• Imaging Science in Dentistry
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• 제41권1호
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• pp.39-42
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• 2011

Facial asymmetry is not an uncommon occurrence in day to day dental practice. It can be caused by various etiologic factors ranging from facial trauma to serious hereditary conditions. Here, we report a rare case of non-syndromic facial asymmetry in a young female, who was born with this condition but was not aware of the progression of asymmetry. No relevant family history was recognized. She was also deficient in both deciduous and permanent teeth in the corresponding region of maxilla. Hence, the cause of this asymmetry was believed to be a segmental odontomaxillary hypoplasia of left maxilla accompanied by agenesis of left maxillary premolars and molars and disuse atrophy of corresponding facial musculature. This report briefly discussed the comparative features of segmental odontomaxillary hypoplasia, hemimaxillofacial dysplasia, and segmental odontomaxillary dysplasia and justified the differences between segmental odontomaxillary hypoplasia and the other two conditions.

• 대한소아치과학회지
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• 제23권3호
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• pp.575-581
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• 1996

Hemophilia is a hereditary condition in which one of the normal blood clotting factors is absent. This sex-linked, recessive disease, transmitted by the female and expressed in some of her male offspring, is characterized by significantly delayed coagulation times and by the tendency to hemorrhage. On the dental treatment especially, surgical procedure, appropriate methods of hemorrhage control are required. These methods are replacement therapy, antifibrinolytic agents, and local hemostatic methods. In this case, we successfully extract residual roots of hemophiliac patient without eccessive post operative bleeding using replacement therapy and surgical splint.

• 대한족부족관절학회지
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• 제1권2호
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• pp.126-131
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• 1997

Hallux valgus is a hereditary deformity whose natural history is influenced by intrinsic and extrinsic factors. The deformity is infrequently noticed in newborns and infants because of its trivial nature that does not draw attention. Because in childhood and adolescence this deformity usually does not lead to functional disability, it is seldom treated actively. Opinions differ concerning the causal relationship of these deformities and appropriate treatment. It is clear, however, that the deviated great toe continues to deform, and leads to a chain of anatomical and functional changes. Thus, the advantages of the immediate treatment is obvious, especially in infancy, when the foot is supple. We are reporting one case of congenital hallux valgus with brief review of literature.

• 대한안전경영과학회지
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• 제2권2호
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• pp.109-116
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• 2000

Compared to last decade, body size of children has been changed because of many factors such as caloric intake, hereditary evolution, individual exercise, and so on. Naturally, children will grow up and they will become teenagers, college students as time goes by. Also, all children will enter into appropriate educational institutes according to age. The objective of this study is to compare and analyze the data of body size of children for safe educational environment. The data are measured by some parts on body such as stature, height, weight, circumferences, length, width, and depth. The samples for this study are randomly chosen from kindergartens in. Seoul and Kangnung during three months (2000. 3 ∼ 2000. 5).

• 한방안이비인후피부과학회지
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• 제16권1호
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• pp.179-190
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• 2003

Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and the course marked by exacerbation and remission. It has the characteristic symptoms of dry, itchy, scaly skin with cracks by typical distribution of lesions. Even though the etiology of atopic dermatitis is not fully understood, it is considered an allergic reaction whose onset is frequently and strongly associated with both hereditary and environmental factors. In the present clinical study, we studied the efficacy of internal herb-medicine, external herb medicine - ex. dermal oints, aqueous solutions, etc -, and steam therapy. The patient's SCORAD index was lowered 55.8 than before of which the SCORAD index was 74.8. On the basis of this study, it should be considered that the treatment of atopic dermatitis should be focused on the external therapy as steam therapy, dermal oint, a aqueous solution etc.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.619-624
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• 2013

Background: Colorectal cancer (CRC) exists in a more common sporadic form and less common hereditary forms, associated with the Lynch syndrome, familial adenomatous polyposis (FAP) and other rare syndromes. Sporadic CRC is believed to arise as a result of close interaction between environmental factors, including dietary and lifestyle habits, and genetic predisposition factors. In contrast, hereditary forms such as those related to the Lynch syndrome result from inheritance of germline mutations of mismatch repair (MMR) genes. However, in certain cases, the influence of low penetrance alleles in familial colorectal cancer susceptibility is also undeniable. Aim: To investigate the genotype frequencies of MLH1 promoter polymorphism -93G>A and to determine whether it could play any role in modulating familial and sporadic CRC susceptibility risk. Methods: A case-control study comprising of 104 histopathologically confirmed CRC patients as cases (52 sporadic CRC and 52 Lynch syndrome patients) and 104 normal healthy individuals as controls was undertaken. DNA was extracted from peripheral blood and the polymorphism was genotyped employing PCR-RFLP methods. The genotypes were categorized into homozygous wild type, heterozygous and homozygous variants. The risk association between these polymorphisms and CRC susceptibility risk was calculated using binary logistic regression analysis and deriving odds ratios (ORs). Results: When risk association was investigated for all CRC patients as a single group, the heterozygous (G/A) genotype showed a significantly higher risk for CRC susceptibility with an OR of 2.273, (95%CI: 1.133-4.558 and p-value=0.021). When analyzed specifically for the 2 types of CRC, the heterozygous (G/A) genotype showed significantly higher risk for sporadic CRC susceptibility with and OR of 3.714, (95%CI: 1.416-9.740 and p-value=0.008). Despite high OR value was observed for Lynch syndrome (OR: 1.600, 95%CI: 0.715-3.581), the risk was not statistically significant (P=0.253). Conclusion: Our results suggest an influence of MLH1 promoter polymorphism -93G>A in modulating susceptibility risk in Malaysian CRC patients, especially those with sporadic disease.

