• 혜화의학회지
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• 제13권1호
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• pp.61-69
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• 2004

I have come to next conclusions in consequence of documentary study about medical books of many generations regarding acupuncture and moxibustion therapy of arthalgia syndrome. 1. Jing point of regular channels is most used. Next there are extraordinary point, ashi point in the acupuncture and moxibustion therapy of arthalgia syndrome. 2. The gall baldder channel of foot-shaoyang is most used. Next there are the urinary bladder channel of foot-taiyang, the large intestine channel of hand-yangming, the stomach channel of foot-yangming, the small intestine channel of hand-taiyang, the spleen channel of foot-taiyin, the liver channel of foot-jueyin, the triple-warmer channel of hand-shaoyang, the du channel, the lung channel of hand-taiyin, the kidney channel of foot-shaoyin, the pericardium channel of hand-jueyin, the heart channel of hand-shaoyin, the ren channel in the order of frequency in used channel among the twelve channels. 3. Three yang channels of foot is most used. Next there are three yang channels of hand, three yin channels of hand, three yin channels of foot in the order of frequency in use among the twelve channels. 4. The gall baldder channel of foot-shaoyang is most used. Next there are the urinary bladder channel of foot-taiyang, the large intestine channel of hand-yangming, the triple-warmer channel of hand-shaoyang, the stomach channel of foot-yangming, the small intestine channel of hand-taiyang, the liver channel of foot-jueyin, the lung channel of hand-taiyin, the spleen channel of foot-taiyin, the kidney channel of foot-shaoyin, the du channel, the pericardium channel of hand-jueyin, the ren channel the heart channel of hand-shaoyin in the order of frequency in used point among the twelve channels. 5. Huantiao is most used. Next there are Weizhong, Quchi, Yangfu, Chize Feiyang Xiyangguan Xiguan Tianjing, Sanli Xiaoluo in the order of frequency in use. 6. Jing point in the order of frequency of use, expel wind-evil and remove wetness-evil on the Acupuncture and Moxibustion Therapy of Arthalgia Syndrome.

• Clinical and Experimental Pediatrics
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• 제52권1호
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• pp.119-123
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• 2009

신세포암은 소아에서는 드물지만 모든 연령에 걸쳐 신 세뇨관의 상피세포에서 기인하는 침습적 악성 종양이다. 종양이 국소화 되어있다면 주위 림프절 절개와 함께 국소적 신절제술로 완벽히 제거될 수 있으나, 주위 림프조직을 침범한 경우나 전이 병변이 동반된 진행된 신세포암 에서는 보조 화학치료, 방사선치료 및 면역치료 등을 이용한다. Sorafenib는 경구, 다(多) kinase (multikinase) 억제제로서 최근 전이성 신장 암에 사용이 입증되었다. 그러나 설사, 피로, 탈모와 고혈압 등의 부작용과 발진이나 낙설 그리고 수족 피부 반응(hand-foot skin reaction)과 같은 피부변화 등이 보고되었다. 특히, 손바닥과 발바닥의 홍반 피부 병변을 보이는 수족 증후군(hand-foot syndrome, HFS)은 대부분 세포증식 억제 화학치료 약에 의해 야기된다. 손바닥 발바닥의 홍반성감각부전으로 알려진 수족 증후군은 저림과 고온의 물체에 대한 과민성 같은 감각이상의 전구증상 등을 특징으로 하며, 약 3- 4일 후 원위 지관절에 홍반과 동통을 수반한 양측에 대칭적 손바닥과 발바닥의 부종이 생긴다. 저자들은 14세 여아의 전이성 신세포암 치료에 sorafenib 사용 시 나타난 수족 증후군과 그에 대한 치료를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한한방소아과학회지
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• 제18권2호
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• pp.225-232
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• 2004

