• The Journal of Pediatrics of Korean Medicine
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• v.18 no.2
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• pp.225-232
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• 2004

Objectives : Hand-Foot-Mouth disease is a highly contagious disease most often seen in children. It is caused most commonly by the coxsackievirus A16 and clinically characterized by vesicles appearing on the hands, feet and in the mouth. The purpose of this study is a approach to the oriental medical treatment of Hand-Foot-Mouth disease. Method : We studied the clinical literatures of traditional chinese medicine about Hand-Foot-Mouth disease after the year 2000. Result : Hand-Foot-Mouth disease are similar to epidemic febrile disease(溫病) dampwarm syndrome(濕溫), and epidemic disease(時疫) in Oriental Medicine. Conclusion : In oriental medical treatment is classified into the treatment of internal use, external use, and combination treatment of chinese and western medicine.

• Journal of Sasang Constitutional Medicine
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• v.34 no.4
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• pp.81-88
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• 2022

Objectives The purpose of this case study is to report the improvement of hand foot and mouth disease after using Galgeunhaegi-tang Methods A Taeumin patient suffering from painful hand foot and mouth disease was treated with herb medicine Galgeunhaegi-tang, acupuncture and cupping therapy. Rhei radix et rhizoma was added or removed from herb medicine according to patient's stool condition. Severity of pain and general symptom was measured using Numerical Rating Scale(NRS), and the picture of patient's hand and foot was taken. Results & Conclusions After taking Galgeunhaegi-tang, symptoms including pain, rash, blisters, and general conditions improved as patient's stool condition improved from constipation to normal. In conclusion, this case report shows that Galgeunhaegi-tang can be effective to Taeumin hand foot and mouth disease patients.

• Journal of Environmental Health Sciences
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• v.43 no.5
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• pp.438-445
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• 2017

Objectives: The purpose of this study was to develop exposure factor data for the Korean child population, with a specific focus on behavior characteristics such as hand-to-mouth and object-to-mouth and an analysis of influential factors. Methods: We divided environments into two places, which were house/indoor and nursery. A total of 400 children (house/indoor) and a total of 162 children (nursery) were recruited from the cities of Seoul, Incheon, Daegu, and Gwangju. The children were divided into two groups. We conducted direct measurement by using one hour of videotaping alongside questionnaire surveys. This was performed to calculate behavior rates, such as how many children perform hand-to-mouth and object-to-mouth behaviors. Results: The respective average frequencies of hand-to-mouth and object-to-mouth were $0.8{\pm}2.23$ and $0.82{\pm}2.64contacts/hr$ for house/indoor. The respective average frequencies of hand-to-mouth and object-to-mouth were $2.87{\pm}4.63$ and $1.47{\pm}3.84contacts/hr$ in the nursery group. For the mouthing participants, the average frequencies of hand-to-mouth and object-to-mouth were 3.31 and 3.20 contacts/hr in house, and 4.80 and 3.26 in nursery. Compared to other countries such as the USA, the frequencies of hand-to-mouth and object-to-mouth behaviors found in this study were relatively lower. Conclusions: Children have the potential for exposure to toxic substances through non-dietary ingestion pathways by mouthing objects or their fingers. In this study, the mouthing frequency was relatively lower than that found in Western countries. This can be explained that mouthing behaviour may be affected by culture and lifestyle characteristics.

• Archives of Craniofacial Surgery
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• v.16 no.1
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• pp.29-30
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• 2015

In cleft palate surgery, the environment is especially critical when suturing. Encum-bered, obstructive space in the environment can hinder a suture while using the Dingman mouth gag. We introduced a novel but simple draping technique. A simple hand towel is placed over the gag. A hole is cut out in the middle according to each patient's mouth. After making the hole, the hand towel is soaked in water and gently squeezed. Then the towel is properly placed over the Dingman mouth gag. Dripping water on the hand towel during the suture helps keep it in place. Using this draping technique, we cut 14 minutes of operation time compared to the average operation time of the past 2 years. There were several disadvantages in previous draping method. First, long suture material may easily get caught. Second, the operation field can easily be contaminated. Third, focusing on the operation becomes difficult due to the obstruction. This draping technique can compensate for the disadvantages of the previous Dingman mouth gag.

