• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.226.3-227
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• 2003

Lactic acid bacteria have been considered as the most beneficial probiotic organisms contributing to inhibition of harmful and putrefactive intestinal bacteria. Among them, Bifidobacterium spp. has been considered as one of the most beneficial probiotic organism that can improve the health of humans, since it is one of the major bacteria flora in human intestine. However, the harmful enzyme-inhibitory activity of lactic acid bacteria of Kimchi, which is a representative Korean fermented food has not been evaluated. (omitted)

• 한국식품조리과학회:학술대회논문집
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• 한국식품조리과학회 2003년도 추계학술대회 및 사단법인 창립총회
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• pp.75-75
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• 2003

The objective of this study is to investigate the effect of Codonopsis lanceolata Bentk et Hook on the growth of lactic acid bacteria and some harmful bacteria. Extract of C. lanceolata was obtained by hydrothermal extraction method and used intactly without concentration. To investigate the inhibitory effect on the growth of harmful bacteria, we used agar dilution method. On agar plate containing more than 25% extract, they showed decreased number of colonies. (omitted)

• 미생물학회지
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• 제51권1호
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• pp.61-67
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• 2015

최근 우리나라는 서구화된 식생활과 생활양식의 변화로 다양한 대사성 질환과 만성 질환이 나타나고 있다. 이러한 질환들은 지속적으로 약물을 복용해야 한다. 또한 많은 사람들이 건강한 삶을 유지하기 위해 건강기능식품과 각종 비타민, 영양제를 복용한다. 하지만 복용하는 약물들이 장내 세균에는 어떠한 영향을 주는 지에 대한 연구는 많이 이뤄지지 않고 있다. 이에 본 연구에서는 흔하게 사용되며 장기간 복용하는 약이 항균활성시험으로 위장 관련 박테리아에 영향을 미치는 지를 조사하였다. 그 결과 비타민 및 미네랄, 중추신경계에 작용하는 약들이 장내 세균과 유산균에 대해 항균력을 나타냈으며, 그 중 중추신경계에 작용하는 약 중 항현훈제의 dexibuprofen는 장내 유익균 인 Lactobacillus casei과 Lactobacillus rhamnosus와 장내 유해균 인 Staphylococcus aureus에 대해 항균력이 높게 작용하였다. 또한 심혈관계, 조혈기계에 작용하는 약 중 항이뇨제 의 fenofibric acid는 장내 유익균인 Lactobacillus casei에 대해 항균력이 나타났다. 비타민 및 미네랄은 대부분의 장내 균에서 항균력을 보이지만, 특히 Vitamin B-Complex/with C와 vitamin C가 유익균인 Bifidobacterium infantis과 장내 유해균 인 Escherichia coli, Enterobacter aerogenes, Shigella flexneri, Salmonella Typhimurium, Staphylococcus aureus에서 높게 나타났다. 따라서 본 연구결과 장내 유해균과 유익균에 다양하게 복용되는 약들이 대체적으로 항균활성을 보이는 것으로 판단된다.

• Archives of Pharmacal Research
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• 제21권1호
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• pp.54-61
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• 1998

Five hundreds of bifidobacteria were isolated from a healthy Korean and the inhibitory effects of these isloated bacteria on harmful enzymes of human intestinal microflora were examined by cocultivation of the isolated bifidobacteria with E. coli or total human intestinal microflora. In comparison with the results of E. coli or intestinal microflora cultivation, Bifidobacterium breve K-110, B. breve K-111 and B. infantis K-525 effectively inhibited harmful enzymes ($\beta$-glucuronidase and tryptophanase) of E. coli and lowered the pH of the culture media. Also they inhibited the harmful enzymes ($\beta$-glucosidase, $\beta$-glucuronidase, tryptophanase and urease) and ammonia production of intestinal microflora, and lowered pH of the culture media by increasing lactic acid bacteria of intestinal microflora. When these isolated bifidobacteria were administered on mice, fecal harmful enzymes were also inhibited. Among tested bifidobacteria, B. breve K-110 had the highest inhibitory effect of fecal harmful enzymes.

