• Journal of the Korean Magnetic Resonance Society
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• v.22 no.4
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• pp.82-90
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• 2018

The term "hangover" refers to symptoms such as headache, heartburn, nausea, and dizziness caused by acetaldehyde created through alcohol decomposition in the body after alcohol intake. Many scientists have conducted research on diverse drugs, foods, and medicinal herbs aimed at eliminating hangovers. However, research on metabolism to objectively verify or measure their effects on hangover symptoms has been lacking. Accordingly, in this study, deep sea water minerals were administered orally at varying concentrations to rats that consumed alcohol, and changes in the levels of amino acids in their bodies were measured using nuclear magnetic resonance spectroscopy to gauge the minerals' effects on hangover symptoms. Thus far, biochemical research on hangover cures has been confined to basic research measuring changes in the levels of alcohol dehydrogenase and acetaldehyde dehydrogenase as well as in the concentrations of ethanol, acetaldehyde, and acetate using spectroscopes such as enzyme-linked immunosorbent assay kits or gas chromatography-mass spectrometers. In comparison, this study presents pharmacokinetic research that simultaneously tracked biomaterials including amino acids and organic acids, metabolites associated with hangover, to clarify hangover mechanisms more specifically. In addition, this study examined hangover mechanisms without an external supply of tracked materials not overlapping with alcohol metabolism-related materials, such as external amino acids and sugars.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.359-367
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• 2019

The purpose of this study was to investigate the effects of ingestion of rabies and ginseng fruit extracts on alcohol hangover, liver damage protection, fatigue recovery, and physical strength improvement. A total of 64 volunteers aged over 20 were participated in this study and the randomized and repeated measures design method was used to divide a group of participants with a random assignment. All participants were divided into 4 groups (n=16) treated with hoveni dulcis thunb extract + ginseng berry extract (ARI 1000), hoveni dulcis thunb extract, ginseng berry extract, and placebo. As a result of respiratory alcohol concentration change, the group treated with ARI 1000 was significantly lower than the group treated with hoveni dulcis thunb extract, ginseng berry extract, and placebo in 1 hour of drinking, and significantly lower than the placebo group in 2 hours and 3 hours of drinking (p<0.05). After 2 and 3 hours of alcohol consumption, blood alcohol concentration of the group treated with rabies ARI 1000 was significantly lower than those of the other 3 groups (p <0.05). In conclusion, ingestion of ARI 1000 before drinking may significantly reduce the respiratory and blood alcohol concentrations, which may induce an effect on the hangover effect.