• YAKHAK HOEJI
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• v.35 no.3
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• pp.236-239
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• 1991

Two triterpenoid saponins were isolated from the methanol extract of Caltha minor leave(Ranunculaceae). The structure of these saponin were elucidated as hederagenin-3-O-$\alpha$-rhamnopyranosyl(1$\rightarrow$2)-$\alpha$-L-arabinopyrano side and 3-O-$\alpha$-L-rhamnopyranosyl(1$\rightarrow$2)-$\alpha$-L-arabinopyranosyl hederagenin 28-O-$\alpha$-L-rhamnopyranosyl(1$\rightarrow$4)-$\beta$-D-glucopyranosyl(1$\rightarrow$6)-$\beta$-D-glucopyranosyl ester.

• Archives of Pharmacal Research
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• v.14 no.1
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• pp.7-11
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• 1991

Three triterpenoid saponins were isolated from the methanol extract of the stem bark of Kalopanax pictum Nakai var. magnificum (Araliaceae). The structures of these saponins were identified as hederagenin 3-O-${\alpha}$-L-arabinopyranoside, hederagenin-3-O-${\alpha}$-L-rhamnopyranosyl$(1{\rightarrow}2)$-${\alpha}$-L-arabinopyranoside and 3-O-${\alpha}$-L-rhamnopyranosyl(1{\rightarrow}2)-${\alpha}$-L-arabinopyranosyl hederagenin 28-O-${\alpha}$-L-rhamnopyranosyl$(1{\rightarrow}4)$-${\beta}$-D-glucopyranosyl$(1{\rightarrow}6)$-${\beta}$-D-glucopyranosyl ester.

• Archives of Pharmacal Research
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• v.12 no.1
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• pp.42-47
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• 1989

From the roots of Puisatiila koreana, three monodesmosides(pulsatilla saponins A, B and D) and two bisdesmosides(pulsatilla saponins F and H) were isolated. The structure of these saponins have been determined as hederagenin 3-O-${\beta}$-L-rhamnopyranosyl($1{\to}2$)- ${\alpha}$-L-arabinopyranoside(A), hederagenin 3-O-${\beta}$-D-glucopyrano syl($1{\to}4$) - ${\alpha}$-L-arabinopyranoside(B), hederagenin 3-O- ${\alpha}$-L-rhamnopyranosyl ($1{\to}2$)-[${\beta}$-D-glucopyranosyl($1{\to}4$]-${\alpha}$-L-arabinopyranoside(D), 3-O-${\alpha}$-L-rhamnopyranosyl($1{\to}2$)-{${\alpha}$-L-arabinopyranosyl hederagenin 28-O-${\alpha}$-L-rhamnopyrano syl($1{\to}4$)-${\beta}$-D-glucopyrano syl($1{\to}6$)-${\beta}$-D-glucopyranosyI ester (F) and 3-O-${\alpha}$-L-rhamnopyranosyl($1{\to}2$)-[${\beta}$-D-glucopyranosyl($1{\to}4$)]- ${\alpha}$-L-arabinopyranosyl hederagenin 28-O-${\alpha}$-L-lharnnopyranosyl($1{\to}4$)-${\beta}$-D-glucopyranosyl($1{\to}6$)-${\beta}$-D-glucop yranosyl ester(H) on the basis of chemical and spectral studies. Pulsatilla saponin B is the first report of its presence in plants but saponins A, D, F, and H have recently been isolated from the same genus p. cernua.

• Archives of Pharmacal Research
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• v.14 no.2
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• pp.124-129
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• 1991

One new triterpenoidal bisdesmoside, saponin C (3) were isolated from the leaves of Kalopanax pictum var. chinense along with two known saponins, saponin B (2, sapindoside C) and saponin A (1, sapoindoside B). On the basis of chemical and spectral evidences, the structure of a new triterpenoidal saponin has been elucidated to be 3-O-$\beta$-D-glucopyranosyl (1$\rightarrow$4)$\beta$-D-xylopyranosyl (1$\rightarrow$3)-$\alpha$-L-rhamnopyranosyl (1$\rightarrow$2)-$\alpha$-L-arabino-pyranosyl-23-hydroxyolean-12-en-28-O-$\alpha$-L-rhamnopyrano syl (1$\rightarrow$4)-$\beta$-D-glucopyranosyl (1$\rightarrow$6)-$\beta$-D-glucopyranosyl ester.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.240-240
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• 1994

1. 천연 항염증 물질의 분리 천연 항염증 약물 개발을 목표로 하여 한방과 민간에서 소염, 진통의 목적으로 이용되는 식물들을 대상으로 Carrageenin에 의해 유도된 백서 후족 부종의 억제를 지표로 Screening을 행한 결과, 2종의 식물의 부탄을 엑스가 항염증 활성을 나타내었다. 즉, 호랑가시나무(flex cornuta L. ) 잎 및 쑥부쟁이 (Aster yomena Makinc)의 부탄을 엑스가 Aspirin(300mg/kg)에 필적하는 항염증작용을 나타내었다. 이 식물들의 부탄을 엑스로 부터 각각 2종의 화합물을 분리하였다. 호랑가시나무로 부터는 01eanane type의 monodesmoside와 Pomolic acid bisdesmoside가, 쑥부쟁이로 부터는 Hederagenin bisdesmoside및 구조 미확정의 물질이 각각 분리되었다. 2.천연 항염증 물질의 구조 변환 항염증 약물로 많이 이용되고 있는 시호(Bupleurum falcatum L.)의 유효성분인 Saikosaponin-a의 용해도 개선을 위하여 그 유도체를 합성하였다. 합성된 Saikosaponin-a hemisuccinate의 K염은, 용해도 시험 결과 현저한 용해도 증가를 보였다.