• Journal of Microbiology and Biotechnology
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• v.27 no.4
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• pp.668-677
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• 2017

Embryo implantation is the crucial step for a successful pregnancy. Diverse factors, including adhesion molecules, growth factors, and cytokines are important for embryo implantation through improving endometrial receptivity. Benzoic acid (BA), a component of various plants, has been shown to have antifungal and antioxidant effects. However, the effect of BA on embryo implantation remains unknown. Here, we showed the contribution of BA for the enhancement of endometrial receptivity through the leukemia inhibitory factor (LIF)-dependent increase of integrin ${\alpha}V$, ${\beta}3$, and ${\beta}5$ expression. Furthermore, in vivo study using a mifepristone-induced implantation failure model showed that BA definitely improves the numbers of implantation embryos. Taken together, we suggest that BA has a novel function for embryo implantation through the up-regulation of LIF-mediated integrins, and may be a candidate for therapeutic medicine to increase the pregnancy rate.

• Korean Journal of Community Nutrition
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• v.11 no.6
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• pp.740-749
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• 2006

The objective of this study was to develop nutrition education materials for older adults, 'nutritional management for healthy aging'. A booklet and four leaflets were developed based on lesson plans. Topics of the lesson plans included eating habit assessment. Korean food guide pyramid, meal planning, eating sensibly and weight management. The titles of the leaflets were 'Eating right for healthy aging', 'Eat calcium-rich foods', 'Enjoy fruits & vegetables' and 'Weight management'. Illustrations and icons appropriate to the texts were designed using illustrator 9.0 and Photoshop 6.0. Booklet (letter size, 5 chapters, 44 pages) and leaflets (B4 size, 6 sections) focused on modifying undesirable eating habits, providing practical tips for desirable behaviors, and behavioral modification such as recording in a food diary, goal setting and increasing self-efficacy. The drafts were pilot-tested by interviews with older adults(n=10), and minor changes were made. The characteristics of revised materials are as follows; i) materials focused on providing desirable eating behaviors for healthy aging, ii) messages were simple and specific, iii) large fonts(13 pt) were used and materials included interesting pictures and illustrations, iv) materials provided tips for balanced diets and recipes fur older adults, v) materials included sections for participation of learners including assessment of nutritional risk factors and obesity, meal planning and games. The revised materials are self-explanatory and can be used by older adults and in nutrition education for older adults.

• Korean Journal of Radiology
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• v.22 no.7
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• pp.1194-1202
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• 2021

Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data. Materials and Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Multivariable regression with the Akaike information criterion, link test, and F test (Ramsey's regression equation specification error test) was performed for 7 models in every brain region to determine the best mathematical model for fitting the relationship between CBF and age. Results: Of all 87 brain regions, 68 brain regions were best fitted by cubic models, 9 brain regions were best fitted by quadratic models, and 10 brain regions were best fitted by linear models. In most brain regions (global gray matter and the other 65 brain regions), CBF decreased nonlinearly with aging, and the rate of CBF reduction decreased with aging, gradually approaching 0 after approximately 60. CBF in some regions of the frontal, parietal, and occipital lobes increased nonlinearly with aging before age 30, approximately, and decreased nonlinearly with aging for the rest of life. Conclusion: In adults, the age-related perfusion patterns in most brain regions were best fitted by the cubic models, and age-dependent CBF changes were nonlinear.

• Nutrition Research and Practice
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• v.8 no.5
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• pp.550-557
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• 2014

BACKGROUND/OBJECTIVES: Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo. SUBJECTS AND MATERIALS: Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (> 60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry. RESULTS: After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05). CONCLUSIONS: Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans.

• International Journal of Advanced Culture Technology
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• v.6 no.3
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• pp.59-68
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• 2018

This study was a cross-sectional descriptive study of the effects of emotional happiness on aging preparation for 45-60 year olds. Participants of this study were 312 volunteers and data was collected online, the collection period was from May 15, 2018 to May 31, 2018. The tools used in the research were the emotional happiness developed by Watson et al (1988) et al., the aging preparation developed by JH Lee (2009). Analysis was done using t-test, ANOVA, Pearson correlation, and regression by SPSS 18.0. As a result of the analysis, 84.0% of participants felt physically healthy and 89.8% felt mental health. The spouses of participants were physically 83.4% healthy and mentally 82.7% healthy. The correlation between emotional happiness, health cognition and aging preparation showed that physical health had a correlation with mental health (r = .482, p <0.01) and emotional happiness (r = .369, p <0.01), economic aging preparation (r = .411, p <0.01), social aging preparation (r = .119, p <0.01). Mental health was correlated with emotional happiness (r = .491, p <0.01), economic aging preparation (r = .411, p <0.01) and social aging preparation. Difference between emotional happiness and retirement preparation according to presence or absence of disease, emotional happiness (t = -4.503, p <0.01) and economic aging preparation (t = -4.960, p <0.01) were statistically significant. Emotional happiness affects the preparation of old age, emotional happiness affects to physical aging preparation under statistical significance (F=25.191, p<0.01), economic aging preparation (F=1131.783, p<0.01), and social aging preparation (F=147.672, p<0.01) which were sub components of aging preparation. Emotional happiness showed a 7.5% effect on the preparation of physical aging, 78.4% on economic aging preparation and 32.3% on social aging preparation. Based on the above results, it can be concluded that physical health and mental health are related to emotional happiness, economic aging preparation, and social aging preparation. And also these results can be inferred that the illness causes emotional less feeling of happiness and economic difficulty. Based on the results of this study, emotional well - being influences the retirement preparation significantly at statistical significance. Therefore, if the concept of emotional happiness is introduced to the old-age preparation program, it will be more client centered program.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.5
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• pp.530-536
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• 2014

