• Toxicological Research
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• 제32권2호
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• pp.89-93
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• 2016

Human cytochrome P450 enzymes (P450s, CYPs) are major oxidative catalysts that metabolize various xenobiotic and endogenous compounds. Many carcinogens induce cancer only after metabolic activation and P450 enzymes play an important role in this phenomenon. P450 1B1 mediates bioactivation of many procarcinogenic chemicals and carcinogenic estrogen. It catalyzes the oxidation reaction of polycyclic aromatic carbons, heterocyclic and aromatic amines, and the 4-hydroxylation reaction of $17{\beta}$-estradiol. Enhanced expression of P450 1B1 promotes cancer cell proliferation and metastasis. There are at least 25 polymorphic variants of P450 1B1 and some of these have been reported to be associated with eye diseases. In addition, P450 1B1 polymorphisms can greatly affect the metabolic activation of many procarcinogenic compounds. It is necessary to understand the relationship between metabolic activation of such substances and P450 1B1 polymorphisms in order to develop rational strategies for the prevention of its toxic effect on human health.

• 한국전문물리치료학회지
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• 제19권1호
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• pp.46-55
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• 2012

The purpose of this study was to investigate the effect of the two different types of chairs on trapezius muscle activation during dictation tasks. Seventeen university students, each of whom were within ${\pm}1$ standard deviation of the mean Korean standard body size, voluntarily participated in this study. Surface electromyography was used to collect electrical signals from both the upper and lower trapezius muscles. Amplitude Probability Distribution Function (APDF) was performed to analyze the muscle activity. The findings of this study were 1) The backrest-point height of the auditorium chair and the height, length and width of the connected desk were shorter than what was suggested by the KS. Another difference was that the auditorium chair had a bigger angle of the backrest compared to the classroom chair. 2) Regarding within-subject effect the sole statistically significant difference was found between activation of the upper trapezius muscle. The upper trapezius muscle's %RVC in the APDF 10th-50th-90th percentile was statistically higher for participants sitting in the auditorium chair than for participants sitting in the classroom chair (p<.05). 3) There was an interaction effect between the 'two chair-types' and the 'two muscle-sides' in the APDF 10th-50th percentile (p<.05). 4) There was an interaction effect between the 'two chair-types' and the 'three gaze-direction' in the APDF 90th percentile (p<.05). The findings of this study indicated that maintaining a writing posture for a prolonged period of time in an auditorium chair significantly increased the left upper trapezius muscle activation compared to a classroom chair.

• BMB Reports
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• 제35권4호
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• pp.377-383
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• 2002

Arsenic trioxide ($As_O_3$) was recently demonstrated to be an effective inducer of apoptosis in patients with relapsed acute promyelocytic leukemia (APL) as well as patients with APL in whom all-trans-retinoic acid and conventional chemotherapy failed. Chronic myelogenous leukemia cells are highly resistant to chemotherapeutic drugs. To determine if $As_O_3$ might be useful for the treatment of chronic myelogenous leukemia, we examined the ability of $As_O_3$ to induce apoptosis in K562 cells. In vitro cytotoxicity of $As_O_3$ was evaluated in K562 cells by a MTT assay: the $IC_50$ value for $As_O_3$ was determined to be $10\;{\mu}m$. When analyzed by agarose gel electorphoresis, the DNA fragments became evident after incubation of the cells with $20\;{\mu}m$ $As_O_3$ for 24 h. We also found morphological changes and chromatin condensation of the cells undergoing apoptosis. Activation of caspase-3 was observed 6 h after treatment with $20\;{\mu}m$ $As_O_3$ by a Western blot analysis. Next, we examined the MAP kinase-signaling pathway of $As_O_3$-induced apoptosis in K562 cells. $As_O_3$ at $10\;{\mu}m$ strongly induced the activation of p38, inhibited $As_O_3$ induced apoptotic cell death. These results suggest that $As_O_3$ is able to induce the apoptotic activity in K562 cells, and its apoptotic mechanism may be associated with the activation of p38.

• Physical Therapy Rehabilitation Science
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• 제6권1호
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• pp.39-44
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• 2017

Objective: The purpose of this study is to show the effectiveness of performing squat exercises at various angles to show the maximum muscle activity of the Vastus Medialis Oblique (VMO) and Biceps femoris (BF). Design: Cross-sectional study. Methods: A total of seventeen healthy young adults (8 males and 9 females) voluntarily participated in the study. All subjects randomly performed three different squat variations as follows: A squat performed with the ankle joint at $0^{\circ}$ of incline, a squat performed with the ankle joint at $5^{\circ}$ of incline, and a squat performed with the ankle joint at $10^{\circ}$ incline. Muscle activity was measured using surface electromyography. Electrodes were placed on the VMO and BF to measure the muscle activity on the various ankle angles for comparison analysis. Results: There was a significant increase in bilateral VMO muscle activation at $10^{\circ}$ of incline compared to $0^{\circ}$ and $5^{\circ}$ (p<0.05). Greater increases in muscle activation and exercise effect was observed with increasing incline angles of the board. Changes in bilateral BF muscle activity were found; however, none were found to be significant. Conclusions: Bilateral VMO activity was found to be significant when the squats were performed at an ankle angle of $10^{\circ}$ of incline when compared to at an ankle angle of $0^{\circ}$ and $5^{\circ}$ of incline. Squats performed on an incline can be recommended as an effective method to facilitate lower extremity muscle activities.

