• Journal of Ginseng Research
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• 제45권1호
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• pp.66-74
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• 2021

Background: Abnormal chloride (Cl-) transport has a detrimental impact on mucociliary clearance in both cystic fibrosis (CF) and non-CF chronic rhinosinusitis. Ginseng is a medicinal plant noted to have anti-inflammatory and antimicrobial properties. The present study aims to assess the capability of red ginseng aqueous extract (RGAE) to promote transepithelial Cl- secretion in nasal epithelium. Methods: Primary murine nasal septal epithelial (MNSE) [wild-type (WT) and transgenic CFTR-/-], fisher-rat-thyroid (FRT) cells expressing human WT CFTR, and TMEM16A-expressing human embryonic kidney cultures were utilized for the present experiments. Ciliary beat frequency (CBF) and airway surface liquid (ASL) depth measurements were performed using micro-optical coherence tomography (μOCT). Mechanisms underlying transepithelial Cl- transport were determined using pharmacologic manipulation in Ussing chambers and whole-cell patch clamp analysis. Results: RGAE (at 30㎍/mL of ginsenosides) significantly increased Cl- transport [measured as change in short-circuit current (ΔISC = ㎂/㎠)] when compared with control in WT and CFTR-/- MNSE (WT vs control = 49.8±2.6 vs 0.1+/-0.2, CFTR-/- = 33.5±1.5 vs 0.2±0.3, p < 0.0001). In FRT cells, the CFTR-mediated ΔISC attributed to RGAE was small (6.8 ± 2.5 vs control, 0.03 ± 0.01, p < 0.05). In patch clamp, TMEM16A-mediated currents were markedly improved with co-administration of RGAE and uridine 5-triphosphate (8406.3 +/- 807.7 pA) over uridine 5-triphosphate (3524.1 +/- 292.4 pA) or RGAE alone (465.2 +/- 90.7 pA) (p < 0.0001). ASL and CBF were significantly greater with RGAE (6.2+/-0.3 ㎛ vs control, 3.9+/-0.09 ㎛; 10.4+/-0.3 Hz vs control, 7.3 ± 0.2 Hz; p < 0.0001) in MNSE. Conclusion: RGAE augments ASL depth and CBF by stimulating Cl- secretion through CaCC, which suggests therapeutic potential in both CF and non-CF chronic rhinosinusitis.

• Physical Therapy Korea
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• 제22권4호
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• pp.62-70
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• 2015

The aims of the current study were to assess reliability of range of motion (ROM) measurement of glenohumeral internal rotation (GIR) with a pressure biofeedback stabilization (PBS) method and to compare the reliability between manual stabilization (MS) and the PBS method. In measurement of pure glenohumeral joint motion, scapular stabilization is necessary. The MS method in GIR ROM measurement was used to restrict scapular motion by pressing the palm of the tester's hand over the subject's clavicle, coracoid process, and humeral head. The PBS method was devised to maintain consistent pressure for scapular stabilization during GIR ROM measurement by using a pressure biofeedback unit. GIR ROM was measured by 2 different stabilization methods in 32 subjects with GIR deficit using a smartphone clinometer application. Repeated measurements were performed in two test sessions by two testers to confirm inter- and intra-rater reliability. After tester A performed measurements in test session 1, tester B's measurements were conducted one hour later on the same day to assess the inter-rater reliability and then tester A performed again measurements in test session 2 for confirming the intra-rater reliability. Intra-class correlation coefficient (ICC) (2,1) was applied to assess the inter-rater reliability and ICC (3,1) was applied to determine the intra-rater reliability of the two methods. In the PBS method, the intra-rater reliability was excellent (ICC=.91) and the inter-rater reliability was good (ICC=.84). The inter-rater and intra-rater reliability of the PBS method was higher than in the MS method. The PBS method could regulate manual scapular stabilization pressure in inter- and intra-rater measuring GIR ROM. Results of the current study recommend that the PBS method can provide reliable measurement data on GIR ROM.

