• Clinical and Experimental Pediatrics
• /
• v.49 no.2
• /
• pp.208-211
• /
• 2006

Dyke-Davidoff-Masson Syndrome (DDMS) is a rare condition characterized by asymmetry of cerebral hemispheric growth with atrophy on one side, ipsilateral compensatory osseous hypertrophy, and contralateral hemiparesis. We experienced a 17 month-old male who presented with left focal clonic or tonic-clonic seizures accompanied by left hemiparesis and developmental delay. Brain MRIs demonstrated progressive atrophy of the right cerebral hemisphere with dilatation of the lateral ventricle, expansion of the ipsilateral frontal sinus with calvarial thickening, and elevation of the petrous pyramid and orbital roof. Brain SPECT showed a decreased volume of the right hemisphere with reduced blood flow. We therefore report a case of DDMS with a review of the literature.

• Journal of the Korea Convergence Society
• /
• v.10 no.3
• /
• pp.275-290
• /
• 2019

The present study aimed to develop a sports psychological skill training program and to test its applicability to improve the performance of national wheelchair curling players. A total of 4 participants completed the study. Subjects have been to 12 sessions of 6 different psychological skills training programs (routine training, attentional focus training, writing practice training in diary, relation training, self-control training, and positive self-talk training). The effectiveness of psychological skills training has been evaluated with 6 questionnaires and EEG measurement. The result was that psychological skills training had improved coping with adversity, peaking under pressure, and concentration, self-management and reduced anxiety of Korean national wheelchair curling player. The result was that the EEG inter-hemispheric asymmetry index showed negative emotional states before psychological skill training but positive emotional states after. The result implies that psychological skill training plays an important mediating role in bringing about positive effects in the psychological elements and competitiveness in national wheelchair curling players.

• Journal of Biomedical Engineering Research
• /
• v.33 no.1
• /
• pp.15-24
• /
• 2012

Classification of human thought is an emerging research field that may allow us to understand human brain functions and further develop advanced brain-computer interface (BCI) systems. In the present study, we introduce a new approach to classify various mental states from noninvasive electrophysiological recordings of human brain activity. We utilized the full spatial and spectral information contained in the electroencephalography (EEG) signals recorded while a subject is performing a specific mental task. For this, the EEG data were converted into a 2D spatiospectral pattern map, of which each element was filled with 1, 0, and -1 reflecting the degrees of event-related synchronization (ERS) and event-related desynchronization (ERD). We evaluated the similarity between a current (input) 2D pattern map and the template pattern maps (database), by taking the inner-product of pattern matrices. Then, the current 2D pattern map was assigned to a class that demonstrated the highest similarity value. For the verification of our approach, eight participants took part in the present study; their EEG data were recorded while they performed four different cognitive imagery tasks. Consistent ERS/ERD patterns were observed more frequently between trials in the same class than those in different classes, indicating that these spatiospectral pattern maps could be used to classify different mental states. The classification accuracy was evaluated for each participant from both the proposed approach and a conventional mental state classification method based on the inter-hemispheric spectral power asymmetry, using the leave-one-out cross-validation (LOOCV). An average accuracy of 68.13% (${\pm}9.64%$) was attained for the proposed method; whereas an average accuracy of 57% (${\pm}5.68%$) was attained for the conventional method (significance was assessed by the one-tail paired $t$-test, $p$ < 0.01), showing that the proposed simple classification approach might be one of the promising methods in discriminating various mental states.

• Annals of Clinical Neurophysiology
• /
• v.1 no.1
• /
• pp.31-35
• /
• 1999

Dignosis of migraine is only based on the medical history, and objective methods to aid the clinical diagnosisare absent. Although transcranial Doppler ultrasonography (TCD) abnormalities in headache-free migraineurs have been reported previously, diagnostic criteria for migraine is still lacking and this may limit the practical application of TCD for migraine. We prospectively studied several abnormal TCD indices in interictal migraineurs and their sensitivity and specificity to define the optimal diagnostic criteria. Young (20 yrs$age=29.0{\pm}6.1yrs$) were compared to 69 controls (M:F=25:44, Mean $age=31.2{\pm}5.5yrs$). Elevated MFV (> 2SD)was observed in 63% of migraineurs while n 12% of control (p<0.01). High AI (>25%) or high HI (>3.0) was present in 17% of migraineurs, while 3% and none in controls (p<0.01). Sensitivity of elevated MFV, high AI, and high HI was 63%, 17%, 17% and specificity was 88%, 97%, 100%, respectively. If all these indices were combined, sensitivity and specificity reached 69% and 86%. These preliminary results suggest pathophysiological implication of vasospasm in interictal migraineurs, and TCD may be practically applicable for migraine. Optimal diagnostic criteria and therapeutic options for patients with abnormal TCD findings remain to bo determined.

