• Information Systems Review
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• v.5 no.2
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• pp.241-256
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• 2003

This empirical study is to explain critical success factors for building effective regional IT cluster from the literature reviews which have some limitations, and is to suggest new key factors from the views of Regional Innovation System and Sectoral Systems of Innovation. For building successful cluster, the new key factors not only stress on regional networks, the spill-over of tacit knowledge through learning by interacting, institutions which contain regional custom, norms, established practices, culture, and characteristics from the Regional Innovation System, but also emphasize on heterogeneous agents who are interacting by each others from Sectoral Systems of Innovation. From these factors we suggest some strategies for building effective "Daegu IT Cluster" as following; making characterized IT brands which are selected and concentrated based on regional and IT sectoral characteristics, strengthening learning competence of tacit knowledge built in multiple heterogeneous agents network, establishing strong agent networks which are composed of universities, companies, institutes and government, and sharing the institution of mind-opening culture in order to correspond with environmental changes and link to other industrial clusters. By putting above strategies in force, the compatabilities of Daegu region are reinforced. Tacit knowledges spill over and the regional innovation competence are accumulated. Also IT cluster plays core role of employment in Daegu for long term. Especially, "Daegu IT Cluster" changes city's image from medium and small manufacturing city to new industrial city based on high technologies.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.2
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• pp.123-130
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• 2015

This paper presents a new formulation for transient simulations of microwave propagation in heterogeneous unbounded domains. In particular, perfectly-matched-layers(PMLs) are introduced to allow for wave absorption at artificial boundaries used to truncate the infinite extent of the physical domains. The development of the electromagnetic PML targets the application to engineering mechanics problems such as structural health monitoring and inverse medium problems. To formulate the PML for plane electromagnetic waves, a complex coordinate transformation is introduced to Maxwell's equations in the frequency-domain. Then the PML-endowed partial differential equations(PDEs) for transient electromagnetic waves are recovered by the application of the inverse Fourier transform to the frequency-domain equations. A mixed finite element method is employed to solve the time-domain PDEs for electric and magnetic fields in the PML-truncated domain. Numerical results are presented for plane microwaves propagating through concrete structures, and the accuracy of solutions is investigated by a series of error analyses.

• Journal of the Korean Institute of Landscape Architecture
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• v.31 no.2
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• pp.12-27
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• 2003

The purpose of this study is to look for an environmental design method based on open narrative structure, and to promote various experiences and interpretations of space through user's engagements. That is to say, the designer does not lead specific events through separate Boning but using the continuous open composition users are provided with margins for their imaginations. Spatial formulation through open narrative structure gives us various thoughts and it plays an important role in making a sequential space. Like an abstract painting, it is a complex story making or arranging a montage of images containing stories that elicit the reader's engagement through diverse interpretations. Like this, open composition exists in an ambiguous state and it is possible to interpret unfinished‘evolving work’within it. Utilizing open narrative structure, this study attempts to apply the idea of sequencing and open composition in the case of designing Arirang Culture Park. Open composition should induce various engagements by users and could be a medium which organically connects nature, culture and people. The spatial strategies of‘ambiguity’ and‘transparency’are like a bundle of complex and heterogeneous factors. Finally, the study focuses on the ‘integration’of the main ideas that compose multilayered space. ‘Voidness’and‘thickening’are also used for spatial strategies in open narrative structure. As alternative plans for undecided programs of the space, the voidness can be a strategic design program with flexibility about changes of futures. Also, thickening can be a strategic design program for functional reinforcement of the space, for the dramatic effects and for the generation of incidental events. Although both voidness and thickening seem paradoxical, we can see they are similar in the way that both focus on various spatial uses and by how they do not function as one-to-one correspondence, but as multiple correspondences. Therefore, open narrative structure is possible to apply in designing space and it can be an alternative design strategy for inducing multiple interpretations of space.

• 한국신재생에너지학회:학술대회논문집
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• 2006.11a
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• pp.40-43
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• 2006

Public demand for the heat pump system as a next generation energy equipment is increasing for its eco-friendly and cost-effective advantage. Many researches have been concentrated on how to calculate and develop its own efficiency, while the possible effect of the heat pump operation on the whole subsurface temperature distribution is relatively less considered, During the current study, subsurface temperature disturbance caused by seasonal surface temperature cycle in Busan area and general W-tube heat pump operation is simulated in 3-dimensional heterogeneous medium. It shows that subsurface deeper than 10m from the surface remains nearly unchanged throughout the 4 seasons and groundwater convect ion in highly permeable layer near the surface acts like a main path of heat plume from heat pump system, This implies the significance of detail descript ion in shallow sedimentary layer or highly permeable layer which plays an important role on the regional flow advection and heat transfer. Also, the effect of groundwater convection increases when the arrangement of the 2 injection pipes and 2 extract ion well is maintained parallel to groundwater flow. Therefore, more careful and detail investigation is required before installation and operation of heat pump system that it may not cause any possible change of microbial ecosystem in the shallow subsurface environment or 'contamination of temperature' for groundwater use as well as the loss of efficiency of the equipment itself. This can also help to design the optimized grouting system for heat pump.

• The Journal of Engineering Geology
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• v.25 no.2
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• pp.273-280
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• 2015

Delays in horizontal well drilling when encountering heterogeneous sediments can have negative effects on the construction process at a riverbank filtration site. Grain size analysis, including calculation of the coefficient of uniformity and the coefficient of curvature, was conducted on soil samples collected at each drilling depth during the process of drilling horizontal wells. These results were then used to develop a linear equation for estimating drilling velocity using the coefficient of uniformity and the coefficient of curvature as inputs. Testing of the linear equation in other horizontal wells indicates that the equation is most appropriate for coarse-sand-sized and well-sorted sediment. Because this study was conducted in a region with small- to medium-sized streams, more data are needed from larger rivers to modify the general equation. Our results will provide better estimates of drilling velocity, in turn enabling more detailed design and more effective construction management at riverbank filtration sites.

