G-FCQ-T and DR-EBQ could be regarded as an important mediating factor in future studies exploring biological mechanisms of weight gain related with pharmacotherapy for bipolar disorder.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.5B
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• pp.413-420
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• 2006

HMIPv6 is designed to reduce the signaling load to external network and improve handover speed of MN by including Mobility Anchor Point(MAP) in local handover. However in this case of macro handover, it's just used pervious MIPv6 handover algorithm. So, it occurs packet loss and transmission delay problem. In this paper, we propose the mechanism applying the HMIPv6 for Fast Handover to choose suitable to the condition buffering handover. The condition for the selection is result distance measurement between MN and CN, between MN and NAR. Furthermore, using F-SNOOP protocol, it is possible to improve wireless network performance. Wireless network has high Bit Error Rate(BER) characteristic because of path loss, fading, noise and interference. TCP regards such errors as congestion and starts congestion control. This congestion control makes packet transmission rate low. However, F-SNOOP improves TCP performance based on SNOOP and Freeze TCP that use Zero Window Advertisement(ZWA) message when handoff occurs in wireless network.

• Journal of Internet Computing and Services
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• v.2 no.4
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• pp.1-10
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• 2001

In this paper, we define requirements for call distribution of service control logic in Intelligent Network, Also, we propose call distribution mechanism for every subscriber with different call distribution rates, The call distribution mechanism had been developed as a function of Premium-rate Service in Intelligent Network. Our call distribution mechanism applies to percentage distribution instead of circular or hierarchical distribution. The call distribution mechanism consists of call input. output. call distribution processing logic part, random number generator, and customers database. We propose the practical implementation of a call distribution mechanism and call distribution decision indicating number computation method. We show three methods, the rand() function in C language, microsecond by system clock, and proposed algorithm, to get call distribution decision indicating number. In order to optimal call distribution mechanism, we estimated the results of three methods on occurrence values and the number of occurrences.

• Journal of Korean Academy of Nursing Administration
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• v.18 no.1
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• pp.76-86
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• 2012

Purpose: As Korea has been rapidly transformed to be a multicultural society, it becomes essential for nurses to develop cultural competency. The purpose of this descriptive study was to assess the cultural competency level of general hospital nurses and to examine its contributing factors adopting ecological model. Method: A convenience sample of 327 nurses from six general hospitals in Seoul metropolitan area was recruited between November 14 to 28, 2011. Cultural competency was measured using the Korean version of the Caffrey Cultural Competence in Healthcare Scale (CCCHS) and Cultural Competence Assessment(CCA). Hierarchical multiple regression analysis was performed to assess the influence of intrapersonal, cultural-experience, and organizational factors on cultural competency. Results: Mean cultural competency in this study was 2.57(${\pm}0.43$). Cultural competency was associated with job position (p=.044) at the intrapersonal level. At the cultural experience level, foreign language classes experience (p=.005), fluency in a foreign language (p=.000), experience of working with foreign health care professionals (p=.000) were associated cultural competency. At the organizational level, training program (p=.000), job description (p=.002), health education materials (p=.016), insufficient job control (p=.000), and interpersonal conflicts (p=.011) showed significant difference. Foreign language class experience, foreign language fluency, experience of working with foreign health care professionals, and job control were the most consistent predictors of cultural competence and explained 20.4% of the total variance in the proposed ecological model. Conclusions: The findings suggest that to enhance cultural competency in general hospital nurses, cultural experience and organizational factors need to be more fully considered than intrapersonal factors.