• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3831-3836
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• 2013

Background: S100A14 has recently been implicated in the progress of several types of cancers. This study aimed to investigate the clinical significance and possible mechanisms of action of S100A14 in the invasion and metastasis of hepatocellular carcinoma (HCC). Methods: S100A14 expression in HCC was detected at mRNA and protein levels and its prognostic significance was assessed. Functional roles of S100A14 in HCC were investigated using MTT, BrdU, wound healing, transwell invasion assay and HCC metastatic mouse model. Results: S100A14 was significantly elevated in HCC tissues, correlated with multiple tumor nodes, high Edmondson-Steiner grade and vascular invasion. Multivariate Cox analysis showed that the S100A14 expression level was a significant and independent prognostic factor for overall survival (OS) of HCC patients (hazard ratio=1.98, 95% confidence interval=1.14-3.46, P=0.013). S100A14 promoted cell proliferation, invasion and metastasis of HCC in vitro and in vivo. Conclusion: These results suggest S100A14 is a novel prognostic marker and therapeutic target for HCC.

• 한국방재학회:학술대회논문집
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• 2007.02a
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• pp.195-198
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• 2007

The type, the length, and the install space of the grate inlets in main street were designed with the consideration of discharge calculated with street surface rainfall. However, the discharge that was not intercepted at transverse grate inlets in steep local roads increases inundation areas around main street Therefore, it is necessary to analyze the flow characteristics and interception capacity at transverse grate inlets in steep local roads. Hydraulic experimental apparatus which can be changed the longitudinal slopes($2{\sim}10%$) of street, the size ($20{\sim}50cm$) and the types(TYPE I, II) of grate inlet was installed for this study. The range of the experimental discharges were from $2{\ell}/sec$ to $24{\ell}/sec$. The interception discharges of transverse grate inlets per unit width changing the longitudinal slope of steep local road were calculated by the hydraulic experimental results. The design method of transverse grate inlets was developed by the interception discharges per unit width. This design method was applied to decide the space and size of transverse grate inlets.

• Journal of the Korean Society of School Health
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• v.26 no.2
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• pp.104-113
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• 2013

Purpose: The aim of this study was to investigate prevalence and ecological characteristics of excessive television viewing among elementary school students in Seoul. Methods: Secondary data, representative sample of 11,082 subjects in Seoul was used. After prevalence of the excessive television viewing was identified by using factor analysis, 6 main factors explaining the ecological indicators was founded. After identifying prevalence of the excessive television viewing, by using factor analysis, we found 6 main factors explaining the ecological indicators. After categorizing factors into socio-psychological and lifestyle characteristics, we were investigated the odds ratio of excessive television viewing per characteristics by using multiple logistic regression. Results: The prevalence of excessive television viewing was 29.7% among the elementary school student in Seoul. The prevalence were higher in male, higher grade, and non-South of the Han River. Socio-psychological indicators which expressed excessive television viewing were annoying or bullying, scolding from teacher, depressed mode, thought for a runaway from home, an experience of diet, and negative body image. Life style indicators were a lower intake of fruit and vegetables, a higher intake of Ramyun and soft drink, a worse life style of hand washing, and wearing safety equipment. Conclusion: Lifestyle of television viewing was the comprehensive results from family, school, and society rather than a personal preference. Therefore, it is necessary to educate the hazard of excessive television viewing, to reenforce the students' health competence, to activate a safe leisure program as an alternate of television viewing, and to develop a recommendation.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.25-28
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• 2014

Background: This study analyzed whether socio-economic factors affect the cause specific survival of soft tissue sarcoma (STS). Methods: Surveillance, Epidemiology and End Results (SEER) soft tissue sarcoma (STS) data were used to identify potential socio-economic disparities in outcome. Time to cause specific death was computed with Kaplan-Meier analysis. Kolmogorov-Smirnov tests and Cox proportional hazard analysis were used for univariate and multivariate tests, respectively. The areas under the receiver operating curve were computed for predictors for comparison. Results: There were 42,016 patients diagnosed STS from 1973 to 2009. The mean follow up time (S.D.) was 66.6 (81.3) months. Stage, site, grade were significant predictors by univariate tests. Race and rural-urban residence were also important predictors of outcome. These five factors were all statistically significant with Cox analysis. Rural and African-American patients had a 3-4% disadvantage in cause specific survival. Conclusions: Socio-economic factors influence cause specific survival of soft tissue sarcoma. Ensuring access to cancer care may eliminate the outcome disparities.

