• Archives of Pharmacal Research
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• 제28권1호
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• pp.1-15
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• 2005

Cancer is still a major global health concern even after an everlasting strive in conquering this dread disease. Emphasis is now given to chemoprevention to reduce the risk of cancer and also to improve the quality of life among cancer afflicted individuals. Recent progress in molecular biology of cancer has identified key components of the cellular signaling network, whose functional abnormality results in undesired alterations in cellular homeostasis, creating a cellular microenvironment that favors premalignant and malignant transformation. Multiple lines of evidence suggest an elevated expression of cyclooxygenase-2 (COX-2) is causally linked to cancer. In response to oxidative/pro-inflammatory stimuli, turning on unusual signaling arrays mediated through diverse classes of kinases and transcription factors results in aberrant expression of COX-2. Population-based as well as laboratory studies have explored a broad spectrum of chemopreventive agents including selective COX-2 inhibitors and a wide variety of anti-inflammatory phytochemicals, which have been shown to target cellular signaling molecules as underlying mechanisms of chemoprevention. Thus, unraveling signaling pathways regulating aberrant COX-2 expression and targeted blocking of one or more components of those signal cascades may be exploited in searching chemopreventive agents in the future.

• 한국정보통신학회논문지
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• 제13권6호
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• pp.1215-1221
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• 2009

본 연구에서는 무선 센서네트워크 환경에서 요구하는 데이터 전달의 신뢰성 향상을 위해 기능성 노드를 제안한다. 생체신호 모니터링을 위해 기존의 지속적인 생체신호 전송시 발생하는 데이터 손실을 줄이기 위해 비정상적인 QRS-complex 검출이 가능한 센서노드를 이용하고, Ad-hoc 네트워크 환경에서 비정상적인 QRS-comoplex 발생시에만 데이터를 전송함으로써 무선 센서네트워크 내에 발생되는 데이터량을 줄일 수 있었다. 본 연구에서 Ad-hoc 환경에서의 기능성 노드를 사용함으로써 그 결과 의료 목적을 위한 무선 센서네트워크에서 전체 패킷발생을 줄여 센서노드의 전력소모를 크게 줄이고 시스템의 신뢰도를 크게 높이는 것으로 확인되었다.

• 대한의생명과학회지
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• 제17권2호
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• pp.129-134
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• 2011

Mosaicism is the presence of two or more chromosomally distinct cell lines, each seen in two or more cells. Chromosomal mosaicism presents one of the most difficult problems in prenatal cytogenetic diagnosis, requiring the differentiation of true mosaicism from pseudomosaicism. To overcome associated problems we investigated 24 cases (amniotic fluid 13 cases, abortus tissue 3 cases, peripheral blood 8 cases) in which mosaicism has been found in cytogenetic analysis. 5 cases (38.5%) of 13 amniotic fluid cells in which mosaicisms showed single cell pseudomosaicism. Chromosomal true mosaicism is found in about 0.28% (8/2,826) of amniotic fluid cell cultures. The 24 cases involved 12 cases (50%) with sex chromosomal abnormalities, 7 cases (29.2%) with autosomal structural defects, 3 cases (12.5%) with autosomal abnormalities, 2 cases (8.3%) with a supernumerary marker. Mosaicism detected in amniotic fluid may represent the true mosaicism or may pseudomosaicism. If the same chromosome abnormality is seen in more than one cell and in two different cultures, it is considered a true mosaicism, whereas single-cell abnormalities from a single culture are regarded as pseudomosaicism. In this study, we describe a mosaicism in chromosome analysis, its diagnostic problems and clinical significance.

• 대한물리치료과학회지
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• 제5권4호
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• pp.763-775
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• 1998

