• 제목/요약/키워드: health span

검색결과 297건 처리시간 0.026초

Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging

  • Park, Joo Hyun;Yoo, Yeongran;Park, Yoon Jung
    • Preventive Nutrition and Food Science
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    • 제22권2호
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    • pp.81-89
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    • 2017
  • Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.

Dynamic deflection monitoring of high-speed railway bridges with the optimal inclinometer sensor placement

  • Li, Shunlong;Wang, Xin;Liu, Hongzhan;Zhuo, Yi;Su, Wei;Di, Hao
    • Smart Structures and Systems
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    • 제26권5호
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    • pp.591-603
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    • 2020
  • Dynamic deflection monitoring is an essential and critical part of structural health monitoring for high-speed railway bridges. Two critical problems need to be addressed when using inclinometer sensors for such applications. These include constructing a general representation model of inclination-deflection and addressing the ill-posed inverse problem to obtain the accurate dynamic deflection. This paper provides a dynamic deflection monitoring method with the placement of optimal inclinometer sensors for high-speed railway bridges. The deflection shapes are reconstructed using the inclination-deflection transformation model based on the differential relationship between the inclination and displacement mode shape matrix. The proposed optimal sensor configuration can be used to select inclination-deflection transformation models that meet the required accuracy and stability from all possible sensor locations. In this study, the condition number and information entropy are employed to measure the ill-condition of the selected mode shape matrix and evaluate the prediction performance of different sensor configurations. The particle swarm optimization algorithm, genetic algorithm, and artificial fish swarm algorithm are used to optimize the sensor position placement. Numerical simulation and experimental validation results of a 5-span high-speed railway bridge show that the reconstructed deflection shapes agree well with those of the real bridge.

University Virtual Environment for Attention Enhancement

  • Kang, Dong-Ju;Kim, Sun-I.
    • 대한의용생체공학회:의공학회지
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    • 제23권2호
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    • pp.155-163
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    • 2002
  • Attention Deficit Hyperactivity Disorder(ADHD) is a childhood syndrome characterized by short attention span. impulsiveness, and hyperactivity, which often leadㄴ to learning disabilities and various behavioral problems. For the treatment of ADHD, medication and cognitive-behavior therapy is applied in recent yearn Although psycho-stimulant medication has been widely used for many rears. current findings suggest that, as the sole treatment for ADHD, it is an inadequate form of intervention in that parents don't want their child to use drug and the effects are limited to the period in which the drugs are physiologically active. On the other hand, EEG biofeedback treatment studies for ADHD have reported promising results not only in significant reductions in hyperactive, inattentive, and disruptive behaviors, but also improvements in academic performance and IQ scores. However it is too boring for children to finish the whole treatment. The recent increase in computer usage in medicine and rehabilitation has changed the way health care is delivered. Virtual Reality technology provides specific stimuli that can be used in removing distractions and providing environments that get the subjects'attention and increasing their ability to concentrate. VR technology can hold a patient's attention for a longer period of time than other methods can, because VR is immersive, interactive and imaginal. Based on these aspects, we developed Attention Enhancement System (AES) using VR technology, EEG biofeedback, and cognitive training method for enhancing attention and made a clinical trial to people who have attention difficulty and behavioral problems.

치과위생사의 감염관리 인식과 수행 (Infection control awareness and performance of dental Hygienist)

  • 이향님
    • 한국치위생학회지
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    • 제17권4호
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    • pp.621-630
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    • 2017
  • Objectives: The purpose of this study is to investigate awareness and performance of infection control by dental hygienist. Methods: A self-reported questionnaire was answered by 239 dental hygienists working in dental clinics from September 7 to 18, 2016 in Gwangju city & Jeonnam region after explaining the purpose of the study and receiving the informed consent. The questionnaire consisted of sociodemographic characteristics and awareness and performance of infection control using Likert 4 point scale. Results: Average of Infection control awareness was $3.33{\pm}0.38$, average of infection control Performance was $3.04{\pm}0.37$ (p<0.05). The awareness and practice of dental equipment management showed the largest difference. The awareness of infection control by general characteristics varied according to position, number of dental units, number of employees, Infection control needs, Received infection control training experience, infection experience, infection control guideline (p<0.05). The relationship between infection control awareness and Infection control performance was r = 0.624 (p<0.001), indicating positive correlation. Conclusions: To improve awareness and performance of dental hygienist's infection control, regular received infection control training experience is needed. It is considered that the dentist's active cooperation is needed in shortening the life span of the dental equipment due to the Infection control performance and securing the quantity.

