• 한국조경학회지
• /
• 제26권3호
• /
• pp.288-296
• /
• 1998

Natural or human disturbances cause landscape changes, which may be measured by the degree of heterogeneity. In a 16km$\times$19km area, divided into 100m$\times$100m cells, of Seoul city and its suburb, land covers are classified into 6 groups in aerial photos and land use maps. The degree of heterogeneity is defined as the number of cells that surround a central cell but have different land cover from the central cell divided by 8. The value of the degree of heterogeneity is between 0 and 1. Major findings are 1) Both urban and natural areas have low degree of heterogeneity, about 0.15~0.17. 2) Suburban area under heavy pressure of development and urbanization has highest degree of heterogeneity, about 0.25. 3) The peak of the degree of heterogeneity moved about 4.5km outward in 22 years. 4) Outer suburban area has lower degree of heterogeneity as the area is a greenbelt or forest. 5) The results show the areas with higher degree of heterogeneity which may need landscape management plans, and natural areas with lower degree of heterogeneity which may need landscape conservation plans. A landscape change model may be built for a specific city when this technique is applied to multiple sectors of the city, and the model may predict future landscape changes of the city.

• 한국IT서비스학회지
• /
• 제7권4호
• /
• pp.87-99
• /
• 2008

As the technologies for telecommunication have been evolving, more enhanced information services and integrated information systems have been introduced, which can manage a variety of information from the heterogeneous systems. The major obstacle for the integrated information systems is the integrating heterogeneous databases in the systems and the heterogeneity problems can be classified into the structural and data heterogeneities. However, the previous researches have mainly highlighted into the solving structural heterogeneity problems. This paper identifies the data heterogeneity problems for multi-database schema integrations and proposes a new solving method. We analyze the semantics equivalence in data values based on the functional dependency, primary and candidate keys, and present a procedural solution of data heterogeneity in the perspective of the concept of attribute equivalence, integration key and conceptual integration table.

• Genomics & Informatics
• /
• 제20권4호
• /
• pp.49.1-49.7
• /
• 2022

Many packages for a meta-analysis of genome-wide association studies (GWAS) have been developed to discover genetic variants. Although variations across studies must be considered, there are not many currently-accessible packages that estimate between-study heterogeneity. Thus, we propose a python based application called Beta-Meta which can easily process a meta-analysis by automatically selecting between a fixed effects and a random effects model based on heterogeneity. Beta-Meta implements flexible input data manipulation to allow multiple meta-analyses of different genotype-phenotype associations in a single process. It provides a step-by-step meta-analysis of GWAS for each association in the following order: heterogeneity test, two different calculations of an effect size and a p-value based on heterogeneity, and the Benjamini-Hochberg p-value adjustment. These methods enable users to validate the results of individual studies with greater statistical power and better estimation precision. We elaborate on these and illustrate them with examples from several studies of infertility-related disorders.

• BMB Reports
• /
• 제54권10호
• /
• pp.505-515
• /
• 2021

Human pluripotent stem cells (hPSCs) include human embryonic stem cells (hESCs) derived from blastocysts and human induced pluripotent stem cells (hiPSCs) generated from somatic cell reprogramming. Due to their self-renewal ability and pluripotent differentiation potential, hPSCs serve as an excellent experimental platform for human development, disease modeling, drug screening, and cell therapy. Traditionally, hPSCs were considered to form a homogenous population. However, recent advances in single cell technologies revealed a high degree of variability between individual cells within a hPSC population. Different types of heterogeneity can arise by genetic and epigenetic abnormalities associated with long-term in vitro culture and somatic cell reprogramming. These variations initially appear in a rare population of cells. However, some cancer-related variations can confer growth advantages to the affected cells and alter cellular phenotypes, which raises significant concerns in hPSC applications. In contrast, other types of heterogeneity are related to intrinsic features of hPSCs such as asynchronous cell cycle and spatial asymmetry in cell adhesion. A growing body of evidence suggests that hPSCs exploit the intrinsic heterogeneity to produce multiple lineages during differentiation. This idea offers a new concept of pluripotency with single cell heterogeneity as an integral element. Collectively, single cell heterogeneity is Janus-faced in hPSC function and application. Harmful heterogeneity has to be minimized by improving culture conditions and screening methods. However, other heterogeneity that is integral for pluripotency can be utilized to control hPSC proliferation and differentiation.