Some segment or segments of the body must compensate for the heel, and the higher the heel the greater the compensation. Such compensation was once generally thought to take place in the lumbar region and therefore to increase the lumbar lordosis. The purpose of this study is to analyze changes of lumbar sagittal curvature in barefoot and 6cm 12cm high-heel stance. We selected 19 subjects(11 males, 8 females} without history of lower back pain, significant spinal abnormality. And lateral view X-ray of lumbar region from T12 to S1 was taken of each individual. On each X-ray film, lumbar lordotic angle lumbosacral angle and lumbar segmental angles were measured by Cobb method. We drew the following interpretations from the analysis of measured variables of the lumbar region. 1. In comparison of barefoot 6cm heel 12cm heel stance, lumbar lordotic angle had a tendency to decrease according as the heel height was higher. The change in lumbar lordosis measured in high-heel stance was inconsistent with clinical forkelord of hyperlordosis in wearers of high-heeled. 2. Lumbar lordotic angle from T12 to L5 showed sex difference, and was more lordotic in female(p<0.05). 3. There was no sex difference in lumbosacral angle and lumbar segmental angles(p>0.05). 4. There was a significant correlation between lumbar lordotic angle and lumbosacral angle(r>0.60).

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.224-233
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• 2002

General massage and sports massage techniques are kneading, petrisage and tappotment. These will be improve physiological reaction. Connective tissue massage is a reflex zone massage in the subcutaneous tissues. These are superficial and deeper fascia, intermuscular septa, blood vessel, perinerve tissue. It is frame work on organs in human-being, Therefore, abnormality of there tissues are a pathologic change of the organs. The pathologic changes are fined with visible investigation, manual investigation and stroking investigation on the reflex zone. The stroking on the reflex zone is the treatment also. Stroking methods are depend upon tissues and area. Short strokings are directed at approximately right angles against bone, muscular or facial board. Long strokings are very often follow the original cleavage lines. The back is divided for treatment purposes into sections. There are basic section, thoracic section and cervical section.

• Journal of Preventive Medicine and Public Health
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• 제22권1호
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• pp.81-89
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• 1989

The authors investigated mortality rate of hospitalized CWP(coal workers' pneumoconiosis) patients. Date, which was composed of age, date of hospitalization, date of death, and radiological findings(profusion of small opacity, type of large opacity, tuberculosis, emphysema, pneumothorax, and cardiac abnormality), was gathered from medical charts and chest x-ray films at the time of hospitalization of CWP patients. Among 738 CWP patients, that were entered survey differently and have followed different period, 160 CWP patients were died during different observational period. Mean value of observational period was 203 weeks, and mean age at hospitalization was 51 years. Because of short observational period, mean survival time could not found. There was statistically significant difference of mortality rate between group of small opacity and that of large opacity. In group of small opacity 5 year survival rate was 0.80 and in group of large opacity that was 0.73. And 80 percentile survival time was 57 months in group of small opacity and that was 40 months in group of large opacity.

• Communications for Statistical Applications and Methods
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• 제28권4호
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• pp.339-350
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• 2021

In medical research, the risk factors associated with human diseases need to be identified to predict the incidence rate and determine the treatment plan. Logistic regression analysis is primarily used in order to select risk factors. However, individuals who are unfamiliar with statistics outcomes have trouble using these methods. In this study, we develop a nomogram that graphically represents the numerical association between the disease and risk factors in order to identify the risk factors for delirium and to interpret and use the results more effectively. By using the logistic regression model, we identify risk factors related to delirium, construct a nomogram and predict incidence rates. Additionally, we verify the developed nomogram using a receiver operation characteristics (ROC) curve and calibration plot. Nursing home, stroke/epilepsy, metabolic abnormality, hemodynamic instability, and analgesics were selected as risk factors. The validation results of the nomogram, built with the factors of training set and the test set of the AUC showed a statistically significant determination of 0.893 and 0.717, respectively. As a result of drawing the calibration plot, the coefficient of determination was 0.820. By using the nomogram developed in this paper, health professionals can easily predict the incidence rate of delirium for individual patients. Based on this information, the nomogram could be used as a useful tool to establish an individual's treatment plan.