• 한국축산식품학회:학술대회논문집
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• 한국축산식품학회 1998년도 추계학술발표회
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• pp.41-57
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• 1998

Five hundreds of bifidobacteria were isolated from an healthy Korean and the inhibitory effects of these isolated bacteria on harmful enzymes of human intestinal microflora were examined by cocultivation of the isolated bifidobacteria with E. coli HGU-3 or total human intestinal microflora. In comparison with the results of E. coli or intestinal microflora cultivation, Bifidobacterium breave K-110, B. breve K-111 and B. infantis K-525 effectively inhibited harmful enzymes (${\beta}-glucuronidase$ and tryptophanase) of E. coli and lowered the pH of the culture media. Also they inhibited the harmful enzymes (${\beta}-glucosidase$, ${\beta}-glucuronidase$, tryptophanase and urease) and ammonia production of intestinal microflora, and lowered pH of the culture media by increasing the number of bifidobateria on intestinal microflora. The inhibitory effect of bifidobacteria on Growth of Helicobacter pylori and Rotavirus infection were exammed. Bifidobacterium K-110 and K-111 inhibited effectively them. When these isolated bifidobacteria were administered to mice, the activities of fecal harmful enzymes were inhibited and the AC and ACF formation were suppressed. Among tested bifidobacteria, B. breve K-110 had high inhibitory effect of fecal harmful enzymes and ACF formation.

• 한국유기농업학회지
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• 제31권4호
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• pp.381-394
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• 2023

This study was conducted to monitor the antibiotics resistance of human-harmful bacteria isolated in the agricultural environment for hot peppers (Capsicum annuum) and tomato (Lycopersicon esculentum). As a result, we isolated 120 bacterial species (34 on fruits, 48 in soil, 21 in water, and 17 in manure), identified them with the 16S rRNA sequence, analyzed minimum inhibitory concentration (MIC) for 26 antibiotics using Sensititre ARIS Hi-Q system and then evaluated whether each bacterial genus acquired resistance for the tested antibiotics or not, according to the CLSI criteria. From difference in MIC between eco-friendly (EFM) and practical (PFM) cultivation farms, Klebsiella spp. isolated from EFM was resistant to ampicillin (AMP) and nalidixic acid (NAL), and that isolated from PFM was resistant to streptomycin (STR) and tetracycline (TET). Enterobacter spp. isolated from EFM was resistant to AMP and azithromycin (AZI), and that isolated from PFM was resistant to AMP, AZI, and STR. Meanwhile, Pseudomonas spp. isolated from EFM and PFM were all resistant to AMP, AZI, cefotaxime (FOT), cefoxitin (FOX), ceftriaxone (AXO), CHL, NAL, and STR. Staphylococcus spp. isolated from EFM and PFM were resistant to gentamycin (GEN), STR, and kanamycin (KAN), and in particular, that from EFM showed resistance for erythromycin (ERY). In conclusion, our study suggested that EFM lead STR antibiotics resistance for human-harmful bacteria to decrease, because only the bacteria isolated from hot pepper and tomato crop with PFM have showed resistance against STR antibiotics, regardless of bacterial genus.

