• KSBB Journal
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• v.26 no.6
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• pp.491-504
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• 2011

This review article provides an overview of the evolution of diphtheria vaccine, its value and its future. Diphtheria is an infectious illness caused by diphtheria toxin produced by pathogenic strains of Corynebacterium diphtheriae. It is characterized by a sore throat with membrane formation due to local tissue necrosis, which can lead to fatal airway obstruction; neural and cardiac damage are other common complications. Diphtheria vaccine was first brought to market in the 1920s, following the discovery that diphtheria toxin can be detoxified using formalin. However, conventional formalin-inactivated toxoid vaccines have some fundamental limitations. Innovative technologies and approaches with the potential to overcome these limitations are discussed in this paper. These include genetic inactivation of diphtheria toxoid, innovative vaccine delivery systems, new adjuvants (both TLR-independent and TLR-dependent adjuvants), and heat- and freeze-stable agents, as well as novel platforms for producing improved conventional vaccine, DNA vaccine, transcutaneous (microneedle-mediated) vaccine, oral vaccine and edible vaccine expressed in transgenic plants. These innovations target improvements in vaccine quality (efficacy, safety, stability and consistency), ease of use and/or thermal stability. Their successful development and use should help to increase global diphtheria vaccine coverage.

• Journal of Information Display
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• v.7 no.2
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• pp.22-25
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• 2006

This paper presents heating process for obtaining standing carbon nanotube emitters to improve field-emission properties from the screen-printed multiwalled carbon nanotube (MWCNT) films. In an atmosphere with optimum combination of nitrogen and air for heat treatment of CNT films, the CNT emitters can be made to protrude from the surface. This allows for high emission current and the formation of very uniform emission sites without special surface treatment. The morphological change of the CNT film by this technique has eliminated additional processing steps, such as surface treatment which may result in secondary contamination and damage to the film. Despite its simplicity the process provides high reproducibility in emission current density which makes the films suitable for practical applications.

• BMB Reports
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• v.46 no.1
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• pp.31-36
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• 2013

Heat shock proteins play an important role in plant stress tolerance and are mainly regulated by heat shock transcription factors (Hsfs). In this study, we generated transgenic rice over-expressing OsHsfA7 and carried out morphological observation and stress tolerance assays. Transgenic plants exhibited less, shorter lateral roots and root hair. Under salt treatment, over-expressing OsHsfA7 rice showed alleviative appearance of damage symptoms and higher survival rate, leaf electrical conductivity and malondialdehyde content of transgenic plants were lower than those of wild type plants. Meanwhile, transgenic rice seedlings restored normal growth but wild type plants could not be rescued after drought and re-watering treatment. These findings indicate that over-expression of OsHsfA7 gene can increase tolerance to salt and drought stresses in rice seedlings.

• Journal of Aquaculture
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• v.20 no.4
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• pp.205-211
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• 2007

Stress-inducible proteins may function in part as molecular chaperones, protecting cells from damage due to various stresses and helping to maintain homeostasis. We examined the mRNA expression patterns of a 68-kDa heat shock protein (HSP68) and 78-kDa glucose-regulated protein (GRP78) in relation to physiological changes in Pacific oyster Crassostrea gigas under osmotic stress. Expression of HSP68 and GRP78 mRNA in the gill significantly increased until 48 h in a hypersaline environment (HRE) and 72 h in a hyposaline environment (HOE), and then decreased. Osmolality and the concentrations of $Na^+$, $Cl^-$, and $Ca^{2+}$ in the hemolymph of HRE oysters significantly increased until 72 h (the highest value) and then gradually decreased; in HOE oysters, these values significantly decreased until 72 h (the lowest value), and then increased. These results suggest that osmolality and $Na^+$, $Cl^-$, and $Ca^{2+}$ concentrations were stabilized by HSP68 and GRP78, and indicate that these two stress-induced proteins play an important role in regulating the metabolism and protecting the cells of the Pacific oysters exposed to salinity changes.

