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HIMALAYAN MEDICINAL RESOURCES: PRESENT AND FUTURE. A CASE STUDY: ANTIDIABETIC ACTIVITY OF SHILAJIT

  • Basnet, Purusotam
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2001.11a
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    • pp.20-33
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    • 2001
  • A major portion of drugs used in Ayurvedic system of medicine which has been practiced since the early human civilization in Indian subcontinent were of plant origin. It should be noted that 70% of the population in this region depends on Ayurveda for their medical treatment and 60% of the drug resources are obtained from the Himalayan region. Therefore, Nepal becomes a potential source of plant drug resource since it occupies a major portion of the Himalaya. In the present paper, in general a current status of medicinal plant resources of Himalayan region especially Nepal will be discussed. In addition to this, a typical example of antidiabetic activity of Shilajit will be taken for the discussion. Shilajit is one of the crucial elements in several formulations including those of Rasayana, a therapy in Ayurveda, which has been practiced in the prevention of ageing and mental disorder. Although, Shilaiit is widely used for the treatment of diabetes, no satisfactory scientific reports are available up to now. The crude Shilajit in the market is a dark brown or black rock-like substance collected from the Himalayan region with a strong smell of cow's stale urine. In our studies, Shilajit (collected in the central Himalayan region) prevented the diabetes in nonobese diabetic (NOD) mice model. Shilajit also prevented the diabetes in the rats against the action of multiple low-dose (10 ㎎/㎏, i.v., 5 times) of streptozotocin. On the other hand, Shilajit did not show antioxidative activity. The preventive action of Shilajit on diabetes is mainly focused on the Th1 and Th2 cell activities, since Th2 cells activity was found to be significantly upregulated. Shilajit, however, showed a mild action in controlling the blood sugar level in young, old, and mild diabetic rats, but not in the severe diabetic rats. It also stimulated the nitric oxide production in macrophages. Based on these evidences, the antidiabetic activities of Shilajit appear to be immunomodulative probably by protecting or strengthening insulin-producing b-cells In the pancreas. further systematic research on constituents of Shilajit and its quality evaluation is necessary to enable the use of natural medicines in the treatment of diabetes.

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Quality Characteristics of Care Food (Jelly) Prepared with Wild Carrot (Daucus carota L.) Juice (야생당근(Daucus carota L.) 주스를 첨가한 개호식품(젤리) 제조 및 품질 특성)

  • Kang, Hee-Sun;Kim, Min-Ju;Rho, Jeong-Ok;Choi, Hyong-Il;Han, Myung-Ryun;Myung, Jeung-Ho;Kim, Ae-Jung
    • Journal of the Korean Dietetic Association
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    • v.23 no.4
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    • pp.337-349
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    • 2017
  • This study evaluated the quality characteristics of jelly prepared with different levels (0%, 5%, 10%, 15%, 20%, and 25%) of wild carrot (WC, Daucus carota L.) juice as a care food for the elderly. The lightness, redness, yellowness, and delta (${\Delta}$) values of the jelly (Control, WCJ5, WCJ10, WCJ15, WCJ20, and WCJ25) decreased with increasing amounts of wild carrot juice added. The mechanical properties, such as hardness, springiness, chewiness, and gumminess, of the jelly were decreased with increasing amounts of wild carrot juice added. The total polyphenol and total flavonoid contents of the jelly increased with increasing amounts of wild carrot juice added. The DPPH radical scavenging activity ($IC_{50}$) also increased with increasing amounts of wild carrot juice added. The ${\alpha}$-glucosidase inhibitory effects of wild carrot (WC) and WCJ25 were 71% and 54.4%, respectively, compared to the positive control (acarbose). The lipase inhibitory effects of WC and WCJ25 were 44.2% and 14.4%, respectively, compared to the positive control group (orlistat). On the other hand, the sensory evaluation score was the best at WCJ20, which contained 20% wild carrot juice. In conclusion, WCJ20 or WCJ25 is expected to be a care food for the elderly with respect to texture as well as the antioxidant and enzymatic activity (${\alpha}$-glucosidase inhibitory and lipase inhibitory activities).

