• Journal of the Korean Data and Information Science Society
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• 제11권2호
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• pp.313-318
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• 2000

This article addresses aspects of combining information, with special attention to meta-analysis. In specific, we consider hierarchical Bayesian models for meta-analysis under priors which are scale mixtures of normal, and thus have tail heavier than that of the normal. Numerical methods of finding Bayes estimators under these heavy tailed prior are given, and are illustrated with an actual example.

• Communications for Statistical Applications and Methods
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• 제15권5호
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• pp.667-674
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• 2008

We develop new family of the t distributions for modeling semicircular data. It has convenient mathematical features. It is extended to the l-axial t distribution and a generalized semicircular t distribution.

• 생명과학회지
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• 제22권12호
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• pp.1608-1613
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• 2012

KIF5/Kinesin-I는 경쇄(light chain)를 통하여 결합함으로써 다양한 운반체들을 미세소관을 따라 운반한다. Kinesin light chains (KLCs)은 tetratricopeptide repeat (TPR) 영역을 매개로 운반체와 결합한다. 현재까지 KLCs와 결합하는 많은 운반체들이 확인되었으나 KLCs가 어떻게 특정운반체를 인식하여 결합하는지는 아직 확실히 밝혀지지 않았다. 본 연구에서 KLC1의 TPR 영역과 결합하는 단백질을 분리하기 위하여 효모 two-hybrid system을 이용하여 탐색한 결과 amyloid precursor protein (APP)과 결합하는 것으로 보고된 protein interacting with APP tail 1 (PAT1)을 분리하였다. KLC1은 PAT1의 C-말단 부위와 결합하며, PAT1은 KLC1의 TPR 영역을 포함한 부위와 결합함을 효모 two-hybrid assay로 확인하였다. 또한 PAT1는 KLC2와도 결합하였지만 kinesin heavy chains (KHCs)인 KIF5A, KIF5B, KIF5C와는 결합하지 않았다. 단백질간 결합은 glutathione S-transferase (GST) pull-down assay와 공동면역침강으로도 확인하였다. 생쥐의 뇌 파쇄액을 PAT1 항체와 APP 항체로 면역침강을 행한 결과 KLC와 KHCs가 같이 침강하였다. 이러한 결과들은 PAT1이 Kinesin-I와 APP 포함 소포간의 상호작용을 매개한다는 것을 시사한다.

• 한국터널지하공간학회 논문집
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• 제12권1호
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• pp.75-85
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• 2010

본 연구는 새로 개발된 쉴드 TBM 테일 보이드 동시주입용 무기계 가소성 그라우트의 현장적용 가능성을 평가하기 위하여 체적변화성 및 투수계수를 측정하였으며, 환경영향성 평가를 실시하였다. 또한, 무기계 가소성 그라우트의 현장 시험 시공에 앞서, 쉴드 TBM 모형주입장치 및 후방주입 공동충전 시험체를 이용하여 실내실험을 실시하였으며, 실제 서울 전력구 쉴드 TBM 시공현장에 시험시공을 수행하였다. 기중에서 14일 양생시킨 공시체를 이용해서 무기계 가소성 그라우트의 체적 변화성을 평가한 결과, 무기계 가소성 그라우트의 체적변화는 거의 발생하지 않았다. 그리고 투수계수를 측정하여 비교한 결과 무기계 가소성 그라우트의 우수한 차수효과를 확인 할 수 있었다. 어독성 시험과 용탈시험을 통한 환경영향성 평가를 수행한 결과, 무기계 가소성 그라우트의 경우 평균 pH가 8.0으로 측정되었으며, 96시간 경과 후 10%의 폐사율을 보였다. 용탈액에 대한 원자흡광분광 시험 결과 용탈에 의한 유해 중금속 성분은 수질관리 기준치 이하로 검출되었다. 가소성 그라우트의 현장 적용성 실험을 위하여 실내 모형실험을 수행한 결과 충전성은 확보되었으며, 실제 시공현장에 적용한 결과 우수한 주입성을 보였다.

