• 제목/요약/키워드: hER

검색결과 336건 처리시간 0.032초

Local mechanical properties of corrosion layers formed on T91 and SS316L steels after exposure to static liquid LBE at 500 ℃ for 1000 h obtained by nano-indentation

  • Zhikun Zhou;Juan Du;Chenwen Tian;Xuhao Peng;Yabo Wu;Xi Lv;Yixiong Zhang;Ziguang Chen
    • Nuclear Engineering and Technology
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    • 제56권8호
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    • pp.3067-3075
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    • 2024
  • Static corrosion tests in LBE under oxygen-saturated and -depleted conditions at 500 ℃ for 1000 h were conducted to investigate the corrosion-induced diffusion layers on T91 and SS316L steels subject to dissolution and oxidation corrosion. Following nano-indentation experiments examined the variations of local mechanical properties within the corrosion layers. Under the present conditions, T91 steel showed better resistance to dissolution corrosion while higher susceptibility to oxidation corrosion against SS316L. For both steels, nano-indentation results showed a gradual decrease in mechanical properties from steel matrix to the corrosion side after dissolution corrosion. When subject to oxidation corrosion, the oxide scale formed on T91 steel showed lower Er-modulus and enhanced hardness in comparison with those of the steel matrix. An obvious decrease in both modulus and hardness was found at the interface between steel matrix and oxide scale.

화행 유형의 하위분류 가능성과 그 문제점 (Moglichkeit der Unterklassifikation des Sprechakttyps und deren Probleme)

  • 강창우
    • 한국독어학회지:독어학
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    • 제9집
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    • pp.195-215
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    • 2004
  • In der vorliegenden Arbeit wird die $M\"{o}glichkeit$ der Unterklassifikation des Sprechakttyps untersucht. Zur Klassifikation von Sprechakten hat Searle (1969) $zw\"{o}lf$ Kriterien vorgeschlagen, und mit den folgenden drei Kriterien hat er funf Sprechaktklassen herausgearbeitet: $illokution\"{a}rer$ Zweck, Entsprechungsrichtung und psychologischer Zustand. Bei der Unterklassifikation dieser $f\"{u}nf$ Sprechaktklassen $k\"{o}nnen$ aber die von Searle vorgeschlagenen Klassifikationskriterien kaum gebraucht werden, so dass zur Unterklassifikation jeder Sprechaktklasse neue Kriterien $eingef\"{u}hrt$ werden mussten. Dabei stellt sich die Frage, was als Unterklassifikationskriterien dienen und wie ausdifferenziert eine Spreckaktklasse bzw. ein Sprechakttyp unterklassifiziert werden kann. Im 1. Kapitel werden neben den Klassifikationskriterien von Searle die Kriterien, die in den bisherigen Unterklassifikationen der Sprechaktklassen verwendet wurden, kritisch betrachtet. Im 2. Kapitel wird auf die Frage der Ausdifferenzierungsgrenze $n\"{a}her$ eingegangen, wobei diskutiert wird, ob die Unterklassifikation der Fragehandlung von Hindelang (1981) und die des Insistierens von Franke (1990) genugend ausdifferenziert sind oder es noch $M\"{o}glichkeiten$ besteht, sie noch weiter auszudifferenzieren. Die Frage nach der Ausdifferenzierungsgrenze ist mit der Frage gleichzusetzen, inwieweit eine Sprechhandlung ohne Verlust ihres Handlungscharakters in Untertypen zerlegt werden kann. Um diese Frage zu beantworten, wird der Begriff 'Basishandlung' $eingef\"{u}hrt$, den von Wright (1974) im Rahmen seiner Theorie der Kausalitat entwickelt hat. In Analogie zu diesem Begriff wird der Begriff 'Basis-Sprechhandlung' vorgeschlagen und wie folgt definiert: 1. Obere Grenze: Eine Basis-Sprechhandlung ist die Sprechhandlung, die nicht durch den Vollzug der anderen Sprechhandlungen ausgefuhrt werden kann. 2. Untere Grenze: Durch eine $\"{A}u{\ss}erung$ bzw. einen Teil der $\"{A}{\ss}erung$ kann nur dann eine Basis-Sprechhandlung vollzogen werden, wenn sieler eine $\"{A}nderung$ des Wissens oder der Handlung des $H\"{o}rers$ $herbeif\"{u}hrt$. Diese These wird anhand der Beispiele $\"{u}berpr\"{u}ft$, deren kommunikative $Selbst\"{a}ndigkeit$ schon durch andere Studien $best\"{a}tigt$ wurde. Als weiteres Kriterium zur Entscheidung $\"{u}ber$ die $M\"{o}glichkeit$ der Unterklassifikation wird im 4. Kapitel der Begriff 'kommunikativer Zweck' $eingef\"{u}hrt$ und $dar\"{u}ber$ diskutiert, wie der kommunikative Zweck der Untertypen einer Sprechaktklasse bzw. eines Sprechakttyps definiert und beschrieben werden kann. Dabei wird festgestellt, dass er durch die Spezifizierung des kommunikativen Zwecks der Sprechaktklasse bzw. des Sprechakttyps, zu der/zu dem die Untertypen $geh\"{o}ren$, definiert und beschrieben werden kann, wobei die semantischen, die kontextuellen und die sitiativen Aspekte $mitbe\"{u}cksichtigt$ werden sollen.

