• Title/Summary/Keyword: health hazard

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Development of a Simultaneous Analysis Method for Disapproved Coloring Agents in Foods Using HPLC (HPLC를 이용한 식품중 허용 외 색소의 동시분석에 관한 연구)

  • Kim, Cheon-Hoe;Lee, Min-Jae;Kim, Keoung-Ok;Lee, Hyoun-Young;Yang, Joo-Hong;Heo, Seok;Park, Jong-Seok;Jang, Yeong-Mi;Kim, Hee-Yun
    • Korean Journal of Food Science and Technology
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    • v.40 no.4
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    • pp.375-381
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    • 2008
  • This study developed the simultaneous analysis method for efficient safety controls of import food of Orange II, Rhodamine B, Para Red, and Sudan dye I-IV among disapproved coloring agents that use is prohibited in foods. The analysis method was developed according to the sample pre-treatment and HPLC conditions, and a documentary survey was used to establish the detection limit of the method, followed by effectiveness verification and recovery percentage examinations. Recovery percentage examination for 26 products resulted Orange II displayed recovery percentage of 96.46-121.26%, Rhodamine B displayed recovery percentage of 70.86-106.53%, Para Red displayed recovery percentage of 97.00-116.86%, Sudan I displayed recovery percentage of 92.93-112.44%, Sudan II displayed recovery percentage of 96.63-115.10%, Sudan III displayed recovery percentage of 92.21-114.73%, Sudan IV displayed recovery percentage of 93.22-122.91%. Correlation coefficient of gradient of this analysis method exhibited more than 0.999, RSD exhibited fewer than 2 as 0.8-1.39%, exactitude exhibited more than 90%. At this time, detection limit and fixed quantity limit decided by each 0.1 mg/L, 0.3 mg/L.

HACCP의 환경 최적화를 위한 식품 클린룸 설계에 관한 연구

  • Won, Yeong-Jae
    • Air Cleaning Technology
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    • v.23 no.3
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    • pp.1-9
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    • 2010
  • This study proposed the optimum design values for the biological clean room system observing the regulations of Hazard Analysis Critical Control Point (HACCP). Even though the standard for industrial clean room system has been well established, the basis for biological food clean room system is the first stage. In order to prevent the contaminations in advance for food storages, processes, and distributions, the criterion of Hazard Analysis Critical Control Point is positively required. This study also suggested the possible ways of how to avoid the hazardous contaminations.

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An Integral Model for Product Liability and Safety using Hazard Analysis.

  • Kal, Won-Mo;Hahm, Hyo-Joon
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.22 no.53
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    • pp.79-88
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    • 1999
  • This paper presents an integral model for product safety and product liability resulting from a defective product. The essence of the paper is the process of supply of manufacturing products which satisfy the product liability and the product safety in terms of consumers expectation levels. The main criteria of the product safety is the hazard level which involves in the severity and frequency. The proposed model shows the process to supply the manufactured products under the conditions that they are suitable in comparison of hazard level and safety level established by each company. If the product do not meet the safety level, this paper proposes that four different types of PL and PS countermeasures for the risk types are forward, respectively.

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Identification of hazardous chemicalsin semiconductor manufacturing (반도체 제조업에서 유해화학물질의 확인)

  • Kim, Soo-Geun
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.22 no.1
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    • pp.20-25
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    • 2012
  • Objectives: Hazard identification is the most important step in occupational health monitoring at the workplace. This paper reviewed the several related stuffs to the hazard identification in the semiconductor industry. Methods: I checked the MSDS system, chemical toxic informations, trade secrets and by-products by experience and the literature used in semiconductor industry. Results: I found and experienced as follows; (1) There are a few inventory and history of chemicals used in workplace. Toxic information of chemicals to be available is very limited. (2) There are many trade secrets in MSDS for chemical mixtures. It is difficult to identify the accurate information from MSDS. (3) By-products is necessary to identify that they will produce in workplace. Conclusions: It is necessary to regulate the obligations of employers which check the inventory and history of chemicals used in workplace. It is necessary to amend the trade secrets in MSDS system.

Investigation and Risk Assessment of Heavy Metals Contamination around an Abandoned Metal Mine in Korea

  • Lee, Jong-Wha;Kwak, Soon-Sun;Hong, Sung-Chul;Park, Sang-Il;Jang, Bong-Ki
    • Journal of Environmental Health Sciences
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    • v.36 no.6
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    • pp.456-464
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    • 2010
  • Recently, heavy metals contamination of the agricultural soil and crops surrounding mining areas has been identified as one of the most serious environmental problems in South Korea. The Ministry of the Environment in Korea conducted a Preliminary National Environmental Health Survey (PNEHS) in abandoned metal mines in 2007. The priority for a subsequent detailed examination was ranked from the results of PNEHS. The studied mine which was ranked as being of the highest priority is located in the midwestern part of Korea and was operated from 1911 to 1985. In this study, the contamination levels of the heavy metals in the abandoned metal mine were investigated. From the results, the average daily dose (ADD), target hazard quotient (THQ) and target cancer risk of the heavy metals were evaluated. The concentration of arsenic (As) in all of the tailings from the mine was higher than its countermeasure standard of Korea. In particular, the highest concentration of As, 330 mg/kg, was up to 15 times higher than its countermeasure standard. The average concentration of As in agricultural soils was higher than the warning standard of Korea, and higher than its countermeasure standard at six sites. The average concentrations of the analyzed heavy metals in agricultural soil were below the warning standard, but concentrations of cadmium (Cd) and lead (Pb) at 4 sites were higher than its warning standard. The average concentration of As in surface water exceeded the warning standard of Korea. The value of the THQ of As for the tailings was higher than the health protection standard 1. The value of THQ of As for the farmlands was lower than the standard, while the hazard index (HI) of As was higher than the standard. The value of target cancer risk (TCR) of As, $6.44{\times}10^{-4}$, were higher than the health protection standard of a lifetime risk for TCR at $1{\times}10^{-6}$. This suggests that the residents around the metal mines are exposed to As pollution with a carcinogenic risk.

