• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.8
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• pp.2607-2625
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• 2014

Previous studies on multiuser multiple-input multiple-output (MIMO) mostly assume a homogeneous signal-to-noise ratio (SNR), where each user has the same average SNR. However, real networks are more likely to feature heterogeneous SNRs (a random-valued average SNR). Motivated by this fact, we analyze a multiuser MIMO downlink with a zero-forcing (ZF) receiver in a heterogeneous SNR environment. A transmitter with Mantennas constructs M orthonormal beams and performs the SNR-based proportional fairness (S-PF) scheduling where data are transmitted to users each with the highest ratio of the SNR to the average SNR per beam. We develop a new analytical expression for the sum throughput of the multiuser MIMO system. Furthermore, simply modifying the expression provides the sum throughput for important special cases such as homogeneous SNR, max-rate scheduling, or high SNR. From the analysis, we obtain new insights (lemmas): i) S-PF scheduling maximizes the sum throughput in the homogeneous SNR and ii) under high SNR and a large number of users, S-PF scheduling yields the same multiuser diversity for both heterogeneous SNRs and homogeneous SNRs. Numerical simulation shows the interesting result that the sum throughput is not always proportional to M for a small number of users.

• The Korean Journal of Applied Statistics
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• v.18 no.2
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• pp.371-379
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• 2005

In this paper, we propose a pattern consistency index for detecting heterogeneous time series that deviate from the representative pattern of each cluster in clustering time course gene expression data using the Pearson correlation coefficient. We examine its usefulness by applying this index to serum time course gene expression data from microarrays.

• Genomics & Informatics
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• v.9 no.1
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• pp.19-27
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• 2011

Gene Expression Omnibus (GEO) has kept the largest amount of gene-expression microarray data that have grown exponentially. Microarray data in GEO have been generated in many different formats and often lack standardized annotation and documentation. It is hard to know if preprocessing has been applied to a dataset or not and in what way. Standard-based integration of heterogeneous data formats and metadata is necessary for comprehensive data query, analysis and mining. We attempted to integrate the heterogeneous microarray data in GEO based on Minimum Information About a Microarray Experiment (MIAME) standard. We unified the data fields of GEO Data table and mapped the attributes of GEO metadata into MIAME elements. We also discriminated non-preprocessed raw datasets from others and processed ones by using a two-step classification method. Most of the procedures were developed as semi-automated algorithms with some degree of text mining techniques. We localized 2,967 Platforms, 4,867 Series and 103,590 Samples with covering 279 organisms, integrated them into a standard-based relational schema and developed a comprehensive query interface to extract. Our tool, GEOQuest is available at http://www.snubi.org/software/GEOQuest/.

• Journal of the Korea Society of Computer and Information
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• v.15 no.10
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• pp.1-9
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• 2010

In this paper, we propose a methodology in which a power-delay product of a binary adder is optimized based on the heterogeneous adder architecture. We formulate the power-delay product of the heterogeneous adder by using integer linear programming(ILP). For the use of ILP optimization, we adopt a transformation technique in which the initial non-linear expression for the power-delay product is converted into linear expression. The experimental result shows the superiority of the suggested method compared to the cases in which only conventional adder is used.

• Genomics & Informatics
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• v.17 no.1
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• pp.2.1-2.12
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• 2019

Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease, featured by airflow obstruction. Recently, a comprehensive analysis of the transcriptome in lung tissue of COPD patients was performed, but the heterogeneity of the sample was not seriously considered in characterizing the mechanistic dysregulation of COPD. Here, we established a new transcriptome analysis pipeline using a deconvolution process to reduce the heterogeneity and clearly identified that these transcriptome data originated from the mild or moderate stage of COPD patients. Differentially expressed or co-expressed genes in the protein interaction subnetworks were linked with mitochondrial dysfunction and the immune response, as expected. Computational protein localization prediction revealed that 19 proteins showing changes in subcellular localization were mostly related to mitochondria, suggesting that mislocalization of mitochondria-targeting proteins plays an important role in COPD pathology. Our extensive evaluation of COPD transcriptome data could provide guidelines for analyzing heterogeneous gene expression profiles and classifying potential candidate genes that are responsible for the pathogenesis of COPD.

• Journal of fish pathology
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• v.16 no.3
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• pp.147-152
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• 2003

The CMV promoter driven luciferase reporter gene coding plasmid (pcDNA-luc) was constructed and used as a model for DNA immunization study. Expression of the recombinant luciferase protein was confirmed in vitro in RTG-2 cell line before using in vivo study in olive flounder. In dose response study, the maximum expression of the luciferase gene was found in the group injected with 10-15μg of plasmid DNA. The kinetic study showed that the luciferase gene expression was reached at the maximum level at one day after injection and slightly decreased after then but significantly high level of expression was sustained until the conducted experiment of 7 days. In the study of tissue distribution of gene expression, it was found that luciferase gene was expressed at the significant level in immune organs such as gill and spleen, located far from the injected site, suggesting the systemic distribution of the intramuscularly injected DNA in olive flounder.