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민간경비원 강제력 행사의 법적 근거 -한국과 독일의 비교를 중심으로- (Rechtliche Handlungsgrundlage des privaten Sicherheitsdienstes)

  • 이성용
    • 시큐리티연구
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    • 제13호
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    • pp.327-350
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    • 2007
  • 민간경비 임무의 본질은 타인의 생명, 신체 재산을 보호하는 것이다. 타인의 법익보호 임무 수행하는 과정에서는 빈번하게 물리력을 사용하여 침해자나 관련 없는 제3자의 법칙을 침해하는 상황이 발생하게 된다. 이러한 민간경비원의 강제력 행사를 정당화하는 법적근거는 단일법령에서 정하지 않고 형법, 형사소송법 등에 산재되어 있으며, 각 개별법학의 이론들을 따르고 있어, 이에 대한 체계적인 연구가 요구된다. 원칙적으로 경비원의 법적권한은 크게 3가지로 구분될 수 있다. 그 첫째는 누구에게나 인정되는 보편적인 긴급권(Notrechte)으로서 정당방위, 긴급구조, 긴급피난, 현행범체포 등이 이에 해당한다. 둘째, 경비사용자로부터 위임받아 행사할 수 있는 권한으로는 자력구제권과 가택관리권을 들 수 있다. 또 다른 하나는 개별법령에 의해서 국가의 고권적 권한을 공무수탁의 형식으로 위임받아 수행하는 형식이 될 것이다. 본고에서는 민간경비원의 법적권한에 관한 독일에서의 논의를 자세히 소개하고, 우리 법제의 해설과 실무적 적용가능성을 검토함으로써, 민간경비원의 적법한 권한행사와 국민적 신뢰제고를 위한 이론적 토대를 마련하고자 하였다.

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Loss of Expression and Aberrant Methylation of the CDH1 (E-cadherin) Gene in Breast Cancer Patients from Kashmir

  • Asiaf, Asia;Ahmad, Shiekh Tanveer;Aziz, Sheikh Aejaz;Malik, Ajaz Ahmad;Rasool, Zubaida;Masood, Akbar;Zargar, Mohammad Afzal
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권15호
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    • pp.6397-6403
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    • 2014
  • Background: Aberrant promoter hypermethylation has been recognized in human breast carcinogenesis as a frequent molecular alteration associated with the loss of expression of a number of key regulatory genes and may serve as a biomarker. The E-cadherin gene (CDH1), mapping at chromosome 16q22, is an intercellular adhesion molecule in epithelial cells, which plays an important role in establishing and maintaining intercellular connections. The aim of our study was to assess the methylation pattern of CDH1 and to correlate it with the expression of E-cadherin, clinicopathological parameters and hormone receptor status in breast cancer patients of Kashmir. Materials and Methods: Methylation specific PCR (MSP) was used to determine the methylation status of CDH1 in 128 invasive ductal carcinomas (IDCs) paired with the corresponding normal tissue samples. Immunohistochemistry was used to study the expression of E-cadherin, ER and PR. Results: CDH1 hypermethylation was detected in 57.8% of cases and 14.8% of normal adjacent controls. Reduced levels of E-cadherin protein were observed in 71.9% of our samples. Loss of E-cadherin expression was significantly associated with the CDH1 promoter region methylation (p<0.05, OR=3.48, CI: 1.55-7.79). Hypermethylation of CDH1 was significantly associated with age at diagnosis (p=0.030), tumor size (p=0.008), tumor grade (p=0.024) and rate of node positivity or metastasis (p=0.043). Conclusions: Our preliminary findings suggest that abnormal CDH1 methylation occurs in high frequencies in infiltrating breast cancers associated with a decrease in E-cadherin expression. We found significant differences in tumor-related CDH1 gene methylation patterns relevant to tumor grade, tumor size, nodal involvement and age at diagnosis of breast tumors, which could be extended in future to provide diagnostic and prognostic information.