• Progress in Medical Physics
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• 제21권3호
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• pp.246-252
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• 2010

The purpose of this study provides measurements of radiation dose from MDCT of head, chest, abdomen and pelvic examinations. A series of dose quantities that are measured of patient weight to compare the dose received during MDCT examinations. Data collected included: weight together with CT dose descriptors, volume CT dose index (CTDIvol) and dose length product (DLP). The effective dose was also estimated and served as collective dose estimation data. Data from 1,774 adult patients attending for a CT examination of the head (n=520) or chest (n=531) or abdomen (n=724) was obtained from spiral CT units using a same CT protocol. Mean values of CTDIvol was a range of 48.6 mGy for head and 6.9, 10.5 mGy for chest, abdomen examinations, respectively. And mean values of DLP was range of 1,604 $mGy{\cdot}cm$ for head, 250 $mGy{\cdot}cm$ for chest, 575 $mGy{\cdot}cm$ for abdomen examinations, respectively. Mean effective dose values for head, chest, abdominal CT were 3.6, 4.2, and 8.6 mSv, respectively. The degree of CTDIvol and DLP was a positive correlation with weight. And there was a positive correlation for weight versus CTDIvol ($r^2$=0.62), DLP ($r^2$=0.694) in chest. And head was also positive correlation with weight versus CTDIvol ($r^2$=0.691), DLP ($r^2$=0.741). We conclude that CTDIvol and DLP is an important determinant of weight within the CT examinations. The results for this study suggest that CT protocol should be tailored according to patient weight.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• 제15권1호
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• pp.31-36
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• 2004

Background and Objectives : It has been shown that the epilaryngeal tube in the human airway is responsible for vocal ring, or the singer's formant. In previous study, authors showed that in trained tenors, besides the conventional singer's formant in the region of ,5500Hz, another energy peak was observed in the region of 8,000Hz. This peak was interpreted as the second resonance of the epilarynx tube. Singers in other voice categories who produce vocal ring are assumed to have the same peak, but no measurements have as yet been made. Materials and Methods : Fifteen tenors, fourteen baritones, seven sopranos and five mezzo sopranos attending the music college, department of vocal music who could reliably produce the head and chest registers were chosen for this study. Each subject was asked to produce an/ah/sound for at least three seconds for the head register sound(tenors ; G4, barions ; E4 sopranos ; F5 and mezzosopranos ; C5) and for the chest register sound (tenors ; C3, baritones ; D3, sopranos ; D4 and Mezzosoprano ; A3). The sound data was analyzed using the Fast Fourier Transform (FFT)-based power spectrum, Long term average(LTA) power spectrum using the FFT algorithm of the Computerized Speech Lab (CSL, Kay elemetrics, Model 4300B, USA). Statistical analysis was performed using the Mann-Whitney test of the Statistical Package for Social sciences(SPSS). Results : For head register sounds, a significant increase was seen in the 2,200-3,400Hz region(p<0.05) and the Similar to the head register sounds, there was a significant increase in energy in the four trained singer group compared with the untrained group in the 2,200-3,100Hz region(p<0.05), the 7,800-8,400Hz region(p<0.05) for the chest register sounds. Conclusions : When good vocal production was made for the head and chest registers, an energy peak was observed near 2,500Hz, a frequency already known as the "singer's formant', in all subjects in the study group. Another region of increased energy was observed around 8,000Hz that had not been noticed previously. The authors believe this region to be the second singer's formant.

• The Journal of the Acoustical Society of Korea
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• 제30권4호
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• pp.167-180
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• 2011

Recently, 3-D audio technologies are commonly implemented through headphones. A major problem of the headphone-based 3-D audio is in-the-head localization, which occurs due to the inaccurate Head-Related Transfer Function (HRTF). Since the individual measurements of HRTFs are impractical, there have been several researches for HRTF customization. In this paper, an efficient method of customizing HRTFs for the sound externalization is proposed. Firstly, it is determined which part will be customized in HRTF through psychoacoustical experiments. Then, the method controlling spectral notches and envelopes to provide individual localization cues are described. Since the proposed method is based on a critical-band rate, the structure is much simpler than that of previous studies, but still effective. The performance was evaluated through a series of subjective tests, and the results confirmed that the customized HRTF using proposed method could replace the measured individual HRTF successfully.

