• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9467-9470
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• 2014

Background: Research indicates that oxidative stress induced by smoking plays a role in breast cancer. In view of these reports, we aimed to study th relationship between smoking and oxidative stress in breast cancer patients from the western region of Nepal. Materials and Methods: The study included a control group of 42 females (non-smoking healthy women) and a test group sudivided into Group I consisting of 46 female breast cancer patients who were smokers and Group II consisting of 42 non-smoking breast cancer patients. Detailed history of the patients was collected with the help of pre-test proforma. Plasma levels of malondialdehyde (MDA), total antioxidant activity (TAA) which represents total dietary antioxidants, vitamin C and ${\alpha}$- tocopherol were estimated by standard methods. Statistical analysis was done using SPSS version 16. Results: The plasma MDA, TAA, vitamin C and ${\alpha}$- tocopherol were $1{\pm}1.4nmol/ml$, $918{\pm}207{\mu}mol/L$, $1{\pm}0.24mg/dL$ and $0.94{\pm}0.31mg/dL$ in controls, $5{\pm}1.2nmol/ml$, $458{\pm}166{\mu}mol/L$, $0.64{\pm}0.32mg/dL$ and $0.5{\pm}0.3mg/dL$ in Group-I and $2.56{\pm}1.2nmol/ml$, $663{\pm}178{\mu}mol/L$, $0.78{\pm}0.2mg/dL$ and $0.77{\pm}0.2mg/dL$ in Group- II, respectively. Vitamin C, ${\alpha}$- tocopherol and TAA (p=0.001) were significantly reduced whereas MDA (p=0.001) was significantly raised in Group-I when compared to controls and Group-II. Conclusions: We observed a significant rise in oxidative stress and low levels of antioxidants in breast cancer patients with smoking habit. It is well known that free radicals facilitate the progression of breast cancer, possibly increasing the risk of progression to the next stage.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1847-1850
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• 2013

We conducted a hospital case-control study by genotyping four potential functional single nucleotide polymorphisms (SNPs) to assess the association of Xeroderma pigmentosum complementation group F (XPF) with gastric cancer susceptibility, and role of XPF polymorphisms in combination with H.pylori infection in risk definition. A total of 331 patients with gastric cancer and 355 controls were collected. Four SNPs of XPF, rs180067, rs1799801, rs2276466 and rs744154, were genotyped by Taqman real-time PCR method with a 7900 HT sequence detector system. The gastric cancer patients were more likely to have smoking habit, a family history of cancer and H.pylori infection. We did not find any significant difference in the genotype distributions of XPF rs180067, rs1799801, rs2276466 and rs744154 between cases and controls. However, multivariate logistic analysis showed a non-significant decreased risk in patients carrying rs180067 G allele, rs1799801 T allele or rs2276466 T allele genotypes. A non-significant increased risk of gastric cancer was found in individuals carrying the rs744154 GG genotype. Stratification by H.pylori infection and smoking was not significantly different in polymorphisms of XPF rs180067, rs1799801, rs2276466 and rs744154. The four XPF SNPs did not show significant interaction with H.pylori infection and smoking status (P for interaction was 0.35 and 0.18, respectively). Our study indicated that polymorphisms in rs180067, rs1799801, rs2276466 and rs744154 may affect the risk of gastric cancer but further large sample size studies are needed to validate any association.

• 한국의상디자인학회지
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• 제10권1호
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• pp.1-9
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• 2008

The purpose of this research is to lay the foundation that middle aged woman takes care of more healthy, beautiful, attractive external features and prepares successful ageing on studying a difference of recognition between an actual somatotype and an ideal somatotype after we examine an actual somatotype and an ideal somatotype in the object of about $40{\sim}50$ middle-aged woman, dwells in Seoul, is the main group of a home consumption socially. The result of comparing a difference between an actual somatotype and an ideal somatotype was showing that in case of a facial form, the group which their faces are an egg-shaped prefers an egg-shaped and the group which their faces are a round-shaped prefers a round-shaped. In case of a silhouette, all groups prefers a normal type most. In case of a shoulder's type, all groups prefer a normal type most. In case of a shoulder-waist line, all groups prefers a Y line most. In case of a breast's form, all groups prefer a normal type most. In case of a back's form, all groups prefer a normal type most. In case of a buttocks' form, all groups prefers a normal type most. In case of a leg's form, all groups prefers a normal type most. On putting together research result as yet, middle aged women wish a similar somatotype irrespective of an age, an obesity measurement and this means a recognition of making an effort to be beautiful is alike. Therefore, it is necessary to recognize a somatotype of middle aged women uprightly and it must be accomplished a continuous, systematic consultation and education about a weight-control on exercising and not to mention of making a desirable eating habit.