Tm2O3 첨가가 MLCC용 $BaTiO3 유전특성에 미치는 영향 (Effect of Tm2O3 addition on dielectric property of barium titanate ceramics for MLCCs)

  • 김진성;이희수;강도원;김정욱
    • 한국결정성장학회지
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    • 제20권1호
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    • pp.25-29
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    • 2010
  • 페로브스카이트 구조를 갖고 $Tm_2O_3$가 첨가된 MLCC용 $BaTiO_3$ 유전체를 제조하기 위하여 환원분위기, $1320^{\circ}C$의 온도조건에서 2시간 동안 소결하였다. 유전특성 측정과 미세구조 관찰을 통하여, $Tm_2O_3$ 첨가에 따라 $BaTiO_3$ 세라믹의 유전특성에 미치는 영향에 대해 연구하였으며 각 유전체의 상분석을 통하여 이차상 유무를 확인하였다. 1 mol%의 $Tm_2O_3$를 첨가한 유전체 시편이 유전특성이 가장 우수한 반면에 2 mol% 이상의 $Tm_2O_3$를 첨가한 시편의 유전상수는 1 mol%를 첨가한 시편에 비해 낮은 값을 보였다. 유전특성에 영향을 미치는 grain 크기 및 pyrochlore 이차상 형성은 미세구조분석과 결정구조분석에 의해 조사되었다. 또한, 이들 데이터를 대표적 희토류인 $Er_2O_3$를 첨가한 유전체 시편과 비교하였고 유전특성과 관련이 있는 pyrochlore상의 형성을 상분석으로써 확인하였으며 이 결과는 세라믹 커패시터의 유전특성이 도핑에 따른 이차상과 $BaTiO_3$ tetragonality의 변화와 관련되어있다고 판단된다.

IVF-ET Program에서 Blastocyst 배아의 발생에 관한 연구 - II. 난구세포 공동배양에 의한 Blastocyst 배아의 발생 (The Studies on the Development of Human Blastocyst Embryos in IVF -ET Program - II. The Development of Human Blastocyst Embryos by co-culture with Cumulus Cells)