• IMMUNE NETWORK
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• v.12 no.6
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• pp.247-252
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• 2012

Pancreatic cancer is the fourth commonest cause of cancer-related deaths in the world. However, no adequate therapy for pancreatic cancer has yet been found. In this study, the antitumor activity of cytokine-induced killer (CIK) cells against the human pancreatic cancer was evaluated in vitro and in vivo. Human peripheral blood mononuclear cells were cultured with IL-2-containing medium in anti-CD3 for 14 days. The resulting populations of CIK cells comprised 94% $CD3^+$, 4% $CD3^-CD56^+$, 41% $CD3^+CD56^+$, 11% $CD4^+$, and 73% $CD8^+$. This heterogeneous cell population was called cytokine-induced killer (CIK) cells. At an effector-target cell ratio of 100 : 1, CIK cells destroyed 51% of AsPC-1 human pancreatic cancer cells, as measured by the $^{51}Cr$-release assay. In addition, CIK cells at doses of 3 and 10 million cells per mouse inhibited 42% and 70% of AsPC-1 tumor growth in nude mouse xenograft assays, respectively. This study suggests that CIK cells may be used as an adoptive immunotherapy for pancreatic cancer patients.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37B no.10
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• pp.877-888
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• 2012

Network virtualization technology is a crucial research issue of Future Internet which pursues a service-oriented architecture so-called NaaS (Network as a Service) or SDN (Software Defined Network). Network virtualization is expected to play an important role in Future Internet researches as a network testbed technology which enables innovative protocols to be experimented independently on a common testbed environment. We propose a control framework in order to provide user defined topology and bandwidth services with network virtualization and to separate and manage multiple-user traffics in a small and medium scale - single domain research network. The proposed framework (VIMS; Virtual network Integrated control and Management System) supports testbed expansions without any changes of heterogeneous virtual network support equipments through accommodation of each equipment's control plane. The framework shows a feasibility through applied to KOREN and we describe the differences and further study directions for improvement the framework comparing with GENI control framework.

• Korean Chemical Engineering Research
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• v.46 no.4
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• pp.647-659
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• 2008

Colloids are a heterogeneous system in which particles of a few nanometers to hundreds micrometers in size are finely dispersed in liquid medium, but show homogeneous properties in macroscopic scale. They have attracted much attention not only as model systems of natural atomic and molecular self-assembled structures but also as novel structural materials of practical applications in a wide range of areas. In particular, recent advances in colloidal science have focused on nano-bio materials and devices which are essential for drug discovery and delivery, diagnostics and biomedical applications. In this review, first we introduce nano-bio colloidal systems and surface modification of colloidal particles which creates various functional groups. Then, various methods of fabrication of colloidal particles using holographic lithography, microfluidics and virus templates are discussed in detail. Finally, various applications of colloids in metal inks, three-dimensional photonic crystals and two-dimensional nanopatterns are also reviewed as representative potential applications.

• Journal of the Korea Concrete Institute
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• v.13 no.4
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• pp.305-313
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• 2001

Conductivity is an important thermal property which governs heat transfer in a solid medium. Generally, the determination of conductivity in concrete is very difficult, because concrete is a heterogeneous material composed of cement, water, aggregate, et cetera and time dependent material of which properties change with curing age. In this study, influencing factors on thermal conductivity of concrete are quantitatively investigated by QTM-D3, a conductivity tester developed in Japan. Then, a prediction equation of thermal conductivity of concrete is suggested from the regression analysis of test results. To consider the factors influencing thermal conductivity of concrete, mortar, and cement paste, seven testing variables (age, amount of cement, types of admixtures, amount of coarse aggregate, fine aggregate ratio, temperature, and humidity condition) of the specimens are used. According to the experimental results, the amount of coarse aggregate and humidity condition of specimen are the main factors affecting the conductivity of concrete. Meanwhile, the conductivity of mortar and cement paste is strongly affected by the amount of cement and types of admixtures. However, the curing age has minor effect on the conductivity variation. Finally, the prediction formula of concrete conductivity as a function of aggregate amount, fine aggregate ratio, specimen temperature, and humidity condition is developed.

• Development and Reproduction
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• v.24 no.3
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• pp.197-205
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• 2020

Diabetes mellitus is a common heterogeneous metabolic disorder, characterized by deposition of extracellular matrix, oxidative stress, and vascular dysfunction, thereby leading to gradual loss of function in multiple organs. However, little attention has been paid to gene expression changes in the lung under hyperglycemic conditions. In this study, we found that diabetes inuced histological changes in the lung of streptozotocin-induced diabetic mice. Global gene expression profiling revealed a set of genes that are up- and down-regulated in the lung of diabetic mice. Among these, expression of Amigo2, Adrb2, and Zbtb16 were confirmed at the transcript level to correlate significantly with hyperglycemia in the lung. We further evaluated the effect of human umbilical cord-derived perivascular stem cells (PVCs) on these gene expression in the lung of diabetic mice. Our results show that administration of PVC-conditioned medium significantly suppressed Amig2, Adrb2, and Zbtb16 upregulation in these mice, suggesting that these genes may be useful indicators of lung injury during hyperglycemia. Furthermore, PVCs offer a promising alternative cell therapy for treating diabetic complications via regulation of gene expression.