• Proceedings of the KSRS Conference
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• 2004.10a
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• pp.314-317
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• 2004

The aim of this study was to evaluate the susceptibility from landslides in the Lai Chau region of Vietnam, using Geographic Information System (GIS) and remote sensing data, focusing on the relationship between tectonic fractures and landslides. Landslide locations were identified from an interpretation of aerial photographs and field surveys. Topographic and geological data and satellite images were collected, processed, and constructed into a spatial database using GIS data and image processing techniques, and a scheme of the tectonic fracturing of the crust in the Lai Chau region was established. In this scheme, Lai Chau was identified as a region with low crustal fractures, with the grade of tectonic fracture having a close relationship with landslide occurrence. The factors found to influence landslide occurrence were: topographic slope, topographic aspect, topographic curvature, distance from drainage, lithology, distance from a tectonic fracture and land cover. Landslide prone areas were analyzed and mapped using the landslide occurrence factors employing the probability-likelihood ratio method. The results of the analysis were verified using landslide location data, and these showed a satisfactory agreement between the hazard map and existing landslide location data.

• Journal of the Korean Society of Safety
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• v.32 no.5
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• pp.103-114
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• 2017

The landslide disaster damage has been increased by mountain development, leading to construction of educational facilities, medical facilities, petty industrial facilities, and large housing complexes. Therefore, effective regulation is required as an effort in urban planning solutions. For suggesting specific mitigation strategies on urban landslide, this study aims to define evaluation criteria for urban planning management of debris-flow disaster. AHP (Analytic Hierarchy Process), one of the multiple criterion decision making methods, was utilized in this study. This study makes use of 16 sub-criteria under the framework of hazard, exposure, and vulnerability, and well-planned expert survey measures their weights. The weights are also applied to evaluate each grid in urban space (min $10{\times}10m$) and classify it with red, orange, yellow, or green grade so that areas at higher risk are clearly identified. This study concludes that the suggested method is useful to support a strategies for urban planning management of debris-flow disaster, particularly in a GIS base.

• Wind and Structures
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• v.31 no.4
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• pp.335-350
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• 2020

In coastal residential communities, especially along the coastline, flooding is a frequent natural hazard that impacts the area. To reduce the adverse effects of flooding, it is recommended to elevate coastal buildings to a certain safe level. However, post storm damage assessment has revealed severe damages sustained by elevated buildings' components such as roofs, walls, and floors. By elevating a structure and creating air gap underneath the floor, the wind velocity increases and the aerodynamics change. This results in varying wind loading and pressure distribution that are different from their slab on grade counterparts. To fill the current knowledge gap, a large-scale aerodynamic wind testing was conducted at the Wall of Wind experimental facility to evaluate the wind pressure distribution over the surfaces of a low-rise gable roof single-story elevated house. The study considered three different stilt heights. This paper presents the observed changes in local and area averaged peak pressure coefficients for the building surfaces of the studied cases. The aerodynamics of the elevated structures are explained. Comparisons are done with ASCE 7-16 and AS/NZS 1170.2 wind loading standards. For the floor surface, the study suggests a wind pressure zoning and pressure coefficients for each stilt height.

• Nuclear Engineering and Technology
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• v.56 no.4
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• pp.1385-1397
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• 2024

Bentonite is a recommended material for the multiple barriers in the final disposal of low-level radioactive waste (LLW) to prevent groundwater intrusion and nuclear species migration. However, after drying-wetting cycling during the repository construction stage and ion exchange with the concrete barrier in the long-term repository, the bentonite mechanical behaviors, including swelling capacity and hydraulic conductivity, would be further influenced by the groundwater intrusion, resulting in radioactive leakage. To comprehensively examine the factors on the mechanical characteristics of bentonite, this study presented scenarios involving MX-80 and KV-1 bentonites subjected to drying-wetting cycling and accelerated ion migration. The experiments subsequently measured free swelling, swelling pressure, and hydraulic conductivity of bentonites with intrusions of seawater, high pH, and low pH solutions. The results indicated that the solutions caused a reduction in swelling volume and pressure, and an increase in hydraulic conductivity. Specifically, the swelling capability of bentonite with drying-wetting cycling in the seawater decreased significantly by 60%, while hydraulic conductivity increased by more than three times. Therefore, the study suggested minimizing drying-wetting cycling and preventing seawater intrusion, ensuring a long service life of the multiple barriers in the LLW repository.