• Journal of Korean Neurosurgical Society
• /
• v.45 no.6
• /
• pp.329-335
• /
• 2009

Objective : Determining language lateralization is important for the presurgical evaluation of patients with medically intractable epilepsy. The Wada test has been the gold standard for lateralization of language dominance before epilepsy surgery. However, it is an invasive test with risk, and have some limitations. Methods : We compared the volumetric analysis with Wada test, and studied the clinical potential of volumetric analysis to assess language laterality in large surgical candidates with temporal lobe epilepsy (TLE). To examine the efficacy of volumetric analysis to determine language lateralization during presurgical evaluation, we compared the volumetric analysis of the bilateral planum temporale with the results of Wada test in 59 patients with chronic intractable TLE (rTLE, n=32; lTLE, n=27) who underwent epilepsy surgery. We measured the gray matter volumes of planum temporale (PT) of each patients using the VoxelPlus2 program (Mevisys, Daejeon, Korea). Results : Overall congruence of the volumetric analysis with the Wada test was 97.75% in rTLE patients and 81.5% in lTLE patients. There were more significant leftward asymmetry of the PT in rTLE patients than lTLE patients. In lTLE patients, relatively high proportion (37%) of the patients showed bilateral or right hemispheric language dominance. Conclusion : These results provide evidence that the volumetric analysis of the PT could be used as an alternatives in language lateralization. Also, the results of the Wada test suggested that there was considerable plasticity of language representation in the brains of patients with intractable TLE and it was associated with an earlier age of brain injury.

• Annual Conference on Human and Language Technology
• /
• 1999.10e
• /
• pp.462-469
• /
• 1999

본 연구에서는 시각적으로 제시되는 단어 자극의 의미 관련성의 차이에 따라 좌우반구의 처리가 어떻게 이루어지는지 알아보고자 하였다. 이를 위해서 명칭성 실어증 환자와 정상인 대학생 피험자를 대상으로 점화 어휘판단 과제를 수행하였다. 이 연구의 기본 논리는 명칭성 실어증 환자의 왼쪽 뇌가 손상되어 있기 때문에 어떤 정보처리가 왼쪽 뇌에서 일어나는 것이라면 정상인과 명칭성 실어증환자간의 수행에서 어떤 차이가 나타날 것을 기대되는 반면, 만일에 우뇌에서 처리되는 것이라면 정상인의 과제 수행 형태와 명칭성 실어증 환자의 것이 일치하는 형태를 보일 것이라는 것이다. 실험 1에서는 수직적 범주관련성이 어느 반구에서 정보처리 되는지를 조사하였다. 그 결과 정상인은 좌반구에서 유의미한 점화효과가 있고 우반구에서는 점화효과가 없었던 반면에, 명칭성 실어증 환자는 정상인과 정반대의 점화 효과를 보이고 있다. 이러한 결과는 좌반구가 일차적으로 수직적 범주 관련성 정보처리와 관련이 있음을 시사해 준다. 또한 수평적 범주 관련성에 따른 실험 은 정상인과 환자 두 집단 모두 수평적 범주관련성이 우반구에서 처리되는 유사한 패턴을 보여주었다. 실험2에서는 연합적 범주관련성에 따른 두 집단간의 점화 효과를 비교하였다. 정상인 집단과 환자 모두 좌우반구에 점화효과를 보여주고 있지만, 정상인 집단의 경우에는 우반구에서, 환자는 좌반구에서 점화량이 더 컸다. 연합관련 정보처리는 좌우반구 모두에서 일어난다고 하는 기존의 견해와 관련하여 볼 때 연합관련 정보처리는 좌우반구에서 일어난다고 해석할 수 있을 것이다. 명칭 실어증 환자의 정보처리는 정상인과 다르게 이루어지므로 이러한 좌우반구에서의 차이가 난 것으로 볼 수 있다. 이상의 실험1과 2의 결과를 종합해 보면, 시각적으로 제시되는 단어의 범주적 관련성이 주는 어휘정보 처리는 반구에 따라 처리하는 기능이 다르다고 결론 내릴 수 있다. 즉, 좌반구는 수직적 범주 관련성을 담당하고 우반구는 수평적 관련성을 담당하며, 연합적 관련성은 좌우반구 모두에서 정보처리 된다는 것이다.