• Journal of the Korea Society of Computer and Information
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• v.24 no.4
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• pp.57-63
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• 2019

In this paper, we propose a new framework to control VR(Virtual reality) contents in real time using user's mouth-wind and acceleration sensor of mobile device. In VR, user interaction technology is important, but various user interface methods is still lacking. Most of the interaction technologies are hand touch screen touch or motion recognition. We propose a new interface technology that can interact with VR contents in real time using user's mouth-wind method with acceleration sensor. The direction of the mouth-wind is determined using the angle and position between the user and the mobile device, and the control position is adjusted using the acceleration sensor of the mobile device. Noise included in the size of the mouth wind is refined using a simple average filter. In order to demonstrate the superiority of the proposed technology, we show the result of interacting with contents in game and simulation in real time by applying control position and mouth-wind external force to the game.

• Journal of the Korean Society of Physical Medicine
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• v.5 no.3
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• pp.467-476
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• 2010

Purpose : This study was performed to understand the relationship between hand and mouth shapes using functional magnetic resonance imaging(fMRI). Methods : Two healthy volunteers without any previous history of physical or neurological illness were recruited. fMRI was done that volunteers was 6 repeated of natural mouth, close mouth and open mouth while power grip and pinch grip movement. Results : Cerebral cortex activation was not well observed for the natural mouth during the power grip exercise. For the closed mouth, the temporal lobe, Broca's area, the prefrontal area related to thinking and judgment, the supplementary motor area, the auditory area and Wernicke's area were activated. For the open mouth, cortical activation was also observed in the temporal lobe, Wernicke's area, the prefrontal area related to thinking and the orbital frontal area related to visual sense. During the pinch grip exercise, cortical activation was observed for the natural mouth in the primary sensory area, Wernicke's area, the primary and supplementary motor area, and the prefrontal area. For the closed mouth, cortical activation was observed in the temporal lobe, Wernicke's area, the prefrontal area related to thinking, the secondary visual area, the primary sensory area and the supplementary motor area. In the case of the open mouth, cortical activation was observed in a few parts in the temporal lobe as well as Wernicke's area, the prefrontal area related to thinking, and other areas related to visual sense such as the primary visual area, the secondary visual area and the visual association area. Conclusion : Brain was more activation for close mouth and open mouth more than natural mouth movement.

• Journal of Microbiology and Biotechnology
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• v.30 no.1
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• pp.38-43
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• 2020

Hand, foot, and mouth disease (HFMD) is caused by enterovirus 71 (EV71) in infants and children under six years of age. HFMD is characterized by fever, mouth ulcers, and vesicular rashes on the palms and feet. EV71 also causes severe neurological manifestations, such as brainstem encephalitis and aseptic meningitis. Recently, frequent outbreaks of EV71 have occurred in the Asia-Pacific region, but currently, no effective antiviral drugs have been developed to treat the disease. In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the Salvia miltiorrhiza root and has been shown to be an effective treatment for subarachnoid hemorrhages and myocardial infarctions. HeLa cells were cultured in 12-well plates and treated with SalB (100 or 10 ㎍/ml) and 10⁶ PFU/ml of EV71. SalB treatment (100 ㎍/ml) significantly decreased the cleavage of the eukaryotic eIF4G1 protein and reduced the expression of the EV71 capsid protein VP1. In addition, SalB treatment showed a dramatic decrease in viral infection, measured by immunofluorescence staining. The Akt signaling pathway, a key component of cell survival and proliferation, was significantly increased in EV71-infected HeLa cells treated with 100 ㎍/ml SalB. RT-PCR results showed that the mRNA for anti-apoptotic protein Bcl-2 and the cell cycle regulator Cyclin-D1 were significantly increased by SalB treatment. These results indicate that SalB activates Akt/PKB signaling and inhibits apoptosis in infected HeLa cells. Taken together, these results suggest that SalB could be used to develop a new therapeutic drug for EV71-induced HFMD.