Affecting Factors and Musculoskeletal Symptoms among Workers in Manufacture of Electronic Components (전자부품제조업 근로자의 근골격계 자각증상과 관련요인)

  • Choi, In-Joon;Won, Jong-Uk;Kim, Chi-Nyon;Kim, Hong-Kwan;Roh, Jae-hoon
    • Journal of the Korea Safety Management & Science
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    • v.19 no.3
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    • pp.71-79
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    • 2017
  • The purpose of this study was to identify the observable symptoms of musculoskeletal disease from electronic components manufacturing workers who involved in many repetitive tasks and to provide the basic data for the prevention and management. The survey was conducted on 721 people from 15 April, 2013 to 17 May, 2013 by self­recording type. The results of the study are as follows. First, symptom complaints based on different body parts are in following order, waist was 12.9%, shoulder was 10.5%, neck was 7.4%, hand/wrist/finger was 7.4%, leg/foot was 4.4%, arm/elbow was 2.8%, and 21.9% of the respondents showed symptoms in more than one body part. Sex, age, marital status, work experience, work intensity, and past accident experience were statistically significant. Second, in the job stress evaluation, all male and female workers were below the median of Korean workers in all of 8 categories. the higher the scores for lack of job autonomy, the higher the symptom complaints of musculoskeletal disease. In the case of patients complain observable symptoms of musculorskeletal disease, they should receive proper outpatient treatment, various programs such as stretching by body parts, setting up a desirable working posture, switching to cyclical work, should b developed as much as possible.

Analysis of Influence of Work and family life priority and Recognition Difference of Work-Family Reconciliation Policy on Satisfaction of Working Condition Using Path Analysis Model : Focused on Industrial Groups Showing Gender Differences (일·가정생활 우선도와 일·가정 양립제도에 대한 인식차이가 근무 만족도에 미치는 영향력 분석 - 성별 차이를 보이는 산업군을 중심으로 -)

  • Park, Min Jung
    • Journal of Family Resource Management and Policy Review
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    • v.23 no.3
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    • pp.43-74
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    • 2019
  • The purpose of this study is to analyze the effect of perceptions of work and family life on employee job satisfaction and to form a policy approach that contributes to the enhancement of worker satisfaction. In particular, we wanted to analyze how the characteristics of each variable appeared in industry groups with different gender ratios of workers. A notable point of the study was that the respondents who answered that work and family had similar importance were satisfied with their working conditions. In addition, it was found that the higher an employee's evaluation of the work-family reconciliation policy, the higher the employee's satisfaction with their working conditions. As a result of a path analysis, it was found that the most male-dominant industry was manufacturing, and the most female-dominant industry was health and social welfare. In the case of respondents who were employed in the most-male dominant industry, the degree of an employee's understanding of the work-family reconciliation policy recognition, rather than the relative priorities of work and family life, had a greater effect on job satisfaction. On the other hand, respondents who were employed in the most-female dominant industry confirmed that their level of education was highly related to the degree of institutional recognition.

Impact of Outliers on the Statistical Measures of the Environmental Monitoring Data in Busan Coastal Sea (이상자료가 연안 환경자료의 통계 척도에 미치는 영향)