• 한국산학기술학회논문지
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• 제15권8호
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• pp.5009-5022
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• 2014

본 연구는 한 대학병원 건강검진센터에서 종합건강검진을 받은 일반 성인들을 대상으로 생활습관에 따른 혈청지질치의 수준을 알아보고, 생활습관 인자들이 혈청지질치에 미치는 영향을 파악하고자 하였다. 조사대상은 2012년 1월부터 2013년 12월까지의 기간에 대전광역시에 소재하고 있는 C대학교병원 건강검진센터에서 건강검진을 받았던 4,112명을 대상으로 하였다. 자료 수집은 건강검진 시에 수검자들에게 배포하여 기입하도록 한 문진표와 건강검진결과표로부터 인구사회학적 특성, 생활습관 및 혈청지질치 등의 자료를 수집하여 분석하였다. 연구결과, 조사대상자의 TC, HDL-C. LDL-C 및 TG 등의 혈청지질치나 동맥경화지수(AI)의 평균치는 남녀 모두 연령, 음주, 흡연, 규칙적인 운동, 과식 및 육류섭취 등의 생활습관 특성에 따라 유의한 차이를 보였다. 조사대상자의 TC, HDL-C. LDL-C, TG 및 AI는 남녀 모두 연령, AUDIT점수와 유의한 양의 상관관계를 나타낸 반면, HPI점수와는 유의한 음의 상관관계를 보였다. 조사대상자의 혈청지질치에 대한 생활습관의 영향요인으로 TC, HDL-C. LDL-C, TG 및 AI가 비정상치에 속할 위험비는 남녀 모두 과식을 매일 한다는 군, 육류섭취를 매일 한다는 군, 흡연군, 규칙적인 운동을 하지 않는다는 군, HPI가 낮은 군에서 그렇지 않다는 군보다 유의하게 증가하였다. 이상과 같은 결과는 조사대상자의 혈청지질치나 AI는 연령증가와 함께 음주, 흡연, 규칙적인 운동, 과식 및 육류 섭취 등의 생활습관 특성에 따라 영향을 받고 있음을 시사한다.

• 한국콘텐츠학회논문지
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• 제21권6호
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• pp.404-414
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• 2021

최근 고령 사회에서는 지역사회중심의료로의 전환에 대한 관심이 증가하고 있다. 이에 일반 노인과 취약계층 노인 각각에 대해 기능중심의 건강상태를 파악하고, 이를 기반으로 의료서비스 이용 경험 및 요구 인식에 대해 살펴보는 것은 필요하다. 본 연구는 2016년 11월부터 12월까지 서울시 일개지역에 거주하는 65세 이상 노인을 방문하여 구조화된 설문을 통해 노인의 건강기능 상태와 의료서비스 이용 행태를 파악하였다. 취약계층 노인은 일반 노인보다 인지기능, 영양, 통증, 낙상 등에서 기능적 건강상태 저하를 더 많이 경험하는 것으로 나타났다. 인지기능, 영양과 같은 기능적 건강문제를 경험한 일반 노인은 취약계층보다 유의하게 의료서비스를 이용하는 것으로 나타났다. 한편 취약계층 노인은 통증 건강문제 영역에 있어서는 일반 노인보다 의료서비스 이용의 필요성을 더 유의하게 인식하는 것으로 나타났다. 이는 지역사회 노인을 대상으로 공공 서비스 확대의 방향과 범위를 설정함에 있어, 일반 노인과 취약계층 노인 간에는 차별화된 정책이 설정되어야 함을 알 수 있었다. 또한 취약계층의 의료접근성 향상을 위해서는 경제적 장벽으로 인해 필요한 의료이용의 장애가 초래되지 않도록 공공의료기관의 적극적인 지원이 이루어져야 하겠다.

• 대한방사선기술학회지:방사선기술과학
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• 제41권4호
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• pp.329-337
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• 2018

This study was investigated quantitative ultrasound (QUS) usage in Korea for the QUS quality control guidelines. A total of 344 questionnaires collected from July 24th to August 25th 2017 were analyzed. Questionnaires were created through user interviews, expert group advice, literature review and field observation. As a result of the general characteristics of quantitative ultrasound holding amounted to 81.98% of clinic and 6.69% of hospitals. The main user was radio-logical technologists as 31.39%. The contact methods of the gel pad (balloon) were the most used at 56.68% and the scan region was 91.9% of calcaneus. The quantitative ultrasound quality control cycle was 67.37% when the abnormality was found in the equipment, and 63.66% when the accuracy control was implemented according to the manual. The phantoms of QUS were 34.30% of the manufacturer's own phantoms. User of QUS had never received education for quality control of quantitative ultrasound as 62.20%. This study was expected to be useful when creating detailed quality control guidelines in the future, as well as guidelines for the quality control of Korea's standard quantitative ultrasound.