• Journal of Biomedical Engineering Research
• /
• v.26 no.1
• /
• pp.9-16
• /
• 2005

One of the most important roles of a brain atlas is providing a spatial reference system in which multiple images can be interpreted in a consistent way. The brain atlase based on Western populations such as the International Consortium for Brain Mapping's 452 T-1 Weighted Average Atlas was widely used; however, they may not be the optimal choice for use with brain images from other ethnic groups, because structural differences between occidental and oriental brains have been reported. Therefore, in this study, we created an average brain atlas from 100 healthy Koreans (100 cases (M/F=53/47), 39.0±17.0 years). The purpose of this study was to make a Korean average-brain atlas and to measure its differences from a widely accepted average brain atlas built on an occidental population. The average brain atlas for Koreans was developed using widely accepted tools and procedures. The comparison between the Korean and occidental averages was performed using tissue probability maps and a registration tool, and it was shown that the global pattern of differences between the two average brains found in this work agreed with previously reported differences: Korean brains are wider and shorter in size, and smaller in volume, yet no hemispheric volume asymmetry was found.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 2000.04a
• /
• pp.113-119
• /
• 2000

The Pansori is a Korean traditional vocal music that has a unique story and melody which converts deep emotion into art. It has both verbal and emotional components. which can be coordinated by large-scale neural network. The purpose of this study is to illustrate the cortical network activated by a Korean traditional opera, Pansori, with different emotional valence using functional MRI (fMRI).Nine right-handed volunteers participated. Their mean age was 25.3 and the mean modified Edinburgh score was +90.1. Activation tasks were designed for the subjects to passively listen to the two parts of Pansories with sad or hilarious emotional valence. White noise was introduced during the control periods. Imaging was conducted on a 1.5T Siemens Vision Vision scanner. Single-shot echoplanar fMRI scans (TR/TE 3840/40 ms, flip angle 90, FOV 220, 64 x 64 matrix, 6mm thickness) were acquired in 20 contiguous slices. Imaging data were motion-corrected, coregistered, normalized, and smoothed using SPM-96 software.Bilateral posterior temporal regions were activated in both of Pansori tasks, but different asymmetry between the tasks was found. The Pansori with sad emotion showed more activation in the light superior temporal regions as well as the right inferior frontal and the orbitofrontal areas than in the right superior temporal regions as well as the right inferior frontal and the orbitofrontal areas than in the left side. In the Pansori with hilarious emotion, there was a remarkable activation in the left hemisphere especially at the posterior temporal and the temporooccipital regions as well as in the left inferior and the prefrontal areas. After subtraction between two tasks, the sad Pansori showed more activation in the right temporoparietal and the orbitofrontal areas, in contrast, the one with hilarious emotion showed more activation in the left temporal and the prefrontal areas. These results suggested that different hemispheric asymmetry and cortical areas are subserved for the processing of different emotional valences carried by the Pansories.

• Investigative Magnetic Resonance Imaging
• /
• v.4 no.1
• /
• pp.52-57
• /
• 2000

Purpose : The purpose of this study was to investigate the pattern of cerebral response to motor tasks in patients with schizophrenia compared with normal subjects using functional MRI. Materials and methods ; Nine right handed-schizophrenic patients and six right-handed normal subjects were included. We used right hand movement as task. Series of 120 consecutive echo-planar images per section were acquired during three cycles of task and rest activations. Lateralization index of cortical response was measured and compared between patients and normal subjects. Results ; Right hand motor task was associated with greater activation in left sensorimotor cortex than the right in normal subjects. Schizophrenia patients showed relatively decreased activation in left cortex and increased activation in right cortex compared with normal subjects. In one patient, reversed lateralization was noted. Conclusion : Normal hemispheric asymmetry of cortical response to motor task was found in different pattern in schizophrenia. Our result is consistent with functional disturbance of motor circuitry in this disorder. Functional MRI will play an important role in diagnosis and research of this disorder.

• Investigative Magnetic Resonance Imaging
• /
• v.1 no.1
• /
• pp.103-107
• /
• 1997

Purpose: To investigate the localization and functional lateralization of the supplementary motor area (SMA) in motor activation tests in comparison to that of the primary motor area. Materials and Methods: Seven healthy volunteers obtained echoplanar imaging blood oxygen level dependent technique. This study was carried on 1.5T Siemens Magnetom Vision system with the standard head coil. Parameters of EPI were followed as; TR/TE : 1.0/66.0msec, flip angle: $90^{\circ}$, field of view: $22cm{\times}22cm,{\;}matrix:{\;}128{\times}128$, slice number/slice thickness/gap: 1O/4mm/0.8mm with fat suppression technique. Motor task as finger opposition in each hand consisted of 3 sets of alternative rest and activation periods. Postprocessing were done on Stimulate 5.0 by using cross-correlation statistics. To compare the functional lateralization of the SMA in the right and left hand tests, each examination was evaluated for the percent change of signal intensity and the number of activated voxels both in the SMA and in the pri¬mary motor area. Hemispheric asymmetry was defined as difference of summation of the activted voxels between each hemisphere. Results: Percent change of signal intensity in the SMA (2.49 -3.06%) is lower than that of primary motor area(4.4 -7.23%). Percent change of signal intensity including activated voxels were observed almost equally in the right and left SMA. As for summation of activated voxels, primary motor area had significant difference between each hemisphere but not did the SMA. Conclusion: Preferred contralateral dominant hemisphere and hemispheric asymmetry were detected in the primary motor area but not in the SMA.