  • Cho, Hong-Yeon;Lee, Ki-Seop;Ahn, Soon-Mo
    • Ocean and Polar Research
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    • v.38 no.2
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    • pp.149-159
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    • 2016
  • The statistical measures of the coastal environmental data are used in a variety of statistical inferences, hypothesis tests, and data-driven modeling. If the measures are biased, then the statistical estimations and models may also be biased and this potential for bias is great when data contain some outliers defined as extraordinary large or small data values. This study aims to suggest more robust statistical measures as alternatives to more commonly used measures and to assess the performance these robust measures through a quantitative evaluation of more typical measures, such as in terms of locations, spreads, and shapes, with regard to environmental monitoring data in the Busan coastal sea. The detection of outliers within the data was carried out on the basis of Rosner's test. About 5-10% of the nutrient data were found to contain outliers based on Rosner's test. After removal (zero-weighting) of the outliers in the data sets, the relative change ratios of the mean and standard deviation between before and after outlier-removal conditions revealed the figures 13 and 33%, respectively. The variation magnitudes of skewness and kurtosis are 1.36 and 8.11 in a decreasing trend, respectively. On the other hand, the change ratios for more robust measures regarding the mean and standard deviation are 3.7-10.5%, and the variation magnitudes of robust skewness and kurtosis are about only 2-4% of the magnitude of the non-robust measures. The robust measures can be regarded as outlier-resistant statistical measures based on the relatively small changes in the scenarios before and after outlier removal conditions.

Evaluation of Creep Reliability of Powder Metallurgy and Cast-type Ni-based Superalloy by Using Ultrasonic Wave (분말야금 및 주조형 니켈기 초내열합금 크리프 신뢰성의 초음파 모니터링)

  • Choi, Chan-Yang;Song, Jin-Hun;Oh, Se-Ung;Kim, Chung-Seok;Kwun, Sook-In;Oh, Sung-Tag;Hyun, Chang-Yong;Byeon, Jai-Won
    • Journal of Powder Materials
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    • v.19 no.3
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    • pp.215-219
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    • 2012
  • An attempt was made to evaluate creep reliability of two commercial Ni-based superalloys by using ultrasonic wave. The materials include fine-grained PM alloy fabricated by mechanical alloying and subsequent hot isostatic pressing, and IN738LC cast alloy with a grain size of a few cm. Microstructural parameters (fraction of creep cavity and size of ${\gamma}^{\prime}$ precipitates) and ultrasonic parameters (velocity, attenuation) were measured to try to find relationships between them. Ultrasonic velocity decreased with creep cavity formation in PM alloy. On the other hand, no distinct changing trend of ultrasonic velocity was observed for IN738LC alloy. Ultrasonic attenuation was found to have a linear correlation with the size of ${\gamma}^{\prime}$ precipitates and was suggested as a potential parameter for monitoring creep reliability of IN738LC alloy.

Ultrasonographic Evaluation of an Atypical De Quervain's Disease - A Case Report - (초음파를 이용하여 진단한 비전형적 De Quervain씨 병 - 1례 보고 -)

  • Koh, In-Jun;Kim, Jung-Man;Song, Chol
    • The Journal of Korean Orthopaedic Ultrasound Society
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    • v.1 no.2
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    • pp.91-93
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    • 2008
  • De Quervain's disease is a stenosing tenosynovitis that affects the synovial sheath of the tendons of the abductor pollicis longus and extensor pollicis brevis; it can be considered a work-related disease, since it frequently is associated with highly repetitive movements in jobs using the hands. The usual sign and symptom of de Quervain's diseases are positive Finkelstein's sign and pain and tenderness around the radial styloid process. The majority of de Quervain's disease has a good results to conservative treatment, but surgery can be performed in case of recurrence or pain last more than 6 months without improvement in spite of conservative treatment. We diagnosed a patient with atypical de Quervain's disease by ultrasonography, treated by local steroid injection and pain was relieved. We report a case of atypical de Quervain's disease evaluated by ultrasonography with brief of literatures.