  • 이석원;윤산현;윤혜균;조현진;허용수;윤혜진;박세필;이원돈;임진호
    • Clinical and Experimental Reproductive Medicine
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    • 제25권1호
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    • pp.35-41
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    • 1998
  • This study was carried out to investigate the development rates of human embryos co-cultured with cumulus cells to each blastocyst stage. Human zygotes were co-cultured on cumulus cell monolayer in YS medium supplemented with 20% hFF. On day 2, if patient had four or more "good" embryos (regular blastomeres without fragmentation), embryos were further cultured for 72hrs. Blastocysts on day 5 were classified into early blastocyst (ErB), early expanding blastocyst (EEB), middle expanding Blastocyst (MEB), and expanded blastocyst (EdB) on the basis of their morphological aspects of trophectoderm cells and blastocoele. Subsequently, maximum 3 of best blastocysts were transferred in 486 cycles. The results in this study were as follows: Patients who had four or more "good" embryos on day 2 were 498 persons, but patients whose embryos could not be transferred due to failure in development to the blastocyst stage on day 5 were 12 persons (2.4%). The development rate of embryos to the blastocyst stage was 58.2% (2,885/4,957) on day 5, and the rates that developed to the ErB, EEB, MEB, and EdB stage were 15.0% (743/4,957), 14.9% (739/4,957), 14.4% (714/ 4,957), and 13.9% (689/4,957), respectively. Total 1366 blastocysts were transferred in 486 cycles (mean number=2.81). The implantation rate and the ongoing implantation rate obtained by observing the number of G-sac and FHB were 29.9% (409/1,366) and 22.5% (308/1,366), respectively. The clinical pregnancy rate was 51.2% (249/486), and the ongoing pregnancy rate' was 39.1% (190/486). Among women showing ongoing pregnancy, women with singleton were 50% (95/190), women with twin were 37.9% (72/190), and women with triplet were 12.1% (23/190). Although triplet pregnancy rate in this study was high such as 12.1%, because many blastocysts with high viability were produced in our co-culture system using cumulus cells on day 5, we really believe that a multiple pregnancy except twin should not occur by selecting good embryos for maximum two blastocyst transfer. These results demonstrate that autologous cumulus cells may be used for the production of blastocysts with high developmental competence, and the use of autologous cumulus cells to be collected easily, and to be treated conveniently at OPU must be an effective means for obtaining high implantation and pregnancy rate.

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새로운 무게센서 재발과 단결정성장(1) (Development of Frequency Weighing Sensor and Single Crystal Growth)

  • 장영남;성낙훈;채수천;배인국;김인종
    • 한국결정학회지
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    • 제8권1호
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    • pp.38-47
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    • 1997
  • 새로운 방식의 결정성장용 직경 자동제어장치를 개발하였다. 이 장치는 금속선의 장력 변화를 주파수로 변환시켜 감지하는 무게센서로서 신호전달 및 전력공급 체계가 무접촉 방식이므로 노이즈가 극소화되며 따라서 안정성, 정밀성이 종래의 센서에 비해 10배 이상 증대된다. 이 장치에서 무게센서 부분은 1) 금속선, 2) 시그날을 형성하는 Sinusoidal Wave Generator, 3) 형성된 시그날의 진폭을 조정하고 안정화 시켜주는 자동 증폭조절회로, 4) 정류장치 및 신호 변환기, 5) 시그날을 관리, 제어하는 PC 보드 등으로 구성하였고, 그 외에 2개의 검증용, 무게보정용, 성장제어용 등 4개의 프로그램을 작성하였다. 이 장치는 표준편차 값이 $\pm0.10g$(1회/sec 측정 때), 분해능이 $5{\times}10^{-5}$이고, 최대 200kg까지 결정을 성장시킬 수 있으며, 또한 압력조건은 진공조건부터 200 atm 이하, 온도조건은 $350^{\circ}C$ 이하에서 일관성, 재현성 있는 작동이 가능했다. 단결정 자동직 경제어에 필요한 정확도를 확보하기 위해 온도범위 $100^{\circ}C$$\pm0.025^{\circ}C$로자동 조절되도록 '시그날 Divider'를 제작하였다. 이 무게 센서를 $Y_3Sc_2Ga_3O_{12},\;Er-Y_3Sc_2Al_3O_{12},\;Bi_{12}GeO_{20}$ 등의 단결정 성장에 응용하였으며 매우 양호한 결정을 성공적으로 성장시킬 수 있었다.

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부유대용융법에 의한 불순이온 주입된 $TiO_2$단결정 성장 연구 (Crystal Growth of rutiles doped with Impurity Ions by Floating Zone Method)