• 미생물학회지
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• 제52권1호
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• pp.40-48
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• 2016

본 연구는 식물성플랑크톤의 대량증식 조절과 관련된 해양성 살조능이 있는 박테리아의 분리와 유해조류에 대한 분리 균주의 살조능 특성에 주로 초점을 맞추고 있다. 해수 표면에서 자연적으로 발생하는 유해조류번성(HAB)은 전세계적으로 많은 환경문제를 일으키고 있다. 본 연구에서는 유해조류 성장을 억제하는 능력을 가진 40개의 박테리아 균주를 마산만, 진해만, 돌섬, 거제도, 통영 앞바다에서 분리하였다. 분리된 균주들은 다양한 유해조류인 Cochlodinium polykrikoides, Chattonella marina, Skeletonema costatum, Heterosigma akashiwo, Heterocapsa triquetra, Prorocentrum minimum, Scrippsiella trochoidea에 대한 살조특성을 추가로 조사하였다. 살조균주의 선별은 이중층 아가배지와 현미경 계수법을 이용하여 진행하였고 Pseudomonas, Vibrio, Bacillus, Pseudoalteromonas, Ruegeria, Joostella, Marinomonas, Stakelama, Porphyrobacter, Albirhodobacter의 속들에 속하는 균주들이었다. 가장 중요한 유해조류인 Co. polykrikoides에 대한 가장 강력한 살조능은 10% 배양상등액으로 6시간 처리했을 때 94%를 보이는 균주였다. 이 연구를 통해 살조효과를 보이는 새로운 속으로 Marinomonas sp. M Jin 1-8, Stakelama sp. ZB Yeonmyeong 1-11 & 1-13, Porphyrobacter sp. M Yeonmyeong 2-22, Albirhodobacter sp. 6-R Jin 6-1를 새롭게 찾았다. 결론적으로 이들 해양박테리아를 이용하면 식물성플랑크톤 번성을 제어하는데 중요한 역할을 할 것으로 예상된다.

• 한국식품과학회지
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• 제33권1호
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• pp.142-145
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• 2001

The objective of this study was to evaluate the in vivo effect of Lentinus edodes on the harmful enzymes of mouse intestinal bacteria. When mouse intestinal microflora were cultured in the anaerobic media containing Lentinus edodes water extract or trehalose (LD) isolated From its extract, final pH of the cultured media was significantly decreased and the activities of harmful enzymes, particulary ${\beta}-glucuronidase$ and tryptophanase, were significantly inhibited. By orally administering Lentinus edodes water extract or LD, mouse fecal ${\beta}-glucuronidase$ and tryptophanase were also signifcantly inhibited.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
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• pp.737-740
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• 2000

Two groups of bacteria, harmful and useful bacteria, coexist in our body. Harmful bacteria and free radicals which cause many diseases and agings could be controlled by not synthetic materials but natural products. 50 kinds of natural products were searched for this purpose, some of them expressed bacterial controlling ability. Clostridium difficle was controlled by Paeonia Japonica and Lycii Fructus, etc., Clostridium perfringens was inhibited by Scutellaria Baicalensis and Astragali Radix, etc., and same way, Listeria monocytogenes; Paeonia Japonica and Scutellaria Baicalensis, E. coli; Scutellaria Baicalensis and Schizandrae Fructus, Staphylococcus aureus; Paeonla Japonica and Scutellaria Baicalensis, Streptococcus mutans; Coptis Rhizoma, respectively. These natural products will play an important role in bio-Industry.

• ALGAE
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• 제28권4호
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• pp.297-305
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• 2013

There is increasing interest in the relationships between marine bacteria and red tide organisms. Some bacteria are known to kill red tide organisms, and may be responsible for accelerating the termination of red tides. Thus, certain algicidal bacteria have been proposed for the control of red tides. Meanwhile, many red tide organisms are known to feed on marine bacteria. The roles of marine bacteria and red tide organisms are therefore reversible. In Korean waters, the killing of red tide organisms by algicidal bacteria, and also the feeding of red tide organisms on marine bacteria have been extensively investigated. The findings of such studies may influence the conventional view of red tide dynamics, and also planktonic food webs. Here, we review the species and concentrations of algicidal bacteria that kill red tide organisms in Korean waters, as well as the ingestion rate and grazing impact of red tide organisms on marine bacteria. Furthermore, we offer an insight into the ecological roles of these 2 components in marine planktonic food webs.