도교(道敎) 내단사상(內丹思想)과 한의학에서 바라본 수승화강(水升火降)의 비교 연구 (Comparative Study on Body Water Rising and Heat Falling through Taoism Nae-dan thought and Traditional Korean Medicine)

  • 이기훈;신민규;김수중
    • 동의생리병리학회지
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    • 제25권3호
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    • pp.382-388
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    • 2011
  • Traditional Korean Medicine and Taoism think of the importance of a life nurturing for one's health and longevity. However, for a life nurturing, Traditional Korean Medicine aims at a person living up to one's natural life span. Taoism lays importance on ascending up to the sky to be a Taoist hermit with supernatural powers. Therefore, they both differ in the pursuit of their goals and their methods in doing respectively. In this study we have shown similarities and differences in the meaning and ways to practice su-seung-hwa-gang (body water rising and heat falling) which Traditional Korean Medicine and Taoism regard highly as a means of the practice of a life nurturing. Su-seung-hwa-gang is a concept that both Traditional Korean Medicine and Taoism set a high value on and at the same time it is a concrete method of a life nurturing demonstrating the possibility of 'non-disease treatment' through the active efforts of Traditional Korean Medicine.

Operation of battery-less and wireless sensor using magnetic resonance based wireless power transfer through concrete

  • Kim, Ji-Min;Han, Minseok;Lim, Hyung Jin;Yang, Suyoung;Sohn, Hoon
    • Smart Structures and Systems
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    • 제17권4호
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    • pp.631-646
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    • 2016
  • Although the deployment of wireless sensors for structural sensing and monitoring is becoming popular, supplying power to these sensors remains as a daunting task. To address this issue, there have been large volume of ongoing energy harvesting studies that aimed to find a way to scavenge energy from surrounding ambient energy sources such as vibration, light and heat. In this study, a magnetic resonance based wireless power transfer (MR-WPT) system is proposed so that sensors inside a concrete structure can be wirelessly powered by an external power source. MR-WPT system offers need-based active power transfer using an external power source, and allows wireless power transfer through 300-mm thick reinforced concrete with 21.34% and 17.29% transfer efficiency at distances of 450 mm and 500 mm, respectively. Because enough power to operate a typical wireless sensor can be instantaneously transferred using the proposed MR-WPT system, no additional energy storage devices such as rechargeable batteries or supercapacitors are required inside the wireless sensor, extending the expected life-span of the sensor.

중년층의 라이프스타일 유형 및 노인주거 특성에 관한 연구 (A Study on the Lilfestyle types of the Middle Ages and Senior Housing Characteristics)

  • 윤정숙;김한나;신수영;강지혜
    • 한국주거학회논문집
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    • 제18권4호
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    • pp.9-15
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    • 2007
  • Recently elderly has been recognized as a healthy and active generation because of extended average life span by medical development, interests in health, and achieved economic power while elderly was regarded as a passive and dependant generation before. The primary purpose of this study was to analyze the lifestyle types and housing consciousness of the middle ages around fifty's who will have more inclinations in the future to consider the hosing problems of elderly. To collect the data, LOV survey method was used for 600 middle ages about their lifestyles and future housing types. The data analysis used SPSS PC 12.0 to find the frequency, chi-square, factor analysis, and cluster analysis. The results of analysis are as follows: First, the lifestyle was segmented into five groups and there were differences on demographics such as education and income, also on housing sizes and types of home-ownership types. Second, there were different preferences on the types of senior housing by different lifestyles whereas there were similar on the location and sizes of houses by different clusters.