  • 이성영;유영문;김병호
    • 한국결정학회:학술대회논문집
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    • 한국결정학회 1999년도 정기총회 및 춘계학술연구발표회
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    • pp.1-1
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    • 1999
  • 부유대용융법에 의하여 불순이온의 종류와 각 이온의 주입 농도를 달리하는 Rutile 단결정을 성장하였다. 성장된 결정으로부터 제조한 박편시료를 이용하여 결정결함과 광투과도에 미치는 각 불순이온의 영향을 조사하였다. 결정성장용 주원료로 99.99%의 TiO2를 사용하고, 불순이온 주입을 위한 원료로서 99.99%의 Al2O3, H3BO3, Ga2O3, Sc2O3, V2O5, Fe2O3, ZrO2, Er2O3, Cr2O3를 각각 사용하였다. 불순이온의 종류에 따르는 영향을 조사하기 위하여 TiO2 99.8 atomic%-불순이온 0.2atomic%의 조성이 되도록 각 이온별로 원료를 정밀하게 평량하고 균일 혼합하였다. 불순 이온의 첨가량에 따르는 영향을 조사하기 위하여 Al2O3는 각각 pure, 0.2, 0.4, 0.6 atomic%를, Cr2O3는 pure, 0.003, 0.05, 0.2 atomic%를 각각 치환하여 원료를 조합하였다. 균일 혼합된 원료를 직경 8mm의 고무 튜브에 넣고 CIP(Cold Isostatic Press0에서 2000kg/$\textrm{cm}^2$의 압력으로 성형한 후 150$0^{\circ}C$에서 1시간 소결함으로서 결정성장용 다결정 원료를 합성하였다. 합성된 다결정을 double ellipsoidal mirror 내에 설치하고,halogen lamp로 가열하여 원료의 한쪽 끝을 용융한 다음, 20rpm의 회전속도, 3-5mm/hr의 성장속도로 하는 유속 1$\ell$/min의 O2 분위기속에서 부유대용융법에 의하여 결정을 성장하였다. 성장된 결정을 성장축에 수직한 방향으로 각각 절단, 연삭, 연마한 박편을 이용하여 편광하에서 low-angle grain boundaries 및 기타의 결정결함을 관찰하였으며, 0.3$\mu\textrm{m}$~0.8$\mu\textrm{m}$ 범위 및 0.6$\mu\textrm{m}$~3.4$\mu\textrm{m}$ 범위에서의 투과 및 흡수 스펙트럼을 측정하였다. 결정 성장 결과 B3+, Er3+, Cr3+ 이온은 Ti4+ 이온과 이온의 크기 차이가 심하여 결정의 정상적인 성장을 방해하는 물성을 나타냈고, V5+, Cr3+ 이온은 흑색의 결정, Fe3+ 이온은 적갈색의 결정으로 성장되었다. Al3+, Zr4+, Al3+의 순서로 투과도가 높아지는 것이 관찰되었다. 불순이온의 농도에 따른 영향으로서 Al3+ 이온의 경우 주입농도가 높아질수록 low angle boundary와 oxygen deficiency가 감소하였고, 투과율은 조금 감소하거나 큰 차이가 없는 것으로 나타났다. 반면에 Cr3+ 이온을 주입한 경우 0.003 atomic%에서 최적의 물성을 보였으며, 주입농도가 높아질수록 결정성장이 어려워지고 광의 투과도가 급격히 저하되었다.

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퍼스와 훔볼트의 기호관 비교 (Vergleich des Zeichens von C. S. Peirce mit dem von W. v. Humboldt)

