• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7835-7838
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• 2014

Background: Neuroendocrine tumors have widespread and different clinical presentations and prognoses. This study was conducted to assess their survival time and prognostic factors in Iran. Materials and Methods: In a retrospective cohort study, 189 patients diagnosed of having neuroendocrine carcinoma were chosen. The tumor and clinical characteristics of the patients were modeled with a Cox proportional hazard approach. Survival was assessed using Kaplan-Meyer curves. Results: Crude median survival time was 30 months. Women survived longer than men (the median survival time for women was 40 and for men was 24 months). Age (<60 vs >60 years old with hazard ratio (HR) of 2.43, 95% CI 1.3-4.5), primary pathology report (carcinoid vs. others with HR 5.85 cm, 95% CI 2.4-14.3), tumor size cm (for 5-10, HR of 3.1, 95% CI 1.6 and for >10 HR of 8.2, 95% with 95% CI 3.1-21.9), and chemotherapy with single drug (taking vs. not taking with a HR 2.2, 95% CI 1.1-4.8) had significant effects on overall survival of patients. Conclusions: Survival time in patients with neuroendocrine carcinomas is related to demographics, clinical characteristics, tumor histology, and subtype specific treatment.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.6 s.40
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• pp.31-43
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• 2004

Seismic risk assessment of bridge is presented using fragility curves which represent the probability of damage of a structure virsus the peak ground acceleration. In theseismic fragility analysis, the structural damage is defined using the rotational ductility at the base of the bridge pier, which is obtained through nonlinear dynamic analysis for various input earthquakes. For the assessment of seismic risk of bridge, peak ground accelerations are obatined for various return periods from the seismic hazard map of Korea, which enables to calculate the probability density function of peak ground acceleration. Combining the probability density function of peak ground acceleration and the seismic fragility analysis, seismic risk assessment is performed. In this study, seismic fragility analysis is developed as a function of not the surface motion which the bridge actually suffers, but the rock outcrop motion which the aseismic design code is defined on, so that further analysis for the seismic hazard assessment may become available. Besides, the effects of the friction pot bearings and the friction pendulum bearings on the seismic fragility and risk analysis are examined. Lastly, three regions in Korea are considered and compared in the seismic risk assessment.

• Journal of the Korean Society of Hazard Mitigation
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• v.6 no.2 s.21
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• pp.25-35
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• 2006

Recently seismic fragility analysis method has been widely used for the seismic probabilistic risk assessment of infrastructures such as nuclear power plants, buildings and bridges because of its probabilistic characteristics. Furthermore, this technique has been applied to large-scale social systems consisted of each infrastructures by combing GIS. In this paper, the applicability of this technique to domestic infrastructural systems was studied. The transportation network was selected as one of these domestic infrastructural systems. Example studies were peformed about Changwon city. Nonlinear time history analysis, with a maximal likelihood approach were conducted to establish the fragility curves of each infrastrucures (bridges). GIS analysis was also applied to the analysis of whole infrastructural systems. The results show that it is very useful to predict seismic probabilistic risk assessment of this domestic transportation network. However, it also shows that further studies such as more suitable damage criterion to domestic structure and precise nonlinear analysis techniques should be developed to predict more precise results.

• Earthquakes and Structures
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• v.11 no.3
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• pp.517-538
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• 2016

This paper presents a probabilistic fragility analysis for two groups of bridges: simply supported and integral bridges. Comparisons are based on the seismic fragility of the bridges subjected to accelerograms of two seismic sources. Three-dimensional finite-element models of the bridges were created for each set of bridge samples, considering the nonlinear behaviour of critical bridge components. When the seismic hazard in the site is controlled by a few seismic sources, it is important to quantify separately the contribution of each fault to the structure vulnerability. In this study, seismic records come from earthquakes that originated in strike-slip and reverse faulting mechanisms. The influence of the earthquake mechanism on the seismic vulnerability of the bridges was analysed by considering the displacement ductility of the piers. An in-depth parametric study was conducted to evaluate the sensitivity of the bridges' seismic responses to variations of structural parameters. The analysis showed that uncertainties related to the presence of lap splices in columns and superstructure type in terms of integral or simply supported spans should be considered in the fragility analysis of the bridge system. Finally, the fragility curves determine the conditional probabilities that a specific structural demand will reach or exceed the structural capacity by considering peak ground acceleration (PGA) and acceleration spectrum intensity (ASI). The results also show that the simply supported bridges perform consistently better from a seismic perspective than integral bridges and focal mechanism of the earthquakes plays an important role in the seismic fragility analysis of highway bridges.

