• 대한수학회보
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• 제52권1호
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• pp.57-68
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• 2015

In this paper, we give a non-existence theorem of Hopf hypersurfaces in complex two-plane Grassmannians $G_2(\mathbb{C}^{m+2})$, $m{\geq}3$, whose shape operator is of Codazzi type in generalized Tanaka-Webster connection $\hat{\nabla}^{(k)}$.

• 대한의생명과학회지
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• 제19권3호
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• pp.266-269
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• 2013

Hox genes encode transcription factors important for anterior-posterior body patterning at early stages of embryonic development. However, the precise mechanisms by which signal pathways are stimulated to regulate Hox gene expression are not clear. In the previous study, protein kinase B alpha (Akt1) has been identified as a putative upstream regulator of Hox genes, and Akt1 has shown to regulate Gcn5, a prototypical histone acetyltransferase (HAT), in a negative way in mouse embryonic fibroblast (MEF) cells. Since the activity of HAT such as the CBP/p300, and PCAF (a Gcn5 homolog), was down-regulated by Akt through a phosphorylation at the Akt consensus substrate motif (RXRXXS/T), the amino acid sequence of Gcn5 protein was analyzed. Mouse Gcn5 contains an Akt consensus substrate motif as RQRSQS sequence while human Gcn5 does not have it. In order to see whether Akt1 directly binds to Gcn5, immunoprecipitation with anti-Akt1 antibody was carried out in wild-type (WT) mouse embryonic fibroblast (MEF) cells, and then western blot analysis was performed with anti-Akt1 and anti-Gcn5 antibodies. Gcn5 protein was detected in the Akt1 immunoprecipitated samples of MEFs. This result demonstrates that Akt1 directly binds to Gcn5, which might have contributed the down regulation of the 5' Hoxc gene expressions in wild type MEF cells.

• Journal of Advanced Marine Engineering and Technology
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• 제27권1호
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• pp.76-81
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• 2003

The purpose of this study is to analyze the collapse characteristics of widely used spot welded section members coated damping material Y1000 and to develop an analysis method for acquiring exact collapse loads and energy absorption ratio. Hat-shaped thin-walled members have the biggest energy absorbing capacity in a front-end collision. The sections were tested on quasi-static and impact loads. Specimens with two type thickness, width ratio and spot weld pitch on the flange have been tested in impact velocities(6.73n0sec and 7.54n1sec) which imitate a real-life car collision. As a result, it was developed the system for acquiring impact energy absorbing characteristics of structure united thin-walled member and damping materials.

• Nuclear Engineering and Technology
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• 제29권6호
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• pp.476-487
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• 1997

To resolve several arguments raised for the current analysis of a structure like top hat, which is composed of flange, cylinder and plate, the dynamic response analysis is performed for the full and half models. The dynamic characteristics are investigated for full and half models and the results are compared between them. The responses such as bolt reactions and stresses due to random loading are also obtained using the analysis capabilities between commercial programs which have the routine for the random vibration analysis. Several general purpose structural analysis programs are used to get the response due to the random loadings. Also the application of the random loading and the effect of correlations such as fully correlated, partially correlated and fully uncorrelated cases are studied and the general directions for the generation of design loads due to random loading are suggested.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1996년도 춘계학술발표회논문집(4)
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• pp.223-228
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• 1996

To resolve several arguments raised for the current analysis of a structure like top hat, which is composed of flange, cylinder and plate, the dynamic response analysis is performed for the full and half models. The dynamic characteristics are investigated for full and half models and the results are compared between them. The responses such as bolt reactions and stresses due to random loading are also obtained using the analysis capabilities between commercial programs which have the routine for the random vibration analysis. Several general purpose structural analysis programs are used to get the response due to the random loadings. Also the application of the random loading and the effect of correlations are studied and the general directions for the generation of design load due to random loading are suggested.

• 소성∙가공
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• 제25권1호
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• pp.21-28
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• 2016

In the current study, reduction of springback is quantified and the reasons for the reduction are investigated. The testing involved a digital servo motion applied to a U-draw bending to produce a hat-type product from high strength steels such as DP780 and DP980. The change in springback is compared between the constant speed motion and three kinds of servocontrolled motions during forming experiments. In order to predict the springback for the servo-controlled tool motion, a finite element method was utilized for the springback analysis considering a kinematic hardening model for the steel. The comparison of springback between the analysis and the experiments shows that they have similar tendencies. Also, the analysis results indicate that the springback reduction is greatly influenced by a decrease in the friction coefficient, which originates from the contact and detach phenomena between the tooling and the blank during the up-and-down motion of the upper die following the servo-controlled motion.