• Journal of Periodontal and Implant Science
• /
• 제23권1호
• /
• pp.1-15
• /
• 1993

P. gingivalis has been implicated as a strong pathogen in periodontal disease and known to have three serotypes of P. gingivalis. The purpose of this study is to investigate on the relationship between virulence, metabolic acids and genetic heterogeneity of P. gingivalis. P. gingivalis W50 standard strain and five strains of P. gingivalis serotype b Korean isolates were used in this study. For in vitro virulence test, lyophilized whole cell P. gingivalis were suspended, and sonicated with ultrasonic dismembranometer. Sonicated samples were applied to cultured cells derived from periodontal ligament, and cell activity was assayed with growth and survival assay. The metabolic acids were also extracted, and determined by High Performance Liquid Chromatography. Pst I-digested bacterial genomic DNA was electrophoresed, and densitometric analysis was performed to study the genetic heterogeneity. All of the P. gingivalis serotype b produced butyric acid. In cell activity study, butyric acid inhibited the cell activity irrespective of its concentration. Densitometric analysis showed restriction fragment length polymorphism. These results suggested that there existed heterogeneity of the metabolic acids and the virulence of P. gingivalis and such heterogeneity might be related to genetic heterogeneity.

• 보건행정학회지
• /
• 제20권1호
• /
• pp.137-154
• /
• 2010

This study empirically analyzed the effects of the Top Management Team (TMT) on organizational performance. We verified whether the age heterogeneity, job heterogeneity (core career, core function and major), and process (communication and integration) of the TMT affect organizational performance (management performance and healthcare service quality evaluation level). We collected data about 473 members of the 2006 TMT in 81 medical institutions. We also utilized statistics of organizational performance from the Ministry for Health, Welfare and Family Affairs and the Korean Institute of Hospital Management. Results of the study showed that the age heterogeneity of TMT exerted a negative effect on the healthcare service quality evaluation level, while the process exerted a positive effect. However, the age heterogeneity, job heterogeneity, and process had no influence on management performance. We discussed the implications of such outcome of the investigation in comparison with the former studies on TMT and organizational performance, and presented its restrictions and future plans.

• 아태비즈니스연구
• /
• 제12권2호
• /
• pp.39-60
• /
• 2021

Purpose - The purpose of this paper is exploring whether the characteristics and heterogeneity of the TMT play a moderating role in CSR and corporate value or not. Design/methodology/approach - The literature research method includes collecting, organizing, and analyzing the literature on the characteristics and heterogeneity of the TMT, the effect of corporate social responsibility (CSR), and corporate value. We analyze the contributions and limitations in existing research, grasp the current research status, and develop the research content of this article. The empirical analysis method is based on the data of Chinese A-share listed companies from 2001 to 2017. This allows us to study the moderating effect of the characteristics and heterogeneity of the TMT on CSR and corporate value. Findings - The TMT age, education degree, overseas background, and compensation have a positive moderating effect on CSR and corporate market value. The comprehensive heterogeneity of the TMT also has a positive effect on CSR and financial performance. Research implications or Originality - The research on the relationship between CSR and corporate value is still inconclusive. Some results have found a positive relationship, while others show a negative relationship. Studies exist that report mixed findings as well. This study has attempted to clarify this problem by adding potentially missing variables related on the TMT characteristics and heterogeneity, investigating causality effects.