• Earthquakes and Structures
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• v.22 no.1
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• pp.25-38
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• 2022

The RC private constructions represent a large part of the housing stock in the north part of Algeria. For various reasons, they are mostly built without any seismic considerations and their seismic vulnerability remains unknown for different levels of seismic intensity possible in the region. To support future seismic risk mitigation efforts in northern Algeria, this document assesses the seismic vulnerability of typical private RC constructions built after the Boumerdes earthquake (May 21, 2003) without considering existing seismic regulation, through the development of analytical fragility curves. The fragility curves are developed for four representative RC frames in terms of slight, moderate, extensive, and complete damage states suggested in HAZUS-MH 2.1, using nonlinear time history analyses. The numerical simulation of the nonlinear seismic response of the structures is performed using the SeismoStruct software. An original intensity measure (IM) is proposed and used in this study. It is the zone acceleration coefficient "A", through which the seismic hazard level is represented in the Algerian Seismic Regulations. The efficiency, practicality, and proficiency of the choice of IM are demonstrated. Incremental dynamic analyses are conducted under fifteen ground motion accelerograms compatible with the elastic target spectrum of the Algerian Seismic Regulations. In order to cover all the seismic zones of northern Algeria, the accelerograms are scaled from 0.1 to 2.5 in increments of 0.1. The results mainly indicate that private constructions built after the Boumerdes earthquake in the moderate and high seismic zones with four (04) or more storeys are highly vulnerable.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.04a
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• pp.97-104
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• 2000

Evaluating a Review-Level Ground Motion is a key to efficiently perform Seismic Margin Assessment of nuclear power plants whose purpose is to determine a ground motion level for which a plant has high-confidence-of-a-low-probability of seismic-induced core damage and to identify any weaker-link components. In this study a method to obtain RLGMs is reviewed which is recommended by Electric Power Research Institute and implemented to be applied to Limerick site in eastern and central U. S as a case study. This method provides reasonable and site-specific RLGMs as minimum required plant HCLPF for SMA that meet a target mean seismic core-damage frequency based on seismic hazard results and generic values of uncertainty and randomness parameters of the core-damage fragility curves. In addition high-frequency RLGM is justifiably modified to reflect the increased seismic capacity of high-frequency components and spatial variation and incoherence of input ground motion on a basemat of large structures by establishing a method to obtain high0-frequency reduction factors according to EPRI guidelines.

• Communications for Statistical Applications and Methods
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• v.23 no.5
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• pp.363-383
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• 2016

The Weibull family of lifetime distributions play a fundamental role in reliability engineering and life testing problems. This paper investigates the potential usefulness of transmuted new generalized Weibull (TNGW) distribution for modeling lifetime data. This distribution is an important competitive model that contains twenty-three lifetime distributions as special cases. We can obtain the TNGW distribution using the quadratic rank transmutation map (QRTM) technique. We derive the analytical shapes of the density and hazard functions for graphical illustrations. In addition, we explore some mathematical properties of the TNGW model including expressions for the quantile function, moments, entropies, mean deviation, Bonferroni and Lorenz curves and the moments of order statistics. The method of maximum likelihood is used to estimate the model parameters. Finally the applicability of the TNGW model is presented using nicotine in cigarettes data for illustration.

• Journal of Ocean Engineering and Technology
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• v.24 no.5
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• pp.48-54
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• 2010

The analysis of the seismic risk of an offshore structure with a control device is presented. First, a probability density function was developed to represent seismic hazard, and seismic fragility under artificial earthquake conditions was determined. Fragility curves for an offshore structure with both passive and active control devices were determined. Displacement criteria were set to evaluate the performance of the structure. Based on numerical analysis, the seismic risk to the structure was considerably reduced when the structure had a seismic control device. The seismic risk to the actively controlled structure was decreased by 80% compared to the uncontrolled case. Reasonable performance evaluations of offshore structure with control devices can be conducted through risk analysis.

• Environmental Analysis Health and Toxicology
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• v.16 no.4
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• pp.205-209
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• 2001

Lemna gibba was newly cultured and provided for toxicity tests. In this study, the chromate toxicity tests for Lemna gibba were performed according to the OECD Lemna growth inhibition test guideline. The test species was Lemna gibba, and the tests were repeated 5 times. To evaluate the toxicity test results, the average specific growth rate, EC50, 95％ confidential limit, and variances were calculated. The test performance was analyzed by the doubling time and test statistics. The average values of EC50 data determined by logistic and linear interpolation curves were 25.9 ppm and 35.4 ppm respectively (by chromate concentration). The doubling time of all controls were below 2.5 day, so all tests passed the criteria for the test performance. This study introduced a new test method, Lemna growth inhibition test, which is provided for the hazard assessment of aquatic environment.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.159-163
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• 2013

Background: This study used Surveillance, Epidemiology and End Results (SEER) pancreatic cancer data to identify predictive models and potential socio-economic disparities in pancreatic cancer outcome. Materials and Methods: For risk modeling, Kaplan Meier method was used for cause specific survival analysis. The Kolmogorov-Smirnov's test was used to compare survival curves. The Cox proportional hazard method was applied for multivariate analysis. The area under the ROC curve was computed for predictors of absolute risk of death, optimized to improve efficiency. Results: This study included 58,747 patients. The mean follow up time (S.D.) was 7.6 (10.6) months. SEER stage and grade were strongly predictive univariates. Sex, race, and three socio-economic factors (county level family income, rural-urban residence status, and county level education attainment) were independent multivariate predictors. Racial and socio-economic factors were associated with about 2% difference in absolute cause specific survival. Conclusions: This study s found significant effects of socio-economic factors on pancreas cancer outcome. These data may generate hypotheses for trials to eliminate these outcome disparities.