• 한국학교보건학회지
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• 제8권1호
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• pp.155-166
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• 1995

The aim of this study was to determine the extent to which sociodemographic and health related life-style variables explain body weight distribution and to understand weight contol behavior. To study this study 298 students were selected, it was consisted of obesity group(101) and control group(197). The average age of subjects was 14.2 and the prevalence of obesity was 2-3 per class as 5.6% among 1,793. 71% among same subject was showed higher weight pattern than last one year, ovesity group which was obesity both in 93 and 94 was 34%. Correlation between body weight(under weight/obesity) and independent variables including sociodemographic factor and health- related life style tested through Multiple Classification Analysis was very significant, explained 36% of the total variance. Sociodemografic and hereditary factors such as education level, age of father and physical features of parents, life style factors as exercise preference and perceived health status showed highly contribution to body weight. Concretely, there were showed a higher obesity prevalence tendency when education level and age of father was high, physical features of parents was obesity. In otherwise, there were showed a higher underweight prevalence tendency when education level and age of father was low. Experience rates of weight control was 53% generally, 84% in obesity group, and 11% in underweight group. There were utilized weight control behaviors through diet method mainly in obesity group, diet and exercise methods in underweight group. There were showed that underweight group are prefer exercise to obesity group. Conclusionally, These findings suggest that education, age, physical features of parents, exercise preference and perceived health status is important factors related to body weight among middle school girls. Therefore, there will be considered as valuable factors when we practice health education and consultation related to body weight. Furthermore it is necessary to provide of various informations about weight control and to develop systematic weight control program.

• Kidney Research and Clinical Practice
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• 제37권4호
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• pp.347-355
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• 2018

Background: Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) is a common complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression of NS. However, the incidence and risk factors of childhood-onset NS in Korea are unclear. Therefore, we studied the incidence, causes, and risk factors of AKI in hospitalized Korean patients with childhood-onset NS. Methods: We conducted a retrospective review of patients with childhood-onset NS who were admitted to our center from January 2015 to July 2017. Patients with decreased renal function or hereditary/secondary NS, as well as those admitted for management of other conditions unrelated to NS, were excluded. Results: During the study period, 65 patients with idiopathic, childhood-onset NS were hospitalized 90 times for management of NS or its complications. Of these 90 cases, 29 met the Kidney Disease Improving Global Outcomes criteria for AKI (32.2%). They developed AKI in association with infection (n = 12), NS aggravation (n = 11), dehydration (n = 3), and intravenous methylprednisolone administration (n = 3). Age ${\geq}9$ years at admission and combined use of cyclosporine and renin-angiotensin system inhibitors were risk factors for AKI. Conclusion: AKI occurred in one-third of the total hospitalizations related to childhood-onset NS, owing to infection, aggravation of NS, dehydration, and possibly high-dose methylprednisolone treatment. Age at admission and use of nephrotoxic agents were associated with AKI. As the AKI incidence is high, AKI should be considered during management of high-risk patients.

• 한방안이비인후피부과학회지
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• 제18권2호
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• pp.109-117
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• 2005

Atopic Dermatitis is chronic eczematous dermatosis which is related strongly to a family history of atopic disease and hereditary disposition. Its threshold of itching is low so that severe itching occurs and causes secondary eczema. The purpose of this study was to estimate the efficiency of oriental medical treatment and management on atopic Dermatitis. We studied 2 patients who visited Wonkwang University Kwangju Oriental Hospital Dept. of Dermatol. with atopic dermatitis from April 2004 to February 2005. We treated him with herb-medication, acupuncture, negative therapy, full spectrum visible ray therapy(by carbon arc). We used the ADSI(Atopic Dermatitis Severity Index) to assess the severity of atopic dermatitis. The grade of the severity of atopic dermatitis was lower only by the traditional chinese medical treatments and management. Considering the above result, more study is needed the factors of increasing severity of atopic dermatitis, and the clinical interchange or atopic Dermatitis between oriental medicine and western medicine.

• Journal of Yeungnam Medical Science
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• 제31권1호
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• pp.52-55
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• 2014

Protein S deficiency is one of the several risk factors for thrombophilia and can cause blood clotting disorders such as deep vein thrombosis and pulmonary embolism. A 54-year-old man was admitted with the complaint of dyspnea and was diagnosed with pulmonary embolism. The patient had very low level of free protein S, total protein S antigen, and protein S activity (type I protein S deficiency). In history taking, we found that his mother, 78 year old, had a history of same disease 10 years ago, and confirmed the pronounced low level of protein S. The patient's son also had very low level of protein S, however there had not been any history of pulmonary embolism yet. This case study suggests that asymptomatic persons with a family history of protein S deficiency and pulmonary embolism should be checked regularly for early detection of the disease, as protein S deficiency can be suspected.