• BMB Reports
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• 제40권1호
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• pp.44-52
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• 2007

Kinesins, as a kind of microtubule-based motor proteins, have a conserved microtubule-binding site in their motor domain. Here we report that two homologous kinesins in Arabidopsis thaliana, KatB and KatC, contain a second microtubule-binding site in their tail domains. The prokaryotic-expressed N-terminal tail domain of the KatC heavy chain can bind to microtubules in an ATP-insensitive manner. To identify the precise region responsible for the binding, a serious of truncated KatC cDNAs encoding KatC N-terminal regions in different lengths, KatC1-128, KatC1-86, KatC1-73 and KatC1-63, fused to Histidine-tags, were expressed in E. coli and affinity-purified. Microtubule cosedimentation assays show that the site at amino acid residues 74-86 in KatC is important for microtubule-binding. By similarity, we obtained three different lengths of KatB N-terminal regions, KatB1-384, KatB1-77, and KatB1-63, and analyzed their microtubule-binding ability. Cosedimentation assays indicate that the KatB tail domain can also bind to microtubules at the same site as and in a similar manner to KatC. Fluorescence microscopic observations show that the microtubule-binding site at the tail domain of KatB or KatC can induce microtubules bundling only when the stalk domain is present. Through pull-down assays, we show that KatB1-385 and KatC1-394 are able to interact specifically with themselves and with each other in vitro. These findings are significant for identifying a previously uncharacterized microtubule-binding site in the two kinesin proteins, KatB and KatC, and the functional relations between them.

• Communications for Statistical Applications and Methods
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• 제28권1호
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• pp.1-19
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• 2021

Heavy tailed distributions are useful for modeling actuarial and financial risk management problems. Actuaries often search for finding distributions that provide the best fit to heavy tailed data sets. In the present work, we introduce a new class of heavy tailed distributions of a special sub-model of the proposed family, called a new extended alpha power transformed Weibull distribution, useful for modeling heavy tailed data sets. Mathematical properties along with certain characterizations of the proposed distribution are presented. Maximum likelihood estimates of the model parameters are obtained. A simulation study is provided to evaluate the performance of the maximum likelihood estimators. Actuarial measures such as Value at Risk and Tail Value at Risk are also calculated. Further, a simulation study based on the actuarial measures is done. Finally, an application of the proposed model to a heavy tailed data set is presented. The proposed distribution is compared with some well-known (i) two-parameter models, (ii) three-parameter models and (iii) four-parameter models.

• Communications for Statistical Applications and Methods
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• 제15권5호
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• pp.775-781
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• 2008

It is developed that a family of the semicircular Laplace distributions for modeling semicircular data by simple projection method. Mathematically it is simple to simulate observations from a semicircular Laplace distribution. We extend it to the l-axial Laplace distribution by a simple transformation for modeling any arc of arbitrary length. Similarly we develop the l-axial log-Laplace distribution based on the log-Laplace distribution. A bivariate version of l-axial Laplace distribution is also developed.

• 한국공간정보시스템학회 논문지
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• 제11권2호
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• pp.13-18
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• 2009

This paper presents the implementation procedure of encoding and decoding algorithms for Tornado code that can provide fault tolerance for storage and transmission system. The degree distribution satisfying heavy tail distribution is produced. Based on this distribution, a good random irregular bipartite graph is attained after plenty of trails. Such graph construction is proved to be efficient, and the experiments also demonstrate that the implementation obtains good performance in terms of decoding overhead.

• Journal of the Korean Data and Information Science Society
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• 제17권4호
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• pp.1309-1317
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• 2006

The paper considers some Bayes estimators of the finite population mean with auxiliary information under priors which are scale mixtures of normal, and thus have tail heavier than that of the normal. The proposed estimators are quite robust in general. Numerical methods of finding Bayes estimators under these heavy tailed priors are given, and are illustrated with an actual example.

• Communications for Statistical Applications and Methods
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• 제23권4호
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• pp.321-334
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• 2016

In this paper, we propose power t distribution based on t distribution. We also study the properties of and inferences for power t model in order to solve the problem of real data showing both skewness and heavy tails. The comparison of skew t and power t distributions is based on density plots, skewness and kurtosis. Note that, at the given degree of freedom, the kurtosis's range of the power t model surpasses that of the skew t model at all times. We draw inferences for two parameters of the power t distribution and four parameters of the location-scale extension of power t distribution via maximum likelihood. The Fisher information matrix derived is nonsingular on the whole parametric space; in addition we obtain the profile log-likelihood functions on two parameters. The response plots for different sample sizes provide strong evidence for the estimators' existence and unicity. An application of the power t distribution suggests that the model can be very useful for real data.