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Evaluation of the Effect of the Discharged Water from Bong Stream after Rainfall Events on the Bacteriological Water Quality in Gangjinman, Korea (강우 발생에 따른 남해군 봉천 방출수가 강진만 해역의 세균학적 수질에 미치는 영향 평가)

  • Park, Kun-Ba-Wui;Jo, Mi-Ra;Lee, Hee-Jung;Kwon, Ji-Young;Son, Kwang-Tae;Lee, Tae-Seek
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.44 no.6
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    • pp.622-629
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    • 2011
  • We investigated the effect of the discharged water from Bong Stream, which is located in the drainage area of Gangjinman area on the bacteriological water quality in the coastal area after rainfall events. Following 12.5 mm of rainfall, water discharged from Bong Stream had a very limited effect on bacteriological water quality in adjacent area and the affected area did not extend to the designated area. On the other hand, after 23 mm rainfall, the density of fecal coliform at stations located in the designated area was higher than at stations located in the adjacent area. The degree of bacteriological contamination at the surveyed stations in the coastal area after rainfall events did not show a relationship with distance from the shoreline. These results indicate that the direction of spread and the range of contaminants from the drainage area were affected by tides at the time of the survey. Therefore, a detailed survey of the effects of tides on the diffusion characteristics of the contaminants from Bong Stream is needed to establish a proper management plan for the surveyed area.

Evaluation of Performance and Economics of Organic Rankine Cycle Integrated into Combined Cycle Cogeneration Plant (복합열병합발전소에 적용된 유기랭킨사이클의 성능 및 경제성 평가)

  • Kim, In Seop;Kim, Chang Min;Kim, Tong Seop;Lee, Jong Jun
    • The KSFM Journal of Fluid Machinery
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    • v.20 no.1
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    • pp.41-47
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    • 2017
  • This study aimed to analyze organic Rankine cycle(ORC) which recovers discarded heat from a gas turbine based combined cycle cogeneration(CC-cogen) plant in terms of both performance and economics. The nominal electric power of the CC-cogen plant is around $120MW_e$, and heat for district heating is $153MW_{th}$. The major purpose of this study is to compare various options in selecting heat source of the ORC. Three heat sources were compared. Case 1 uses the exhaust gas from the HRSG, which is purely wasted to environment in normal plant operation without ORC. Case 2 also uses the exhaust gas from the HRSG. On the other hand, in this case, the DH economizer, which is located at the end of the HRSG, does not operate. Case 3 generates power using some of the district heating water which is supplied to consumers. The estimated ORC power generation ranges between 0.3 to 2.3% of the power generation capacity of the CC-cogen plant. Overall, Case 3 is evaluated to be better than other two options in terms of system design flexibility and power generation capacity.

Issues and Solutions of Restructuring Private Universities (사립대학의 구조조정을 둘러싼 쟁점과 합리적 해결 방안)

  • Choe, Ho-Seong
    • Journal of Fisheries and Marine Sciences Education
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    • v.24 no.6
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    • pp.901-919
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    • 2012
  • The purpose of this study is to conceptualize some issues around university restructuring in Korea, and explore rational-practical solutions ensuring the survival of higher education institutes confronting many challenges like rapid decreasing rate of birth, global open market of higher education system, and the phenomena of concentration on capital city area etc.. In order to achieve study goals, higher education policies and provisions of past governments from DaeJung Kim's to current MeongBak Lee's were analyzed, and also characteristics and directions of university restructuring of each government were identified. Through this analysis, it was evident that the main concern of university restucturing discourse was primarily focused on how to make public universities have high level of competitiveness. On the other hand, private universities had been totally alienated from university restructuring discourse since 1990's, despite their historical and great contributions to national development of our country. Based on some criticisms of educational policies of national government and partial revision proposal of the higher education act initiated by a few assemblymen, this study suggested eight solutions for developmental restructuring of private universities; constructing comprehensive framework of university restructuring, keeping market-friendly restructuring principle to allow universities take an autonomous position, revising methods, criteria and indexes of university evaluation, reducing the number of enrolling students, not the number of universities and colleges, a new policy to develop local universities allying with universities located at capital city area, differentiating private universities into two types of semi- or quasi-national university and complete autonomous university, legislating financial supports to private universities, and lastly, equal treatment of public and private universities in pursuit of half price tuition.