• BMB Reports
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• v.55 no.10
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• pp.512-517
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• 2022

Traumatic brain injury (TBI) is brain damage which is caused by the impact of external mechanical forces. TBI can lead to the temporary or permanent impairment of physical and cognitive abilities, resulting in abnormal behavior. We recently observed that a single session of early exercise in animals with TBI improved their behavioral performance in the absence of other cognitive abnormalities. In the present study, we investigated the therapeutic effects of continuous exercise during the early stages of TBI in rats. We found that continuous low-intensity exercise in early-stage improves the locomotion recovery in the TBI of animal models; however, it does not significantly enhance short-term memory capabilities. Moreover, continuous early exercise not only reduces the protein expression of cerebral damage-related markers, such as Glial Fibrillary Acid Protein (GFAP), Neuron-Specific Enolase (NSE), S100β, Protein Gene Products 9.5 (PGP9.5), and Heat Shock Protein 70 (HSP70), but it also decreases the expression of apoptosis-related protein BAX and cleaved caspase 3. Furthermore, exercise training in animals with TBI decreases the microglia activation and the expression of inflammatory cytokines in the serum, such as CCL20, IL-13, IL-1α, and IL-1β. These findings thus demonstrate that early exercise therapy for TBI may be an effective strategy in improving physiological function, and that serum protein levels are useful biomarkers for the predicition of the effectiveness of early exercise therapy.

• Journal of Wind Energy
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• v.14 no.4
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• pp.50-56
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• 2023

With the abnormal weather phenomena caused by global warming, the frequency and intensity of lightning strikes are increasing, and lightning accidents are becoming one of the biggest causes of failures and accidents in offshore wind turbines. In order to secure generator operation reliability, effective and practical measures are needed to reduce lightning damage. Because offshore wind turbines are tall structures installed at sea, the possibility of direct lightning strikes is very high compared to other structures, and the role of surge protection devices to minimize damage to the electrical and electronic circuits inside the wind turbine is very important. In this study, a varistor, which is a key element for a class 1 surge protection device for direct lightning protection, was developed. The current density was improved by changing the varistor composition, and the distance between the electrode located on the varistor surface and the edge of the varistor was optimized through a simulation program to improve the fabrication process. Considering the combined effects of heat distribution, electric field distribution, and current density on the optimized varistor surface, silver electrodes were formed with a gap of 0.5 mm. The varistor developed in this study was confirmed to have an energy tolerance of 10/350 ㎲, 50kA, which is a representative direct lightning current waveform, and good protection characteristics with a limiting voltage of 2 kV or less.

• Korean Journal of Poultry Science
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• v.43 no.3
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• pp.177-189
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• 2016

This study was conducted to verify the relationships between the expression values of stress-related markers and their production performances in 25 strains of Korean domestic chicken breeds. For stress response markers, the amount of telomeric DNA; expression levels of heat shock protein (HSP)-70, $HSP-90{\alpha}$, and $HSP-90{\beta}$; and comet scores were analyzed. Production performances were measured by the survival rate, body weights, days at first egg laying, egg weight and hen housed egg production. The results showed that the production traits and values of stress-related markers showed significant differences between strains. In general, the stress response of pure bred chickens with heavy weights was relatively high, while that of hybrid chickens with light weights was relatively low. The correlation coefficients between telomere contents and body weights showed that there were weak negative relationships. However, the correlations of telomere content with the survival rate and egg production were weakly positive after 20 weeks old. The expression levels of HSP genes and DNA damage rate (comet scores) were positively correlated to body weight, but were negatively correlated to the survival rate and egg production. The results implied that increasing body weight was associated with increasing HSPs expression and the DNA damage rate was associated with decreasing telomere content. In addition, increasing HSPs expression and the DNA damage rate decreased the survival rate and egg production, but the relationships with the telomere content was the reverse. Correlations among the stress-related markers showed that there were significant correlation coefficients between all of the marker values. HSPs expression was negatively correlated to the telomere content, while it was positively correlated to the DNA damage rate. There was a highly negative correlation between the telomere content and DNA damage rate. In conclusion, increasing the HSP values and DNA damage rate can promote telomere reduction, which led to a decrease in disease resistance and robustness of the chicken. Thus, increasing the stress response was verified to adversely affect the laying performance and viability of chickens.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.5
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• pp.657-662
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• 2008

To develop transgenic orchardgrass (Dactylis glomerata L.) resistant to high temperature, the recombinant DgHSP17.2 gene was introduced into orchardgrass plants using the Agrobacterium-mediated transformation method and expressed constitutively under the control of the CaMV 35S promoter. The results of genomic DNA PCR and Southern analysis showed a DNA band and hybridization signal on agarose gel and X-ray film in transgenic orchardgrass plants harboring the recombinant DgHSP17.2 gene, but a DNA band and hybridization signal were not observed in the wild type and empty vector control plants. The same result was also obtained in RT-PCR and Southern blot analysis, and these transgenic orchardgrass plants did not show any morphological aberration both in the culture bottle and soil mixture. When leaf discs cut from transgenic orchardgrass plants with recombinant DgHsp17.2 gene were exposed to lethal temperature (heat treatment at $60^{\circ}C$ for 50 min), 60-80% of the leaf discs showed only damage symptoms, but non-transgenic leaf discs showed a lethal condition. These results indicate that the DgHsp17.2 gene may act as a protector from heat stress in plants.