• 자원ㆍ환경경제연구
• /
• 제21권4호
• /
• pp.921-945
• /
• 2012

조건부 로짓(Conditional Logit: CL)모형은 모형추정 및 결과해석이 비교적 용이하다는 장점으로 널리 사용되는 반면에 응답자의 선호이질성(preference heterogeneity)을 충분히 반영하지 못한다는 한계를 가지고 있다. 본 연구에서는 최근 지배적인 방식으로 제시되고 있는 두개의 모형인 혼합로짓(Mixed Logit; ML)모형과 잠재계층모형(Latent Class Model; LCM)을 사용하여 우리나라 보령댐 주변 습지보호에 있어서 응답자간 선호이질성을 설명하고자 하였다. 6대광역시와 보령시 표본에 대하여 응답자별 이질성의 존재여부를 검토한 결과 두 지역간 뚜렷한 차이가 있음을 알 수 있었다. 즉 보령시의 경우에는 응답자간 선호이질성이 뚜렷하게 나타난데 반하여 6대광역시의 경우 응답자간 선호이질성이 거의 나타나지 않았다. 따라서 6대광역시의 경우에는 모수추정을 위해 CL 모형의 사용이 가능하나 보령시의 경우에는 선호이질성을 반영하기 위해 ML모형이나 LCM에 근거한 모수추정이 요구된다. 선호이질성의 원인을 규명하기 위하여 교차항이 있는 혼합로짓모형과 잠재계층모형을 고려할 수 있다. 교차항이 있는 혼합로짓모형의 경우 관찰되지 않은 개인단위의 이질성을 설명할 수 있는 장점이 있다. 그러나 두 모형을 비교한 결과 LCM이 교차항이 있는 ML모형이 제공하지 않는 추가적인 정보를 보여주는 것으로 나타나고 있다. 따라서 본 연구에서의 응답자간 선호이질성은 혼합로짓모형에 의한 개인적인 수준보다 잠재계층모형에 의한 계층단위에서 더 잘 설명될 수 있다고 할 수 있다.

• 한국통신학회논문지
• /
• 제36권11A호
• /
• pp.870-877
• /
• 2011

IEEE 802.11 장비가 널리 사용되고 있으며, 저비용 IEEE 802.11 장비들이 보급됨에 따라 단말들은 다중 IEEE 802.11 라디오를 장착할 수 있게 되었다. 최신 IEEE 802.11 장비들은 다수 채널 (multi-channel)과 전송률 (multi-rate)을 제공한다. 실제 다중 채널 네트워크에서는 같은 노드에 대해 채널들이 서로 다른 신호 특성을 가지는 채널 이질성 (channel heterogeneity)이 있으므로, 네트워크 용량을 향상시키기 위해 다수의 채널을 효율적으로 할당해야 한다. 또한, 다중 전송률 네트워크에서는 같은 채널 상의 낮은 전송률 링크가 높은 전송률 링크의 성능을 심각히 저하시키는 성능 이상 (performance anomaly) 현상이 발생한다. 따라서, 본 논문에서는 채널 이질성과 성능 이성을 반영하여 네트워크 성능을 향상시키는 HACA (Heterogeneity Aware Channel Assignment) 알고리즘을 제안한다. NS-2 시뮬레이션을 통해 HACA 알고리즘이 채널 이질성을 반영하지 못하는 기존 채널 할당 알고리즘에 비해 향상된 성능을 보임을 검증하였다.

• 대한교통학회지
• /
• 제20권3호
• /
• pp.83-92
• /
• 2002

화물수단선택모형 구축은 화물 및 물류관련 연구에 있어서 중요한 역할을 차지한다. 그러나 이러한 화물수단 선택 모형을 구축하기 위해 실제 관측되는 자료(Revealed Preference:RP)를 이용하는 데는 한계가 존재하며 따라서 선호의식 기법을 활용한 Stated Preference(SP) 자료가 화물수단 선택 모형을 구축하는데 중요한 자료로 사용된다 SP 자료는 이처럼 화물교통 자료의 현실적인 한계를 극복할 수 있지만 SP자료를 이용하여 구축되어지는 화물수단모형인 경우 조사기법의 한계로 RP자료에는 존재하지 않는 편의가 발생한다. 본 논문은 SP 자료를 이용하여 수단선택모형 구축시 발생하는 편의 제거에 대한 연구이다. 특히 본 논문에서는 시뮬레이션 방법을 이용하여 개인의 다양한 선택행태 다양성(heterogeneity)과 이러한 다양성이 SP 다음 질문에 전이되는 문제점을 극복하는 새로운 개념의 화물수단 선택 로짓모형을 제시한다. 또한 단순 로짓모형이 갖고 있는 IIA 특성을 극복하는 화물수단 선택모형도 제시한다. 본 연구를 통해 화물교통에 존재하는 화주의 다양한 선택행태 분석뿐만 아니라 SP 수단선택 모형이 갖는 편의 극복에 본 연구가 일조하기를 기대한다.