  • 안정오
    • 한국독어학회지:독어학
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    • 제3집
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    • pp.35-55
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    • 2001
  • In der Semiotik ist es sehr wichtig, den Rahmenbereich des Zeichens festzustellen, weil der Bereich des Zeichens je nach Wissenschaftler unterschiedlich ist. Dementsprechend muss jedes Forschungsergebnis in der Semiotik hinterfragt werden, um sichergehen zu $k\"{o}nnen$, ob es zur Semiotik $geh\"{o}rt$ oder nicht. Daher besteht $zun\"{a}chst$ die Notwendigkeit, zu bestimmen, was ein Zeichen ist. In diesem Zusammenhang versuchten wir in diesem Aufsatz, damit wir den Begriff 'Zeichen' besser erfassen $k\"{o}nnen$. das Zeichen von C. S. Peirce mit dem van W. v. Humboldt zu vergleichen. Zu Beginn dieses Aufsatzes stellten wir dar, was ein Zeichen ist. Dieser Vorgang ist notwendig, damit mit Hilfe des allgemeinen Begriffes des Zeichens ein Vergleich zwischen Peirce und Humboldt angestellt werden kann. Danach stellten wir die Zeichentheorie von Peirce vor. Nach Peirce ist die Sprache eine Untergattung von drei Zeichensorten, die Ikon, Index und Symbol genannt werden. Nach ihm gehbrt das Symbol zur Sprache. $F\"{u}r$ ihn ist der Interpretant im Zeichenbegriff am wichtigsten, weil ein Zeichen immer eines Interpretantes bedarf, der das Zeichen interpretiert. Aber der Interpretant ist kein Individuum, sondern ein interpretierendes $Bewu{\ss}tsein$, also eine traditionelle Gesellschaft, die ein Muster zum Interpretieren bietet. $Anschlie{\ss}end\;besch\"{a}ftigten$ wir uns mit der Theorie von Humboldt. Er benutzt verschiedene Zeichenbegriffe wie z.B. Schriftzeichen, Lautzeichen, Sprachzeichen, grammatische Zeichen, $h\"{o}rbare$ Zeichen, zeitliche Zeichen und $r\"{a}umliche$ Zeichen. Bei ihm ist die Unterscheidung zwischen Wort und Zeichen besonders wichtig, weil das Wort nicht zum Zeichen $geh\"{o}rt$, wie wir es normalerweise annehmen. Er behauptet, dass das Wort beim Produzieren motiviert ist. Daher ist nach ihm das Wort transsemiotisch. $Dar\"{u}ber$ hinaus muss das Zeichen und das Wort im Zusammenhang zwischen Sprache und Denken betrachtet werden. Wenn man das Wort als Zeichen betrachtet, ist das Wort ein Zwischending zwischen dem Sprechenden und dem Ding. Damit $k\"{o}nnen$ wir schlussfolgern; 1) Bei Humboldt ist das Zeichen em Mittel zum Denken, das sich vom transsemiotischen Wort unterscheidet. 2) Nach Peirce besteht ein Zeichen aus Ikon, Index und Symbol. Im Zeichen, das aus Reprasentamen, Interpretant und Objekt besteht, ist der Interpretant am wichtigsten, denn ein Zeichen, dass keinen Interpretant hat, ist kein Zeichen mehr, das interpretierbar ist.

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Ni-Cr-Mo계 고강도 저합금강 용접클래드 계면의 미세조직 특성 평가 (Microstructural Characterization of Clad Interface in Welds of Ni-Cr-Mo High Strength Low Alloy Steel)

  • 김홍은;이기형;김민철;이호진;김경호;이창희
    • 대한금속재료학회지
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    • 제49권8호
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    • pp.628-634
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    • 2011
  • SA508 Gr.4N Ni-Cr-Mo low alloy steel, in which Ni and Cr contents are higher than in commercial SA508 Gr.3 Mn-Mo-Ni low alloy steels, may be a candidate reactor pressure vessel (RPV) material with higher strength and toughness from its tempered martensitic microstructure. The inner surface of the RPV is weld-cladded with stainless steels to prevent corrosion. The goal of this study is to evaluate the microstructural properties of the clad interface between Ni-Cr-Mo low alloy steel and stainless weldment, and the effects of post weld heat treatment (PWHT) on the properties. The properties of the clad interface were compared with those of commercial Mn-Mo-Ni low alloy steel. Multi-layer welding of model alloys with ER308L and ER309L stainless steel by the SAW method was performed, and then PWHT was conducted at $610^{\circ}C$ for 30 h. The microstructural changes of the clad interface were analyzed using OM, SEM and TEM, and micro-Vickers hardness tests were performed. Before PWHT, the heat affected zone (HAZ) showed higher hardness than base and weld metals due to formation of martensite after welding in both steels. In addition, the hardness of the HAZ in Ni-Cr-Mo low alloy steel was higher than that in Mn-Mo-Ni low alloy steel due to a comparatively high martensite fraction. The hardness of the HAZ decreased after PWHT in both steels, but the dark region was formed near the fusion line in which the hardness was locally high. In the case of Mn-Mo-Ni low alloy steel, formation of fine Cr-carbides in the weld region near the fusion line by diffusion of C from the base metal resulted in locally high hardness in the dark region. However, the precipitates of the region in the Ni-Cr-Mo low alloy steel were similar to that in the base metal, and the hardness in the region was not greatly different from that in the base metal.