• Clinical and Experimental Pediatrics
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• v.58 no.3
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• pp.112-115
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• 2015

Hand, foot, and mouth disease (HFMD) is an acute, mostly self-limiting infection. Patients usually recover without any sequelae. However, a few cases are life threatening, especially those caused by enterovirus 71 (EV71). A 12-month-old boy was admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet. After 3 days, he experienced 3 seizure episodes and was referred to our hospital. On admission, he was conscious and his chest radiograph was normal. However, 6 hours later, he suddenly lost consciousness and had developed a massive pulmonary hemorrhage that continued until his death. He experienced several more intermittent seizures, and diffuse infiltration of both lung fields was observed on chest radiography. Intravenous immunoglobulin, dexamethasone, cefotaxime, leukocyte-depleted red blood cells, fresh frozen plasma, inotropics, vitamin K, and endotracheal epinephrine were administered. The patient died 9 hours after intubation, within 3 days from fever onset. EV71 subgenotype C4a was isolated retrospectively from serum and nasopharyngeal swab by real-time reverse transcription-polymerase chain reaction. Here, we report a fatal case of EV71-associated HFMD with sudden-onset massive pulmonary hemorrhage and suspected encephalitis.

• Journal of Korean society of Dental Hygiene
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• v.9 no.3
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• pp.545-557
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• 2009

Objectives : This study was to investigate the use of mouth-guards and maxillofacial injuries and to examined the relationship among variables in athletes group. Methods : The subjects were 459(86.5%), who were 18 years or older with mean age of 20.7 years. Data was collected using a self administrated questionnaire from May 25 to June 15, 2009. We surveyed maxillofacial injuries(temporo-mandibular disorders contained) and mouth-guards usage and confidence concerning mouth-guards in athletes. The data were analysed with chi-square analysis, fisher's exact test and logistic regression using the SPSS 15.0 windows. Results : Prevalence of body or maxillofacial injuries experiences was 54.5% for athletes and 47.1% for non-athletes groups(p>0.05). The other hand, the incidence temporo-mandibular disorders was 67.0% for athletes and 49.8% for non-athletes groups(p<0.05). The experience of the use of mouth-guards was 83.3% for athletes and 78.8% for non-athletes, there were not significant differences between athletes and non-athletes groups (p>0.05). Risk factors found to be significantly related to the occurrence of maxillofacial injury were: unused mouth-guards(OR=2.83), no rules for use of mouth-guards(OR=2.46). Conclusions : Based on the findings, maxillofacial injuries experience is highly associated with mouth-guards usage, not only athletes also general people should be educated on the use of mouth-guard in order to reduce the incidence of maxillofacial injuries.

• The Journal of Internal Korean Medicine
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• v.42 no.5
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• pp.1102-1108
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• 2021

Objective: This report describes the case of a patient with essential tremors of the mouth and hands, which were improved by Yeokhan-san treatment. Methods: To relieve the symptoms, Korean medicine treatments, including Yeokhan-san, Ohaeng-Hwa acupuncture, and electronic moxibustion, were performed. To evaluate the effects of the treatments, the visual analog scale and Fahn-Tolosa-Marin clinical rating scale for tremor were used. Results: After the treatment, the patient's clinical symptoms were improved. The visual analog scale score decreased from 10 to 2 for the hand tremor and from 10 to 1 for the mouth tremor. The Fahn-Tolosa-Marin tremor scores decreased from 3 to 1 for both the hand and mouth tremors. Conclusions: The present case suggests that Yeokhan-san and Ohaeng-Hwa acupuncture are effective for the treatment of essential tremor.