Objectives : Hand-Foot-Mouth disease is a highly contagious disease most often seen in children. It is caused most commonly by the coxsackievirus A16 and clinically characterized by vesicles appearing on the hands, feet and in the mouth. The purpose of this study is a approach to the oriental medical treatment of Hand-Foot-Mouth disease. Method : We studied the clinical literatures of traditional chinese medicine about Hand-Foot-Mouth disease after the year 2000. Result : Hand-Foot-Mouth disease are similar to epidemic febrile disease(溫病) dampwarm syndrome(濕溫), and epidemic disease(時疫) in Oriental Medicine. Conclusion : In oriental medical treatment is classified into the treatment of internal use, external use, and combination treatment of chinese and western medicine.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1781-1786
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• 2013

Objective: The study was designed to assess the skin and subcutaneous toxicity in patients with advanced colorectal carcinoma treated with four different schedules of FOLFOX. Methods: The patients with histologically confirmed advanced colorectal carcinoma (CRC) were included in the study as per specified inclusion criteria. Toxicity was graded according to CTC v2.0. The frequency of grade 3 and 4 adverse effects were comparatively assessed in each treatment arm. Results: Very severe toxicity was attributed to the FOLFOX7 schedule. The difference between the incidence rate of grade 4 toxicity with all other grades for all parameters of skin and subcutaneous toxicity was highly significant (p=0.00<0.001). Grade 4 hand and foot syndrome was reported only in the FOLFOX7 treatment arm. The most frequent adverse symptom of skin and subcutaneous toxicity reported in the patients treated with modified schedule of FOLFOX was pruritus (grade 1). Frequency and onset of skin and subcutaneous toxic symptoms like alopecia (p=0.000), nail discoloration (p=0.021) and pruritis (p=0.000) was significantly different in each FOLFOX treatment arm. A few cases of oncholysis were also reported in the FOLFOX7 treatment arm. Hand and foot syndrome was fast progressing in patients with grade 1 toxicity. Conclusion: Higher frequency and severity of hand and foot syndrome and pruritus wasa found in the FOLFOX7 treatment arm. Skin and subcutaneous toxicity was comparatively low in the FOLFOX6 treatment arm.

• 혜화의학회지
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• 제28권2호
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• pp.54-59
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• 2019

Objectives : The purpose of this case study is to report the effect of Korean medicine on hand-foot syndrome(HFS) casued by sorafenib(nexavar) in hepatocellular carcinoma. Methods : The patient, 77-year-old patient complaining with pain, swelling and erythema on both hands and feet which is characterized as HFS was treated with Jaungo. We evaluated the symptoms by Numeric Rating Scale and pictures. Results : The symptoms of HFS has been alleviated during the treatment. Conclusions : We suggest Jaungo as one of the alternative therapies for HFS due to sorafenib.

• 대한한방내과학회지
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• 제39권2호
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• pp.259-267
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• 2018

Hand-foot syndrome (HFS) frequently occurs after receiving chemotherapy, such as sorafenib, in patients with hepatocellular carcinoma (HCC), and this impairs quality of life (QOL). The prevalence of HFS due to sorafenib is 10-28%. The effective methods to treat HFS are not established aside from temporary discontinuation of chemotherapy agents and drug dosage adjustment because the mechanism of HFS has not been elucidated. According to a previous study, modified Dohongsamul-tang was effective in the treatment of patients with HFS and improved patients' QOL. Based on these results, we administered the soaking method with modified Dohongsamul-tang to a 50-year-old male patient with HCC complaining of HFS due to sorafenib. After two weeks, the symptoms of HFS were improved despite taking sorafenib. We suggest that modified Dohongsamul-tang is a novel method for treating HFS.

• Journal of Acupuncture Research
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• 제17권3호
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• pp.25-35
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• 2000

Objectives : The characteristic of meridian system has been similar to this of electric potentials in human body. Therefore to measure the electric potentials in healthy volunteers and patients, and to find out the characteristic of meridian system and also to do that of differences between them. Methods : Twenty-nine healthy volunteers, thirty patients diagnosed as a cerebral infarction and wind-syndrome caused by hyperactivity of the liver-yang(肝陽化風) were examined into electric potential of well(井穴) and sea(合穴) points in branches of the twelve meridians by physiograph. Results : Measurements were analyzed by factor analysis, then we obtained that both the right and the left electric potential of well and sea points in branches of the twelves meridians in healthy volunteers were divided into two factors, hand meridian and foot meridian. Where as the left electric potential of those in patients with cerebral infarction were divided into three factors, one is foot meridian, another is hand meridian with the exception of large intestine meridian, and the other is large intestine meridian and also the right electric potential were divided into three factors, foot meridian, hand meridian with the exception of large intestine and lung meridian, and large intestine and lung meridian. Conclusions : In the results, healthy volunteers differ from patients in characteristic of electrical potentials, which means that we are able to catch the characteristic of meridian system by electrical potentials of well and sea points.