• KIEAE Journal
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• v.12 no.4
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• pp.13-19
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• 2012

The Earth's surface temperature still continues to rise, and extreme weather phenomena such as heat waves, drought, and precipitation have been repeated every year. It is reported that international communities attribute the main cause of the Earth's surface temperature rise to the excessive use of the fossil energy. Recently, the damage caused by climate change is getting worse, and the place where we live is suffering the most. Cities have been continuously growing not only meeting the basic functions of human habitation, work and leisure but also being places for various economic and social activities. But Cities, the victims of climate change, have grown only considering human needs and convenience rather than predicting their physical and ecological systems(Albedo effects, urban microclimate, resources and energy of the circulatory system, etc). In other words, the cities offer the cause of the problems of climate change, and even worsen the extreme weather phenomena without coping with them. Therefore, it is urgent priorities to protect the climate, to prevent the causes of the extreme weather phenomena and to enhance the adaptive capacity for the worse weather events. This study is to derive the concept for adapting to these climate changes which can make cities escape from exposure to these climate change impacts and make themselves safer places to live. And it analyzes some European cities and present developing models to implement planning methods. In this study, the concept of the climate adaptive cities will be suggested to prepare the adaptation measures for urban planners, and climate change adaptation models will be presented by analyzing some preliminary cases.

• Journal of the Korean Institute of Gas
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• v.20 no.5
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• pp.17-26
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• 2016

Chemical plants and oil gas refinery facilities are intrinsically vulnerable to industrial hazards, such as explosion or fire. Especially, the fire is extremely dangerous to facility structures and plant personnel because of direct flame, radiant heat and smoke. In addition, it has the ripple effect of destroying infra-structures and polluting the environment. In an effort to tackle these potential industrial risks, the procedure of FRA techniques in chemical plants were investigated. The main focus was put on the time variation of physical properties of the main building, i.e. control rooms, warehouses and electrical substations, from a direct flame contact and radiant heat. The deformation of a building due to fire was monitored and modeled with respect to time variable. A variety of case studies, domestic and abroad, was tested in the model to verify the FRA procedure. The developed model was proven to be highly effective to reduce the possible risks at chemical plants. An accurate accident frequency prediction and damage quantification was made by the developed model.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.6 no.1
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• pp.50-56
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• 2010

Fatigue has been known as a major degradation mechanism of ASME class 1 components in nuclear power plants. Fatigue damage could be accelerated by combined interaction of several loads and environmental factors. However, the environmental effect is not explicitly addressed in the ASME S-N curve which is based on air at room temperature. Therefore many studies have been performed to understand the environmental effects on fatigue behavior of materials used in nuclear power plants. As a part of efforts, we performed low cycle fatigue tests under various environmental conditions and analyzed the environmental effects on the fatigue life of SA508 Gr. 1a low alloy steel by comparing with higuchi's model. Test results show that the fatigue life depends on water temperature, dissolved oxygen and strain rate. But strain rate over 0.4%/s has little effect on the fatigue life. To find the cause of different fatigue life with ANL's and higuchi's model, another test performed with different heat numbered and heat treated materials of SA508 Gr. 1a. On a metallurgical point of view, the material with bainite microstructure shows much longer fatigue life than that with ferrite/pearlite microstructure. And the characteristics of crack propagation as different microstructure seem to be the main cause of different fatigue life.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.3
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• pp.111-119
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• 2014

Objectives This study aims to analyze a thermal distribution in biological living tissue during warm needling therapy by using a finite element method. The analysis provides an understanding of warm needling's efficacy and safety. Methods A model which consisted of four-layered tissue and stainless steel needle was adopted to analyze the thermal distribution in living tissue with a bioheat transfer analysis. The governing equation for the analysis was a Pennes' bioheat equation. A heat source characteristic of warm needling therapy was obtained by previous experimental measurements. The first analysis of the time-dependent temperature distribution was conducted through points on a boundary between the needle and the tissue. The second analysis was conducted to visualize the horizontal temperature distribution. Results When heat source's peak temperatures was above $500^{\circ}C$ and temperature rising rates were relatively slow, the peak temperature at skin surface exceeded a threshold of pain and tissue damage ($45^{\circ}C$), whereas when the peak temperature was around $400^{\circ}C$, the peak temperature at the skin surface was within a safe limit. In addition, the conduction of combustion energy from the moxa was limited to the skin layer around the needle. Conclusions The results suggest that the skin layer around the needle can be heated effectively by warm needling therapy, but it appears to have little effect at the deeper tissue. These findings enhance our understanding of the efficacy and the safety of the warm needling therapy.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.1
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• pp.13-19
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• 2017

The use of ultrasonic surgery units and scalers are steadily increasing in the field of dentistry. Such units and scalers should be evaluated before they are commercialized because the mechanical performance and stability of equipment is crucial for patients. Hence, we created a hand-piece moving system that can test bone cutting and teeth scaling. The purpose of this study was to evaluate the teeth scaling performance of ultrasonic scaler unit. Additionally, we measured the temperature distribution and noise during the test. through an experimental test, we found that a high output of an Ultrasonic NX device can cause serious damage to the teeth surface, and it was not within range in heat generation distribution and noise test.

• Journal of Energy Engineering
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• v.29 no.3
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• pp.7-17
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• 2020

Heat recovery steam generator(HRSG) generate steam using the high-temperature exhaust energy of gas turbines. Structures of HRSG are damaged by flow induced vibration of flue gas in some cases. In order to evaluate fatigue life to predict damage to a structure, a vibration analysis caused from flue gas should be used to derive the Power Spectral Density(PSD). However, it is very difficult to experimentally derive the vibrations generated by the exhaust gas form of gas turbines, which is very fast and complex. It was able to establish a way to identify vibration characteristics depending on the location of the structure by using high computing resources, large eddy simulation (LES). Random vibration analysis through these vibration characteristics(PSD) can evaluate the fatigue life of a structure.