Black Hispanic and Black Non-Hispanic Breast Cancer Survival Data Analysis with Half-normal Model Application

  • Khan, Hafiz Mohammad Rafiqullah;Saxena, Anshul;Vera, Veronica;Abdool-Ghany, Faheema;Gabbidon, Kemesha;Perea, Nancy;Stewart, Tiffanie Shauna-Jeanne;Ramamoorthy, Venkataraghavan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9453-9458
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    • 2014
  • Background: Breast cancer is the second leading cause of cancer death for women in the United States. Differences in survival of breast cancer have been noted among racial and ethnic groups, but the reasons for these disparities remain unclear. This study presents the characteristics and the survival curve of two racial and ethnic groups and evaluates the effects of race on survival times by measuring the lifetime data-based half-normal model. Materials and Methods: The distributions among racial and ethnic groups are compared using female breast cancer patients from nine states in the country all taken from the National Cancer Institute's Surveillance, Epidemiology, and End Results cancer registry. The main end points observed are: age at diagnosis, survival time in months, and marital status. The right skewed half-normal statistical probability model is used to show the differences in the survival times between black Hispanic (BH) and black non-Hispanic (BNH) female breast cancer patients. The Kaplan-Meier and Cox proportional hazard ratio are used to estimate and compare the relative risk of death in two minority groups, BH and BNH. Results: A probability random sample method was used to select representative samples from BNH and BH female breast cancer patients, who were diagnosed during the years of 1973-2009 in the United States. The sample contained 1,000 BNH and 298 BH female breast cancer patients. The median age at diagnosis was 57.75 years among BNH and 54.11 years among BH. The results of the half-normal model showed that the survival times formed positive skewed models with higher variability in BNH compared with BH. The Kaplan-Meir estimate was used to plot the survival curves for cancer patients; this test was positively skewed. The Kaplan-Meier and Cox proportional hazard ratio for survival analysis showed that BNH had a significantly longer survival time as compared to BH which is consistent with the results of the half-normal model. Conclusions: The findings with the proposed model strategy will assist in the healthcare field to measure future outcomes for BH and BNH, given their past history and conditions. These findings may provide an enhanced and improved outlook for the diagnosis and treatment of breast cancer patients in the United States.

Exposure and Risk Assessment of Nitrogen Dioxide and Ozone for Sub-population Groups using Monte-Carlo Simulations (Monte-Carlo 모의실험을 통한 부분 인구집단별 이산화질소와 오존의 노출 및 위해성 평가)

  • Park, Jinhyeon;Ryu, Hyeonsu;Yang, So Young;Park, Yunkyung;Heo, Jung;Kim, Eunchae;Choe, Youngtae;Cho, Mansu;Yang, Wonho
    • Journal of Environmental Health Sciences
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    • v.45 no.2
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    • pp.113-125
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    • 2019
  • Objectives: Although the risk assessments for nitrogen dioxide ($NO_2$) and ozone ($O_3$) have been extensively studied, most of the existing risk assessments were limited mainly to indoor environments such as workplaces, schools, and multi-use facilities. Therefore, integrated risk assessment is needed to consider exposure in all microenvironments, including outdoors. The purpose of this study was to assess the differences in risk among sub-population groups according to time-activity patterns and reported concentrations, as well as the lifetime risk of Koreans. Methods: In this study, we estimated time-weighted average exposure concentrations of $NO_2$ and $O_3$ for preschool children, students, housewives, workers, and seniors using residential time and indoor concentrations (house, school or workplace, other), outdoors, and transport by meta-analysis method. The risk for $NO_2$ and $O_3$ were assessed by hazard quotient using reference concentrations 30 and 60 ppb, respectively. The risk assessments were conducted through 1,000,000 Monte-Carlo simulations for probabilistic analysis. Results: Preschool children, students, housewives, workers, and seniors spent 91.9, 86.0, 79.8, 82.2, and 77.3% of their day in a house, school, or workplace, respectively. The risk assessment for the lifetime of a housewife and a worker showed that 33.8 and 28.4% of hazard quotients of $NO_2$ exceed 1, respectively, and more than 99% of hazard quotient of $O_3$ were less than 1. Conclusions: The risk of $NO_2$ and $O_3$ by sub-population group and for the lifetime of housewives and workers were assessed. The risk for $NO_2$ was higher than for $O_3$ and showed a different risk by sub-population group. Both $NO_2$ and $O_3$ showed a higher risk for housewives than for workers. This study can be used as a basis for lifetime exposure and risk assessment for $NO_2$ and $O_3$.