Ambient Vibration measurements and finite element modelling for the Hong Kong Ting Kau Bridge

  • Au, F.T.K.;Tham, L.G.;Lee, P.K.K.;Su, C.;Han, D.J.;Yan, Q.S.;Wong, K.Y.
    • Structural Engineering and Mechanics
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    • 제15권1호
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    • pp.115-134
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    • 2003
  • The Ting Kau Bridge in Hong Kong is a cable-stayed bridge comprising two main spans and two side spans. The bridge deck is supported by three towers, an end pier and an abutment. Each of the three towers consists of a single reinforced concrete mast which reduces its section in steps, and it is strengthened by transverse cables and struts in the transverse vertical plane. The bridge deck is supported by four inclined planes of cables emanating from anchorages at the tower tops. In view of the threat from typhoons, the dynamic behaviour of long-span cable-supported bridges in the region is always an important consideration in their design. This paper is devoted to the ambient vibration measurements of the bridge for evaluation of dynamic characteristics including the natural frequencies and mode shapes. It also describes the modelling of the bridge. A few finite element models are developed and calibrated to match with the field data and the results of subsequent structural health monitoring of the bridge.

Damage detection in truss bridges using vibration based multi-criteria approach

  • Shih, H.W.;Thambiratnam, D.P.;Chan, T.H.T.
    • Structural Engineering and Mechanics
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    • 제39권2호
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    • pp.187-206
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    • 2011
  • This paper uses dynamic computer simulation techniques to develop and apply a multi-criteria procedure using non-destructive vibration-based parameters for damage assessment in truss bridges. In addition to changes in natural frequencies, this procedure incorporates two parameters, namely the modal flexibility and the modal strain energy. Using the numerically simulated modal data obtained through finite element analysis of the healthy and damaged bridge models, algorithms based on modal flexibility and modal strain energy changes before and after damage are obtained and used as the indices for the assessment of structural health state. The application of the two proposed parameters to truss-type structures is limited in the literature. The proposed multi-criteria based damage assessment procedure is therefore developed and applied to truss bridges. The application of the approach is demonstrated through numerical simulation studies of a single-span simply supported truss bridge with eight damage scenarios corresponding to different types of deck and truss damage. Results show that the proposed multi-criteria method is effective in damage assessment in this type of bridge superstructure.

조직분권화, 의사결정참여, 직무만족이 간호 관리자의 조직몰입에 미치는 영향 (Influence of Decentralization, Participation in Decision Making, Job Satisfaction on Nurse Managers' Organizational Commitment)

  • 유미;김경숙
    • 간호행정학회지
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    • 제17권3호
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    • pp.357-367
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    • 2011
  • Purpose: The purpose of this study was to examine the influence of decentralization, participation in decision making, job satisfaction on organizational commitment among hospital nurse managers. Method: The data were derived from the self-reported questionnaire responses of 198 nurse managers from January to March, 2006 at four general hospitals over 900 beds in Seoul and Gyungi province and analyzed by frequency and percentage, t-test, ANOVA and Sheffe's test and stepwise multiple regression. Result: Mean of decentralization was 3.53${\pm}$0.52, participation in decision making was 5.04${\pm}$0.83, job satisfaction 3.54${\pm}$0.48, and organizational commitment was 5.30${\pm}$0.76. There were significant differences between participation in decision-making and career of manager, field of practice, span of control, especially in staffing decision. A significant correlation was found between organizational commitment and decentralization (r=.22, p<.001), participation in decision making (r=.40, p<.001), job satisfaction (r=.64, p<.001). The job satisfaction has the highest significant predictor of organizational commitment ($R^2$=43%). Conclusions: Nursing managers' job satisfaction and organizational commitment will be promoted by granting participation in decision-making.