• 한국안전학회지
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• 제37권1호
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• pp.30-40
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• 2022

The death rate in the construction industry, which is more than twice that of other industries, increases the need to solve chronic safety problems. In a situation in which the safety management measures that have been maintained thus far are unable to reduce construction accidents, the introduction of smart construction safety technology (SCST) that reflects the 4th industrial technology is required for the safety management of workers. Large corporations or public institutions have introduced SCST and are operating pilot sites, but SCST is still in its infancy and there have yet to exist field data regarding necessity and effectiveness. In this study, the concept of SCST, which has still to be established, is defined, and the actual condition of SCST was analyzed through a survey. Through the analysis of the necessity of SCST introduction, convenience, and effectiveness before and after its application, problems such as problems from the field point of view as well as other factors hindering the introduction of such technology are derived in detail. In addition, an effective combination of technologies for safety management at the current level is determined and an activation plan is presented.

• 대한예방한의학회지
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• 제11권1호
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• pp.131-138
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• 2007

Herbal medicine has been traditional used for prevention and treatment of treatment of disease, because herbal medicine has few side effects in the human body. Anti-medicines such as antimicrobial medicine and anti-cancer medicine, which contains herbal medicine, are being studied vigorously by researchers. The effects of Geum Japonicum Thumb are restorative, blood circulation and detoxification. It also treats hematemesis, menstruation and furunculus. The ingredients of Geum Japonicum Thumb include geoside and tannin. The study measured antioxidative activation and antifungal activation by using Geum Japonicum Thumb water and methanol extract. The crude extract, which was used for this study, was Korean herbal medicine and the results are as follows. As Geum Japonicum Thumb extracts get stronger, the antioxidative activation tended to increase. The antioxidative activation hit its peak when the density of methanol extract was 120ug/ml. The experiment showed that a 1.0mm clear zone appeared when the density of the Geum Japonicum Thumb methanol extracts were 1000ug/ml in the Staphylococcus epidermidis and 1.1mm clear zone at Pseudomonas aeruginosa. The results of this study concludes that the antioxidative activation is lubricated in the Geum Japonicum Thumb extracts. In addition, the antifungal activation occurred in the fungus of the Staphylococcus epidermidis and the Pseudomonas aeruginosa.

• 한국전문물리치료학회지
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• 제15권1호
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• pp.46-53
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• 2008

The aim of the present study was to determine the effect of proprioceptive neuromuscular facilitation (PNF) leg patterns on the muscle activation of neck flexors. Twenty healthy subjects participated in this study. Each subject performed bilateral asymmetrical PNF leg patterns against manual resistance under four conditions: through the full range of motion toward the right side, left side, and the end range in the right side, left side. Electromyographic (EMG) data was collected from the sternocleidomastoid (SCM) muscles as neck flexors. The root mean square (RMS) value of the SCM was measured and normalized from maximal EMG activity of the SCM. The data were analyzed using the paired t-test and repeated analysis of variance (ANOV A) was used to compare the statistical significance. The results of this study are summarized as follows: Firstly, the RMS values of SCM were significantly higher in all four PNF leg patterns than in the resting condition (p<.05). Secondly, there was no significant difference in muscle activation according to the direction of PNF leg patterns (p>.05). Thirdly, there was no significant difference in muscle activation according to the point of range of the motion of leg patterns (p>.05). It is suggested that PNF bilateral asymmetrical leg patterns have a considerable effect on muscle activation of the SCM, regardless of the range of motion and direction of PNF bilateral asymmetrical leg patterns.

• PNF and Movement
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• 제17권3호
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• pp.441-450
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• 2019

Purpose: This study identified the co-activation of quadriceps and hamstring muscles during hamstring strengthening exercises in healthy adults. Methods: Twenty-one participants were required for the present study design to achieve 80% power, 0.8 effect size (η2), and an alpha level of 0.05. Thus, this study recruited 21 healthy adults. All participants performed Nordic exercises, bridge exercises, and one-leg deadlifts randomly. The activity of the rectus femoris, vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF), and semitendinosus (SM) were measured. In addition, the ratios of VM/VL and hamstring/quadriceps (HQ) were measured during the three hamstring strengthening exercises using electromyography. One-way ANOVA was used to compare the co-activation of quadriceps and hamstring muscles in the three exercises. Results: The activity of VM and VL during the performance of one-leg deadlifts was significantly higher than the other two exercises. The BF had significantly higher activity during the Nordic exercises compared to the other two exercises. In addition, the SM activation was significantly greater during Nordic exercises than one-leg deadlifts. Additionally, there was significant difference in HQ ratio among hamstring strengthening exercises. In specific, the one-leg deadlifts yielded a significantly lower HQ ratio. Conclusion: This study revealed that one-leg deadlifts are effective in rehabilitation for anterior cruciate ligament injury. In addition, Nordic exercises can be recommended to facilitate hamstring muscle activation.

• 한국융합학회논문지
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• 제9권11호
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• pp.385-391
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• 2018

본 논문의 평발인 대상자가 하이힐을 신고 계단을 내려갈 때 하지의 근활성도 변화를 알아보고자 한다. 이 연구의 대상자는 30명의 여학생으로 구성되어 있다. NDT를 이용하여 평발군과 정상군을 구분하였으며 표전근전도를 사용해 측정하였다. MG와 LG근활성도와 안, 가쪽 근공동활성도는 평발군에서 낮게 나타났고 근활성도 비율은 평발군이 안쪽에서 더 높게 나타났다. 그러므로 하이힐을 신은 평발군은 정상군보다 무릎관절 정렬에 더 많은 손상을 가질 가능성이 더 높으므로 계단을 내려갈 때 더 많은 주의가 필요할 것이다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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• pp.249-249
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• 2002