• 대한한의학회지
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• 제16권1호통권29호
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• pp.21-35
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• 1995

The female's part-cold hypersensitivity syndrome is a disease which the oriental people better than the western people suffer from and if it would be sick for a long time, it could bring into the other diseases. In the Oriental Medicine, the coldness is regarded as one of the most important causes which induce female's diseases. Nowadays the number of the female patients are ascending that serously appeal the coldness-sense and pain-sense at the particular part of the body, for example, hand, foot, abdomen, waist, external genital portion and so on. These are caused by female's own characteristics of the menstration and delivery, and the influence of the circumstances. The Oriental Medicine have better effects by the diagnosis and treatment according per symptom in the contrast with the Western Medicine having difficulties in the point of accurate diagnosis and treatment. This epidemiologic study was undertaken by using specifically designed questionair and physical examination to evaluate the incidence and degree of female's part-cold hypersensitivity syndrome in 362 parous women, Who were randomly selected among the patients visiting the Department of Gynecology, Kyung Hee Medical Center from Feb. to Jul. 1995. The results were as follows: 1. The overall incident of female's part-cold hypersensitivity syndrome was 92.8%. 2. Subdivision of 336 patients was made according to severity Grade I - 31.9%, severity Grade II - 46.9%, severity Grade III - 21.4%. 3. As for the appealed portion of female's part-cold hypersensitivity syndrome, foot and hand, lower abdomen, knee, waist, hip, shoulder, leg, and ankle were in desending order. 4. As for the causes of female's part-cold hypersensitivity syndrome, it was deeply associated with the management of the abortion, delivery and puerperium. 5. The incidence of female's part-cold hypersensitivity syndrome did not show incerased tenency according to the quantity and quality of female's menstration, leukorrhea, and the increase of parity. 6. 165 patients among 336 patients wanted the treatments of the Oriental Medicine.

• 대한한방내과학회지
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• 제42권3호
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• pp.340-350
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• 2021

Objectives: Hand-foot syndrome (HFS) is a common adverse effect of chemotherapy in cancer patients. This review synthesizes research results to assess the effect of traditional Korean medicine (TKM) on HFS in cancer patients. Methods: Four databases (PubMed, The Cochrane Central Register of Controlled Trials, Research Information Sharing Service, China National Knowledge Infrastructure) were searched for randomized controlled trials (RCTs) to assess the effects of TKM on HFS. The effects and quality of RCTs were assessed with the Cochrane risk of bias (ROB) tool. Results: Six RCTs met our study criteria. In all six, TKM showed improvement in HFS symptoms as well as quality of life scores when compared to the control group. However, the methodological quality of RCTs was relatively low due to the unclear or high ROB. Conclusions: TKM would be helpful to patients with HFS after chemotherapy. To clarify the clinical efficacy of TKM, well-designed studies are required in the future.

• Journal of Veterinary Science
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• 제24권6호
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• pp.76.1-76.6
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• 2023

An 11-year-old neutered male Miniature Poodle with a stage 3 apocrine gland adenocarcinoma was started on chemotherapy with toceranib phosphate after surgery. Beginning on day 10 of toceranib, the dog's foot pads became erythematous and hyperkeratinized. The dog complained of pain, inability to walk, depression, and loss of appetite. The symptoms resolved when toceranib was discontinued and reappeared when toceranib was resumed. Grade 3 palmar-plantar erythrodysesthesia was identified as an adverse event of toceranib based on the VCOG-CTCAE and Naranjo scale. Although very rare in veterinary medicine, clinicians should consider that palmar-plantar erythrodysesthesia can occur after toceranib administration.