• 지역사회간호학회지
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• 제2권1호
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• pp.221-222
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• 1990

• 지역사회간호학회지
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• 제2권1호
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• pp.143-144
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• 1990

• 부모자녀건강학회지
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• 제4권1호
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• pp.116-123
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• 2001

• The Journal of Advanced Prosthodontics
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• 제7권4호
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• pp.294-302
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• 2015

PURPOSE. The purpose of this study was to verify the clinical-feasibility of additive manufacturing by comparing the accuracy of four different manufacturing methods for metal coping: the conventional lost wax technique (CLWT); subtractive methods with wax blank milling (WBM); and two additive methods, multi jet modeling (MJM), and micro-stereolithography (Micro-SLA). MATERIALS AND METHODS. Thirty study models were created using an acrylic model with the maxillary upper right canine, first premolar, and first molar teeth. Based on the scan files from a non-contact blue light scanner (Identica; Medit Co. Ltd., Seoul, Korea), thirty cores were produced using the WBM, MJM, and Micro-SLA methods, respectively, and another thirty frameworks were produced using the CLWT method. To measure the marginal and internal gap, the silicone replica method was adopted, and the silicone images obtained were evaluated using a digital microscope (KH-7700; Hirox, Tokyo, Japan) at 140X magnification. Analyses were performed using two-way analysis of variance (ANOVA) and Tukey post hoc test (${\alpha}=.05$). RESULTS. The mean marginal gaps and internal gaps showed significant differences according to tooth type (P<.001 and P<.001, respectively) and manufacturing method (P<.037 and P<.001, respectively). Micro-SLA did not show any significant difference from CLWT regarding mean marginal gap compared to the WBM and MJM methods. CONCLUSION. The mean values of gaps resulting from the four different manufacturing methods were within a clinically allowable range, and, thus, the clinical use of additive manufacturing methods is acceptable as an alternative to the traditional lost wax-technique and subtractive manufacturing.

• The Journal of Advanced Prosthodontics
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• 제9권4호
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• pp.239-243
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• 2017

PURPOSE. The purpose of this study is to compare single and three-unit metal frameworks that are produced by micro-stereolithography. MATERIALS AND METHODS. Silicone impressions of a selected molar and a premolar were used to make master abutments that were scanned into a stereolithography file. The file was processed with computer aided design software to create single and three-unit designs from which resin frameworks were created using micro-stereolithography. These resin frameworks were subjected to investment, burnout, and casting to fabricate single and three-unit metal ones that were measured under a digital microscope by using the silicone replica technique. The measurements were verified by means of the Mann-Whitney U test (${\alpha}=.05$). RESULTS. The marginal gap was $101.9{\pm}53.4{\mu}m$ for SM group and $104.3{\pm}62.9{\mu}m$ for TUM group. The measurement of non-pontics in a single metal framework was $93.6{\pm}43.9{\mu}m$, and that of non-pontics in a three-unit metal framework was $64.9{\pm}46.5{\mu}m$. The dimension of pontics in a single metal framework was $110.2{\pm}61.4{\mu}m$, and that of pontics in a three-unit metal framework was $143.7{\pm}51.8{\mu}m$. CONCLUSION. The marginal gap was smaller for the single metal framework than for the three-unit one, which requires further improvement before it can be used for clinical purposes.

• 대한인간공학회지
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• 제31권2호
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• pp.363-370
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• 2012

Objective: The objective of this study is to analyze standards of ISO 9001, ISO 14001, KOSHA 18001, GAP and ISO 22000 to make an integrated system and check whether an integrated system can be used at small size companies. Background: There are many certification criteria for quality, safety and health such as ISO 9001, ISO 14001, KOSHA 18001, GAP and ISO 22000. However, these criteria are difficult and complicated to be used at a small size company. Thus. it is not easy for small size companies to obtain certifications using these criteria. But customers and workers of small size companies want the key points of these systems to be implemented. Method: ISO 9001, ISO 14001, KOSHA 18001, GAP and ISO 22000 were analyzed to find the commonality and duplications as well as the importance of the items in these standards. And a survey was conducted to check whether certain aspects of the anticipated integrated system can be implemented at small size companies. Results: Items were classified into categories based upon the importance to food safety, quality, safety, environment, and health. Items which are common among standards were also identified and thus give ideas to make the new standards simpler than the currently available standards. Items which were important but may not be easily implemented at the small size companies were also identified. Conclusion: By considering the fact that the currently used accreditation standards have many similar aspects, these systems can be integrated into one new system which small size companies can use relatively easily.

• 한국환경성돌연변이발암원학회지
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• 제23권1호
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• pp.11-15
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• 2003

Gap junctional intercellular communication (GJIC) plays a key role during development, process of tissue differentiation, and in maintenance of adult tissue homeostasis. Neural stem cells leading to formation of cell clusters termed 'neurospheres', can differentiate into neurons, oligodendrocytes, and astrocytes. We investigated the expression levels and distribution of connexin43 (Cx43) and connexin32 (Cx32), abundant gap junctional protein in neural cells and in neurospheres isolated from rat fetus embryonic day (ED) 17. During differentiation of neurospheres, expression of Cx43 and 32 were increased time-dependently within 72 h, and then decreased at 7 day in western blot analysis. TPA-induced inhibition of GJIC was confirmed by decreased fluorescence by SL/DT assay, and induced hyperphosphorylation of Cx43 while no changes in Cx32 levels in western blot assay. Our results indicate that GJIC may be a crucial role in the differentiation of neuronal stem cell. And this GJIC can be inhibited by TPA through the hyperphosphorylation of Cx43.

