• Genomics & Informatics
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• v.2 no.2
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• pp.67-74
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• 2004

Cells consistently face stressful conditions, which cause them to modulate a variety of intracellular processes and adapt to these environmental changes via regulation of gene expression. Hyperosmotic and oxidative stresses are significant stressors that induce cellular damage, and finally cell death. In this study, oligonucleotide microarrays were employed to investigate mRNA level changes in cells exposed to hyperosmotic or oxidative conditions. In addition, since heat shock protein 70 (HSP70) is one of the most inducible stress proteins and plays pivotal role to protect cells against stressful condition, we performed microarray analysis in HSP70-overexpressing cells to identify the genes expressed in a HSP70-dependent manner. Under hyperosmotic or oxidative stress conditions, a variety of genes showed altered expression. Down­regulation of protein phosphatase1 beta (PP1 beta) and sphingosine-1-phosphate phosphatase 1 (SPPase1) was detected in both stress conditions. Microarray analysis of HSP70-overexpressing cells demonstrated that diverse mRNA species depend on the level of cellular HSP70. Genes encoding Iysyl oxidase, thrombospondin 1, and procollagen displayed altered expression in all tested conditions. The results of this study will be useful to construct networks of stress response genes.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.22 no.5
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• pp.425-430
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• 2009

$ZrO_2$ film was deposited by facing target sputtering (FTS) system on polyethylene naphthalate (PEN) substrate as a gas barrier layer for flexible organic light emitting devices (FOLEDs), In order to control the heat of the FTS system caused by the ion bombardment in the cathode compared with the conventional sputtering system, the process characteristics of the FTS apparatus are investigated under various sputtering conditions such as the distance between two targets ($d_{TT}$), the distance between the target and the substrate ($d_{TS}$), and the deposition time. The $ZrO_2$ film by the FTS system can reduce the damage on the films because the ion bombardment with high-energy particles like gamma-electrons, Moreover, the $ZrO_2$ film with optimized condition ($d_{TT}$=140 mm) as a function of the distance from center to edge showed a very uniform thickness below 5 % for a deposition time of 3 hours, which can improve the interface property between the anode and the plastics substrate for flexible displays, It is concluded that the $ZrO_2$ film prepared by the FTS system can be applied as a gas barrier layer or an interlayer between the anode and the plastic substrate with good properties of an uniform thickness and a low deposition-temperature.

• Journal of Institute of Control, Robotics and Systems
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• v.15 no.9
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• pp.877-880
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• 2009

A curing process in post-printing section of R2R process is required for an electrical property of the printed pattern when devices such as RFID, Solar cell are printed. PEN as well as heat-stabilized PET which is used as a plastic substrate would be deformed at high temperature due to change of its elastic modulus. And crack in the printed pattern, which is on the plastic substrate is occurred due to the deformation of the substrate. The occurrence of crack causes electrical resistance to increase and the quality of the device to deteriorate. In case of RFID antenna, the range of reading distance is shortened as the electrical resistance of the antenna is increased. Therefore, the deformation of the plastic substrate, which causes the occurrence of crack, should be minimized by setting up low operating tension in R2R process. In low tension, slippage between a moving substrate and a roller would be generated when the operating speed is increased. And scratch would be occurred when slippage is generated due to an air entrainment, which is related to the thickness of the air film. The thickness of the air film is increased when operating speed is increased as shown by simulation based on mathematical model. The occurrence of scratch in conductive pattern printed by roll to roll process is a critical damage because it causes degradation or failure of electrical property of it.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.165-172
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• 2004

LE-7A is the main engine of the H-IIA launch vehicle. Under its development, the nozzle suffered from two troubles during startup and shutdown transients of the engine. One is a large side load, which damages the actuator of the nozzle, and the other is damage on regenerative cooling tubes due to high heat load. It has been considered that these problems are caused by a peculiar separation pattern called Restricted Shock Separation (RSS). RSS is observed in several rocket nozzles, for example, LE-7A nozzle, Vulcain nozzle and so on. Their contours are not conventional truncated perfect (TP) nozzle - LE-7A nozzle is a compressed truncated perfect (CTP) nozzle and Vulcain nozzle is a thrust optimized (TO) nozzle. Although it is believed that the occurrence of RSS is affected by the nozzle contour, the mechanisms are not clarified sufficiently yet. In the present paper, a parametric numerical study is carried out to investigate the mechanisms of the occurrence of RSS in CTP nozzles during startup transient. The results show that RSS is caused by the adverse pressure gradient downstream of the Mach disk. The adverse pressure gradient is caused by the interaction of the pressure wave and Mach disk. The method to avoid the occurrence of RSS is also examined. A small step inside the nozzle affects the position of the separation point and prevents RSS. The result shows that the possibility that RSS can be suppressed by controlling the position of the separation point.

• Journal of the Korea Safety Management & Science
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• v.20 no.3
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• pp.27-36
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• 2018

The steel pipe manufacturing industry deals with facilities and materials. Especially thermal facilities are close to vapor cloud explosion (VCE) and may cause secondary damage to facilities because they deal with corrosive substances such as hydrofluoric acid, sulfuric acid and acid, fire, explosion, leakage etc. It is in danger. In this study, hazard identification method was conducted using HAZOP techniques and quantitative risk analysis was conducted using e-CA, a program that supports accident impact analysis. Equipment in the influence range of ERPG - 3 was determined to be a facility requiring replacement. It was decided that neutralization is necessary using slaked lime. Based on the cost of loss, We presented the proper replacement which is the timing of the dangerous facility. As a result, It was ideal to replace the facilities with 20 years of heat treatment facilities, one year of hydrofluoric acid storage tank, 20 years of sulfuric acid storage tank, and 5 years of hydrochloric acid storage tank.