• Journal of the Society of Naval Architects of Korea
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• 제37권1호
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• pp.91-98
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• 2000

The present paper is Part 2 of three-part paper for an experimental study on breaking waves generated by a submerged cylinder. Measurements of velocity and head loss profiles at the wakes of cylinder and breaker as well as the turbulent intensities in breaking region were made to elucidate the viscous aspects of breaking waves. Their mutual correlation is also investigated. It is found that the head loss profile is an excellent indicator of the strength and extent of breaker. Very high turbulent intensities measured at and just downstream of the breaker indicate the consequence of energy transfer of wave breaking into turbulence.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• 제27권2호
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• pp.1-6
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• 2013

In this paper, we implemented a polarimetric strain sensor using a Sagnac birefringence interferometer composed of a polarization-maintaining photonic crystal fiber (PM-PCF). By changing the length of the PM-PCF employed as the sensor head of the proposed sensor, the length dependence of the strain sensitivity was investigated. With respect to 5.0-, 7.5-, and 10.0-cm-long PM-PCFs, strain measurements were done in a measurement range of $0{\sim}6m{\varepsilon}$, and strain sensitivities of ~2.04, ~1.92, and ${\sim}1.73pm/{\mu}{\varepsilon}$ were obtained, respectively. If an ideal PM-PCF with no length dependence of a modal birefringence is used for the proposed sensor, the strain sensitivity is independent of the length of the sensor head (PM-PCF). In the practical PM-PCF used in experiments, however, a shorter PM-PCF has a higher length dependence of the modal birefringence due to its imperfectness and nonuniformity of the internal structure, resulting in a higher length dependence of the strain sensitivity.

• Nuclear Engineering and Technology
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• 제52권4호
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• pp.776-783
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• 2020

As the refueling of a sodium-cooled fast reactor is conducted by rotating part of the reactor head without opening it, the monitoring of existing obstacles that can disturb the rotation of the reactor head is one of the most important issues. This paper deals with the ultrasonic ranging technique that directly monitors the existence of possible obstacles located in a lateral gap between the upper internal structure and the reactor core in a prototype generation IV sodium-cooled fast reactor (PGSFR). A 10 m long plate-type ultrasonic waveguide sensor, whose feasibility has been successfully demonstrated through preliminary tests, was employed for the ultrasonic ranging technique. The design of the sensor's wave radiating section was modified to improve the radiation performance, and the radiated field was investigated through beam profile measurements. A test facility simulating the lower part of the upper internal structure and the upper part of the reactor core with the same shapes and sizes as those in the PGSFR was newly constructed. Several under-water performance tests were then carried out at room temperature to investigate the applicability of the developed ranging technique using the plate-type ultrasonic waveguide sensor with the actual geometry of the PGSFR's internal structures.

• Child Health Nursing Research
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• 제17권4호
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• pp.281-287
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• 2011

Purpose: The study was done to explore growth variation in head circumference (HC) in extremely premature infants (EPI) with brain injury. Methods: A retrospective cohort study was conducted with 79 cohort samples from the archives of the catch-up growth project. Mean age of the infants was 29.2 weeks of gestation and mean HC, 27.1 cm at birth. Their HC measurements were retrieved from the archives up to 6 month of corrected age (CA) and analyzed against history of brain injury during hospitalization. Results: Overall growth retardation in HC was observed in the cohort sample compared to longer gestation premature infants. EPI with brain injury showed decreased HC compared to infants without brain injury, and resulting growth variation across 6 month of CA. Highest retardation in HC growth was observed in male infants with brain injury. Conclusion: Extreme preterm birth itself may function as a major obstacle against HC growth toward term age in EPI. Sustainability of brain injury could be observed with higher HC growth retardation after term. Evolutionary favor to female infants may exist in HC growth of EPI. Intensive education on HC monitoring is highly suggested for parents of EPI, particularly with children with brain injury.

• Transactions of the Korean Society of Mechanical Engineers B
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• 제24권8호
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• pp.1029-1037
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• 2000

The present study investigates the local heat/mass transfer characteristics on a rotating disk which is the top disk covered with a shroud in HDD. The naphthalene sublimation technique is employed to determine the local heat/mass transfer coefficients on the rotating disk. Flow field measurements using Laser Doppler Anemometry (LDA) and numerical calculations are performed to analyze the flow patterns induced by the disk rotation. HDD has been developed for compactness and speedy data access, thus the rotating velocity of the disk is increased and the height of a hub is decreased. The experiments are conducted for the various hub heights of 5, 10 and 15 mm, for the rotating Reynolds numbers of $5.5{\times}10^4$ to $1.1{\times}10^5$ and for the effects of the presence of a read/write head arm. The results show that the heat transfer on the rotating disk is enhanced considerably for the decrease of the hub height and for the increase of the rotating Reynolds number. The head arm inserted in the cavity decreases the heat transfer despite the enhancement of tangential RMS velocity because of the deficit of the momentum in the flow field.