• 한국식품영양학회지
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• 제29권1호
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• pp.43-51
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• 2016

This study aimed to evaluate the health concern, eating habits, dietary behavior, and psychological stress among middle-aged adults in Chungnam according to their exercise status. A total of 437 adults with a mean age of 42.6 years participated in this study and completed a questionnaire survey. The subjects were divided into one of three groups according to their exercise status: never doing exercise (NDE; n=144), doing exercise once a week (DEO; n=186), and doing exercise twice a week or more (DET; n=107). Results demonstrated significant differences in concern about health, subjective health status, meal regularity, dietary problems, and stress score among the three groups. The DET and DEO groups were more concerned about their health (p<0.001), and had a perception that their health status was better than that of the NDE group (p<0.01). A larger percentage of the DET group had breakfast everyday (p<0.05) and a smaller percentage of the DET group had dietary problems such as irregular mealtime and skipping meals (p<0.01), compared to the other groups. The average stress score of the DET group was significantly lower than that of the DEO and NDE groups (p<0.05). The results reveal that doing regular exercising at least twice a week is associated with higher health concern, more desirable dietary habits, and lower psychological stress in middle-aged adults. These findings support the beneficial effects of regular exercise for health, dietary habits, and stress control.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1453-1461
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• 2016

Regarding 'mate' intake (infusion of Ilex paraguariensis herb, a staple beverage in temperate South American regions), most epidemiologic studies showed positive associations with risk of some cancers, (e.g. upper aerodigestive tract), but evidence on breast cancer (BC) risk is limited to a previous multi-site study, which reported a non significant odds ratio [OR]=0.85, 95% confidence interval [95% CI] 0.67-1.09, p for trend=0.31) for the highest quartile of intake. The present study was conducted in order to further assess associations of 'mate' intake with BC risk. We combined two databases of women belonging to public and private healthcare hospitals. The sample included 572 BC incident cases and 889 controls interviewed with a specific questionnaire featured by socio-demographic, reproductive and lifestyle variables, and a food frequency questionnaire of 64 items, also analyzing 'mate' intake (consumer status, daily intake, age at start, age at quit, duration of habit, intensity of intake). ORs and their 95%CI were calculated through unconditional logistic regression, adjusting for relevant potential confounders. The highest quartile of 'mate' intake was inversely associated with BC risk (OR=0.40, 95%CI 0.26-0.57, p for trend <0.001). Stratified analyses also displayed strong significant inverse associations for 'mate' in frequent tea drinkers (OR=0.22), high energy intake (OR=0.23), high body mass index (OR=0.29) and in postmenopausal women (OR=0.36), among other results. As conclusions, we found evidence of a significant inverse association for 'mate' intake and BC risk.

• 동아시아식생활학회지
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• 제25권1호
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• pp.49-63
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• 2015

The purpose of this study was to investigate body recognition, eating patterns, and health status of female college students in Seoul according to body mass index. In this study, we classified subjects as underweight, normal weight, and obese according to BMI. The mean age of subjects was $20.69{\pm}1.72$ years. Average height, weight or BMI of subjects were $161.49{\pm}5.39cm$, $52.17{\pm}6.53kg$ and $20.01{\pm}2.35kg/m^2$, respectively. Body satisfaction rate was 11.5% for 'Yes', whereas body dissatisfaction rate was 88.5% (p<0.05). Body dissatisfaction rates for the 'overweight', 'body dissatisfaction' and 'underweight' groups were 54.7%, 37.5% and 3.1%, respectively. The most common reason for controlling weight was 52.8% for 'to look pretty', whereas 'stress' at 45.5% was the most common in the obese group. 'Exercise + diet therapy' was used by 48.7%, followed by 'hungry' (23.9%), 'exercise' (17.3%) and 'intermittent diet' (6.1%). 'Regular exercise' 35.3%, 'A good rest & sleep' 32.4% and 'Regular meals & taking nutrition' 26.6% were significantly important (p<0.05). Overeating was lower among obese subjects, whereas consumption of fried foods and high-fat meats was higher (p<0.05). These results suggest the need for proper nutrition education for college students.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3061-3064
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• 2012

Aim: An epidemiological shift has resulted in increase in the prevalence of non-communicable diseases (NCD). Unlike other NCDs which are easily and definitely preventable, the knowledge of cancer prevention is still limited at present. Various aetiological factors are difficult to control since those are habit forming. Hence an available remedy remains its secondary and tertiary prevention for which appropriate planning is of paramount importance. Evidence based planning requires careful analysis of data with a view to prioritize various cancers. Keeping in view the fact that the adaptation of smoking free status in Chandigarh city might have a far reaching positive effect on the cancer related morbidity of the people, the following study was undertaken to provide base line data to be used for future comparisons. Methods: The registers maintained in the Department of Radiotherapy were checked and those belonging to the years 1999 to 2009 were utilized to analyze the cancer morbidity in respect to age, sex, and year of presentation to health care facility. Results: A total of 4,600 cancer patients (males=2276, females=2324) demonstrated a gradual increase in the number of cancer cases from 150 in the year 1999 to 783 in the year 2009. The most common cancers amongst males were cancer of gastro-intestinal tract (GIT) and lung (including larynx) constituting 37.3% and 27.1% of the total, respectively. In females these were cancers of breast and cervix representing 33.3% & 17.6% of total cancer cases, respectively, and lung cancer constituted 5.3%. The maximum cases of bone cancer (53.8% of all bone cancers) were observed amongst children aged less than 20 years and lung cancer (48.2% of all lung cancers) among the elderly aged 60-69 years. The.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2923-2933
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• 2016