• 한국치위생학회지
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• 제7권4호
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• pp.405-418
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• 2007

The purpose of this study was to examine the interest level of mothers in oral health. The subjects in this study were 184 mothers whose children attended daycare centers in the city of K. A survey was conducted from March 15 through April 30, 2007, and SPSS WIN 11.5 program was employed to analyze their answer sheets. The findings of the study were as follows: 1. A group of mothers whose children brushed their teeth three times a day on the average made up 55.7 percent of those who were at the age of 35 and under. Among the mothers having three or more children, those mothers accounted for 59.1 percent. The daily mean toothbrushing frequency of children was higher among the better-educated mothers. 2. Concerning dietary and oral guidance, the mothers whose academic background was better curbed their children's excessive sugar intake more often, and the gap between them and the others was statistically significant(pE.05). As to the importance of oral health by the number of child and academic credential, those who had two children(36.0%) taught them the importance of oral health frequently(pE.01), and the better-educated mothers taught about it often(pE.05). The gap between the groups and the others was significant. 3. As for experience of visiting dental institutions, the working mothers visited dental institutions more often than the stay-at-home mothers, and the gap between them was statistically significant(pE.05). Regarding purpose of the visit, the largest group aimed to get treatment(64.6%), followed by having a dental checkup(14.6%) and receiving preventive treatment(13.5%). As to any inconveniences in using dental institutions, those who were working and who were in the upper income bracket found it more inconvenient to do that because of a long distance or time constraints. The gap between them and the others was significant. 4. In regard to concern for dental care, the mothers who were better educated(pE.001) and whose family income was 3 million won or more had their teeth scaled more often, and the gap between them and the others was statistically significant(pE.01). The rate of the regular visitors of dental institutions stood at 32.7 percent of the junior-college graduates, 31.0 percent of the mothers receiving college or higher education and 10.1 percent of the high-school graduates(pE.01). And those who earned larger income paid a visit to dental institutions more often and on a regular basis. The gap between them and the others was statistically significant(pE.05).

• 대한수의학회지
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• 제43권4호
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• pp.649-656
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• 2003

We have a cultured method to grow rat mammary epithelial cells (RMEC) for 1 to 14 days in 1:1 mixture of Dulbecco's Modified Eagle Medium: Nutrient and F-12 (DMEM/F-12) containing 10% fetal bovine serum (FBS), human EGF, insulin, hydrocortisone, human transferrin and $17{\beta}$-estradiol in vitro. We were able to isolate and distinguish two cell types, luminal epithelial cells and myoepithelial cells, from primary clutures of RMEC. Immunocytochemical stains were used to distingusih luminal epithelial cells and myoepithelial cells. Peanut lectin (PNA) was stained in most alveolar epithelail cells and luminal epithelial cells of rats, while Thy-1.1, a maker of potential rat mammary myoepithelial cells, was expressed in myoepithelial cells in the rat. Also, we examined the expression patterns of three types of gap junction proteins, connexin 26 ($C{\times}26$), connexins 32 ($C{\times}32$) and connexin 43 ($C{\times}43$) by immunocytochemistry and western blot analysis. In the cell types, the results show that at the early stage of culture, luminal epithelial cells were increased and these cells were surrounded by myoepithelial cells. At the late stage of culture, luminal epithelial cells were decreased, in contrast myoepithelial cells were increased. In the expression pattern of gap junction, $C{\times}26$ maintained it's expression until day 3, but afterwards gradually decreased in intensity. Expression of $C{\times}32$ remained until day 5, then decreased slightly. $C{\times}43$ gradually increased untill the middle time of culture then decreased in intensity. These results suggest that connexins may be important for the control of growth in rat mammary epithelial cell types.

• Journal of the Korean Data and Information Science Society
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• 제25권2호
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• pp.327-336
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• 2014

재발 사건 자료란 연구대상이 같은 종류의 사건을 반복적으로 경험할 때 발생하는 자료이다. 이러한 재발 사건은 사회과학, 자연과학, 공학, 의약학 등 다양한 분야에서 나타날 수 있다. 재발 사건자료를 분석할 때 연구자의 관심에 따라 사건 발생시간이나 사건 발생간의 소요시간을 이용하여 분석할 수 있다. 이 논문에서는 사건 발생시점간의 소요시간을 이용하여 불완전한 관측을 가진 재발 사건자료를 분석하고자 한다. 이 자료의 특징은 일부 관측대상들이 일정기간 동안 연구에서 제외되는 관측틈을 갖는다는 것이다. 이 때 관측틈은 불완전한 형태로 나타나게 되는데 그 이유는 관측틈의 시작시점은 알고 있지만 종료시점은 알 수 없기 때문이다. 이러한 미지의 종료시점을 추정하기 위해서 구간 중도 절단 방법이 적용된다. 따라서 종료시점이 추정된 후 프레일티를 포함한 회귀모형을 적용하여 공변량이 사건 재발에 미치는 영향을 알아볼 수 있다. 또한 제안한 방법을 실제자료에 적용하여 관측틈을 고려한 경우와 고려하지 않은 경우를 비교하고자 한다.