• Journal of Life Science
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• v.24 no.9
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• pp.1019-1024
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• 2014

Skeletal muscle atrophy can be defined as a decrease in or a disease of the muscle tissue, or as a disorder of the nerves that control the muscle, through injury or lack of use. This condition is associated with reactive oxygen species (ROS), resulting in various muscular disorders. Exposure to ROS induces muscle atrophy through several biological factors, such as SOD1 and HSP70. We found that cymbidium root extract reduced the $H_2O_2$-induced viability loss in C2C12 myoblasts and inhibited apoptosis. In addition, we showed that the cymbidium root extract increased the expression of HSP70 and decreased the expression of SOD1 in the $H_2O_2$-induced C2C12 myoblasts. These results suggest that cymbidium root extract might have therapeutic value in reducing ROS-induced muscle atrophy.

• Journal of the Korea Concrete Institute
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• v.13 no.4
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• pp.406-413
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• 2001

Up to this day, reinforced spun concrete pipes have been widely used as drain pipes. However, many reinforced spun concrete pipes are exposed to the deteriorated environment such as freezing-thawing damage and chemical attack by the growth of a sulfur-oxidizing bacterium isolated from corroded concrete. The purpose of this study is to evaluate the effects of lining by polymer-modified mortar using polymer dispersions as cement modifier on the development in durability of reinforced spun concrete pipe. The polymer-modified mortars were prepared with various polymer types and polymer-cement ratios, and tested for compressive and flexural strengths, acid, freezing-thawing, and heat resistances. And then, the reinforced spun concrete pipe product lined by polymer-modified mortars was tested for adhesion in tension and surface conditions according to curing temperatures in the field. From the test results, it is apparent that the polymer-modified mortars have good mechanical properties and durability as a lining material. In practice, all polymers can be used as lining the materials for reinforced spun concrete pipe, and types of polymer, and polymer-cement ratio and curing conditions are controlled for a good lining product.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.6
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• pp.812-817
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• 2012

In "The region of the body in which abdomen pain manifests(腹痛有部分)" of "Dongeuibogam(東醫寶鑑)", the abdomen is divided into the upper abdomen(大腹), umbilicus area(臍腹) and lower abdomen(小腹), which are in turn assigned to 3 Yins of greater yin(太陰), lesser yin(少陰) and reverting yin(厥陰) respectively to explain the causes and treatments of abdomen pain according to their locations. Meanwhile, the present Korean medicine tends to issue herbal formula without considering the cause of regional abdomen pain and the aspect of cold and heat(寒熱), deficiency and excess(虛實) in the symptom. This fragmentary treatment may bring out a serious failure. For the correction of this problem, the literature study on "The region of the body in which abdomen pain manifests(腹痛有部 分)" of "Dongeuibogam(東醫寶鑑)" was carried out to obtain the following conclusions. In "The region of the body in which abdomen pain manifest (腹痛有部分)" of "Dongeuibogam(東醫寶鑑)", it turned out that the use of herbal formula for the abdomen pain was the integrated one of herbal formulas for the abdomen pain in the external contraction such as cold damage yin condition(傷寒陰證) and cold in the middle condition(中寒證) and that the cause of abdomen pain was the explanation of diverse internal causes for the abdomen pain. And it was also found that the assignment of the upper abdomen(大腹), umbilicus area(臍腹) and lower abdomen(小腹) to 3 Yins had the locational and meridian meanings of 3 Yins according to internal causes and external contraction to get the basis of abdomen pain treatment in dividing it into 3 Yins.

• Journal of the Institute of Convergence Signal Processing
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• v.17 no.2
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• pp.71-76
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• 2016

Digital image processing is being utilized in various fields including medical industry, satellite photos, and factory automation image recognition. However, this kind of image data produces heat by an external cause in the course of being processed, transmitted, and stored. Most typical noises added in the images are AWGN and salt and pepper. MF, CWMF, and AWMF are methods used to restore images damaged by AWGN and the existing methods are likely to damage detailed information such as an edge. Therefore, this paper suggests an algorithm applying weight of average filter, average filter depending on pixel, and spatial weight filter based on edge size of local mask in an AWGN environment, in a different way. Also, this paper compares functions of existing methods by using PSNR to prove excellence of the suggested algorithm.

• Journal of the Korean Society of Hazard Mitigation
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• v.5 no.4 s.19
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• pp.79-84
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• 2005

When polymeric materials are exposed to fire condition, a lot of heat and toxic gases evolved and cause damage to property and human being. Especially toxic gases are major hazard to life safety. This study FTIR(Fourier Transform Infrared) spectrometer analysis was performaed to etermine the gas analysis and the concentration of gases evolved from PVC, FRP, SMC and Ureathane foam using ASTM E 1678 fire model. And FED toxicity index calculated from FTIR data also presented. By the comparison of animal test adopted in KS F 2271 and FTIR gas analysis method, FTIR gas analysis method can replace current animal toxicity test and produce precise and quantitative combustion gas data.