• 한국기계가공학회지
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• 제14권4호
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• pp.118-125
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• 2015

The roll-forming process is a highly productive incremental forming process and is suitable for manufacturing thin, high-strength steel products. Recently, this process has been considered one of the most productive processes in manufacturing high-strength steel automotive structural parts. However, it is very difficult to develop the roll-forming process when the cross-sectional shape of the product changes in the longitudinal direction. In this study, a roll-forming process for manufacturing high-strength steel automotive parts with a linearly variable symmetric hat-type cross-section was developed. The forming rolls were designed by the 3D CAD system, CATIA. Additionally, the designed forming rolls were modified by the simulation through the 3D elastic-plastic finite element analysis software, MARC. The results of the finite element analysis show that the final roll-forming roll can successfully produce the desired high-strength steel automotive part with a variable cross-section.

• 한국의류산업학회지
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• 제17권3호
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• pp.364-371
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• 2015

This study investigated and analyzed Sadanggut for General Namyi, Agisee Gutdang in Haengdang-dong, Dodanggut in Bonghwa Mountainto examine the type and characteristics of official hats for shaman's costumes based on Seoul village gutas a spiritualistic shaman revealing the divinity of music for gutthrough singing, dancing, divine material and official hats. Commonly worn official hats were Goggal(conical hats), Jeonlip(soldier's felt hats), and Heuklip(black hats) for Seoul village gut as the object of thisstudy. Each official hat had a close relationship with subjects for divinity and musical meaning for gut. Julip(Red hats), Jokduri(bride's headpiece), helmets, Iksubgwan(King's official hat), and Daesu(Queen's a big wig with various hairpins) were also worn. Official hats worn for Seoul village gutwere understood to symbolize divinity and raise authority and dignity to the public through aggressive appearance, exaggeration and splendor. Concretely, official hats at Seoul village gut first had roles to materialize the divinity of each music of gut. Second, recognized as a part of performance or traditional culture in present day, aggressive official hats were favored to supply splendid attraction and maximize scenes of divined heroic epic poem in gut. Third, for Seoul village gut, colors and silhouettes of modern traditional costumes were reflected pursuing partial change and focused on exaggeration and splendor to express the mirth and festival of gutwhile maintaining traditional costumes.

• Structural Engineering and Mechanics
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• 제54권6호
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• pp.1135-1152
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• 2015

Most of current bridge decks are made of reinforced concrete and often deteriorate at a relatively rapid rate in operational environments. The quick deterioration of the deck often impacts other critical components of the bridge. Another disadvantage of the concrete deck is its high weight in long-span bridges. Therefore, it is essential to examine new materials and innovative designs using hybrid system consisting conventional materials such as concrete and steel with FRP plates which is also known as composite deck. Since these decks are relatively new, so it would be useful to evaluate their performances in more details. The present study is dedicated to Hat-Shape composite girder with concrete slab. The structural performance of girder was evaluated with nonlinear finite element method by using ABAQUS and numerical results have been compared with experimental results of other researches. After ensuring the validity of numerical modeling of composite deck, parametric studies have been conducted; such as investigating the effects of constituent properties by changing the compressive strength of concrete slab and Elasticity modulus of GFRP materials. The efficacy of the GFRP box girders has been studied by changing GFRP material to steel and aluminum. In addition, the effect of Cross-Sectional Configuration has been evaluated. It was found that the behavior of this type of composite girders can be studied with numerical methods without carrying out costly experiments. The material properties can be modified to improve ultimate load capacity of the composite girder. strength-to-weight ratio of the girder increased by changing the GFRP material to aluminum and ultimate load capacity enhanced by deformation of composite girder cross-section.

• Biomolecules & Therapeutics
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• 제32권2호
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• pp.214-223
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• 2024

Metabolic abnormalities in the liver are closely associated with diverse metabolic diseases such as non-alcoholic fatty liver disease, type 2 diabetes, and obesity. The aim of this study was to evaluate the ameliorating effect of robinetin (RBN) on the significant pathogenic features of metabolic failure in the liver and to identify the underlying molecular mechanism. RBN significantly decreased triglyceride (TG) accumulation by downregulating lipogenesis-related transcription factors in AML-12 murine hepatocyte cell line. In addition, mice fed with Western diet (WD) containing 0.025% or 0.05% RBN showed reduced liver mass and lipid droplet size, as well as improved plasma insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) values. CD38 was identified as a target of RBN using the BioAssay database, and its expression was increased in OPA-treated AML-12 cells and liver tissues of WD-fed mice. Furthermore, RBN elicited these effects through its anti-histone acetyltransferase (HAT) activity. Computational simulation revealed that RBN can dock into the HAT domain pocket of p300, a histone acetyltransferase, which leads to the abrogation of its catalytic activity. Additionally, knock-down of p300 using siRNA reduced CD38 expression. The chromatin immunoprecipitation (ChIP) assay showed that p300 occupancy on the promoter region of CD38 was significantly decreased, and H3K9 acetylation levels were diminished in lipid-accumulated AML-12 cells treated with RBN. RBN improves the pathogenic features of metabolic failure by suppressing the p300-CD38 axis through its anti-HAT activity, which suggests that RBN can be used as a new phytoceutical candidate for preventing or improving this condition.