• Journal of the Society of Disaster Information
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• v.17 no.4
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• pp.694-709
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• 2021

Purpose: In this study, earthquake-induced landslide risk assessment was conducted to provide basic data for efficient and preemptive damage prevention by selecting the erosion control work before the earthquake and the prediction and restoration priorities of the damaged area after the earthquake. Method: The study analyzed the previous studies abroad to examine the evaluation methodology and to derive the evaluation factors, and examine the utilization of the landslide hazard map currently used in Korea. In addition, the earthquake-induced landslide hazard map was also established on a pilot basis based on the fault zone and epicenter of Pohang using seismic attenuation. Result: The earthquake-induced landslide risk assessment study showed that China ranked 44%, Italy 16%, the U.S. 15%, Japan 10%, and Taiwan 8%. As for the evaluation method, the statistical model was the most common at 59%, and the physical model was found at 23%. The factors frequently used in the statistical model were altitude, distance from the fault, gradient, slope aspect, country rock, and topographic curvature. Since Korea's landslide hazard map reflects topography, geology, and forest floor conditions, it has been shown that it is reasonable to evaluate the risk of earthquake-induced landslides using it. As a result of evaluating the risk of landslides based on the fault zone and epicenter in the Pohang area, the risk grade was changed to reflect the impact of the earthquake. Conclusion: It is effective to use the landslide hazard map to evaluate the risk of earthquake-induced landslides at the regional scale. The risk map based on the fault zone is effective when used in the selection of a target site for preventive erosion control work to prevent damage from earthquake-induced landslides. In addition, the risk map based on the epicenter can be used for efficient follow-up management in order to prioritize damage prevention measures, such as to investigate the current status of landslide damage after an earthquake, or to restore the damaged area.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5177-5182
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• 2012

Purpose: To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitormonotherapy (EFGR-TKIs: gefitinib or erlotinib) with standard second-line chemotherapy (single agent docetaxel or pemetrexed) in previously treated advanced non-small-cell lung cancer (NSCLC). Methods: We systematically searched for randomized clinical trials that compared EGFR-TKI monotherapy with standard second-line chemotherapy in previously treated advanced NSCLC. The end points were overall survival (OS), progression-free survival (PFS), overall response rate (ORR), 1-year survival rate (1-year SR) and grade 3 or 4 toxicities. The pooled hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: Eight randomized controlled trials (totally 3218 patients) were eligible. Our meta-analysis results showed that EGFR-TKIs were comparable to standard second-line chemotherapy for advanced NSCLC in terms of overall survival (HR 1.00, 95%CI 0.92-1.10; p=0.943), progression-free survival (HR 0.90, 95%CI 0.75-1.08, P=0.258) and 1-year-survival rate (RR 0.97, 95%CI 0.87-1.08, P=0.619), and the overall response rate was higher in patients who receiving EGFR-TKIs(RR 1.50, 95%CI 1.22-1.83, P=0.000). Sub-group analysis demonstrated that EGFR-TKI monotherapy significantly improved PFS (HR 0.73, 95%CI: 0.55-0.97, p=0.03) and ORR (RR 1.96, 95%CI: 1.46-2.63, p=0.000) in East Asian patients, but it did not translate into increase in OS and 1-year SR. Furthermore, there were fewer incidences of grade 3 or 4 neutropenia, febrile neutropenia and neutrotoxicity in EGFR-TKI monotherapy group, excluding grade 3 or 4 rash. Conclusion: Both interventions had comparable efficacy as second-line treatments for patients with advanced NSCLC, and EGFR-TKI monotherapy was associated with less toxicity and better tolerability. Moreover, our data also demonstrated that EGFR-TKImonotherapy tended to be more effective in East Asian patients in terms of PFS and ORR compared with standard second-line chemotherapy. These results should help inform decisions about patient management and design of future trials.