Root barks of Paeonia suffruticosa Andrews (PS) was reported as contraindicated drugs of pregnancy by many Korean medical classics. Recently, a major ingredient component of PS, paeonol was reported that has contraceptive effect on early pregnancy in rats. However, the accurate molecular mechanism is not clear. In this study, we showed that PS decreased the expression of receptor for leukemia inhibitory factor (LIFR) in human endometrial Ishikawa cells at non-toxic dose, although the expression of leukemia inhibitory factor (LIF) was increased by PS. In addition, PS inhibited the adhesion of human trophoblastic JAR cells onto Ishikawa cells. Given importance of LIF-LIFR signaling pathway in the process of embryo implantation, the decreased LIFR expression by PS will be a good explanation on the PS- or its ingredient compounds-induced contraception.

• Journal of Digital Convergence
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• v.16 no.5
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• pp.361-372
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• 2018

The purpose of this study was to develop an assessment scale for healthy aging of middle aged women. The data were collected from 385 middle aged women in two large cities in Korea. The development processes of the scale were followed: Development of preliminary items; Verification of content validity and reliability; Factor analysis and criterion validity of final items. Results: Factor analysis resulted in the creation of the final scale, which consisted of 38 items that were grouped into 9 factors: self achievement, physical change adaptation, psychological change adaptation, interpersonal relationships, menopausal symptom adaptation, economic stability, physical health, social support, social change adaptation. The explanatory variance was 64.03%. The reliability of the scale was Cronbach's ${\alpha}=.90$. Correlation of the scale with healthy aging and depression, established its construct and concurrent validity was r=-.69, p<.001. The scale was confirmed to have a relatively high validity and reliability. The findings of the study can be useful as a measurement to evaluate healthy aging of middle aged women. Future researches with the scale will be helpful for basic data for the program development to support healthy aging of middle aged women.

• 한국노년학
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• v.29 no.1
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• pp.117-134
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• 2009

The purpose of this study was designed to develop an questionnaire for healthy aging. The subjects of this study were total 335 people who participated in regular exercise and went to welfare centers in Seoul. The validity and reliability were tested for verifying the developed questionnaire for healthy aging. The data were collected between June 12, 2006 and October 27, 2006. The mean, standard deviation, kurtosis, skewness, reliability, exploratory factor analysis and confirmatory factor were analyzed for statistical purpose using by SPSS-Win 12.0 program. The results were as follows; First, to obtain content validity, the results of previous research and the value system responses were submitted to a judgement group. Second, the results of the factor analysis of the 20 items making up the questionnaire were classified into the following 3 factors; physiological health(6 items), cognitive-mental health(6 items), social-support health(8 items). Third, the reliability of the questionnaire for healthy aging was 0.891(Cronbach's alpha). In the factor analysis Cronbach's alpha correlations for the 4 factors ranged from 0.642 to 0.885. Fourth, the results of confirmatory factor analysis, all the index values(NFI, RFI, CFI, Delta 2 IFI) were close to 1. Thus, this questionnaire demonstrated good reliability and validity and therefore it was an appropriate measurement of healthy aging.

• Journal of the Korea Society of Computer and Information
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• v.20 no.7
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• pp.115-120
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• 2015

The old people's feelings, emotions, and self-evaluative judgements fluctuate overtime. The purpose of this paper is to proof relations among well-being factors in social activity. Major results of this paper was as follows. First, the social activity participated elderly had higher health status, self-esteem, mental-health, and successful aging than the non-participated elderly. Second, self-esteem and mental health were exposed as important variable for all of the two groups to improve the successful aging. Thus, self-esteem and mental health can become significant indicator of self-empowering and psychological resilience. Third, the strongest total causal effect of successful aging was health status in social activity participated elderly, while self-esteem was the greatest total causal effect of it in the non-participated elderly. Health status had higher indirect effect of successful aging than direct effect of it in both of them.

• Proceedings of the Korean Nutrition Society Conference
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• 2002.11a
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• pp.128-128
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• 2002