• International journal of advanced smart convergence
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• v.7 no.1
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• pp.48-63
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• 2018

The combination of Simian Virus40 (SV40)'s large T antigen with its replication origin is commonly used in molecular studies to enhance the expression of heterogeneous genes through multiplying the plasmid copy number. There are no reports related to the impact of the SV40 T antigen on plant, multiple fissional, cell-type. This study explores the response of two multiple-fission microalgal cells, Scenedesmus quadricauda and Chlorella vulgaris, to the expression of the T-antigen, with aim of applying SV40 T-antigen to increase the expression efficiency of foreign genes in the two species. Different levels of low-expression have been constructed to control the expression of SV40 T antigen using three heterogenous promoters (NOS, CaMV35S, and CMV). Chlorella cultures showed slowdown in the growth rate for samples harboring the T antigen under the control of CaMV35S and CMV promoters, unlike Scenedesmus cultures which showed no significant difference between samples and could have silenced the expression.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.9
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• pp.3762-3781
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• 2020

Infrared pedestrian target recognition is a vital problem of significant interest in computer vision. In this work, a novel infrared pedestrian target recognition method that uses heterogeneous features with multi-kernel transfer learning is proposed. Firstly, to exploit the characteristics of infrared pedestrian targets fully, a novel multi-scale monogenic filtering-based completed local binary pattern descriptor, referred to as MSMF-CLBP, is designed to extract the texture information, and then an improved histogram of oriented gradient-fisher vector descriptor, referred to as HOG-FV, is proposed to extract the shape information. Second, to enrich the semantic content of feature expression, these two heterogeneous features are integrated to get more complete representation for infrared pedestrian targets. Third, to overcome the defects, such as poor generalization, scarcity of tagged infrared samples, distributional and semantic deviations between the training and testing samples, of the state-of-the-art classifiers, an effective multi-kernel transfer learning classifier called MK-TrAdaBoost is designed. Experimental results show that the proposed method outperforms many state-of-the-art recognition approaches for infrared pedestrian targets.

• Microbiology and Biotechnology Letters
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• v.22 no.2
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• pp.152-157
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• 1994

Inulinase of Kluyveromyces marxianus origin was produced by recombinant yeast Saccharomyces cerevisiae under the control of GAL1 promoter, to examine the expression and localization of inulinase in a repressed(galactose-free) or derepressed(galactose-containinga) medium. The inulinase gene(INU1A) was constitutively expressed at 6.7 units/ml in a repressed medium. When the cell started to utilize galactose in a derepressed medium, the INU1A gene began to be expressed, and the final expression level reached about 45 units/ml. According to be the nondenaturingPAGE analysis, inulinase produced by S. cerevisiae was found to be less glycosylated than the bakers yeast invertase. In addition, its glycosylation pattern was less heterogeneous than the K. marxianus inulinase. The supplementation of inulin or raffinose into the derepressed medium increased the cell growth rate, while the expression of INU1A was repressed. Regardless of the carbon sources examined, most of inulinase activity (more than 98%) was found in the extracellular medium, indicating excellent secretion efficiency.

• Journal of the Korean Society of Costume
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• v.66 no.3
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• pp.18-31
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• 2016

In response to increasing preference for tattoos during the 2000s, the demand for Japanesestyle tattoo fashion increased. Ukiyoe, the prototype of Japanese tattoo popular in the Edo period has been preserved traditional expression techniques to the present, It is characterized by the following: first, the tattoos share literary lyricism through plays borrowed from the classics. second, it displays harmony and equivocal expression of heterogeneous elements samurai and kabuki mono. third, humorous images are expressed in picture-in-picture form. And fourth, presence of fixed characters based on the publication culture. Tattoo fashion is characterized by the following: First, eclectic fashion based on pastiche; second, characters emphasizing fun and comicality; third, the adoption of tattoo models for establishing brand images; and fourth, Cultural association for the new composition of culture consumption. Pastiche, harmony of heterogeneous elements, fun and comicality, and fixed characters were found to be common between tattoo ukiyoe and tattoo fashion. That is, it attempted to meet the sensitive consumers' needs to keep up with the trends by adopting tattoo incorporated into the subculture of neo pop. This shows clearly the characteristics of fashion, which creates new trends through interacting with the contemporary culture.