• Journal of Mechanical Science and Technology
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• v.14 no.7
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• pp.715-721
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• 2000

Residual stress is one of the causes which makes defects in engineering components and materials. These residual stresses can occur in many engineering structures and can sometimes lead to premature failures. There are commonly used methods by which residual stresses are currently measured. But these methods have a little damage and other problems; therefore, a new experimental technique has been devised to measure residual stress in materials with a combination of electronic laser interferometry, laser heating and finite element method. The electronic laser interferometer measures in-plane deformations while the laser heating and cooling provides for very localized stress relief. FEM is used for determining the heat temperature and other parameters. The residual stresses are determined by the amount of strain that is measured subsequent to the heat-up and cool-down of the region being interrogated. A simple model is presented to provide a description of the method. In this paper, the ambiguity problem for the fringe patterns has solved by a phase shifting method.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2004.10a
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• pp.40-48
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• 2004

The object of this study is to investigate the effect of joinability by using acoustic emission (AE) signals and doing a pattern recognition for weld heat affected zone (HAZ) in tensile testing. This study was carried out an SWS 490A high tension steel for electric shielded metal arc welding (SMAW), $CO_2$ gas arc welding and TIG welding. And correspondingly, the root openings are 3, 4 and 2.8mm. The results of the tensile test of weld HAZ come out electric shield arc welding > $CO_2$ gas arc welding > TIG welding in case of single welding. It is believed that this is a phenomenon where difference of its root opening or base metal thickness. Also, the technique of AE is ideally suited to study variables which control time and stress dependent fracture or damage process in metallic materials.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.373-378
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• 2003

It is important that overheat protection of super heated tube in boiler operation and maintenance. The overheat of super heat tube can make damage and rupture of tube material, which causes accidental shutdown of boiler. The super heated tube overheat is almost due to the lack of uniformity of gas temperature distribution. There are two ways to protect overheat of super heated tube. The one is to control hot gas operation pattern which is temperature or flow distribution. the other is to control super heated steam flow distribution. The former is difficult than the later, because of control device design. In this paper steam flow control method which uses orifices is proposed to protect overheat of super heat tube.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.4
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• pp.245-253
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• 2016

The friction and deformation of a tire causes heat generation, which causes a temperature rise of the tire. This temperature rise can be a source of tire damage. The object of this study is to investigate the cooling effect of the application of a fin to the tire side to suppress the temperature rise. Eight different fin shapes were considered, and the sidewall surface temperature reduction owing to the cooling fin shape was numerically analyzed. In addition, the flow characteristics and heat transfer characteristics of the vortex of the pin rear were compared.

• Journal of the Korean Society of Combustion
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• v.20 no.1
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• pp.32-42
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• 2015

The combustion instability was experimentally investigated in model gas turbine combustor with dual swirl burner. When such instability occurs, a strong coupling between pressure oscillation and unsteady heat release excites a self-sustained acoustic wave which results in a loud sound, and can even cause fatal damage to the combustor and entire system. In present study, to understand the combustion instability with a premixed mixture, the detailed periods of pressure and heat release data in unstable flame mode were investigated by various measurement methods at relatively rich condition and lean condition near flammable limits. Also, to prepare the utilization of synthetic natural gas (SNG) fuel in gas turbine system, an investigation was conducted using a simulated SNG including methane as a reference fuel to examine the effects of $H_2$ content on flame stability. These results provide that the instability due to flash-back behaviour like CIVB phenomenon occurred at rich condition, while the repetition of relighting and extinction caused the oscillation of lean condition near flammable limit. From the analysis of $H_2$ content effects, it is also confirmed that the instability frequency is proportional to the laminar burning velocity at both rich and lean condition.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.61-61
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• 2009

This paper has been performed in order to figure out the reason of failure in T23 weldments used for boiler tube at 550 $^{\circ}C$. Defects such as cracks and cavities occurred in CGHAZ (coarse grain heat-affected-zone) and multi pass of weld metal, and these crack propagated along grain boundary. Microstructure evolution such as grain growth and carbide precipitation was investigated by optical microscope (OM), transmission electron microscope(TEM). Moreover, Auger electron spectroscope (AES) was employed in order to examine segregation along the grain boundaries. There is significant difference in grain size and precipitation distribution in the region where cracking took place. In addition, sulfur segregation was observed. Based on the results of this investigation, it has been possible to establish that this type of cracks were consistent with reheat cracking and creep damage. Selection of optimal filler metal, heat input, and PWHT temperature is required for prevention in order to avoid this type of cracking.