Recently, we reported an inverse association between high 'mate' intake (infusion of Ilex paraguariensis herb, a staple beverage in temperate South America) and breast cancer (BC) risk. Stronger inverse associations were found in high strata of tea, vegetable, fruit and energy intakes, and in overweight/obese women, suggesting possible roles for 'mate' mainly from its antioxidant contribution. The present study attempted to thoroughly explore possible associations among 'mate' and tea intake, dietary antioxidants and BC risk. Combining two databases of previous studies, 572 BC incident cases and 889 controls were interviewed with a specific questionnaire featuring socio-demographic, reproductive and lifestyle variables, and a food frequency questionnaire (64 items), focusing on 'mate' intake (consumer status, daily intake, age at start, age at quit, duration of habit). Food-derived nutrients were calculated from available databases. Odds ratios (OR) and their 95% confidence intervals were calculated through unconditional logistic regression, adjusting for relevant potential confounders. The highest 'mate' intake was significantly inversely associated with BC risk for both low and high carotenoids (OR=0.40 vs. 0.41), vitamin C (OR=0.33 vs. 0.50), vitamin E (OR=0.37 vs. 0.45), flavonols (OR=0.38 vs. 0.48) and reduced glutathione (OR=0.48 vs. 0.46) strata. High tea intake showed significant inverse risk associations only with high carotenoids (OR=0.41), vitamin E (OR=0.48) and reduced glutathione (OR=0.43) strata. In conclusion, a strong and inverse association for 'mate' intake and BC was found, independent of dietary antioxidant levels. Also strong inverse associations with tea intake were more evident only at high levels of certain dietary antioxidants.

• 한국생활과학회지
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• 제5권2호
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• pp.37-52
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• 1996

The purpose of this study was to explore the nature of parent education programs for fathers with children aged 1 through 5 year-old. One-Hundred forty-four fathers were answered using questionaire designed to elicit their perception of fathering, the details of domain parent education, and parent education program. Data were analyzed quantitatively and qualitatively to determine the contents of parent education program as perceived by the fathers. The results of this study were as follows; 1. Fathers perceived about parent education as 'The training of living behavior', 'The education about essential method of living manners and the guidance for children.' Also, fathers commented some difficult points of raising children as; 'children' sickness', 'Parents' permission or control', and 'Childrens' stubborness'. Many fathers pointed their shortages; 'to be a model of habit and behavior', 'Lacking of enough experience and imagination to their children', and 'Limiting parent's patience to their children'. 2. On the domain of parent education, six subscales of requisite degree was very high. The highest requisite domains like three questions of 34 subordinate question was; 'to encourage their children their children', knowledge about how to develop children' emotions', 'knowledge of their influence to their children' humanity'. 3. Fathers answered that a parent education was needed in infant period. They choose suitable time and place, from p.m.6 to p.m. 9 on a day and once in a week in the kindergarten. Also, the contents of parent education program were needed in order as follows; 'Communication method with a child', 'Formation of living behavior'. Moreover, 77.6% of fathers wanted to participate in the parent education program.

• Biomolecules & Therapeutics
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• 제26권2호
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• pp.218-223
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• 2018

The liver is an essential organ for the detoxification of exogenous xenobiotics, drugs and toxic substances. The incidence rate of non-alcoholic liver injury increases due to dietary habit change and drug use increase. Our previous study demonstrated that Ecklonia stolonifera (ES) formulation has hepatoprotective effect against alcohol-induced liver injury in rat and tacrine-induced hepatotoxicity in HepG2 cells. This present study was designated to elucidate hepatoprotective effects of ES formulation against carbon tetrachloride ($CCl_4$)-induced liver injury in Sprague Dawley rat. Sixty rats were randomly divided into six groups. The rats were treated orally with ES formulation and silymarin (served as positive control, only 100 mg/kg/day) at a dose of 50, 100, or 200 mg/kg/day for 21 days. Seven days after treatment, liver injury was induced by intraperitoneal injection of $CCl_4$ (1.5 ml/kg, twice a week for 14 days). The administration of $CCl_4$ exhibited significant elevation of hepatic enzymes (like AST and ALT), and decrease of antioxidant related enzymes (superoxide dismutase, glutathione peroxidase and catalase) and glutathione. Then, it leaded to DNA damages (8-oxo-2'-deoxyguanosine) and lipid peroxidation (malondialdehyde). Administration of ES formulation inhibited imbalance of above factors compared to $CCl_4$ induced rat in a dose dependent manner. Real time PCR analysis indicates that CYP2E1 was upregulated in $CCl_4$ induced rat. However, increased gene expression was compromised by ES formulation treatment. These findings suggests that ES formulation could protect hepatotoxicity caused by $CCl_4$ via two pathways: elevation of antioxidant enzymes and normalization of CYP2E1 enzyme.